Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9R5_LEIBR

TriTrypDb:

LbrM.18.1670 , LBRM2903_180022800

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9R5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005509	calcium ion binding	5	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.602
CLV_C14_Caspase3-7	223	227	PF00656	0.571
CLV_NRD_NRD_1	104	106	PF00675	0.545
CLV_NRD_NRD_1	236	238	PF00675	0.492
CLV_NRD_NRD_1	74	76	PF00675	0.428
CLV_NRD_NRD_1	85	87	PF00675	0.459
CLV_NRD_NRD_1	92	94	PF00675	0.476
CLV_PCSK_KEX2_1	236	238	PF00082	0.487
CLV_PCSK_KEX2_1	74	76	PF00082	0.436
CLV_PCSK_KEX2_1	80	82	PF00082	0.453
CLV_PCSK_KEX2_1	85	87	PF00082	0.487
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.508
CLV_PCSK_PC7_1	81	87	PF00082	0.494
CLV_PCSK_SKI1_1	154	158	PF00082	0.488
DEG_APCC_DBOX_1	153	161	PF00400	0.550
DEG_APCC_DBOX_1	172	180	PF00400	0.315
DOC_CKS1_1	187	192	PF01111	0.572
DOC_PP1_RVXF_1	129	136	PF00149	0.378
DOC_PP1_RVXF_1	31	38	PF00149	0.416
DOC_USP7_UBL2_3	246	250	PF12436	0.419
DOC_USP7_UBL2_3	83	87	PF12436	0.610
DOC_WW_Pin1_4	186	191	PF00397	0.522
LIG_14-3-3_CanoR_1	140	146	PF00244	0.497
LIG_14-3-3_CanoR_1	96	102	PF00244	0.576
LIG_CaM_NSCaTE_8	209	216	PF13499	0.473
LIG_deltaCOP1_diTrp_1	134	138	PF00928	0.330
LIG_FHA_1	12	18	PF00498	0.409
LIG_FHA_1	140	146	PF00498	0.460
LIG_FHA_1	39	45	PF00498	0.494
LIG_FHA_2	123	129	PF00498	0.665
LIG_FHA_2	180	186	PF00498	0.476
LIG_FHA_2	187	193	PF00498	0.464
LIG_FHA_2	219	225	PF00498	0.454
LIG_FHA_2	50	56	PF00498	0.398
LIG_LIR_Apic_2	216	220	PF02991	0.437
LIG_LIR_Gen_1	134	139	PF02991	0.327
LIG_LIR_Gen_1	22	32	PF02991	0.414
LIG_LIR_Nem_3	134	138	PF02991	0.330
LIG_LIR_Nem_3	22	28	PF02991	0.391
LIG_Rb_LxCxE_1	134	153	PF01857	0.350
LIG_SH2_NCK_1	18	22	PF00017	0.393
LIG_SH2_PTP2	217	220	PF00017	0.441
LIG_SH2_STAT5	217	220	PF00017	0.441
LIG_SH3_3	4	10	PF00018	0.605
LIG_SUMO_SIM_par_1	174	182	PF11976	0.561
LIG_TRAF2_1	220	223	PF00917	0.468
LIG_UBA3_1	176	183	PF00899	0.338
LIG_UBA3_1	24	33	PF00899	0.470
LIG_WRC_WIRS_1	34	39	PF05994	0.394
MOD_CK1_1	11	17	PF00069	0.419
MOD_CK1_1	167	173	PF00069	0.617
MOD_CK2_1	122	128	PF00069	0.594
MOD_CK2_1	186	192	PF00069	0.479
MOD_CK2_1	218	224	PF00069	0.566
MOD_Cter_Amidation	103	106	PF01082	0.685
MOD_GSK3_1	165	172	PF00069	0.474
MOD_GSK3_1	8	15	PF00069	0.435
MOD_NEK2_1	171	176	PF00069	0.548
MOD_NEK2_1	38	43	PF00069	0.512
MOD_PIKK_1	218	224	PF00454	0.539
MOD_PKA_2	104	110	PF00069	0.614
MOD_PKA_2	139	145	PF00069	0.417
MOD_PKA_2	97	103	PF00069	0.591
MOD_Plk_1	122	128	PF00069	0.452
MOD_Plk_1	38	44	PF00069	0.556
MOD_Plk_4	104	110	PF00069	0.608
MOD_Plk_4	195	201	PF00069	0.428
MOD_Plk_4	213	219	PF00069	0.392
MOD_Plk_4	33	39	PF00069	0.394
MOD_Plk_4	58	64	PF00069	0.578
MOD_Plk_4	8	14	PF00069	0.434
MOD_ProDKin_1	186	192	PF00069	0.520
MOD_SUMO_for_1	79	82	PF00179	0.499
MOD_SUMO_rev_2	123	133	PF00179	0.493
TRG_DiLeu_BaEn_1	192	197	PF01217	0.538
TRG_DiLeu_BaEn_4	152	158	PF01217	0.456
TRG_ER_diArg_1	73	75	PF00400	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL1	Leptomonas seymouri	72%	100%
A0A0S4IRK8	Bodo saltans	48%	84%
A0A1X0P7F4	Trypanosomatidae	57%	98%
A0A3S7WVC9	Leishmania donovani	84%	100%
A0A422NPY0	Trypanosoma rangeli	49%	99%
A4HY34	Leishmania infantum	84%	100%
D0A550	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	70%
E9ARU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QDM5	Leishmania major	85%	100%
V5D4P1	Trypanosoma cruzi	52%	99%