4a-hydroxytetrahydrobiopterin dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pterin-4-alpha-carbinolamine dehyddrogenase

Species:

Leishmania braziliensis

UniProt:

A4H9T6_LEIBR

TriTrypDb:

LbrM.19.0100 , LBRM2903_190005600

Length:

128

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9T6

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006729	tetrahydrobiopterin biosynthetic process	6	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0019751	polyol metabolic process	4	10
GO:0034311	diol metabolic process	5	10
GO:0034312	diol biosynthetic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0042558	pteridine-containing compound metabolic process	4	10
GO:0042559	pteridine-containing compound biosynthetic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	10
GO:0046146	tetrahydrobiopterin metabolic process	5	10
GO:0046165	alcohol biosynthetic process	4	10
GO:0046173	polyol biosynthetic process	5	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1901615	organic hydroxy compound metabolic process	3	10
GO:1901617	organic hydroxy compound biosynthetic process	4	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	5	10
GO:0016829	lyase activity	2	10
GO:0016835	carbon-oxygen lyase activity	3	10
GO:0016836	hydro-lyase activity	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_1	1	4	PF02207	0.470
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.174
DOC_PP2B_LxvP_1	30	33	PF13499	0.277
DOC_USP7_UBL2_3	106	110	PF12436	0.251
LIG_14-3-3_CanoR_1	19	27	PF00244	0.489
LIG_14-3-3_CanoR_1	69	75	PF00244	0.271
LIG_FHA_2	106	112	PF00498	0.241
LIG_FHA_2	97	103	PF00498	0.265
LIG_LIR_Gen_1	58	68	PF02991	0.372
LIG_LIR_Gen_1	88	98	PF02991	0.256
LIG_LIR_Nem_3	58	64	PF02991	0.256
LIG_LIR_Nem_3	88	94	PF02991	0.256
LIG_Pex14_1	87	91	PF04695	0.277
LIG_SH2_CRK	91	95	PF00017	0.256
LIG_SH2_GRB2like	70	73	PF00017	0.332
LIG_SH2_STAT5	59	62	PF00017	0.372
MOD_CK1_1	38	44	PF00069	0.426
MOD_GlcNHglycan	20	23	PF01048	0.467
MOD_GlcNHglycan	30	33	PF01048	0.422
MOD_GSK3_1	6	13	PF00069	0.467
MOD_NEK2_1	18	23	PF00069	0.543
MOD_PIKK_1	105	111	PF00454	0.280
MOD_PKA_2	18	24	PF00069	0.468
MOD_PKA_2	7	13	PF00069	0.491
TRG_ENDOCYTIC_2	122	125	PF00928	0.450
TRG_ENDOCYTIC_2	91	94	PF00928	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV76	Leptomonas seymouri	68%	100%
A0A0S4KHT1	Bodo saltans	40%	97%
A0A1X0NV87	Trypanosomatidae	49%	96%
A0A3Q8I7V7	Leishmania donovani	85%	100%
A0A3R7MSR6	Trypanosoma rangeli	58%	100%
A0M1H4	Gramella forsetii (strain KT0803)	38%	100%
A1SSU3	Psychromonas ingrahamii (strain 37)	34%	100%
A2BPX4	Prochlorococcus marinus (strain AS9601)	35%	100%
A2BVF3	Prochlorococcus marinus (strain MIT 9515)	33%	100%
A2C7K4	Prochlorococcus marinus (strain MIT 9303)	40%	100%
A3PBL6	Prochlorococcus marinus (strain MIT 9301)	35%	100%
A4HUT4	Leishmania infantum	84%	100%
A4YEM3	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	38%	100%
A5E8P9	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)	46%	100%
A5UPS5	Roseiflexus sp. (strain RS-1)	35%	100%
A5VN26	Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)	37%	100%
A6UE17	Sinorhizobium medicae (strain WSM419)	39%	100%
A6VSD2	Marinomonas sp. (strain MWYL1)	33%	100%
A6WV21	Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37)	38%	100%
A7HSX5	Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)	48%	100%
A8G3K7	Prochlorococcus marinus (strain MIT 9215)	35%	100%
A9AXS2	Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785 / 114-95)	30%	100%
A9M6T4	Brucella canis (strain ATCC 23365 / NCTC 10854)	37%	100%
A9WI69	Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)	38%	100%
B0CIJ4	Brucella suis (strain ATCC 23445 / NCTC 10510)	37%	100%
B0T207	Caulobacter sp. (strain K31)	42%	100%
B1XN71	Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6)	37%	100%
B1ZY08	Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)	46%	100%
B2IVV2	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	30%	100%
B2S7X9	Brucella abortus (strain S19)	37%	100%
B2T7M8	Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)	39%	100%
B2UGY6	Ralstonia pickettii (strain 12J)	42%	100%
B3Q9E4	Rhodopseudomonas palustris (strain TIE-1)	48%	100%
B4RBN1	Phenylobacterium zucineum (strain HLK1)	41%	100%
B5ZTF5	Rhizobium leguminosarum bv. trifolii (strain WSM2304)	43%	100%
B6JAT9	Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)	46%	100%
B8G3F7	Chloroflexus aggregans (strain MD-66 / DSM 9485)	38%	100%
B8GYB5	Caulobacter vibrioides (strain NA1000 / CB15N)	42%	100%
B8HU56	Cyanothece sp. (strain PCC 7425 / ATCC 29141)	34%	100%
B9JCJ2	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)	45%	100%
B9JUA0	Agrobacterium vitis (strain S4 / ATCC BAA-846)	40%	100%
B9L1Y8	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)	43%	100%
B9LCC8	Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)	38%	100%
C0RGE2	Brucella melitensis biotype 2 (strain ATCC 23457)	37%	100%
C1F425	Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)	40%	100%
C3MAI8	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	40%	100%
D0A7M7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ANG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O66462	Aquifex aeolicus (strain VF5)	29%	100%
O86722	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	31%	100%
P61734	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	48%	100%
P65722	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	37%	100%
P65723	Brucella suis biovar 1 (strain 1330)	37%	100%
P73790	Synechocystis sp. (strain PCC 6803 / Kazusa)	42%	100%
Q0I8H5	Synechococcus sp. (strain CC9311)	41%	100%
Q116J2	Trichodesmium erythraeum (strain IMS101)	32%	100%
Q11D07	Chelativorans sp. (strain BNC1)	40%	100%
Q13D98	Rhodopseudomonas palustris (strain BisB5)	45%	100%
Q13SM2	Paraburkholderia xenovorans (strain LB400)	37%	100%
Q16BN1	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	38%	100%
Q1IP68	Koribacter versatilis (strain Ellin345)	43%	100%
Q1MAM8	Rhizobium leguminosarum bv. viciae (strain 3841)	46%	100%
Q1QHE0	Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)	45%	100%
Q28VA7	Jannaschia sp. (strain CCS1)	44%	100%
Q2K3A7	Rhizobium etli (strain CFN 42 / ATCC 51251)	43%	100%
Q2RNC0	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	38%	100%
Q2YNV0	Brucella abortus (strain 2308)	37%	100%
Q31C42	Prochlorococcus marinus (strain MIT 9312)	34%	100%
Q3JXT0	Burkholderia pseudomallei (strain 1710b)	42%	100%
Q3SNS9	Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)	45%	100%
Q46VT8	Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)	43%	100%
Q4FVF3	Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)	49%	100%
Q4J6J6	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	32%	100%
Q4QH58	Leishmania major	83%	100%
Q57FT6	Brucella abortus biovar 1 (strain 9-941)	37%	100%
Q5LM31	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	42%	100%
Q5R7K1	Pongo abelii	36%	100%
Q62FU4	Burkholderia mallei (strain ATCC 23344)	42%	100%
Q63PF1	Burkholderia pseudomallei (strain K96243)	42%	100%
Q7NVH7	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	35%	100%
Q7U5B3	Parasynechococcus marenigrum (strain WH8102)	39%	100%
Q7V689	Prochlorococcus marinus (strain MIT 9313)	40%	100%
Q7VD93	Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)	35%	100%
Q89WZ6	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	46%	100%
Q8DHW8	Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)	39%	100%
Q8UC22	Agrobacterium fabrum (strain C58 / ATCC 33970)	43%	100%
Q8YNL6	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	34%	100%
Q92L66	Rhizobium meliloti (strain 1021)	39%	100%
Q96YL0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	41%	100%
Q97WM6	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	31%	100%
Q98E92	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	45%	100%
Q9ABI2	Caulobacter vibrioides (strain ATCC 19089 / CB15)	42%	100%
Q9CZL5	Mus musculus	40%	94%
Q9DG45	Gallus gallus	38%	100%
Q9H0N5	Homo sapiens	37%	98%