Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4H9R1_LEIBR

TriTrypDb:

LbrM.18.1630 , LBRM2903_180022400

Length:

791

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9R1

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0016787	hydrolase activity	2	5
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.227
CLV_C14_Caspase3-7	477	481	PF00656	0.449
CLV_C14_Caspase3-7	612	616	PF00656	0.678
CLV_NRD_NRD_1	151	153	PF00675	0.354
CLV_NRD_NRD_1	187	189	PF00675	0.335
CLV_NRD_NRD_1	367	369	PF00675	0.600
CLV_NRD_NRD_1	4	6	PF00675	0.444
CLV_NRD_NRD_1	409	411	PF00675	0.601
CLV_NRD_NRD_1	47	49	PF00675	0.449
CLV_NRD_NRD_1	561	563	PF00675	0.602
CLV_NRD_NRD_1	679	681	PF00675	0.536
CLV_NRD_NRD_1	739	741	PF00675	0.551
CLV_NRD_NRD_1	769	771	PF00675	0.746
CLV_PCSK_FUR_1	313	317	PF00082	0.408
CLV_PCSK_KEX2_1	150	152	PF00082	0.350
CLV_PCSK_KEX2_1	187	189	PF00082	0.319
CLV_PCSK_KEX2_1	315	317	PF00082	0.392
CLV_PCSK_KEX2_1	367	369	PF00082	0.598
CLV_PCSK_KEX2_1	4	6	PF00082	0.444
CLV_PCSK_KEX2_1	409	411	PF00082	0.568
CLV_PCSK_KEX2_1	47	49	PF00082	0.449
CLV_PCSK_KEX2_1	561	563	PF00082	0.602
CLV_PCSK_KEX2_1	739	741	PF00082	0.551
CLV_PCSK_KEX2_1	768	770	PF00082	0.727
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.408
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.727
CLV_PCSK_PC7_1	147	153	PF00082	0.339
CLV_PCSK_SKI1_1	280	284	PF00082	0.447
CLV_PCSK_SKI1_1	561	565	PF00082	0.531
CLV_PCSK_SKI1_1	63	67	PF00082	0.417
CLV_PCSK_SKI1_1	68	72	PF00082	0.397
CLV_PCSK_SKI1_1	739	743	PF00082	0.547
CLV_PCSK_SKI1_1	778	782	PF00082	0.794
CLV_Separin_Metazoa	117	121	PF03568	0.447
DOC_CDC14_PxL_1	420	428	PF14671	0.504
DOC_CYCLIN_RxL_1	736	743	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	754	757	PF00134	0.520
DOC_MAPK_DCC_7	151	161	PF00069	0.227
DOC_MAPK_DCC_7	418	428	PF00069	0.505
DOC_MAPK_gen_1	208	216	PF00069	0.347
DOC_MAPK_gen_1	4	12	PF00069	0.414
DOC_MAPK_MEF2A_6	106	115	PF00069	0.463
DOC_MAPK_MEF2A_6	120	129	PF00069	0.438
DOC_MAPK_MEF2A_6	208	216	PF00069	0.320
DOC_MAPK_MEF2A_6	270	278	PF00069	0.335
DOC_MAPK_MEF2A_6	4	12	PF00069	0.414
DOC_PP1_RVXF_1	211	217	PF00149	0.447
DOC_PP2B_LxvP_1	394	397	PF13499	0.602
DOC_PP2B_LxvP_1	754	757	PF13499	0.647
DOC_PP2B_PxIxI_1	157	163	PF00149	0.447
DOC_USP7_MATH_1	196	200	PF00917	0.368
DOC_USP7_MATH_1	633	637	PF00917	0.753
DOC_USP7_MATH_1	721	725	PF00917	0.752
DOC_USP7_MATH_1	727	731	PF00917	0.759
DOC_WW_Pin1_4	226	231	PF00397	0.335
DOC_WW_Pin1_4	379	384	PF00397	0.596
DOC_WW_Pin1_4	392	397	PF00397	0.647
DOC_WW_Pin1_4	589	594	PF00397	0.678
DOC_WW_Pin1_4	652	657	PF00397	0.738
DOC_WW_Pin1_4	705	710	PF00397	0.644
DOC_WW_Pin1_4	733	738	PF00397	0.713
DOC_WW_Pin1_4	740	745	PF00397	0.665
DOC_WW_Pin1_4	75	80	PF00397	0.447
DOC_WW_Pin1_4	759	764	PF00397	0.576
LIG_14-3-3_CanoR_1	187	191	PF00244	0.327
LIG_14-3-3_CanoR_1	194	204	PF00244	0.313
LIG_14-3-3_CanoR_1	20	26	PF00244	0.490
LIG_14-3-3_CanoR_1	224	228	PF00244	0.335
LIG_14-3-3_CanoR_1	245	250	PF00244	0.324
LIG_14-3-3_CanoR_1	257	265	PF00244	0.309
LIG_14-3-3_CanoR_1	309	317	PF00244	0.335
LIG_14-3-3_CanoR_1	47	51	PF00244	0.424
LIG_14-3-3_CanoR_1	488	497	PF00244	0.594
LIG_14-3-3_CanoR_1	603	608	PF00244	0.663
LIG_Actin_WH2_2	301	317	PF00022	0.335
LIG_APCC_ABBA_1	130	135	PF00400	0.335
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_DLG_GKlike_1	591	599	PF00625	0.645
LIG_eIF4E_1	50	56	PF01652	0.447
LIG_FHA_1	165	171	PF00498	0.346
LIG_FHA_1	271	277	PF00498	0.373
LIG_FHA_1	28	34	PF00498	0.447
LIG_FHA_1	286	292	PF00498	0.329
LIG_FHA_1	309	315	PF00498	0.335
LIG_FHA_1	406	412	PF00498	0.578
LIG_FHA_1	558	564	PF00498	0.577
LIG_FHA_1	590	596	PF00498	0.742
LIG_FHA_1	609	615	PF00498	0.673
LIG_FHA_1	653	659	PF00498	0.740
LIG_FHA_1	724	730	PF00498	0.734
LIG_FHA_1	736	742	PF00498	0.493
LIG_FHA_1	96	102	PF00498	0.329
LIG_FHA_2	246	252	PF00498	0.335
LIG_FHA_2	320	326	PF00498	0.665
LIG_FHA_2	771	777	PF00498	0.712
LIG_KLC1_Yacidic_2	131	135	PF13176	0.480
LIG_LIR_Apic_2	435	440	PF02991	0.501
LIG_LIR_Gen_1	326	336	PF02991	0.692
LIG_LIR_Nem_3	431	437	PF02991	0.436
LIG_LIR_Nem_3	498	503	PF02991	0.441
LIG_LIR_Nem_3	84	90	PF02991	0.323
LIG_MYND_1	392	396	PF01753	0.498
LIG_NRBOX	273	279	PF00104	0.335
LIG_PDZ_Class_1	786	791	PF00595	0.623
LIG_Pex14_2	434	438	PF04695	0.445
LIG_SH2_GRB2like	266	269	PF00017	0.335
LIG_SH2_SRC	133	136	PF00017	0.468
LIG_SH2_STAP1	310	314	PF00017	0.335
LIG_SH2_STAP1	430	434	PF00017	0.537
LIG_SH2_STAT5	133	136	PF00017	0.468
LIG_SH2_STAT5	266	269	PF00017	0.335
LIG_SH2_STAT5	281	284	PF00017	0.335
LIG_SH2_STAT5	310	313	PF00017	0.344
LIG_SH2_STAT5	433	436	PF00017	0.416
LIG_SH2_STAT5	437	440	PF00017	0.419
LIG_SH2_STAT5	447	450	PF00017	0.393
LIG_SH2_STAT5	513	516	PF00017	0.431
LIG_SH2_STAT5	540	543	PF00017	0.574
LIG_SH2_STAT5	99	102	PF00017	0.468
LIG_SH3_1	152	158	PF00018	0.349
LIG_SH3_3	152	158	PF00018	0.349
LIG_SH3_3	224	230	PF00018	0.447
LIG_SH3_3	453	459	PF00018	0.595
LIG_SH3_3	542	548	PF00018	0.449
LIG_SH3_3	699	705	PF00018	0.766
LIG_SH3_3	726	732	PF00018	0.791
LIG_SH3_3	741	747	PF00018	0.689
LIG_SH3_3	76	82	PF00018	0.381
LIG_SH3_5	296	300	PF00018	0.480
LIG_Sin3_3	751	758	PF02671	0.526
LIG_SUMO_SIM_anti_2	271	278	PF11976	0.335
LIG_SUMO_SIM_anti_2	750	756	PF11976	0.536
LIG_SUMO_SIM_par_1	157	163	PF11976	0.382
LIG_UBA3_1	204	208	PF00899	0.335
LIG_WRC_WIRS_1	287	292	PF05994	0.408
LIG_WW_3	395	399	PF00397	0.504
LIG_WW_3	708	712	PF00397	0.796
MOD_CDC14_SPxK_1	395	398	PF00782	0.504
MOD_CDC14_SPxK_1	708	711	PF00782	0.632
MOD_CDC14_SPxK_1	736	739	PF00782	0.541
MOD_CDC14_SPxK_1	743	746	PF00782	0.692
MOD_CDK_SPxK_1	392	398	PF00069	0.502
MOD_CDK_SPxK_1	705	711	PF00069	0.705
MOD_CDK_SPxK_1	733	739	PF00069	0.585
MOD_CDK_SPxK_1	740	746	PF00069	0.644
MOD_CDK_SPxxK_3	733	740	PF00069	0.540
MOD_CK1_1	169	175	PF00069	0.373
MOD_CK1_1	183	189	PF00069	0.341
MOD_CK1_1	198	204	PF00069	0.265
MOD_CK1_1	22	28	PF00069	0.373
MOD_CK1_1	244	250	PF00069	0.335
MOD_CK1_1	285	291	PF00069	0.359
MOD_CK1_1	594	600	PF00069	0.701
MOD_CK1_1	602	608	PF00069	0.666
MOD_CK1_1	632	638	PF00069	0.696
MOD_CK1_1	676	682	PF00069	0.748
MOD_CK1_1	703	709	PF00069	0.714
MOD_CK1_1	95	101	PF00069	0.335
MOD_CK2_1	101	107	PF00069	0.355
MOD_CK2_1	245	251	PF00069	0.335
MOD_CK2_1	46	52	PF00069	0.389
MOD_CK2_1	495	501	PF00069	0.586
MOD_CK2_1	606	612	PF00069	0.736
MOD_CK2_1	676	682	PF00069	0.700
MOD_CK2_1	770	776	PF00069	0.715
MOD_Cter_Amidation	45	48	PF01082	0.480
MOD_GlcNHglycan	296	299	PF01048	0.451
MOD_GlcNHglycan	37	41	PF01048	0.321
MOD_GlcNHglycan	496	500	PF01048	0.367
MOD_GlcNHglycan	525	528	PF01048	0.550
MOD_GlcNHglycan	542	545	PF01048	0.576
MOD_GlcNHglycan	557	560	PF01048	0.348
MOD_GlcNHglycan	608	611	PF01048	0.635
MOD_GlcNHglycan	630	634	PF01048	0.734
MOD_GlcNHglycan	635	638	PF01048	0.648
MOD_GlcNHglycan	688	691	PF01048	0.789
MOD_GlcNHglycan	733	736	PF01048	0.682
MOD_GlcNHglycan	747	750	PF01048	0.759
MOD_GlcNHglycan	788	791	PF01048	0.498
MOD_GlcNHglycan	94	97	PF01048	0.335
MOD_GSK3_1	164	171	PF00069	0.346
MOD_GSK3_1	182	189	PF00069	0.245
MOD_GSK3_1	219	226	PF00069	0.335
MOD_GSK3_1	235	242	PF00069	0.315
MOD_GSK3_1	27	34	PF00069	0.403
MOD_GSK3_1	282	289	PF00069	0.454
MOD_GSK3_1	304	311	PF00069	0.324
MOD_GSK3_1	327	334	PF00069	0.507
MOD_GSK3_1	351	358	PF00069	0.650
MOD_GSK3_1	446	453	PF00069	0.555
MOD_GSK3_1	589	596	PF00069	0.701
MOD_GSK3_1	598	605	PF00069	0.696
MOD_GSK3_1	614	621	PF00069	0.714
MOD_GSK3_1	629	636	PF00069	0.631
MOD_GSK3_1	665	672	PF00069	0.732
MOD_GSK3_1	723	730	PF00069	0.686
MOD_GSK3_1	731	738	PF00069	0.581
MOD_GSK3_1	759	766	PF00069	0.719
MOD_GSK3_1	91	98	PF00069	0.361
MOD_N-GLC_1	239	244	PF02516	0.335
MOD_N-GLC_1	355	360	PF02516	0.595
MOD_N-GLC_1	400	405	PF02516	0.483
MOD_N-GLC_1	669	674	PF02516	0.781
MOD_N-GLC_2	21	23	PF02516	0.480
MOD_NEK2_1	269	274	PF00069	0.350
MOD_NEK2_1	282	287	PF00069	0.335
MOD_NEK2_1	308	313	PF00069	0.342
MOD_NEK2_1	372	377	PF00069	0.582
MOD_NEK2_1	400	405	PF00069	0.683
MOD_NEK2_1	474	479	PF00069	0.420
MOD_NEK2_1	489	494	PF00069	0.434
MOD_NEK2_1	595	600	PF00069	0.736
MOD_NEK2_1	614	619	PF00069	0.595
MOD_NEK2_2	203	208	PF00069	0.355
MOD_PIKK_1	256	262	PF00454	0.368
MOD_PIKK_1	308	314	PF00454	0.335
MOD_PKA_2	186	192	PF00069	0.344
MOD_PKA_2	19	25	PF00069	0.393
MOD_PKA_2	196	202	PF00069	0.319
MOD_PKA_2	223	229	PF00069	0.335
MOD_PKA_2	244	250	PF00069	0.346
MOD_PKA_2	256	262	PF00069	0.335
MOD_PKA_2	269	275	PF00069	0.333
MOD_PKA_2	308	314	PF00069	0.324
MOD_PKA_2	319	325	PF00069	0.615
MOD_PKA_2	405	411	PF00069	0.650
MOD_PKA_2	46	52	PF00069	0.354
MOD_PKA_2	602	608	PF00069	0.660
MOD_PKA_2	703	709	PF00069	0.804
MOD_PKA_2	745	751	PF00069	0.733
MOD_PKB_1	11	19	PF00069	0.480
MOD_Plk_1	239	245	PF00069	0.335
MOD_Plk_1	270	276	PF00069	0.355
MOD_Plk_1	342	348	PF00069	0.636
MOD_Plk_1	372	378	PF00069	0.533
MOD_Plk_1	614	620	PF00069	0.646
MOD_Plk_1	629	635	PF00069	0.543
MOD_Plk_4	223	229	PF00069	0.447
MOD_Plk_4	245	251	PF00069	0.335
MOD_Plk_4	272	278	PF00069	0.370
MOD_Plk_4	286	292	PF00069	0.291
MOD_Plk_4	450	456	PF00069	0.592
MOD_Plk_4	474	480	PF00069	0.427
MOD_Plk_4	548	554	PF00069	0.467
MOD_Plk_4	614	620	PF00069	0.722
MOD_ProDKin_1	226	232	PF00069	0.335
MOD_ProDKin_1	379	385	PF00069	0.600
MOD_ProDKin_1	392	398	PF00069	0.649
MOD_ProDKin_1	589	595	PF00069	0.678
MOD_ProDKin_1	652	658	PF00069	0.740
MOD_ProDKin_1	705	711	PF00069	0.648
MOD_ProDKin_1	733	739	PF00069	0.716
MOD_ProDKin_1	740	746	PF00069	0.664
MOD_ProDKin_1	75	81	PF00069	0.447
MOD_ProDKin_1	759	765	PF00069	0.579
MOD_SUMO_for_1	563	566	PF00179	0.585
MOD_SUMO_for_1	662	665	PF00179	0.545
MOD_SUMO_rev_2	325	335	PF00179	0.581
MOD_SUMO_rev_2	706	715	PF00179	0.553
MOD_SUMO_rev_2	716	721	PF00179	0.482
TRG_DiLeu_BaEn_1	336	341	PF01217	0.556
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.630
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.583
TRG_ENDOCYTIC_2	266	269	PF00928	0.335
TRG_ER_diArg_1	10	13	PF00400	0.395
TRG_ER_diArg_1	149	152	PF00400	0.346
TRG_ER_diArg_1	317	320	PF00400	0.519
TRG_ER_diArg_1	367	369	PF00400	0.600
TRG_ER_diArg_1	4	6	PF00400	0.450
TRG_ER_diArg_1	409	411	PF00400	0.564
TRG_ER_diArg_1	561	563	PF00400	0.602
TRG_ER_diArg_1	739	741	PF00400	0.551
TRG_ER_diArg_1	769	772	PF00400	0.798
TRG_NLS_MonoExtC_3	767	772	PF00514	0.712
TRG_NLS_MonoExtN_4	313	319	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F8	Leptomonas seymouri	65%	94%
A0A1X0P728	Trypanosomatidae	49%	89%
A0A3R7KGY3	Trypanosoma rangeli	48%	90%
A0A3S5H747	Leishmania donovani	80%	99%
A4HY30	Leishmania infantum	80%	99%
D0A556	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	91%
E9ARU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4QDM9	Leishmania major	79%	100%
V5D4P5	Trypanosoma cruzi	52%	100%