Nucleolar complex protein 2 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Noc2p family, putative

Species:

Leishmania braziliensis

UniProt:

A4H9R2_LEIBR

TriTrypDb:

LbrM.18.1640 , LBRM2903_180022500

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0030689	Noc complex	3	1
GO:0030690	Noc1p-Noc2p complex	4	1
GO:0030691	Noc2p-Noc3p complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H9R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9R2

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.539
CLV_C14_Caspase3-7	120	124	PF00656	0.641
CLV_C14_Caspase3-7	94	98	PF00656	0.558
CLV_NRD_NRD_1	182	184	PF00675	0.467
CLV_NRD_NRD_1	25	27	PF00675	0.485
CLV_NRD_NRD_1	446	448	PF00675	0.164
CLV_NRD_NRD_1	634	636	PF00675	0.461
CLV_NRD_NRD_1	651	653	PF00675	0.643
CLV_PCSK_KEX2_1	226	228	PF00082	0.328
CLV_PCSK_KEX2_1	25	27	PF00082	0.486
CLV_PCSK_KEX2_1	446	448	PF00082	0.164
CLV_PCSK_KEX2_1	571	573	PF00082	0.241
CLV_PCSK_KEX2_1	634	636	PF00082	0.505
CLV_PCSK_KEX2_1	644	646	PF00082	0.592
CLV_PCSK_KEX2_1	651	653	PF00082	0.592
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.422
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.300
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.522
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.605
CLV_PCSK_PC7_1	222	228	PF00082	0.340
CLV_PCSK_PC7_1	647	653	PF00082	0.707
CLV_PCSK_SKI1_1	192	196	PF00082	0.424
CLV_PCSK_SKI1_1	226	230	PF00082	0.368
CLV_PCSK_SKI1_1	264	268	PF00082	0.331
CLV_PCSK_SKI1_1	27	31	PF00082	0.429
CLV_PCSK_SKI1_1	313	317	PF00082	0.241
CLV_PCSK_SKI1_1	368	372	PF00082	0.241
CLV_PCSK_SKI1_1	45	49	PF00082	0.513
CLV_PCSK_SKI1_1	461	465	PF00082	0.256
CLV_PCSK_SKI1_1	8	12	PF00082	0.460
DEG_APCC_DBOX_1	141	149	PF00400	0.453
DEG_APCC_DBOX_1	624	632	PF00400	0.546
DEG_Kelch_Keap1_1	123	128	PF01344	0.563
DOC_CDC14_PxL_1	453	461	PF14671	0.256
DOC_CYCLIN_RxL_1	220	233	PF00134	0.370
DOC_CYCLIN_yCln2_LP_2	451	457	PF00134	0.387
DOC_MAPK_gen_1	217	225	PF00069	0.410
DOC_MAPK_gen_1	226	232	PF00069	0.284
DOC_MAPK_gen_1	446	453	PF00069	0.164
DOC_MAPK_gen_1	540	547	PF00069	0.243
DOC_MAPK_MEF2A_6	429	437	PF00069	0.241
DOC_MAPK_MEF2A_6	446	455	PF00069	0.241
DOC_MAPK_MEF2A_6	461	470	PF00069	0.238
DOC_PP2B_LxvP_1	451	454	PF13499	0.387
DOC_PP4_FxxP_1	185	188	PF00568	0.433
DOC_PP4_FxxP_1	425	428	PF00568	0.241
DOC_USP7_MATH_1	194	198	PF00917	0.496
DOC_USP7_MATH_1	231	235	PF00917	0.518
DOC_USP7_MATH_1	281	285	PF00917	0.426
DOC_USP7_MATH_1	396	400	PF00917	0.289
DOC_USP7_MATH_1	519	523	PF00917	0.233
DOC_USP7_MATH_1	533	537	PF00917	0.257
DOC_USP7_MATH_1	598	602	PF00917	0.325
DOC_USP7_UBL2_3	12	16	PF12436	0.446
DOC_USP7_UBL2_3	200	204	PF12436	0.405
DOC_USP7_UBL2_3	213	217	PF12436	0.388
DOC_USP7_UBL2_3	268	272	PF12436	0.317
DOC_USP7_UBL2_3	567	571	PF12436	0.300
DOC_USP7_UBL2_3	7	11	PF12436	0.460
DOC_WW_Pin1_4	424	429	PF00397	0.241
DOC_WW_Pin1_4	462	467	PF00397	0.256
DOC_WW_Pin1_4	477	482	PF00397	0.256
LIG_14-3-3_CanoR_1	178	185	PF00244	0.577
LIG_14-3-3_CanoR_1	461	466	PF00244	0.241
LIG_14-3-3_CanoR_1	559	568	PF00244	0.228
LIG_14-3-3_CanoR_1	625	629	PF00244	0.501
LIG_14-3-3_CterR_2	651	654	PF00244	0.504
LIG_Actin_WH2_2	256	274	PF00022	0.310
LIG_Actin_WH2_2	353	370	PF00022	0.256
LIG_BIR_II_1	1	5	PF00653	0.517
LIG_BIR_III_2	132	136	PF00653	0.511
LIG_BIR_III_4	620	624	PF00653	0.605
LIG_BRCT_BRCA1_1	308	312	PF00533	0.241
LIG_FHA_1	219	225	PF00498	0.364
LIG_FHA_1	244	250	PF00498	0.241
LIG_FHA_1	265	271	PF00498	0.341
LIG_FHA_1	487	493	PF00498	0.256
LIG_FHA_1	513	519	PF00498	0.292
LIG_FHA_2	101	107	PF00498	0.570
LIG_FHA_2	139	145	PF00498	0.438
LIG_FHA_2	345	351	PF00498	0.241
LIG_FHA_2	398	404	PF00498	0.335
LIG_FHA_2	65	71	PF00498	0.476
LIG_GBD_Chelix_1	224	232	PF00786	0.415
LIG_GBD_Chelix_1	363	371	PF00786	0.241
LIG_LIR_Apic_2	182	188	PF02991	0.500
LIG_LIR_Apic_2	399	404	PF02991	0.300
LIG_LIR_Apic_2	423	428	PF02991	0.241
LIG_LIR_Gen_1	356	365	PF02991	0.232
LIG_LIR_Gen_1	600	611	PF02991	0.411
LIG_LIR_Gen_1	70	80	PF02991	0.461
LIG_LIR_Nem_3	215	219	PF02991	0.414
LIG_LIR_Nem_3	309	315	PF02991	0.256
LIG_LIR_Nem_3	356	360	PF02991	0.232
LIG_LIR_Nem_3	393	397	PF02991	0.325
LIG_LIR_Nem_3	449	455	PF02991	0.241
LIG_LIR_Nem_3	529	534	PF02991	0.241
LIG_LIR_Nem_3	68	74	PF02991	0.455
LIG_LIR_Nem_3	9	13	PF02991	0.463
LIG_PCNA_PIPBox_1	338	347	PF02747	0.300
LIG_Pex14_2	312	316	PF04695	0.241
LIG_Pex14_2	527	531	PF04695	0.241
LIG_PTB_Apo_2	381	388	PF02174	0.241
LIG_PTB_Phospho_1	381	387	PF10480	0.241
LIG_SH2_CRK	290	294	PF00017	0.439
LIG_SH2_GRB2like	387	390	PF00017	0.241
LIG_SH2_NCK_1	401	405	PF00017	0.241
LIG_SH2_PTP2	452	455	PF00017	0.335
LIG_SH2_SRC	387	390	PF00017	0.241
LIG_SH2_SRC	401	404	PF00017	0.241
LIG_SH2_SRC	452	455	PF00017	0.335
LIG_SH2_STAT3	359	362	PF00017	0.241
LIG_SH2_STAT5	262	265	PF00017	0.381
LIG_SH2_STAT5	359	362	PF00017	0.241
LIG_SH2_STAT5	366	369	PF00017	0.241
LIG_SH2_STAT5	387	390	PF00017	0.241
LIG_SH2_STAT5	452	455	PF00017	0.260
LIG_SH2_STAT5	458	461	PF00017	0.222
LIG_SH2_STAT5	512	515	PF00017	0.241
LIG_SH2_STAT5	74	77	PF00017	0.457
LIG_SH3_3	252	258	PF00018	0.318
LIG_SH3_3	451	457	PF00018	0.252
LIG_SH3_3	522	528	PF00018	0.335
LIG_SH3_3	542	548	PF00018	0.120
LIG_SUMO_SIM_anti_2	88	95	PF11976	0.655
LIG_TRAF2_1	141	144	PF00917	0.493
LIG_TRAF2_1	280	283	PF00917	0.356
LIG_TRAF2_1	51	54	PF00917	0.622
LIG_UBA3_1	486	494	PF00899	0.387
LIG_WRC_WIRS_1	206	211	PF05994	0.449
MOD_CDK_SPK_2	424	429	PF00069	0.241
MOD_CK1_1	150	156	PF00069	0.527
MOD_CK1_1	215	221	PF00069	0.453
MOD_CK1_1	295	301	PF00069	0.408
MOD_CK1_1	552	558	PF00069	0.189
MOD_CK2_1	138	144	PF00069	0.464
MOD_CK2_1	150	156	PF00069	0.424
MOD_CK2_1	28	34	PF00069	0.489
MOD_CK2_1	344	350	PF00069	0.241
MOD_CK2_1	397	403	PF00069	0.335
MOD_CK2_1	567	573	PF00069	0.270
MOD_CK2_1	64	70	PF00069	0.466
MOD_CK2_1	96	102	PF00069	0.476
MOD_Cter_Amidation	642	645	PF01082	0.694
MOD_GlcNHglycan	128	132	PF01048	0.706
MOD_GlcNHglycan	152	155	PF01048	0.471
MOD_GlcNHglycan	163	166	PF01048	0.288
MOD_GlcNHglycan	246	249	PF01048	0.436
MOD_GlcNHglycan	498	501	PF01048	0.404
MOD_GlcNHglycan	620	624	PF01048	0.608
MOD_GlcNHglycan	639	642	PF01048	0.433
MOD_GSK3_1	146	153	PF00069	0.563
MOD_GSK3_1	204	211	PF00069	0.406
MOD_GSK3_1	21	28	PF00069	0.575
MOD_GSK3_1	302	309	PF00069	0.370
MOD_GSK3_1	315	322	PF00069	0.314
MOD_GSK3_1	464	471	PF00069	0.306
MOD_GSK3_1	517	524	PF00069	0.254
MOD_GSK3_1	594	601	PF00069	0.302
MOD_GSK3_1	96	103	PF00069	0.584
MOD_LATS_1	176	182	PF00433	0.630
MOD_N-GLC_2	276	278	PF02516	0.367
MOD_NEK2_1	148	153	PF00069	0.373
MOD_NEK2_1	230	235	PF00069	0.338
MOD_NEK2_1	249	254	PF00069	0.179
MOD_NEK2_1	271	276	PF00069	0.356
MOD_NEK2_1	306	311	PF00069	0.241
MOD_NEK2_1	319	324	PF00069	0.241
MOD_NEK2_1	486	491	PF00069	0.241
MOD_NEK2_2	212	217	PF00069	0.446
MOD_NEK2_2	281	286	PF00069	0.417
MOD_NEK2_2	302	307	PF00069	0.369
MOD_NEK2_2	602	607	PF00069	0.300
MOD_PIKK_1	372	378	PF00454	0.241
MOD_PIKK_1	540	546	PF00454	0.311
MOD_PIKK_1	562	568	PF00454	0.299
MOD_PKA_1	25	31	PF00069	0.493
MOD_PKA_1	41	47	PF00069	0.387
MOD_PKA_2	138	144	PF00069	0.487
MOD_PKA_2	25	31	PF00069	0.493
MOD_PKA_2	624	630	PF00069	0.499
MOD_Plk_1	281	287	PF00069	0.338
MOD_Plk_1	534	540	PF00069	0.241
MOD_Plk_2-3	100	106	PF00069	0.570
MOD_Plk_2-3	624	630	PF00069	0.514
MOD_Plk_2-3	70	76	PF00069	0.450
MOD_Plk_4	205	211	PF00069	0.541
MOD_Plk_4	231	237	PF00069	0.354
MOD_Plk_4	249	255	PF00069	0.224
MOD_Plk_4	315	321	PF00069	0.254
MOD_Plk_4	330	336	PF00069	0.215
MOD_Plk_4	353	359	PF00069	0.232
MOD_Plk_4	527	533	PF00069	0.171
MOD_Plk_4	598	604	PF00069	0.378
MOD_Plk_4	627	633	PF00069	0.510
MOD_Plk_4	70	76	PF00069	0.408
MOD_Plk_4	78	84	PF00069	0.424
MOD_ProDKin_1	424	430	PF00069	0.241
MOD_ProDKin_1	462	468	PF00069	0.256
MOD_ProDKin_1	477	483	PF00069	0.256
MOD_SUMO_rev_2	34	44	PF00179	0.456
TRG_DiLeu_BaEn_1	186	191	PF01217	0.471
TRG_DiLeu_BaEn_1	509	514	PF01217	0.256
TRG_DiLeu_BaEn_1	78	83	PF01217	0.463
TRG_DiLeu_BaEn_4	143	149	PF01217	0.469
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.356
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.449
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.256
TRG_ENDOCYTIC_2	290	293	PF00928	0.286
TRG_ENDOCYTIC_2	452	455	PF00928	0.335
TRG_ENDOCYTIC_2	603	606	PF00928	0.277
TRG_ENDOCYTIC_2	72	75	PF00928	0.442
TRG_ER_diArg_1	137	140	PF00400	0.602
TRG_ER_diArg_1	645	648	PF00400	0.689
TRG_ER_diArg_1	650	652	PF00400	0.665
TRG_NLS_Bipartite_1	634	648	PF00514	0.583
TRG_NLS_MonoExtC_3	643	648	PF00514	0.657
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P383	Leptomonas seymouri	85%	100%
A0A0S4IWR5	Bodo saltans	61%	99%
A0A1X0P734	Trypanosomatidae	68%	100%
A0A3R7MKH6	Trypanosoma rangeli	66%	100%
A0A3S7WV72	Leishmania donovani	88%	100%
A4HY31	Leishmania infantum	88%	100%
D0A554	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9ARU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P39744	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	92%
Q4QDM8	Leishmania major	88%	100%
Q9P7G0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	93%
Q9VIF0	Drosophila melanogaster	25%	85%
Q9WV70	Mus musculus	27%	88%
V5B4B0	Trypanosoma cruzi	65%	100%