Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9T2_LEIBR

TriTrypDb:

LbrM.19.0060 , LBRM2903_190005200

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9T2

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0005996	monosaccharide metabolic process	3	11
GO:0006006	glucose metabolic process	5	11
GO:0006094	gluconeogenesis	6	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0016051	carbohydrate biosynthetic process	4	11
GO:0019318	hexose metabolic process	4	11
GO:0019319	hexose biosynthetic process	5	11
GO:0044238	primary metabolic process	2	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046364	monosaccharide biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004611	phosphoenolpyruvate carboxykinase activity	5	11
GO:0005488	binding	1	11
GO:0016829	lyase activity	2	11
GO:0016830	carbon-carbon lyase activity	3	11
GO:0016831	carboxy-lyase activity	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0036094	small molecule binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	541	545	PF00656	0.557
CLV_NRD_NRD_1	300	302	PF00675	0.463
CLV_NRD_NRD_1	482	484	PF00675	0.603
CLV_NRD_NRD_1	69	71	PF00675	0.643
CLV_PCSK_KEX2_1	180	182	PF00082	0.606
CLV_PCSK_KEX2_1	221	223	PF00082	0.509
CLV_PCSK_KEX2_1	287	289	PF00082	0.564
CLV_PCSK_KEX2_1	300	302	PF00082	0.450
CLV_PCSK_KEX2_1	482	484	PF00082	0.602
CLV_PCSK_KEX2_1	69	71	PF00082	0.643
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.642
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.441
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.578
CLV_PCSK_PC7_1	478	484	PF00082	0.593
CLV_PCSK_SKI1_1	221	225	PF00082	0.491
CLV_PCSK_SKI1_1	255	259	PF00082	0.420
CLV_PCSK_SKI1_1	395	399	PF00082	0.514
CLV_PCSK_SKI1_1	556	560	PF00082	0.436
CLV_PCSK_SKI1_1	575	579	PF00082	0.302
CLV_PCSK_SKI1_1	589	593	PF00082	0.427
CLV_PCSK_SKI1_1	71	75	PF00082	0.676
DEG_Nend_UBRbox_3	1	3	PF02207	0.508
DOC_CYCLIN_yClb5_NLxxxL_5	468	475	PF00134	0.401
DOC_MAPK_gen_1	167	176	PF00069	0.448
DOC_MAPK_gen_1	203	212	PF00069	0.356
DOC_MAPK_gen_1	300	306	PF00069	0.425
DOC_MAPK_gen_1	392	401	PF00069	0.533
DOC_MAPK_HePTP_8	389	401	PF00069	0.560
DOC_MAPK_MEF2A_6	392	401	PF00069	0.532
DOC_PP1_RVXF_1	187	193	PF00149	0.536
DOC_PP2B_LxvP_1	382	385	PF13499	0.494
DOC_PP4_FxxP_1	314	317	PF00568	0.497
DOC_PP4_FxxP_1	323	326	PF00568	0.506
DOC_PP4_FxxP_1	490	493	PF00568	0.687
DOC_PP4_FxxP_1	511	514	PF00568	0.553
DOC_USP7_MATH_1	118	122	PF00917	0.611
DOC_USP7_MATH_1	163	167	PF00917	0.361
DOC_USP7_MATH_1	385	389	PF00917	0.446
DOC_USP7_MATH_1	524	528	PF00917	0.596
DOC_USP7_MATH_1	548	552	PF00917	0.527
DOC_USP7_MATH_1	576	580	PF00917	0.566
DOC_WW_Pin1_4	18	23	PF00397	0.706
DOC_WW_Pin1_4	245	250	PF00397	0.420
DOC_WW_Pin1_4	289	294	PF00397	0.581
DOC_WW_Pin1_4	313	318	PF00397	0.537
DOC_WW_Pin1_4	411	416	PF00397	0.453
LIG_14-3-3_CanoR_1	10	18	PF00244	0.668
LIG_14-3-3_CanoR_1	144	148	PF00244	0.536
LIG_14-3-3_CanoR_1	181	187	PF00244	0.612
LIG_14-3-3_CanoR_1	288	294	PF00244	0.583
LIG_14-3-3_CanoR_1	337	343	PF00244	0.497
LIG_14-3-3_CanoR_1	395	400	PF00244	0.557
LIG_14-3-3_CanoR_1	460	466	PF00244	0.543
LIG_14-3-3_CanoR_1	482	492	PF00244	0.651
LIG_14-3-3_CanoR_1	528	538	PF00244	0.302
LIG_Actin_WH2_2	551	569	PF00022	0.306
LIG_APCC_ABBAyCdc20_2	556	562	PF00400	0.417
LIG_BRCT_BRCA1_1	310	314	PF00533	0.454
LIG_deltaCOP1_diTrp_1	295	299	PF00928	0.525
LIG_eIF4E_1	505	511	PF01652	0.627
LIG_eIF4E_1	99	105	PF01652	0.632
LIG_FHA_1	12	18	PF00498	0.494
LIG_FHA_1	144	150	PF00498	0.537
LIG_FHA_1	169	175	PF00498	0.558
LIG_FHA_1	363	369	PF00498	0.384
LIG_FHA_1	396	402	PF00498	0.398
LIG_FHA_1	449	455	PF00498	0.548
LIG_FHA_2	106	112	PF00498	0.610
LIG_FHA_2	400	406	PF00498	0.466
LIG_FHA_2	82	88	PF00498	0.605
LIG_LIR_Apic_2	296	302	PF02991	0.482
LIG_LIR_Apic_2	311	317	PF02991	0.453
LIG_LIR_Apic_2	321	326	PF02991	0.545
LIG_LIR_Apic_2	341	347	PF02991	0.408
LIG_LIR_Apic_2	487	493	PF02991	0.700
LIG_LIR_Gen_1	125	134	PF02991	0.549
LIG_LIR_Gen_1	378	389	PF02991	0.449
LIG_LIR_Gen_1	431	441	PF02991	0.426
LIG_LIR_Nem_3	125	130	PF02991	0.559
LIG_LIR_Nem_3	252	257	PF02991	0.439
LIG_LIR_Nem_3	378	384	PF02991	0.461
LIG_LIR_Nem_3	431	437	PF02991	0.417
LIG_MAD2	318	326	PF02301	0.555
LIG_PDZ_Class_1	593	598	PF00595	0.575
LIG_Pex14_1	143	147	PF04695	0.537
LIG_Pex14_1	492	496	PF04695	0.590
LIG_Rb_LxCxE_1	396	414	PF01857	0.301
LIG_RPA_C_Fungi	5	17	PF08784	0.629
LIG_SH2_CRK	254	258	PF00017	0.403
LIG_SH2_CRK	307	311	PF00017	0.399
LIG_SH2_CRK	344	348	PF00017	0.425
LIG_SH2_CRK	35	39	PF00017	0.665
LIG_SH2_CRK	99	103	PF00017	0.626
LIG_SH2_GRB2like	133	136	PF00017	0.555
LIG_SH2_GRB2like	35	38	PF00017	0.636
LIG_SH2_NCK_1	133	137	PF00017	0.547
LIG_SH2_NCK_1	35	39	PF00017	0.665
LIG_SH2_SRC	133	136	PF00017	0.555
LIG_SH2_SRC	35	38	PF00017	0.666
LIG_SH2_STAP1	496	500	PF00017	0.501
LIG_SH2_STAP1	560	564	PF00017	0.529
LIG_SH2_STAT5	145	148	PF00017	0.529
LIG_SH2_STAT5	238	241	PF00017	0.403
LIG_SH2_STAT5	265	268	PF00017	0.360
LIG_SH2_STAT5	277	280	PF00017	0.450
LIG_SH2_STAT5	381	384	PF00017	0.524
LIG_SH2_STAT5	496	499	PF00017	0.476
LIG_SH2_STAT5	90	93	PF00017	0.552
LIG_SH3_3	19	25	PF00018	0.633
LIG_SH3_3	434	440	PF00018	0.448
LIG_SUMO_SIM_anti_2	282	287	PF11976	0.650
LIG_SUMO_SIM_anti_2	396	402	PF11976	0.434
LIG_SUMO_SIM_anti_2	532	538	PF11976	0.421
LIG_SUMO_SIM_par_1	396	402	PF11976	0.434
LIG_SUMO_SIM_par_1	535	541	PF11976	0.438
LIG_TRAF2_1	279	282	PF00917	0.491
LIG_TRAF2_1	65	68	PF00917	0.625
LIG_TRFH_1	152	156	PF08558	0.448
LIG_TYR_ITSM	250	257	PF00017	0.445
MOD_CDK_SPK_2	313	318	PF00069	0.542
MOD_CDK_SPK_2	411	416	PF00069	0.326
MOD_CDK_SPxK_1	249	255	PF00069	0.455
MOD_CK1_1	125	131	PF00069	0.572
MOD_CK1_1	20	26	PF00069	0.657
MOD_CK1_1	388	394	PF00069	0.436
MOD_CK1_1	464	470	PF00069	0.563
MOD_CK2_1	399	405	PF00069	0.452
MOD_CK2_1	587	593	PF00069	0.457
MOD_Cter_Amidation	178	181	PF01082	0.538
MOD_Cter_Amidation	219	222	PF01082	0.436
MOD_Cter_Amidation	480	483	PF01082	0.621
MOD_GlcNHglycan	139	142	PF01048	0.558
MOD_GlcNHglycan	215	218	PF01048	0.509
MOD_GlcNHglycan	441	444	PF01048	0.534
MOD_GlcNHglycan	550	553	PF01048	0.444
MOD_GSK3_1	118	125	PF00069	0.598
MOD_GSK3_1	17	24	PF00069	0.678
MOD_GSK3_1	243	250	PF00069	0.410
MOD_GSK3_1	255	262	PF00069	0.412
MOD_GSK3_1	338	345	PF00069	0.453
MOD_GSK3_1	395	402	PF00069	0.496
MOD_GSK3_1	435	442	PF00069	0.440
MOD_N-GLC_1	118	123	PF02516	0.607
MOD_N-GLC_1	125	130	PF02516	0.559
MOD_N-GLC_1	494	499	PF02516	0.557
MOD_NEK2_1	331	336	PF00069	0.509
MOD_NEK2_1	361	366	PF00069	0.370
MOD_NEK2_1	399	404	PF00069	0.417
MOD_NEK2_1	417	422	PF00069	0.447
MOD_NEK2_1	6	11	PF00069	0.673
MOD_NEK2_2	576	581	PF00069	0.547
MOD_NEK2_2	90	95	PF00069	0.569
MOD_PIKK_1	125	131	PF00454	0.572
MOD_PIKK_1	287	293	PF00454	0.586
MOD_PKA_1	180	186	PF00069	0.625
MOD_PKA_1	287	293	PF00069	0.585
MOD_PKA_2	143	149	PF00069	0.526
MOD_PKA_2	180	186	PF00069	0.625
MOD_PKA_2	287	293	PF00069	0.574
MOD_PKA_2	524	530	PF00069	0.529
MOD_Plk_1	118	124	PF00069	0.604
MOD_Plk_1	125	131	PF00069	0.553
MOD_Plk_1	281	287	PF00069	0.635
MOD_Plk_1	362	368	PF00069	0.386
MOD_Plk_4	100	106	PF00069	0.578
MOD_Plk_4	119	125	PF00069	0.596
MOD_Plk_4	281	287	PF00069	0.645
MOD_Plk_4	385	391	PF00069	0.398
MOD_Plk_4	395	401	PF00069	0.344
MOD_Plk_4	587	593	PF00069	0.339
MOD_ProDKin_1	18	24	PF00069	0.707
MOD_ProDKin_1	245	251	PF00069	0.423
MOD_ProDKin_1	289	295	PF00069	0.579
MOD_ProDKin_1	313	319	PF00069	0.543
MOD_ProDKin_1	411	417	PF00069	0.450
MOD_SUMO_rev_2	166	171	PF00179	0.363
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.704
TRG_ENDOCYTIC_2	254	257	PF00928	0.406
TRG_ENDOCYTIC_2	35	38	PF00928	0.636
TRG_ENDOCYTIC_2	381	384	PF00928	0.524
TRG_ENDOCYTIC_2	99	102	PF00928	0.622
TRG_ER_diArg_1	159	162	PF00400	0.513
TRG_ER_diArg_1	299	301	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F9	Leptomonas seymouri	80%	100%
A0A0S4IUG4	Bodo saltans	53%	100%
A0A1X0NVG4	Trypanosomatidae	66%	97%
A0A3S5H6I1	Leishmania donovani	91%	100%
A4HUT8	Leishmania infantum	91%	100%
D0A7M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	99%
E9ANH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QH54	Leishmania major	91%	100%
V5BB32	Trypanosoma cruzi	65%	100%