RECA_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rad51, putative

Species:

Leishmania braziliensis

UniProt:

A4H9T5_LEIBR

TriTrypDb:

LbrM.19.0090 , LBRM2903_190005500

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9T5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	6
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	6
GO:0006974	DNA damage response	4	6
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	6
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	6
GO:0051716	cellular response to stimulus	2	6
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000730	DNA recombinase assembly	7	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0042148	strand invasion	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090735	DNA repair complex assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140299	small molecule sensor activity	1	7
GO:0140612	DNA damage sensor activity	2	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0140664	ATP-dependent DNA damage sensor activity	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0000150	DNA strand exchange activity	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	476	480	PF00656	0.520
CLV_C14_Caspase3-7	511	515	PF00656	0.689
CLV_MEL_PAP_1	126	132	PF00089	0.535
CLV_NRD_NRD_1	214	216	PF00675	0.346
CLV_NRD_NRD_1	380	382	PF00675	0.559
CLV_NRD_NRD_1	412	414	PF00675	0.551
CLV_NRD_NRD_1	85	87	PF00675	0.705
CLV_PCSK_KEX2_1	214	216	PF00082	0.346
CLV_PCSK_KEX2_1	355	357	PF00082	0.346
CLV_PCSK_KEX2_1	380	382	PF00082	0.559
CLV_PCSK_KEX2_1	412	414	PF00082	0.551
CLV_PCSK_KEX2_1	85	87	PF00082	0.705
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.346
CLV_PCSK_SKI1_1	141	145	PF00082	0.541
CLV_PCSK_SKI1_1	17	21	PF00082	0.578
CLV_PCSK_SKI1_1	352	356	PF00082	0.238
CLV_PCSK_SKI1_1	440	444	PF00082	0.475
DEG_APCC_DBOX_1	483	491	PF00400	0.600
DEG_ODPH_VHL_1	542	554	PF01847	0.764
DEG_SCF_FBW7_2	94	100	PF00400	0.583
DOC_CKS1_1	94	99	PF01111	0.587
DOC_CYCLIN_yCln2_LP_2	490	496	PF00134	0.472
DOC_MAPK_gen_1	482	489	PF00069	0.623
DOC_PP1_RVXF_1	438	444	PF00149	0.534
DOC_PP1_RVXF_1	480	486	PF00149	0.653
DOC_PP2B_LxvP_1	196	199	PF13499	0.619
DOC_PP2B_LxvP_1	494	497	PF13499	0.483
DOC_PP2B_LxvP_1	504	507	PF13499	0.555
DOC_PP4_FxxP_1	379	382	PF00568	0.556
DOC_USP7_MATH_1	128	132	PF00917	0.717
DOC_USP7_MATH_1	189	193	PF00917	0.643
DOC_USP7_MATH_1	36	40	PF00917	0.606
DOC_USP7_MATH_1	405	409	PF00917	0.713
DOC_USP7_MATH_1	553	557	PF00917	0.471
DOC_USP7_MATH_1	75	79	PF00917	0.693
DOC_USP7_MATH_1	88	92	PF00917	0.571
DOC_WW_Pin1_4	121	126	PF00397	0.612
DOC_WW_Pin1_4	309	314	PF00397	0.619
DOC_WW_Pin1_4	373	378	PF00397	0.515
DOC_WW_Pin1_4	464	469	PF00397	0.715
DOC_WW_Pin1_4	489	494	PF00397	0.531
DOC_WW_Pin1_4	93	98	PF00397	0.503
LIG_14-3-3_CanoR_1	104	110	PF00244	0.509
LIG_14-3-3_CanoR_1	116	126	PF00244	0.552
LIG_14-3-3_CanoR_1	129	136	PF00244	0.732
LIG_14-3-3_CanoR_1	215	225	PF00244	0.546
LIG_14-3-3_CanoR_1	427	435	PF00244	0.481
LIG_14-3-3_CanoR_1	505	511	PF00244	0.581
LIG_Actin_WH2_2	198	216	PF00022	0.546
LIG_Actin_WH2_2	2	19	PF00022	0.532
LIG_Actin_WH2_2	439	455	PF00022	0.501
LIG_AP2alpha_2	558	560	PF02296	0.689
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BIR_III_2	72	76	PF00653	0.751
LIG_BIR_III_4	52	56	PF00653	0.612
LIG_BRCT_BRCA1_1	375	379	PF00533	0.612
LIG_Clathr_ClatBox_1	319	323	PF01394	0.543
LIG_Clathr_ClatBox_1	554	558	PF01394	0.708
LIG_deltaCOP1_diTrp_1	558	567	PF00928	0.412
LIG_FHA_1	154	160	PF00498	0.524
LIG_FHA_1	309	315	PF00498	0.550
LIG_FHA_1	324	330	PF00498	0.539
LIG_FHA_2	148	154	PF00498	0.782
LIG_FHA_2	544	550	PF00498	0.776
LIG_GSK3_LRP6_1	373	378	PF00069	0.515
LIG_LIR_Apic_2	376	382	PF02991	0.550
LIG_LIR_Gen_1	156	163	PF02991	0.700
LIG_LIR_Gen_1	342	351	PF02991	0.462
LIG_LIR_Gen_1	561	569	PF02991	0.589
LIG_LIR_Nem_3	156	160	PF02991	0.706
LIG_LIR_Nem_3	169	173	PF02991	0.432
LIG_LIR_Nem_3	3	9	PF02991	0.532
LIG_LIR_Nem_3	342	347	PF02991	0.462
LIG_LIR_Nem_3	561	565	PF02991	0.609
LIG_NRBOX	296	302	PF00104	0.546
LIG_OCRL_FandH_1	5	17	PF00620	0.522
LIG_PDZ_Class_2	566	571	PF00595	0.642
LIG_Pex14_1	406	410	PF04695	0.717
LIG_SH2_CRK	13	17	PF00017	0.521
LIG_SH2_NCK_1	562	566	PF00017	0.585
LIG_SH2_STAP1	344	348	PF00017	0.438
LIG_SH2_STAP1	69	73	PF00017	0.550
LIG_SH2_STAT3	302	305	PF00017	0.438
LIG_SH2_STAT5	562	565	PF00017	0.557
LIG_SH3_1	122	128	PF00018	0.484
LIG_SH3_3	122	128	PF00018	0.539
LIG_SH3_3	371	377	PF00018	0.476
LIG_SH3_3	417	423	PF00018	0.790
LIG_SH3_3	514	520	PF00018	0.683
LIG_SH3_3	538	544	PF00018	0.690
LIG_SH3_3	54	60	PF00018	0.676
LIG_SUMO_SIM_anti_2	206	211	PF11976	0.438
LIG_SUMO_SIM_anti_2	549	556	PF11976	0.719
LIG_SUMO_SIM_par_1	318	324	PF11976	0.546
LIG_SUMO_SIM_par_1	364	369	PF11976	0.546
LIG_SUMO_SIM_par_1	553	558	PF11976	0.721
LIG_TRAF2_1	143	146	PF00917	0.540
LIG_TRAF2_1	270	273	PF00917	0.617
LIG_TRAF2_1	391	394	PF00917	0.564
LIG_TRAF2_1	398	401	PF00917	0.527
LIG_UBA3_1	350	355	PF00899	0.261
LIG_UBA3_1	365	370	PF00899	0.261
MOD_CDK_SPK_2	124	129	PF00069	0.509
MOD_CDK_SPxxK_3	373	380	PF00069	0.525
MOD_CK1_1	124	130	PF00069	0.677
MOD_CK1_1	197	203	PF00069	0.407
MOD_CK1_1	23	29	PF00069	0.544
MOD_CK1_1	265	271	PF00069	0.331
MOD_CK1_1	308	314	PF00069	0.421
MOD_CK1_1	385	391	PF00069	0.759
MOD_CK1_1	428	434	PF00069	0.497
MOD_CK1_1	464	470	PF00069	0.666
MOD_CK1_1	508	514	PF00069	0.559
MOD_CK2_1	147	153	PF00069	0.782
MOD_CK2_1	257	263	PF00069	0.367
MOD_CK2_1	289	295	PF00069	0.261
MOD_CK2_1	321	327	PF00069	0.290
MOD_CK2_1	427	433	PF00069	0.496
MOD_CK2_1	543	549	PF00069	0.773
MOD_Cter_Amidation	410	413	PF01082	0.554
MOD_GlcNHglycan	132	135	PF01048	0.677
MOD_GlcNHglycan	136	139	PF01048	0.696
MOD_GlcNHglycan	177	180	PF01048	0.770
MOD_GlcNHglycan	257	260	PF01048	0.465
MOD_GlcNHglycan	307	310	PF01048	0.501
MOD_GlcNHglycan	38	41	PF01048	0.601
MOD_GlcNHglycan	414	417	PF01048	0.655
MOD_GlcNHglycan	430	433	PF01048	0.512
MOD_GlcNHglycan	475	479	PF01048	0.581
MOD_GlcNHglycan	531	537	PF01048	0.606
MOD_GlcNHglycan	89	93	PF01048	0.570
MOD_GSK3_1	117	124	PF00069	0.558
MOD_GSK3_1	128	135	PF00069	0.693
MOD_GSK3_1	171	178	PF00069	0.648
MOD_GSK3_1	190	197	PF00069	0.390
MOD_GSK3_1	224	231	PF00069	0.433
MOD_GSK3_1	274	281	PF00069	0.353
MOD_GSK3_1	304	311	PF00069	0.403
MOD_GSK3_1	346	353	PF00069	0.411
MOD_N-GLC_1	274	279	PF02516	0.261
MOD_N-GLC_1	428	433	PF02516	0.489
MOD_N-GLC_2	165	167	PF02516	0.500
MOD_NEK2_1	175	180	PF00069	0.742
MOD_NEK2_1	241	246	PF00069	0.328
MOD_NEK2_1	366	371	PF00069	0.411
MOD_PIKK_1	114	120	PF00454	0.618
MOD_PIKK_1	543	549	PF00454	0.773
MOD_PK_1	194	200	PF00069	0.261
MOD_PKA_1	412	418	PF00069	0.548
MOD_PKA_2	128	134	PF00069	0.678
MOD_PKA_2	241	247	PF00069	0.308
MOD_PKA_2	412	418	PF00069	0.612
MOD_PKA_2	461	467	PF00069	0.552
MOD_PKB_1	503	511	PF00069	0.440
MOD_Plk_1	148	154	PF00069	0.782
MOD_Plk_1	26	32	PF00069	0.546
MOD_Plk_1	88	94	PF00069	0.558
MOD_Plk_4	166	172	PF00069	0.501
MOD_Plk_4	262	268	PF00069	0.284
MOD_Plk_4	346	352	PF00069	0.290
MOD_ProDKin_1	121	127	PF00069	0.618
MOD_ProDKin_1	309	315	PF00069	0.513
MOD_ProDKin_1	373	379	PF00069	0.520
MOD_ProDKin_1	464	470	PF00069	0.718
MOD_ProDKin_1	489	495	PF00069	0.532
MOD_ProDKin_1	93	99	PF00069	0.509
TRG_DiLeu_BaEn_1	550	555	PF01217	0.719
TRG_DiLeu_BaEn_2	563	569	PF01217	0.534
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.542
TRG_ENDOCYTIC_2	13	16	PF00928	0.507
TRG_ENDOCYTIC_2	344	347	PF00928	0.298
TRG_ENDOCYTIC_2	562	565	PF00928	0.594
TRG_ER_diArg_1	213	215	PF00400	0.411
TRG_ER_diArg_1	379	381	PF00400	0.557
TRG_ER_diArg_1	481	484	PF00400	0.679
TRG_ER_diArg_1	502	505	PF00400	0.493
TRG_ER_diArg_1	85	87	PF00400	0.705
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF4	Leptomonas seymouri	36%	100%
A0A3Q8IB69	Leishmania donovani	69%	100%
A4HUT5	Leishmania infantum	69%	100%
E9ANG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QH57	Leishmania major	68%	100%