P-type H+-ATPase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

P-type H+-ATPase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9S2_LEIBR

TriTrypDb:

LbrM.18.1740 , LBRM2903_180021700

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H9S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9S2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0016462	pyrophosphatase activity	5	3
GO:0016787	hydrolase activity	2	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	3
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	3
GO:0016887	ATP hydrolysis activity	7	3
GO:0017076	purine nucleotide binding	4	3
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	6	10	PF00656	0.841
CLV_NRD_NRD_1	293	295	PF00675	0.393
CLV_NRD_NRD_1	32	34	PF00675	0.688
CLV_PCSK_KEX2_1	293	295	PF00082	0.393
CLV_PCSK_KEX2_1	32	34	PF00082	0.688
CLV_PCSK_KEX2_1	426	428	PF00082	0.562
CLV_PCSK_KEX2_1	82	84	PF00082	0.393
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.562
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.393
CLV_PCSK_SKI1_1	293	297	PF00082	0.477
CLV_PCSK_SKI1_1	394	398	PF00082	0.562
CLV_PCSK_SKI1_1	60	64	PF00082	0.477
CLV_Separin_Metazoa	391	395	PF03568	0.774
DEG_APCC_DBOX_1	393	401	PF00400	0.758
DEG_SPOP_SBC_1	314	318	PF00917	0.677
DOC_ANK_TNKS_1	224	231	PF00023	0.677
DOC_CYCLIN_yCln2_LP_2	55	58	PF00134	0.807
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.577
DOC_PP1_RVXF_1	292	299	PF00149	0.593
DOC_PP2B_LxvP_1	169	172	PF13499	0.593
DOC_PP2B_LxvP_1	55	58	PF13499	0.807
DOC_USP7_MATH_1	179	183	PF00917	0.677
DOC_USP7_MATH_1	186	190	PF00917	0.589
DOC_USP7_MATH_1	320	324	PF00917	0.677
DOC_USP7_UBL2_3	147	151	PF12436	0.793
DOC_USP7_UBL2_3	324	328	PF12436	0.677
DOC_WW_Pin1_4	16	21	PF00397	0.872
DOC_WW_Pin1_4	81	86	PF00397	0.677
LIG_14-3-3_CanoR_1	32	37	PF00244	0.868
LIG_14-3-3_CanoR_1	427	433	PF00244	0.739
LIG_BRCT_BRCA1_1	455	459	PF00533	0.762
LIG_EH1_1	297	305	PF00400	0.677
LIG_FHA_1	151	157	PF00498	0.677
LIG_FHA_1	16	22	PF00498	0.817
LIG_FHA_1	233	239	PF00498	0.578
LIG_FHA_1	242	248	PF00498	0.521
LIG_FHA_1	314	320	PF00498	0.677
LIG_FHA_1	351	357	PF00498	0.775
LIG_FHA_1	377	383	PF00498	0.725
LIG_FHA_1	397	403	PF00498	0.500
LIG_FHA_1	435	441	PF00498	0.683
LIG_FHA_2	367	373	PF00498	0.776
LIG_FHA_2	429	435	PF00498	0.739
LIG_FHA_2	61	67	PF00498	0.677
LIG_GBD_Chelix_1	104	112	PF00786	0.577
LIG_LIR_Gen_1	159	170	PF02991	0.677
LIG_LIR_Gen_1	411	421	PF02991	0.758
LIG_LIR_Nem_3	159	165	PF02991	0.677
LIG_LIR_Nem_3	411	416	PF02991	0.752
LIG_LIR_Nem_3	417	421	PF02991	0.691
LIG_LIR_Nem_3	84	90	PF02991	0.677
LIG_NBox_RRM_1	292	302	PF00076	0.677
LIG_PDZ_Class_2	458	463	PF00595	0.779
LIG_Pex14_2	288	292	PF04695	0.599
LIG_REV1ctd_RIR_1	238	247	PF16727	0.677
LIG_SH2_STAT5	234	237	PF00017	0.677
LIG_SH2_STAT5	283	286	PF00017	0.677
LIG_SH2_STAT5	90	93	PF00017	0.677
LIG_SH3_2	27	32	PF14604	0.896
LIG_SH3_3	14	20	PF00018	0.861
LIG_SH3_3	24	30	PF00018	0.817
LIG_SH3_3	302	308	PF00018	0.677
LIG_SH3_3	417	423	PF00018	0.768
LIG_SUMO_SIM_par_1	192	199	PF11976	0.677
LIG_SUMO_SIM_par_1	300	306	PF11976	0.677
LIG_SUMO_SIM_par_1	307	312	PF11976	0.589
LIG_SUMO_SIM_par_1	316	323	PF11976	0.464
LIG_TRAF2_1	12	15	PF00917	0.824
LIG_TRAF2_1	369	372	PF00917	0.773
LIG_TRAF2_1	63	66	PF00917	0.677
LIG_WRC_WIRS_1	289	294	PF05994	0.677
LIG_WW_3	391	395	PF00397	0.774
MOD_CK1_1	250	256	PF00069	0.599
MOD_CK1_1	35	41	PF00069	0.839
MOD_CK1_1	350	356	PF00069	0.773
MOD_CK2_1	186	192	PF00069	0.677
MOD_CK2_1	334	340	PF00069	0.749
MOD_CK2_1	366	372	PF00069	0.778
MOD_CK2_1	60	66	PF00069	0.677
MOD_GlcNHglycan	179	182	PF01048	0.477
MOD_GlcNHglycan	336	339	PF01048	0.427
MOD_GlcNHglycan	342	345	PF01048	0.451
MOD_GSK3_1	146	153	PF00069	0.784
MOD_GSK3_1	203	210	PF00069	0.677
MOD_GSK3_1	228	235	PF00069	0.677
MOD_GSK3_1	320	327	PF00069	0.677
MOD_GSK3_1	334	341	PF00069	0.675
MOD_GSK3_1	35	42	PF00069	0.840
MOD_GSK3_1	350	357	PF00069	0.621
MOD_GSK3_1	371	378	PF00069	0.616
MOD_GSK3_1	421	428	PF00069	0.771
MOD_GSK3_1	56	63	PF00069	0.635
MOD_N-GLC_1	127	132	PF02516	0.577
MOD_N-GLC_1	3	8	PF02516	0.608
MOD_N-GLC_1	453	458	PF02516	0.547
MOD_N-GLC_1	46	51	PF02516	0.591
MOD_NEK2_1	146	151	PF00069	0.787
MOD_NEK2_1	241	246	PF00069	0.677
MOD_NEK2_1	288	293	PF00069	0.665
MOD_NEK2_1	303	308	PF00069	0.486
MOD_NEK2_1	376	381	PF00069	0.676
MOD_NEK2_1	441	446	PF00069	0.742
MOD_NEK2_2	133	138	PF00069	0.690
MOD_NEK2_2	152	157	PF00069	0.439
MOD_NEK2_2	236	241	PF00069	0.677
MOD_NMyristoyl	1	7	PF02799	0.809
MOD_PK_1	32	38	PF00069	0.861
MOD_PKA_1	32	38	PF00069	0.861
MOD_PKA_2	157	163	PF00069	0.677
MOD_PKA_2	32	38	PF00069	0.861
MOD_PKA_2	434	440	PF00069	0.767
MOD_Plk_1	127	133	PF00069	0.577
MOD_Plk_1	186	192	PF00069	0.677
MOD_Plk_4	152	158	PF00069	0.677
MOD_Plk_4	236	242	PF00069	0.574
MOD_Plk_4	32	38	PF00069	0.861
MOD_Plk_4	376	382	PF00069	0.616
MOD_Plk_4	396	402	PF00069	0.496
MOD_Plk_4	414	420	PF00069	0.536
MOD_Plk_4	83	89	PF00069	0.677
MOD_ProDKin_1	16	22	PF00069	0.871
MOD_ProDKin_1	81	87	PF00069	0.677
MOD_SUMO_rev_2	9	18	PF00179	0.903
TRG_DiLeu_BaEn_1	66	71	PF01217	0.677
TRG_DiLeu_BaEn_2	413	419	PF01217	0.672
TRG_DiLeu_BaEn_4	371	377	PF01217	0.757
TRG_ENDOCYTIC_2	289	292	PF00928	0.552
TRG_ENDOCYTIC_2	413	416	PF00928	0.752
TRG_ER_diArg_1	292	294	PF00400	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KPA7	Bodo saltans	26%	100%
A0RA13	Bacillus thuringiensis (strain Al Hakam)	23%	67%
A4HY21	Leishmania infantum	90%	90%
A4W860	Enterobacter sp. (strain 638)	26%	68%
A7FFQ9	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	25%	67%
A9MUE0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	26%	68%
A9VFM1	Bacillus mycoides (strain KBAB4)	23%	66%
B1JR96	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	25%	67%
B4SZB1	Salmonella newport (strain SL254)	26%	68%
B4TBA6	Salmonella heidelberg (strain SL476)	26%	68%
B4TQ22	Salmonella schwarzengrund (strain CVM19633)	26%	68%
B5BCA4	Salmonella paratyphi A (strain AKU_12601)	26%	68%
B5EZE3	Salmonella agona (strain SL483)	26%	68%
B5FNE0	Salmonella dublin (strain CT_02021853)	26%	68%
B5QWE9	Salmonella enteritidis PT4 (strain P125109)	26%	68%
B5R670	Salmonella gallinarum (strain 287/91 / NCTC 13346)	26%	68%
B7HDF9	Bacillus cereus (strain B4264)	23%	66%
B7HWG1	Bacillus cereus (strain AH187)	23%	66%
B7II09	Bacillus cereus (strain G9842)	23%	66%
B7JRB8	Bacillus cereus (strain AH820)	23%	66%
C1EYK0	Bacillus cereus (strain 03BB102)	23%	67%
C3LF99	Bacillus anthracis (strain CDC 684 / NRRL 3495)	23%	66%
C4LDL7	Tolumonas auensis (strain DSM 9187 / TA4)	25%	67%
P0A007	Staphylococcus aureus (strain Mu50 / ATCC 700699)	24%	69%
P0A008	Staphylococcus aureus (strain N315)	24%	69%
P59219	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	26%	67%
Q4LAI2	Staphylococcus haemolyticus (strain JCSC1435)	24%	69%
Q57RN0	Salmonella choleraesuis (strain SC-B67)	26%	68%
Q5HK64	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	24%	69%
Q5PCJ7	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	26%	68%
Q63FR0	Bacillus cereus (strain ZK / E33L)	23%	66%
Q667S4	Yersinia pseudotuberculosis serotype I (strain IP32953)	25%	67%
Q6GKN3	Staphylococcus aureus (strain MRSA252)	24%	69%
Q6HN78	Bacillus thuringiensis subsp. konkukian (strain 97-27)	23%	66%
Q72TM6	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	25%	67%
Q81HQ0	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	24%	66%
Q8ZQW2	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	68%
Q926K7	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	26%	67%
Q93MV5	Myxococcus xanthus	23%	67%
Q9ZL53	Helicobacter pylori (strain J99 / ATCC 700824)	24%	67%