Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9S5_LEIBR

TriTrypDb:

LbrM.18.1770 , LBRM2903_180014900

Length:

879

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9S5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.647
CLV_C14_Caspase3-7	314	318	PF00656	0.612
CLV_C14_Caspase3-7	491	495	PF00656	0.450
CLV_C14_Caspase3-7	684	688	PF00656	0.506
CLV_C14_Caspase3-7	796	800	PF00656	0.718
CLV_NRD_NRD_1	28	30	PF00675	0.545
CLV_NRD_NRD_1	42	44	PF00675	0.559
CLV_NRD_NRD_1	421	423	PF00675	0.676
CLV_NRD_NRD_1	457	459	PF00675	0.611
CLV_NRD_NRD_1	583	585	PF00675	0.660
CLV_NRD_NRD_1	757	759	PF00675	0.549
CLV_NRD_NRD_1	830	832	PF00675	0.710
CLV_PCSK_FUR_1	419	423	PF00082	0.667
CLV_PCSK_FUR_1	754	758	PF00082	0.613
CLV_PCSK_KEX2_1	292	294	PF00082	0.787
CLV_PCSK_KEX2_1	41	43	PF00082	0.598
CLV_PCSK_KEX2_1	418	420	PF00082	0.633
CLV_PCSK_KEX2_1	421	423	PF00082	0.684
CLV_PCSK_KEX2_1	457	459	PF00082	0.611
CLV_PCSK_KEX2_1	583	585	PF00082	0.660
CLV_PCSK_KEX2_1	756	758	PF00082	0.545
CLV_PCSK_KEX2_1	830	832	PF00082	0.715
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.535
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.435
CLV_PCSK_PC7_1	453	459	PF00082	0.585
CLV_PCSK_SKI1_1	607	611	PF00082	0.532
CLV_PCSK_SKI1_1	668	672	PF00082	0.459
CLV_PCSK_SKI1_1	813	817	PF00082	0.487
DEG_APCC_DBOX_1	40	48	PF00400	0.578
DEG_SCF_FBW7_1	117	124	PF00400	0.782
DEG_SCF_FBW7_1	85	90	PF00400	0.560
DEG_SPOP_SBC_1	221	225	PF00917	0.669
DEG_SPOP_SBC_1	689	693	PF00917	0.766
DEG_SPOP_SBC_1	87	91	PF00917	0.770
DOC_CKS1_1	345	350	PF01111	0.527
DOC_CKS1_1	402	407	PF01111	0.486
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.406
DOC_MAPK_DCC_7	518	526	PF00069	0.490
DOC_MAPK_gen_1	400	409	PF00069	0.496
DOC_MAPK_gen_1	41	49	PF00069	0.605
DOC_MAPK_gen_1	591	601	PF00069	0.522
DOC_MAPK_gen_1	754	763	PF00069	0.612
DOC_MAPK_MEF2A_6	400	409	PF00069	0.496
DOC_MAPK_MEF2A_6	518	526	PF00069	0.490
DOC_MAPK_MEF2A_6	594	603	PF00069	0.533
DOC_PP1_RVXF_1	823	829	PF00149	0.509
DOC_PP2B_LxvP_1	211	214	PF13499	0.791
DOC_PP2B_LxvP_1	517	520	PF13499	0.664
DOC_PP2B_PxIxI_1	782	788	PF00149	0.530
DOC_SPAK_OSR1_1	758	762	PF12202	0.546
DOC_USP7_MATH_1	121	125	PF00917	0.674
DOC_USP7_MATH_1	200	204	PF00917	0.667
DOC_USP7_MATH_1	212	216	PF00917	0.699
DOC_USP7_MATH_1	220	224	PF00917	0.453
DOC_USP7_MATH_1	296	300	PF00917	0.681
DOC_USP7_MATH_1	336	340	PF00917	0.513
DOC_USP7_MATH_1	414	418	PF00917	0.483
DOC_USP7_MATH_1	495	499	PF00917	0.432
DOC_USP7_MATH_1	554	558	PF00917	0.625
DOC_USP7_MATH_1	688	692	PF00917	0.515
DOC_USP7_MATH_1	750	754	PF00917	0.805
DOC_USP7_MATH_1	777	781	PF00917	0.728
DOC_USP7_MATH_1	791	795	PF00917	0.663
DOC_USP7_MATH_1	87	91	PF00917	0.747
DOC_USP7_MATH_1	99	103	PF00917	0.740
DOC_WW_Pin1_4	117	122	PF00397	0.712
DOC_WW_Pin1_4	229	234	PF00397	0.632
DOC_WW_Pin1_4	283	288	PF00397	0.765
DOC_WW_Pin1_4	334	339	PF00397	0.683
DOC_WW_Pin1_4	344	349	PF00397	0.462
DOC_WW_Pin1_4	377	382	PF00397	0.578
DOC_WW_Pin1_4	401	406	PF00397	0.478
DOC_WW_Pin1_4	748	753	PF00397	0.688
DOC_WW_Pin1_4	761	766	PF00397	0.782
DOC_WW_Pin1_4	83	88	PF00397	0.630
LIG_14-3-3_CanoR_1	147	156	PF00244	0.550
LIG_14-3-3_CanoR_1	448	452	PF00244	0.612
LIG_14-3-3_CanoR_1	673	678	PF00244	0.566
LIG_14-3-3_CanoR_1	758	764	PF00244	0.583
LIG_14-3-3_CanoR_1	825	829	PF00244	0.707
LIG_14-3-3_CanoR_1	830	836	PF00244	0.753
LIG_BIR_III_4	687	691	PF00653	0.516
LIG_BRCT_BRCA1_1	4	8	PF00533	0.500
LIG_eIF4E_1	180	186	PF01652	0.506
LIG_EVH1_2	138	142	PF00568	0.604
LIG_FHA_1	233	239	PF00498	0.612
LIG_FHA_1	321	327	PF00498	0.567
LIG_FHA_1	380	386	PF00498	0.530
LIG_FHA_1	397	403	PF00498	0.489
LIG_FHA_1	471	477	PF00498	0.544
LIG_FHA_1	677	683	PF00498	0.707
LIG_FHA_1	690	696	PF00498	0.691
LIG_FHA_1	708	714	PF00498	0.497
LIG_FHA_1	76	82	PF00498	0.770
LIG_FHA_1	782	788	PF00498	0.530
LIG_FHA_1	850	856	PF00498	0.713
LIG_FHA_1	868	874	PF00498	0.710
LIG_FHA_2	16	22	PF00498	0.570
LIG_FHA_2	193	199	PF00498	0.458
LIG_FHA_2	312	318	PF00498	0.611
LIG_FHA_2	344	350	PF00498	0.534
LIG_IBAR_NPY_1	308	310	PF08397	0.693
LIG_LIR_Apic_2	559	564	PF02991	0.487
LIG_LIR_Gen_1	124	135	PF02991	0.530
LIG_LIR_Gen_1	151	160	PF02991	0.658
LIG_LIR_Gen_1	17	26	PF02991	0.568
LIG_LIR_Gen_1	172	181	PF02991	0.428
LIG_LIR_Gen_1	349	360	PF02991	0.501
LIG_LIR_Nem_3	124	130	PF02991	0.712
LIG_LIR_Nem_3	151	156	PF02991	0.656
LIG_LIR_Nem_3	172	176	PF02991	0.546
LIG_LIR_Nem_3	349	355	PF02991	0.493
LIG_LIR_Nem_3	364	369	PF02991	0.541
LIG_LIR_Nem_3	464	469	PF02991	0.449
LIG_LIR_Nem_3	512	517	PF02991	0.492
LIG_MYND_1	183	187	PF01753	0.633
LIG_PCNA_yPIPBox_3	575	584	PF02747	0.618
LIG_PDZ_Class_1	874	879	PF00595	0.791
LIG_Pex14_2	169	173	PF04695	0.601
LIG_Pex14_2	707	711	PF04695	0.490
LIG_PTB_Apo_2	854	861	PF02174	0.522
LIG_PTB_Phospho_1	854	860	PF10480	0.523
LIG_RPA_C_Fungi	144	156	PF08784	0.657
LIG_RPA_C_Fungi	38	50	PF08784	0.579
LIG_SH2_CRK	259	263	PF00017	0.561
LIG_SH2_CRK	736	740	PF00017	0.537
LIG_SH2_NCK_1	313	317	PF00017	0.604
LIG_SH2_SRC	651	654	PF00017	0.750
LIG_SH2_STAP1	363	367	PF00017	0.507
LIG_SH2_STAP1	651	655	PF00017	0.486
LIG_SH2_STAT5	14	17	PF00017	0.571
LIG_SH2_STAT5	310	313	PF00017	0.613
LIG_SH2_STAT5	496	499	PF00017	0.432
LIG_SH2_STAT5	502	505	PF00017	0.420
LIG_SH2_STAT5	566	569	PF00017	0.637
LIG_SH2_STAT5	723	726	PF00017	0.594
LIG_SH2_STAT5	860	863	PF00017	0.518
LIG_SH3_1	204	210	PF00018	0.514
LIG_SH3_2	135	140	PF14604	0.760
LIG_SH3_3	1	7	PF00018	0.696
LIG_SH3_3	104	110	PF00018	0.545
LIG_SH3_3	132	138	PF00018	0.644
LIG_SH3_3	204	210	PF00018	0.613
LIG_SH3_3	227	233	PF00018	0.572
LIG_SH3_3	342	348	PF00018	0.557
LIG_SH3_3	367	373	PF00018	0.665
LIG_SH3_3	399	405	PF00018	0.492
LIG_SH3_3	462	468	PF00018	0.634
LIG_SH3_3	517	523	PF00018	0.739
LIG_SH3_3	543	549	PF00018	0.697
LIG_SH3_3	716	722	PF00018	0.566
LIG_SH3_CIN85_PxpxPR_1	135	140	PF14604	0.507
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.424
LIG_SUMO_SIM_par_1	322	327	PF11976	0.317
LIG_SUMO_SIM_par_1	77	84	PF11976	0.772
LIG_WW_3	137	141	PF00397	0.570
LIG_WW_3	206	210	PF00397	0.558
MOD_CDC14_SPxK_1	751	754	PF00782	0.556
MOD_CDK_SPxK_1	748	754	PF00069	0.558
MOD_CDK_SPxxK_3	377	384	PF00069	0.683
MOD_CK1_1	126	132	PF00069	0.632
MOD_CK1_1	215	221	PF00069	0.716
MOD_CK1_1	225	231	PF00069	0.696
MOD_CK1_1	232	238	PF00069	0.550
MOD_CK1_1	282	288	PF00069	0.647
MOD_CK1_1	299	305	PF00069	0.717
MOD_CK1_1	337	343	PF00069	0.718
MOD_CK1_1	380	386	PF00069	0.556
MOD_CK1_1	614	620	PF00069	0.725
MOD_CK1_1	654	660	PF00069	0.571
MOD_CK1_1	676	682	PF00069	0.689
MOD_CK1_1	691	697	PF00069	0.540
MOD_CK1_1	737	743	PF00069	0.677
MOD_CK1_1	748	754	PF00069	0.597
MOD_CK1_1	790	796	PF00069	0.709
MOD_CK1_1	803	809	PF00069	0.612
MOD_CK1_1	83	89	PF00069	0.747
MOD_CK1_1	867	873	PF00069	0.612
MOD_CK1_1	91	97	PF00069	0.759
MOD_CK2_1	148	154	PF00069	0.547
MOD_CK2_1	192	198	PF00069	0.454
MOD_CK2_1	343	349	PF00069	0.604
MOD_CK2_1	829	835	PF00069	0.746
MOD_Cter_Amidation	828	831	PF01082	0.549
MOD_GlcNHglycan	102	105	PF01048	0.820
MOD_GlcNHglycan	150	153	PF01048	0.631
MOD_GlcNHglycan	160	163	PF01048	0.539
MOD_GlcNHglycan	214	217	PF01048	0.738
MOD_GlcNHglycan	224	227	PF01048	0.804
MOD_GlcNHglycan	370	373	PF01048	0.622
MOD_GlcNHglycan	374	377	PF01048	0.670
MOD_GlcNHglycan	423	426	PF01048	0.594
MOD_GlcNHglycan	490	493	PF01048	0.454
MOD_GlcNHglycan	552	555	PF01048	0.677
MOD_GlcNHglycan	567	570	PF01048	0.616
MOD_GlcNHglycan	62	65	PF01048	0.717
MOD_GlcNHglycan	653	656	PF01048	0.616
MOD_GlcNHglycan	695	698	PF01048	0.609
MOD_GlcNHglycan	747	750	PF01048	0.628
MOD_GlcNHglycan	789	792	PF01048	0.715
MOD_GlcNHglycan	793	796	PF01048	0.699
MOD_GlcNHglycan	844	848	PF01048	0.692
MOD_GlcNHglycan	866	869	PF01048	0.518
MOD_GlcNHglycan	97	100	PF01048	0.796
MOD_GSK3_1	117	124	PF00069	0.648
MOD_GSK3_1	126	133	PF00069	0.572
MOD_GSK3_1	2	9	PF00069	0.651
MOD_GSK3_1	221	228	PF00069	0.753
MOD_GSK3_1	275	282	PF00069	0.703
MOD_GSK3_1	299	306	PF00069	0.700
MOD_GSK3_1	320	327	PF00069	0.369
MOD_GSK3_1	336	343	PF00069	0.661
MOD_GSK3_1	368	375	PF00069	0.558
MOD_GSK3_1	496	503	PF00069	0.407
MOD_GSK3_1	548	555	PF00069	0.709
MOD_GSK3_1	611	618	PF00069	0.732
MOD_GSK3_1	627	634	PF00069	0.629
MOD_GSK3_1	67	74	PF00069	0.678
MOD_GSK3_1	689	696	PF00069	0.682
MOD_GSK3_1	744	751	PF00069	0.779
MOD_GSK3_1	75	82	PF00069	0.670
MOD_GSK3_1	777	784	PF00069	0.645
MOD_GSK3_1	787	794	PF00069	0.745
MOD_GSK3_1	83	90	PF00069	0.747
MOD_GSK3_1	862	869	PF00069	0.601
MOD_GSK3_1	91	98	PF00069	0.615
MOD_N-GLC_1	574	579	PF02516	0.670
MOD_N-GLC_1	67	72	PF02516	0.601
MOD_N-GLC_1	849	854	PF02516	0.652
MOD_N-GLC_2	298	300	PF02516	0.523
MOD_NEK2_1	130	135	PF00069	0.751
MOD_NEK2_1	15	20	PF00069	0.590
MOD_NEK2_1	311	316	PF00069	0.655
MOD_NEK2_1	322	327	PF00069	0.435
MOD_NEK2_1	341	346	PF00069	0.327
MOD_NEK2_1	355	360	PF00069	0.577
MOD_NEK2_1	423	428	PF00069	0.605
MOD_NEK2_1	469	474	PF00069	0.599
MOD_NEK2_1	527	532	PF00069	0.656
MOD_NEK2_1	565	570	PF00069	0.628
MOD_NEK2_1	632	637	PF00069	0.783
MOD_NEK2_1	707	712	PF00069	0.492
MOD_NEK2_1	759	764	PF00069	0.608
MOD_NEK2_1	815	820	PF00069	0.446
MOD_PIKK_1	324	330	PF00454	0.357
MOD_PIKK_1	412	418	PF00454	0.501
MOD_PIKK_1	632	638	PF00454	0.752
MOD_PIKK_1	794	800	PF00454	0.786
MOD_PIKK_1	88	94	PF00454	0.800
MOD_PKA_1	421	427	PF00069	0.655
MOD_PKA_1	745	751	PF00069	0.807
MOD_PKA_2	148	154	PF00069	0.724
MOD_PKA_2	158	164	PF00069	0.588
MOD_PKA_2	421	427	PF00069	0.661
MOD_PKA_2	447	453	PF00069	0.607
MOD_PKA_2	824	830	PF00069	0.704
MOD_PKA_2	873	879	PF00069	0.538
MOD_PKB_1	419	427	PF00069	0.655
MOD_Plk_1	263	269	PF00069	0.359
MOD_Plk_1	361	367	PF00069	0.578
MOD_Plk_1	574	580	PF00069	0.678
MOD_Plk_1	849	855	PF00069	0.594
MOD_Plk_2-3	447	453	PF00069	0.536
MOD_Plk_2-3	681	687	PF00069	0.488
MOD_Plk_4	126	132	PF00069	0.697
MOD_Plk_4	172	178	PF00069	0.616
MOD_Plk_4	181	187	PF00069	0.624
MOD_Plk_4	355	361	PF00069	0.514
MOD_Plk_4	461	467	PF00069	0.673
MOD_Plk_4	734	740	PF00069	0.530
MOD_Plk_4	777	783	PF00069	0.718
MOD_ProDKin_1	117	123	PF00069	0.710
MOD_ProDKin_1	229	235	PF00069	0.624
MOD_ProDKin_1	283	289	PF00069	0.767
MOD_ProDKin_1	334	340	PF00069	0.679
MOD_ProDKin_1	344	350	PF00069	0.461
MOD_ProDKin_1	377	383	PF00069	0.570
MOD_ProDKin_1	401	407	PF00069	0.479
MOD_ProDKin_1	748	754	PF00069	0.689
MOD_ProDKin_1	761	767	PF00069	0.780
MOD_ProDKin_1	83	89	PF00069	0.632
MOD_SUMO_rev_2	482	490	PF00179	0.413
MOD_SUMO_rev_2	606	611	PF00179	0.773
MOD_SUMO_rev_2	740	748	PF00179	0.541
TRG_DiLeu_BaEn_1	172	177	PF01217	0.428
TRG_DiLeu_BaEn_1	431	436	PF01217	0.619
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.449
TRG_DiLeu_BaLyEn_6	465	470	PF01217	0.620
TRG_DiLeu_BaLyEn_6	512	517	PF01217	0.400
TRG_DiLeu_BaLyEn_6	577	582	PF01217	0.609
TRG_ENDOCYTIC_2	650	653	PF00928	0.689
TRG_ENDOCYTIC_2	723	726	PF00928	0.594
TRG_ENDOCYTIC_2	736	739	PF00928	0.717
TRG_ER_diArg_1	147	150	PF00400	0.657
TRG_ER_diArg_1	156	159	PF00400	0.671
TRG_ER_diArg_1	41	43	PF00400	0.601
TRG_ER_diArg_1	419	422	PF00400	0.680
TRG_ER_diArg_1	457	459	PF00400	0.611
TRG_ER_diArg_1	582	584	PF00400	0.646
TRG_ER_diArg_1	754	757	PF00400	0.669
TRG_ER_diArg_1	807	810	PF00400	0.670
TRG_NLS_MonoExtC_3	417	422	PF00514	0.431
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	580	585	PF00026	0.640
TRG_PTS1	876	879	PF00515	0.722

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBC4	Leptomonas seymouri	50%	100%
A0A3Q8IB49	Leishmania donovani	77%	100%
A0A422P1W2	Trypanosoma rangeli	26%	100%
A4HXW0	Leishmania infantum	76%	100%
E9ARM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QDV6	Leishmania major	76%	100%