RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H9Q8_LEIBR

TriTrypDb:

LbrM.18.1600 , LBRM2903_180023500

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Q8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.564
CLV_PCSK_SKI1_1	41	45	PF00082	0.533
DEG_APCC_DBOX_1	142	150	PF00400	0.233
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.417
DOC_USP7_MATH_1	96	100	PF00917	0.516
DOC_USP7_UBL2_3	18	22	PF12436	0.564
DOC_WW_Pin1_4	55	60	PF00397	0.417
DOC_WW_Pin1_4	82	87	PF00397	0.560
LIG_14-3-3_CanoR_1	52	56	PF00244	0.487
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_FHA_1	114	120	PF00498	0.485
LIG_FHA_1	66	72	PF00498	0.632
LIG_SH3_3	114	120	PF00018	0.425
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.546
LIG_WW_1	91	94	PF00397	0.641
MOD_CDK_SPxxK_3	82	89	PF00069	0.423
MOD_CK1_1	129	135	PF00069	0.454
MOD_CK1_1	138	144	PF00069	0.239
MOD_GlcNHglycan	1	4	PF01048	0.627
MOD_GSK3_1	51	58	PF00069	0.478
MOD_GSK3_1	76	83	PF00069	0.578
MOD_N-GLC_1	135	140	PF02516	0.233
MOD_N-GLC_2	137	139	PF02516	0.339
MOD_NEK2_1	43	48	PF00069	0.560
MOD_NEK2_1	71	76	PF00069	0.565
MOD_NEK2_2	113	118	PF00069	0.485
MOD_OFUCOSY	121	127	PF10250	0.439
MOD_PIKK_1	94	100	PF00454	0.516
MOD_PKA_2	51	57	PF00069	0.484
MOD_Plk_1	33	39	PF00069	0.524
MOD_Plk_4	113	119	PF00069	0.344
MOD_Plk_4	43	49	PF00069	0.558
MOD_Plk_4	51	57	PF00069	0.542
MOD_Plk_4	65	71	PF00069	0.545
MOD_ProDKin_1	55	61	PF00069	0.417
MOD_ProDKin_1	82	88	PF00069	0.552
TRG_DiLeu_BaEn_1	5	10	PF01217	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D9	Leptomonas seymouri	59%	100%
A0A1X0P747	Trypanosomatidae	33%	100%
A0A3S7WV41	Leishmania donovani	88%	100%
A0A422NPM7	Trypanosoma rangeli	36%	100%
A4HY27	Leishmania infantum	88%	100%
D0A558	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ARU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QDN2	Leishmania major	88%	99%