Prephenate dehydratase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9R4_LEIBR

TriTrypDb:

LbrM.18.1660 , LBRM2903_180022700

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9R4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.350
CLV_PCSK_KEX2_1	102	104	PF00082	0.320
CLV_PCSK_SKI1_1	118	122	PF00082	0.513
CLV_PCSK_SKI1_1	172	176	PF00082	0.398
CLV_PCSK_SKI1_1	200	204	PF00082	0.317
CLV_PCSK_SKI1_1	8	12	PF00082	0.405
DEG_Nend_UBRbox_2	1	3	PF02207	0.356
DOC_CDC14_PxL_1	30	38	PF14671	0.408
DOC_CYCLIN_RxL_1	78	86	PF00134	0.463
DOC_MAPK_DCC_7	89	99	PF00069	0.232
DOC_MAPK_gen_1	102	108	PF00069	0.239
DOC_MAPK_MEF2A_6	189	196	PF00069	0.335
DOC_MAPK_MEF2A_6	89	96	PF00069	0.325
DOC_MAPK_RevD_3	90	103	PF00069	0.376
DOC_USP7_MATH_1	208	212	PF00917	0.434
DOC_WW_Pin1_4	151	156	PF00397	0.464
LIG_14-3-3_CanoR_1	172	177	PF00244	0.527
LIG_Actin_WH2_2	104	120	PF00022	0.369
LIG_BIR_III_2	152	156	PF00653	0.411
LIG_BIR_III_4	129	133	PF00653	0.308
LIG_FHA_1	138	144	PF00498	0.434
LIG_FHA_1	64	70	PF00498	0.460
LIG_FHA_1	77	83	PF00498	0.341
LIG_FHA_2	39	45	PF00498	0.292
LIG_LIR_Gen_1	101	111	PF02991	0.333
LIG_LIR_Gen_1	157	163	PF02991	0.315
LIG_LIR_Nem_3	101	107	PF02991	0.325
LIG_LIR_Nem_3	157	161	PF02991	0.350
LIG_LYPXL_yS_3	33	36	PF13949	0.398
LIG_PTB_Apo_2	133	140	PF02174	0.500
LIG_PTB_Phospho_1	133	139	PF10480	0.383
LIG_SH2_CRK	104	108	PF00017	0.297
LIG_SH2_STAP1	104	108	PF00017	0.297
LIG_SH2_STAP1	139	143	PF00017	0.357
LIG_SH2_STAT5	139	142	PF00017	0.426
LIG_SH2_STAT5	18	21	PF00017	0.413
LIG_SH2_STAT5	39	42	PF00017	0.410
LIG_SH3_3	89	95	PF00018	0.302
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.407
LIG_SUMO_SIM_par_1	195	201	PF11976	0.473
LIG_SUMO_SIM_par_1	8	14	PF11976	0.362
LIG_SUMO_SIM_par_1	95	101	PF11976	0.344
LIG_TRAF2_1	98	101	PF00917	0.278
MOD_CK1_1	154	160	PF00069	0.422
MOD_CK2_1	38	44	PF00069	0.438
MOD_GlcNHglycan	140	143	PF01048	0.520
MOD_GlcNHglycan	204	207	PF01048	0.454
MOD_GSK3_1	172	179	PF00069	0.318
MOD_GSK3_1	208	215	PF00069	0.418
MOD_N-GLC_1	135	140	PF02516	0.332
MOD_NEK2_1	1	6	PF00069	0.430
MOD_NEK2_1	11	16	PF00069	0.369
MOD_NEK2_1	174	179	PF00069	0.340
MOD_NEK2_1	212	217	PF00069	0.341
MOD_NEK2_1	83	88	PF00069	0.495
MOD_PIKK_1	111	117	PF00454	0.593
MOD_PKA_2	63	69	PF00069	0.566
MOD_PKA_2	83	89	PF00069	0.584
MOD_Plk_1	1	7	PF00069	0.523
MOD_Plk_1	135	141	PF00069	0.353
MOD_Plk_1	159	165	PF00069	0.409
MOD_Plk_4	212	218	PF00069	0.358
MOD_Plk_4	35	41	PF00069	0.425
MOD_ProDKin_1	151	157	PF00069	0.464
TRG_ENDOCYTIC_2	104	107	PF00928	0.297
TRG_ENDOCYTIC_2	18	21	PF00928	0.313
TRG_ENDOCYTIC_2	33	36	PF00928	0.351
TRG_ER_diArg_1	102	104	PF00400	0.334
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M1	Leptomonas seymouri	50%	99%
A0A0S4IUU2	Bodo saltans	29%	97%
A0A1X0P852	Trypanosomatidae	35%	97%
A0A3R7NTK0	Trypanosoma rangeli	35%	98%
A0A3S7WV54	Leishmania donovani	70%	99%
A4HY33	Leishmania infantum	70%	99%
D0A552	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	97%
E9ARU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4QDM6	Leishmania major	71%	100%