Inorganic diphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acidocalcisomal pyrophosphatase

Species:

Leishmania braziliensis

UniProt:

A4H9T7_LEIBR

TriTrypDb:

LbrM.19.0110 , LBRM2903_190005700

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4H9T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9T7

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0044237	cellular metabolic process	2	16

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	16
GO:0003824	catalytic activity	1	16
GO:0004427	inorganic diphosphate phosphatase activity	6	16
GO:0005488	binding	1	16
GO:0016462	pyrophosphatase activity	5	16
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	16
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0005509	calcium ion binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	224	230	PF00089	0.444
CLV_NRD_NRD_1	11	13	PF00675	0.735
CLV_NRD_NRD_1	226	228	PF00675	0.510
CLV_NRD_NRD_1	435	437	PF00675	0.399
CLV_NRD_NRD_1	439	441	PF00675	0.459
CLV_PCSK_KEX2_1	107	109	PF00082	0.510
CLV_PCSK_KEX2_1	225	227	PF00082	0.530
CLV_PCSK_KEX2_1	439	441	PF00082	0.447
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.482
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.447
CLV_PCSK_SKI1_1	408	412	PF00082	0.279
CLV_PCSK_SKI1_1	436	440	PF00082	0.563
CLV_PCSK_SKI1_1	48	52	PF00082	0.625
DOC_CKS1_1	206	211	PF01111	0.367
DOC_MAPK_DCC_7	336	345	PF00069	0.557
DOC_MAPK_gen_1	12	19	PF00069	0.738
DOC_MAPK_gen_1	129	137	PF00069	0.539
DOC_MAPK_gen_1	416	424	PF00069	0.463
DOC_MAPK_MEF2A_6	129	137	PF00069	0.558
DOC_PP4_FxxP_1	189	192	PF00568	0.491
DOC_USP7_UBL2_3	214	218	PF12436	0.484
DOC_USP7_UBL2_3	280	284	PF12436	0.454
DOC_USP7_UBL2_3	437	441	PF12436	0.457
DOC_WW_Pin1_4	205	210	PF00397	0.372
DOC_WW_Pin1_4	226	231	PF00397	0.337
DOC_WW_Pin1_4	41	46	PF00397	0.577
LIG_14-3-3_CanoR_1	112	119	PF00244	0.397
LIG_14-3-3_CanoR_1	30	34	PF00244	0.699
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BRCT_BRCA1_1	110	114	PF00533	0.480
LIG_BRCT_BRCA1_1	185	189	PF00533	0.508
LIG_deltaCOP1_diTrp_1	163	169	PF00928	0.373
LIG_deltaCOP1_diTrp_1	295	303	PF00928	0.497
LIG_FHA_1	100	106	PF00498	0.524
LIG_FHA_1	159	165	PF00498	0.484
LIG_FHA_1	179	185	PF00498	0.412
LIG_FHA_1	308	314	PF00498	0.456
LIG_FHA_2	169	175	PF00498	0.575
LIG_FHA_2	242	248	PF00498	0.449
LIG_FHA_2	44	50	PF00498	0.515
LIG_IRF3_LxIS_1	122	128	PF10401	0.289
LIG_LIR_Apic_2	186	192	PF02991	0.495
LIG_LIR_Apic_2	4	10	PF02991	0.725
LIG_LIR_Gen_1	111	122	PF02991	0.486
LIG_LIR_Gen_1	147	156	PF02991	0.556
LIG_LIR_Gen_1	180	189	PF02991	0.660
LIG_LIR_Gen_1	229	238	PF02991	0.361
LIG_LIR_Gen_1	32	40	PF02991	0.485
LIG_LIR_Nem_3	111	117	PF02991	0.483
LIG_LIR_Nem_3	147	153	PF02991	0.530
LIG_LIR_Nem_3	161	165	PF02991	0.275
LIG_LIR_Nem_3	180	185	PF02991	0.528
LIG_LIR_Nem_3	229	234	PF02991	0.365
LIG_LIR_Nem_3	274	279	PF02991	0.456
LIG_LIR_Nem_3	32	36	PF02991	0.649
LIG_LIR_Nem_3	358	362	PF02991	0.449
LIG_LIR_Nem_3	393	398	PF02991	0.476
LIG_PCNA_yPIPBox_3	360	374	PF02747	0.464
LIG_PDZ_Class_3	439	444	PF00595	0.520
LIG_Pex14_1	168	172	PF04695	0.471
LIG_Pex14_1	394	398	PF04695	0.469
LIG_Pex14_2	162	166	PF04695	0.354
LIG_Pex14_2	303	307	PF04695	0.512
LIG_SH2_CRK	7	11	PF00017	0.728
LIG_SH2_SRC	124	127	PF00017	0.496
LIG_SH2_STAP1	420	424	PF00017	0.517
LIG_SH2_STAT3	193	196	PF00017	0.415
LIG_SH2_STAT5	124	127	PF00017	0.379
LIG_SH2_STAT5	136	139	PF00017	0.397
LIG_SH2_STAT5	216	219	PF00017	0.378
LIG_SH2_STAT5	237	240	PF00017	0.400
LIG_SH2_STAT5	248	251	PF00017	0.444
LIG_SH3_2	275	280	PF14604	0.504
LIG_SH3_3	235	241	PF00018	0.541
LIG_SH3_3	272	278	PF00018	0.493
LIG_SH3_3	363	369	PF00018	0.557
LIG_SH3_3	39	45	PF00018	0.664
LIG_TYR_ITIM	122	127	PF00017	0.467
LIG_UBA3_1	149	154	PF00899	0.579
MOD_CDK_SPxxK_3	205	212	PF00069	0.359
MOD_CDK_SPxxK_3	41	48	PF00069	0.462
MOD_CK1_1	183	189	PF00069	0.538
MOD_CK1_1	2	8	PF00069	0.659
MOD_CK1_1	35	41	PF00069	0.599
MOD_CK2_1	241	247	PF00069	0.438
MOD_CK2_1	43	49	PF00069	0.522
MOD_CMANNOS	166	169	PF00535	0.371
MOD_GlcNHglycan	114	117	PF01048	0.389
MOD_GlcNHglycan	185	188	PF01048	0.546
MOD_GlcNHglycan	318	321	PF01048	0.339
MOD_GlcNHglycan	411	414	PF01048	0.293
MOD_GSK3_1	108	115	PF00069	0.478
MOD_GSK3_1	168	175	PF00069	0.453
MOD_GSK3_1	183	190	PF00069	0.494
MOD_GSK3_1	303	310	PF00069	0.447
MOD_GSK3_1	55	62	PF00069	0.535
MOD_LATS_1	106	112	PF00433	0.503
MOD_N-GLC_1	139	144	PF02516	0.526
MOD_NEK2_1	101	106	PF00069	0.493
MOD_NEK2_1	117	122	PF00069	0.313
MOD_NEK2_1	125	130	PF00069	0.379
MOD_NEK2_1	19	24	PF00069	0.718
MOD_NEK2_1	66	71	PF00069	0.650
MOD_PIKK_1	117	123	PF00454	0.286
MOD_PIKK_1	139	145	PF00454	0.585
MOD_PIKK_1	99	105	PF00454	0.532
MOD_PKA_2	29	35	PF00069	0.523
MOD_Plk_1	117	123	PF00069	0.463
MOD_Plk_1	187	193	PF00069	0.538
MOD_Plk_1	416	422	PF00069	0.484
MOD_Plk_1	425	431	PF00069	0.445
MOD_Plk_2-3	77	83	PF00069	0.756
MOD_ProDKin_1	205	211	PF00069	0.362
MOD_ProDKin_1	226	232	PF00069	0.339
MOD_ProDKin_1	41	47	PF00069	0.577
MOD_SUMO_for_1	200	203	PF00179	0.544
MOD_SUMO_for_1	266	269	PF00179	0.469
MOD_SUMO_rev_2	147	156	PF00179	0.508
MOD_SUMO_rev_2	353	362	PF00179	0.469
MOD_SUMO_rev_2	44	53	PF00179	0.672
TRG_ENDOCYTIC_2	124	127	PF00928	0.481
TRG_ENDOCYTIC_2	300	303	PF00928	0.462
TRG_ER_diArg_1	224	227	PF00400	0.540
TRG_ER_diLys_1	439	444	PF00400	0.564
TRG_NES_CRM1_1	356	368	PF08389	0.557
TRG_NLS_MonoExtC_3	435	440	PF00514	0.484
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDG0	Leptomonas seymouri	80%	99%
A0A0S4JW75	Bodo saltans	63%	100%
A0A1X0NVA1	Trypanosomatidae	66%	100%
A0A1X0NVH4	Trypanosomatidae	72%	100%
A0A1X0NWW9	Trypanosomatidae	67%	100%
A0A3R7KMZ3	Trypanosoma rangeli	64%	100%
A0A3S7WRH5	Leishmania donovani	94%	100%
A4H3Q3	Leishmania braziliensis	39%	100%
A4HUT3	Leishmania infantum	94%	100%
D0A7N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
D0A7N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9ANG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QH59	Leishmania major	93%	100%
V5BB26	Trypanosoma cruzi	63%	100%