Sec20 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sec20, putative

Species:

Leishmania braziliensis

UniProt:

A4H9S8_LEIBR

TriTrypDb:

LbrM.19.0020 , LBRM2903_110021700

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4H9S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9S8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	10
GO:0016192	vesicle-mediated transport	4	10
GO:0048193	Golgi vesicle transport	5	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10

Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	10
GO:0030674	protein-macromolecule adaptor activity	2	10
GO:0060090	molecular adaptor activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	280	286	PF00089	0.485
CLV_NRD_NRD_1	180	182	PF00675	0.382
CLV_NRD_NRD_1	32	34	PF00675	0.366
CLV_PCSK_KEX2_1	180	182	PF00082	0.382
CLV_PCSK_KEX2_1	32	34	PF00082	0.366
CLV_PCSK_PC7_1	176	182	PF00082	0.369
CLV_PCSK_SKI1_1	180	184	PF00082	0.395
CLV_PCSK_SKI1_1	217	221	PF00082	0.280
CLV_PCSK_SKI1_1	223	227	PF00082	0.271
CLV_PCSK_SKI1_1	269	273	PF00082	0.290
DEG_APCC_DBOX_1	175	183	PF00400	0.636
DEG_APCC_DBOX_1	20	28	PF00400	0.567
DOC_CYCLIN_RxL_1	211	224	PF00134	0.493
DOC_CYCLIN_RxL_1	266	276	PF00134	0.490
DOC_MAPK_gen_1	100	110	PF00069	0.619
DOC_MAPK_gen_1	171	179	PF00069	0.542
DOC_MAPK_gen_1	266	274	PF00069	0.509
DOC_MAPK_HePTP_8	280	292	PF00069	0.260
DOC_MAPK_MEF2A_6	103	112	PF00069	0.504
DOC_MAPK_MEF2A_6	223	230	PF00069	0.465
DOC_MAPK_MEF2A_6	277	284	PF00069	0.502
DOC_MAPK_MEF2A_6	70	78	PF00069	0.651
DOC_MAPK_NFAT4_5	277	285	PF00069	0.514
DOC_PP2B_LxvP_1	16	19	PF13499	0.558
DOC_USP7_MATH_1	145	149	PF00917	0.741
DOC_USP7_MATH_1	215	219	PF00917	0.501
DOC_USP7_MATH_1	241	245	PF00917	0.508
DOC_USP7_MATH_1	66	70	PF00917	0.699
DOC_USP7_MATH_1	95	99	PF00917	0.625
DOC_WW_Pin1_4	143	148	PF00397	0.774
DOC_WW_Pin1_4	47	52	PF00397	0.555
DOC_WW_Pin1_4	62	67	PF00397	0.718
LIG_14-3-3_CanoR_1	223	229	PF00244	0.534
LIG_14-3-3_CanoR_1	266	272	PF00244	0.496
LIG_14-3-3_CanoR_1	283	291	PF00244	0.344
LIG_14-3-3_CanoR_1	70	78	PF00244	0.537
LIG_Actin_WH2_2	165	182	PF00022	0.655
LIG_Actin_WH2_2	267	285	PF00022	0.490
LIG_FHA_1	191	197	PF00498	0.682
LIG_FHA_1	306	312	PF00498	0.485
LIG_FHA_1	69	75	PF00498	0.669
LIG_FHA_1	99	105	PF00498	0.655
LIG_FHA_2	160	166	PF00498	0.738
LIG_FHA_2	310	316	PF00498	0.455
LIG_LIR_Gen_1	307	316	PF02991	0.521
LIG_LIR_Nem_3	307	313	PF02991	0.488
LIG_MYND_1	22	26	PF01753	0.568
LIG_NRBOX	215	221	PF00104	0.490
LIG_PCNA_yPIPBox_3	265	277	PF02747	0.485
LIG_SH2_PTP2	295	298	PF00017	0.466
LIG_SH2_PTP2	310	313	PF00017	0.481
LIG_SH2_STAP1	3	7	PF00017	0.628
LIG_SH2_STAT5	295	298	PF00017	0.344
LIG_SH2_STAT5	310	313	PF00017	0.418
LIG_SH3_1	17	23	PF00018	0.557
LIG_SH3_3	16	22	PF00018	0.612
LIG_SH3_3	7	13	PF00018	0.706
LIG_SUMO_SIM_par_1	224	229	PF11976	0.543
LIG_TRAF2_1	154	157	PF00917	0.742
LIG_TRAF2_1	162	165	PF00917	0.712
LIG_TRFH_1	302	306	PF08558	0.474
LIG_TYR_ITIM	293	298	PF00017	0.233
LIG_TYR_ITSM	306	313	PF00017	0.410
LIG_WW_3	18	22	PF00397	0.554
MOD_CK1_1	11	17	PF00069	0.569
MOD_CK1_1	141	147	PF00069	0.769
MOD_CK1_1	155	161	PF00069	0.756
MOD_CK1_1	205	211	PF00069	0.726
MOD_CK1_1	224	230	PF00069	0.561
MOD_CK1_1	243	249	PF00069	0.531
MOD_CK1_1	69	75	PF00069	0.619
MOD_CK1_1	98	104	PF00069	0.589
MOD_CK2_1	159	165	PF00069	0.709
MOD_CK2_1	183	189	PF00069	0.526
MOD_CK2_1	256	262	PF00069	0.563
MOD_CK2_1	309	315	PF00069	0.450
MOD_GlcNHglycan	140	143	PF01048	0.587
MOD_GlcNHglycan	206	210	PF01048	0.514
MOD_GlcNHglycan	284	287	PF01048	0.444
MOD_GlcNHglycan	3	6	PF01048	0.347
MOD_GlcNHglycan	56	59	PF01048	0.491
MOD_GSK3_1	141	148	PF00069	0.747
MOD_GSK3_1	155	162	PF00069	0.713
MOD_GSK3_1	201	208	PF00069	0.721
MOD_GSK3_1	215	222	PF00069	0.420
MOD_GSK3_1	246	253	PF00069	0.494
MOD_GSK3_1	305	312	PF00069	0.445
MOD_GSK3_1	62	69	PF00069	0.629
MOD_GSK3_1	8	15	PF00069	0.567
MOD_N-GLC_2	195	197	PF02516	0.390
MOD_NEK2_1	1	6	PF00069	0.656
MOD_NEK2_1	219	224	PF00069	0.490
MOD_NEK2_1	250	255	PF00069	0.514
MOD_NEK2_1	267	272	PF00069	0.585
MOD_NEK2_1	282	287	PF00069	0.344
MOD_NEK2_1	8	13	PF00069	0.589
MOD_NEK2_1	89	94	PF00069	0.595
MOD_NEK2_1	96	101	PF00069	0.561
MOD_PIKK_1	146	152	PF00454	0.629
MOD_PIKK_1	98	104	PF00454	0.610
MOD_PKA_2	200	206	PF00069	0.762
MOD_PKA_2	282	288	PF00069	0.336
MOD_PKA_2	69	75	PF00069	0.524
MOD_Plk_4	305	311	PF00069	0.455
MOD_ProDKin_1	143	149	PF00069	0.774
MOD_ProDKin_1	47	53	PF00069	0.556
MOD_ProDKin_1	62	68	PF00069	0.714
MOD_SUMO_rev_2	224	233	PF00179	0.561
TRG_ENDOCYTIC_2	295	298	PF00928	0.466
TRG_ENDOCYTIC_2	310	313	PF00928	0.481
TRG_ER_diArg_1	179	181	PF00400	0.575
TRG_ER_diArg_1	31	33	PF00400	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V7	Leptomonas seymouri	61%	100%
A0A1X0NV60	Trypanosomatidae	47%	100%
A0A3S5ISC5	Trypanosoma rangeli	40%	100%
A0A3S7WRJ0	Leishmania donovani	83%	100%
A4HUU1	Leishmania infantum	83%	100%
E9ANH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QH50	Leishmania major	82%	100%
V5BBG4	Trypanosoma cruzi	45%	100%