Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9S9_LEIBR

TriTrypDb:

LbrM.19.0030 , LBRM2903_110021800

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9S9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.517
CLV_C14_Caspase3-7	138	142	PF00656	0.546
CLV_C14_Caspase3-7	277	281	PF00656	0.525
CLV_C14_Caspase3-7	388	392	PF00656	0.558
CLV_C14_Caspase3-7	489	493	PF00656	0.535
CLV_NRD_NRD_1	257	259	PF00675	0.718
CLV_NRD_NRD_1	72	74	PF00675	0.641
CLV_PCSK_FUR_1	255	259	PF00082	0.641
CLV_PCSK_FUR_1	66	70	PF00082	0.644
CLV_PCSK_KEX2_1	255	257	PF00082	0.726
CLV_PCSK_KEX2_1	386	388	PF00082	0.628
CLV_PCSK_KEX2_1	68	70	PF00082	0.649
CLV_PCSK_KEX2_1	71	73	PF00082	0.710
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.706
CLV_PCSK_PC7_1	66	72	PF00082	0.519
CLV_PCSK_SKI1_1	111	115	PF00082	0.590
CLV_PCSK_SKI1_1	341	345	PF00082	0.653
CLV_PCSK_SKI1_1	37	41	PF00082	0.380
CLV_PCSK_SKI1_1	377	381	PF00082	0.672
CLV_PCSK_SKI1_1	477	481	PF00082	0.562
CLV_PCSK_SKI1_1	57	61	PF00082	0.488
CLV_Separin_Metazoa	474	478	PF03568	0.541
DEG_SCF_FBW7_1	131	138	PF00400	0.664
DEG_SPOP_SBC_1	196	200	PF00917	0.513
DOC_ANK_TNKS_1	386	393	PF00023	0.678
DOC_CKS1_1	132	137	PF01111	0.802
DOC_CKS1_1	269	274	PF01111	0.690
DOC_CKS1_1	328	333	PF01111	0.544
DOC_CYCLIN_RxL_1	335	347	PF00134	0.676
DOC_CYCLIN_RxL_1	34	43	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	379	382	PF00134	0.538
DOC_PP2B_LxvP_1	127	130	PF13499	0.702
DOC_PP2B_LxvP_1	379	382	PF13499	0.538
DOC_PP4_FxxP_1	269	272	PF00568	0.697
DOC_USP7_MATH_1	10	14	PF00917	0.562
DOC_USP7_MATH_1	130	134	PF00917	0.659
DOC_USP7_MATH_1	135	139	PF00917	0.629
DOC_USP7_MATH_1	166	170	PF00917	0.788
DOC_USP7_MATH_1	196	200	PF00917	0.646
DOC_USP7_MATH_2	309	315	PF00917	0.550
DOC_USP7_UBL2_3	293	297	PF12436	0.502
DOC_USP7_UBL2_3	490	494	PF12436	0.539
DOC_WW_Pin1_4	131	136	PF00397	0.612
DOC_WW_Pin1_4	152	157	PF00397	0.607
DOC_WW_Pin1_4	162	167	PF00397	0.731
DOC_WW_Pin1_4	213	218	PF00397	0.629
DOC_WW_Pin1_4	268	273	PF00397	0.622
DOC_WW_Pin1_4	324	329	PF00397	0.803
LIG_14-3-3_CanoR_1	11	16	PF00244	0.515
LIG_14-3-3_CanoR_1	255	263	PF00244	0.580
LIG_14-3-3_CanoR_1	312	320	PF00244	0.541
LIG_14-3-3_CanoR_1	459	464	PF00244	0.553
LIG_14-3-3_CanoR_1	477	482	PF00244	0.626
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_Clathr_ClatBox_1	343	347	PF01394	0.676
LIG_Clathr_ClatBox_1	478	482	PF01394	0.509
LIG_FHA_1	126	132	PF00498	0.653
LIG_FHA_1	227	233	PF00498	0.532
LIG_FHA_1	23	29	PF00498	0.431
LIG_FHA_1	269	275	PF00498	0.749
LIG_FHA_1	395	401	PF00498	0.520
LIG_FHA_1	458	464	PF00498	0.518
LIG_FHA_1	471	477	PF00498	0.441
LIG_FHA_1	88	94	PF00498	0.532
LIG_FHA_2	117	123	PF00498	0.714
LIG_FHA_2	198	204	PF00498	0.508
LIG_FHA_2	22	28	PF00498	0.437
LIG_LIR_Apic_2	266	272	PF02991	0.542
LIG_LIR_Apic_2	369	373	PF02991	0.665
LIG_LIR_Gen_1	20	31	PF02991	0.468
LIG_LIR_Gen_1	287	295	PF02991	0.457
LIG_LIR_Gen_1	413	423	PF02991	0.708
LIG_LIR_Nem_3	20	26	PF02991	0.503
LIG_LIR_Nem_3	287	292	PF02991	0.491
LIG_LIR_Nem_3	413	418	PF02991	0.719
LIG_MYND_1	378	382	PF01753	0.671
LIG_Pex14_1	411	415	PF04695	0.448
LIG_SH2_CRK	370	374	PF00017	0.671
LIG_SH2_CRK	415	419	PF00017	0.585
LIG_SH2_NCK_1	23	27	PF00017	0.444
LIG_SH2_STAP1	35	39	PF00017	0.357
LIG_SH2_STAP1	415	419	PF00017	0.585
LIG_SH2_STAT5	23	26	PF00017	0.459
LIG_SH2_STAT5	284	287	PF00017	0.508
LIG_SH2_STAT5	320	323	PF00017	0.536
LIG_SH3_3	129	135	PF00018	0.606
LIG_SH3_3	322	328	PF00018	0.694
LIG_SH3_3	372	378	PF00018	0.723
LIG_SH3_4	184	191	PF00018	0.559
LIG_SUMO_SIM_par_1	24	30	PF11976	0.414
LIG_SUMO_SIM_par_1	283	290	PF11976	0.504
LIG_TRAF2_1	410	413	PF00917	0.447
LIG_TRFH_1	344	348	PF08558	0.671
LIG_TRFH_1	479	483	PF08558	0.494
LIG_WRC_WIRS_1	232	237	PF05994	0.533
MOD_CDC14_SPxK_1	165	168	PF00782	0.596
MOD_CDK_SPxK_1	162	168	PF00069	0.663
MOD_CDK_SPxxK_3	268	275	PF00069	0.627
MOD_CK1_1	139	145	PF00069	0.703
MOD_CK1_1	155	161	PF00069	0.613
MOD_CK1_1	17	23	PF00069	0.578
MOD_CK1_1	205	211	PF00069	0.630
MOD_CK1_1	234	240	PF00069	0.634
MOD_CK1_1	248	254	PF00069	0.611
MOD_CK1_1	287	293	PF00069	0.618
MOD_CK1_1	327	333	PF00069	0.545
MOD_CK1_1	450	456	PF00069	0.552
MOD_CK2_1	147	153	PF00069	0.558
MOD_CK2_1	239	245	PF00069	0.684
MOD_CK2_1	354	360	PF00069	0.786
MOD_GlcNHglycan	141	144	PF01048	0.654
MOD_GlcNHglycan	167	171	PF01048	0.739
MOD_GlcNHglycan	185	188	PF01048	0.550
MOD_GlcNHglycan	191	194	PF01048	0.579
MOD_GlcNHglycan	241	244	PF01048	0.555
MOD_GlcNHglycan	250	253	PF01048	0.554
MOD_GlcNHglycan	259	262	PF01048	0.558
MOD_GlcNHglycan	356	359	PF01048	0.696
MOD_GlcNHglycan	391	395	PF01048	0.670
MOD_GlcNHglycan	465	469	PF01048	0.546
MOD_GSK3_1	10	17	PF00069	0.535
MOD_GSK3_1	116	123	PF00069	0.563
MOD_GSK3_1	131	138	PF00069	0.646
MOD_GSK3_1	148	155	PF00069	0.702
MOD_GSK3_1	162	169	PF00069	0.765
MOD_GSK3_1	179	186	PF00069	0.551
MOD_GSK3_1	18	25	PF00069	0.504
MOD_GSK3_1	231	238	PF00069	0.617
MOD_GSK3_1	244	251	PF00069	0.650
MOD_GSK3_1	257	264	PF00069	0.666
MOD_GSK3_1	280	287	PF00069	0.558
MOD_GSK3_1	320	327	PF00069	0.588
MOD_GSK3_1	390	397	PF00069	0.589
MOD_GSK3_1	445	452	PF00069	0.616
MOD_GSK3_1	466	473	PF00069	0.609
MOD_GSK3_1	477	484	PF00069	0.506
MOD_GSK3_1	87	94	PF00069	0.658
MOD_N-GLC_1	11	16	PF02516	0.521
MOD_N-GLC_1	81	86	PF02516	0.559
MOD_NEK2_1	1	6	PF00069	0.571
MOD_NEK2_1	116	121	PF00069	0.530
MOD_NEK2_1	125	130	PF00069	0.629
MOD_NEK2_1	146	151	PF00069	0.524
MOD_NEK2_1	177	182	PF00069	0.550
MOD_NEK2_1	195	200	PF00069	0.515
MOD_NEK2_1	235	240	PF00069	0.634
MOD_NEK2_1	244	249	PF00069	0.591
MOD_NEK2_1	40	45	PF00069	0.480
MOD_NEK2_1	427	432	PF00069	0.604
MOD_NEK2_1	60	65	PF00069	0.511
MOD_NEK2_1	81	86	PF00069	0.600
MOD_NEK2_2	284	289	PF00069	0.471
MOD_PIKK_1	111	117	PF00454	0.676
MOD_PIKK_1	120	126	PF00454	0.562
MOD_PIKK_1	40	46	PF00454	0.451
MOD_PIKK_1	60	66	PF00454	0.473
MOD_PKA_1	256	262	PF00069	0.636
MOD_PKA_2	10	16	PF00069	0.555
MOD_PKA_2	188	194	PF00069	0.534
MOD_PKA_2	239	245	PF00069	0.667
MOD_PKA_2	256	262	PF00069	0.706
MOD_PKA_2	311	317	PF00069	0.547
MOD_PKA_2	450	456	PF00069	0.612
MOD_PKA_2	458	464	PF00069	0.667
MOD_PKB_1	255	263	PF00069	0.641
MOD_PKB_1	457	465	PF00069	0.593
MOD_Plk_1	11	17	PF00069	0.539
MOD_Plk_1	156	162	PF00069	0.662
MOD_Plk_1	202	208	PF00069	0.689
MOD_Plk_1	21	27	PF00069	0.454
MOD_Plk_1	400	406	PF00069	0.488
MOD_Plk_2-3	203	209	PF00069	0.649
MOD_Plk_2-3	22	28	PF00069	0.439
MOD_Plk_4	11	17	PF00069	0.560
MOD_Plk_4	231	237	PF00069	0.613
MOD_Plk_4	280	286	PF00069	0.563
MOD_ProDKin_1	131	137	PF00069	0.615
MOD_ProDKin_1	152	158	PF00069	0.609
MOD_ProDKin_1	162	168	PF00069	0.731
MOD_ProDKin_1	213	219	PF00069	0.623
MOD_ProDKin_1	268	274	PF00069	0.619
MOD_ProDKin_1	324	330	PF00069	0.804
MOD_SUMO_for_1	292	295	PF00179	0.485
MOD_SUMO_rev_2	290	298	PF00179	0.492
MOD_SUMO_rev_2	489	496	PF00179	0.682
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.547
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.520
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.538
TRG_ENDOCYTIC_2	23	26	PF00928	0.500
TRG_ENDOCYTIC_2	35	38	PF00928	0.331
TRG_ENDOCYTIC_2	415	418	PF00928	0.599
TRG_ER_diArg_1	255	258	PF00400	0.738
TRG_ER_diArg_1	66	69	PF00400	0.719
TRG_ER_diArg_1	70	73	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV85	Leptomonas seymouri	25%	100%
A0A3S7WRI4	Leishmania donovani	60%	100%
A4HUU0	Leishmania infantum	60%	100%
E9ANH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
Q4QH51	Leishmania major	58%	99%