VASt domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H9R0_LEIBR

TriTrypDb:

LbrM.18.1620 , LBRM2903_180022300

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H9R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9R0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.434
CLV_NRD_NRD_1	44	46	PF00675	0.668
CLV_PCSK_KEX2_1	18	20	PF00082	0.685
CLV_PCSK_KEX2_1	198	200	PF00082	0.441
CLV_PCSK_KEX2_1	44	46	PF00082	0.700
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.685
CLV_PCSK_SKI1_1	131	135	PF00082	0.658
CLV_PCSK_SKI1_1	200	204	PF00082	0.437
DEG_Nend_UBRbox_4	1	3	PF02207	0.382
DOC_MAPK_gen_1	16	25	PF00069	0.438
DOC_MAPK_gen_1	44	51	PF00069	0.500
DOC_MAPK_gen_1	56	64	PF00069	0.395
DOC_PP1_RVXF_1	198	205	PF00149	0.668
DOC_PP4_FxxP_1	129	132	PF00568	0.453
DOC_USP7_MATH_1	210	214	PF00917	0.683
DOC_USP7_MATH_1	3	7	PF00917	0.371
DOC_USP7_MATH_1	79	83	PF00917	0.452
DOC_WW_Pin1_4	149	154	PF00397	0.500
LIG_14-3-3_CanoR_1	145	149	PF00244	0.471
LIG_14-3-3_CanoR_1	174	182	PF00244	0.277
LIG_14-3-3_CanoR_1	199	205	PF00244	0.639
LIG_14-3-3_CanoR_1	209	215	PF00244	0.652
LIG_BIR_III_2	150	154	PF00653	0.497
LIG_BRCT_BRCA1_1	60	64	PF00533	0.444
LIG_BRCT_BRCA1_2	60	66	PF00533	0.446
LIG_FHA_1	101	107	PF00498	0.451
LIG_FHA_1	65	71	PF00498	0.474
LIG_FHA_2	108	114	PF00498	0.480
LIG_FHA_2	133	139	PF00498	0.432
LIG_FHA_2	153	159	PF00498	0.454
LIG_FHA_2	81	87	PF00498	0.488
LIG_Integrin_RGD_1	136	138	PF01839	0.591
LIG_LIR_Apic_2	126	132	PF02991	0.453
LIG_LIR_Gen_1	107	116	PF02991	0.450
LIG_LIR_Gen_1	82	91	PF02991	0.506
LIG_LIR_Nem_3	107	111	PF02991	0.451
LIG_LIR_Nem_3	213	217	PF02991	0.726
LIG_LIR_Nem_3	47	53	PF02991	0.440
LIG_LIR_Nem_3	65	71	PF02991	0.446
LIG_LIR_Nem_3	82	87	PF02991	0.460
LIG_PDZ_Class_1	212	217	PF00595	0.694
LIG_Pex14_2	129	133	PF04695	0.452
LIG_REV1ctd_RIR_1	131	140	PF16727	0.450
LIG_SH2_CRK	68	72	PF00017	0.449
LIG_SH2_CRK	90	94	PF00017	0.452
LIG_SH2_NCK_1	90	94	PF00017	0.498
LIG_SH2_PTP2	108	111	PF00017	0.452
LIG_SH2_STAT5	108	111	PF00017	0.452
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.227
LIG_TYR_ITIM	106	111	PF00017	0.451
MOD_CK1_1	152	158	PF00069	0.495
MOD_CK1_1	173	179	PF00069	0.476
MOD_CK2_1	107	113	PF00069	0.447
MOD_CK2_1	152	158	PF00069	0.395
MOD_CK2_1	162	168	PF00069	0.406
MOD_CK2_1	36	42	PF00069	0.484
MOD_CK2_1	80	86	PF00069	0.488
MOD_Cter_Amidation	16	19	PF01082	0.670
MOD_GlcNHglycan	164	167	PF01048	0.675
MOD_GlcNHglycan	176	179	PF01048	0.549
MOD_GSK3_1	132	139	PF00069	0.453
MOD_GSK3_1	158	165	PF00069	0.527
MOD_GSK3_1	170	177	PF00069	0.584
MOD_GSK3_1	30	37	PF00069	0.442
MOD_GSK3_1	58	65	PF00069	0.474
MOD_N-GLC_1	158	163	PF02516	0.660
MOD_NEK2_1	11	16	PF00069	0.435
MOD_NEK2_1	32	37	PF00069	0.434
MOD_NEK2_1	64	69	PF00069	0.446
MOD_OFUCOSY	2	7	PF10250	0.574
MOD_PIKK_1	158	164	PF00454	0.421
MOD_PK_1	58	64	PF00069	0.442
MOD_PKA_2	144	150	PF00069	0.490
MOD_PKA_2	173	179	PF00069	0.455
MOD_PKB_1	198	206	PF00069	0.687
MOD_Plk_1	58	64	PF00069	0.442
MOD_Plk_2-3	107	113	PF00069	0.479
MOD_Plk_4	180	186	PF00069	0.347
MOD_Plk_4	58	64	PF00069	0.442
MOD_ProDKin_1	149	155	PF00069	0.498
TRG_DiLeu_BaEn_1	115	120	PF01217	0.454
TRG_ENDOCYTIC_2	108	111	PF00928	0.452
TRG_ENDOCYTIC_2	68	71	PF00928	0.448
TRG_ER_diArg_1	198	200	PF00400	0.707
TRG_ER_diArg_1	53	56	PF00400	0.438
TRG_NES_CRM1_1	47	59	PF08389	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I127	Leptomonas seymouri	60%	100%
A0A3S7WV60	Leishmania donovani	84%	100%
A4HY29	Leishmania infantum	84%	100%
E9ARU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QDN0	Leishmania major	84%	100%