LeishMANIAdb
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Flavin_Reduct domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Flavin_Reduct domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H9R6_LEIBR
TriTrypDb:
LbrM.18.1680 , LBRM2903_180022900
Length:
118

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 10
Silverman et al. no yes: 0
Pissara et al. yes yes: 27
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 31
NetGPI no yes: 0, no: 31
Cellular components
Term Name Level Count
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 2

Expansion

Sequence features

A4H9R6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9R6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 52 54 PF00675 0.527
CLV_PCSK_SKI1_1 110 114 PF00082 0.449
DOC_PP2B_PxIxI_1 14 20 PF00149 0.419
DOC_USP7_UBL2_3 106 110 PF12436 0.402
DOC_WW_Pin1_4 44 49 PF00397 0.635
LIG_Actin_WH2_2 79 97 PF00022 0.471
LIG_BIR_II_1 1 5 PF00653 0.589
LIG_BRCT_BRCA1_1 75 79 PF00533 0.490
LIG_EVH1_2 57 61 PF00568 0.403
LIG_FHA_1 68 74 PF00498 0.612
LIG_FHA_1 75 81 PF00498 0.518
LIG_LIR_Gen_1 47 57 PF02991 0.611
LIG_LIR_Gen_1 76 86 PF02991 0.463
LIG_LIR_Nem_3 108 114 PF02991 0.470
LIG_LIR_Nem_3 18 23 PF02991 0.573
LIG_LIR_Nem_3 47 52 PF02991 0.589
LIG_LIR_Nem_3 76 82 PF02991 0.463
LIG_PALB2_WD40_1 56 64 PF16756 0.410
LIG_REV1ctd_RIR_1 109 118 PF16727 0.492
LIG_SUMO_SIM_par_1 6 11 PF11976 0.414
LIG_SUMO_SIM_par_1 81 89 PF11976 0.491
LIG_UBA3_1 19 24 PF00899 0.523
LIG_WW_3 56 60 PF00397 0.335
MOD_CK1_1 38 44 PF00069 0.594
MOD_GlcNHglycan 1 4 PF01048 0.510
MOD_GlcNHglycan 96 99 PF01048 0.422
MOD_GSK3_1 31 38 PF00069 0.487
MOD_GSK3_1 63 70 PF00069 0.569
MOD_N-GLC_1 31 36 PF02516 0.510
MOD_N-GLC_2 37 39 PF02516 0.659
MOD_NEK2_1 31 36 PF00069 0.559
MOD_NEK2_1 6 11 PF00069 0.403
MOD_NEK2_1 94 99 PF00069 0.517
MOD_NEK2_2 15 20 PF00069 0.547
MOD_NEK2_2 74 79 PF00069 0.478
MOD_PIKK_1 63 69 PF00454 0.508
MOD_PKA_2 94 100 PF00069 0.532
MOD_Plk_1 24 30 PF00069 0.477
MOD_Plk_1 31 37 PF00069 0.499
MOD_Plk_4 74 80 PF00069 0.525
MOD_ProDKin_1 44 50 PF00069 0.625
TRG_ENDOCYTIC_2 109 112 PF00928 0.557

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3C7 Leptomonas seymouri 36% 94%
A0A0N1HW96 Leptomonas seymouri 40% 100%
A0A0N1IHI7 Leptomonas seymouri 82% 100%
A0A0S4IPF2 Bodo saltans 41% 100%
A0A0S4IRP9 Bodo saltans 58% 99%
A0A0S4JBB4 Bodo saltans 44% 99%
A0A0S4JFI1 Bodo saltans 37% 100%
A0A1X0NKC2 Trypanosomatidae 30% 99%
A0A1X0P0Q8 Trypanosomatidae 46% 94%
A0A1X0P259 Trypanosomatidae 36% 100%
A0A1X0P760 Trypanosomatidae 61% 100%
A0A3Q8IB96 Leishmania donovani 85% 100%
A0A3R7K0R9 Trypanosoma rangeli 38% 100%
A0A3S7X3W3 Leishmania donovani 37% 100%
A0A3S7X6I1 Leishmania donovani 38% 70%
A0A422N867 Trypanosoma rangeli 43% 94%
A0A422NFX4 Trypanosoma rangeli 29% 98%
A0A422NPM1 Trypanosoma rangeli 61% 100%
A4HIL9 Leishmania braziliensis 38% 100%
A4HLA1 Leishmania braziliensis 40% 94%
A4HY35 Leishmania infantum 85% 100%
A4I5W4 Leishmania infantum 37% 100%
A4I8S7 Leishmania infantum 37% 94%
C9ZR85 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
D0A4S3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 94%
E9ARU9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9B3P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 94%
Q4Q707 Leishmania major 37% 100%
Q4QDM4 Leishmania major 86% 100%
V5BMX8 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS