BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H9Q7_LEIBR

TriTrypDb:

LbrM.18.1580 , LBRM2903_180022000

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.445
CLV_NRD_NRD_1	197	199	PF00675	0.452
CLV_NRD_NRD_1	200	202	PF00675	0.447
CLV_NRD_NRD_1	249	251	PF00675	0.668
CLV_NRD_NRD_1	255	257	PF00675	0.624
CLV_NRD_NRD_1	320	322	PF00675	0.395
CLV_NRD_NRD_1	344	346	PF00675	0.399
CLV_NRD_NRD_1	389	391	PF00675	0.563
CLV_PCSK_FUR_1	198	202	PF00082	0.423
CLV_PCSK_KEX2_1	149	151	PF00082	0.339
CLV_PCSK_KEX2_1	197	199	PF00082	0.452
CLV_PCSK_KEX2_1	200	202	PF00082	0.447
CLV_PCSK_KEX2_1	249	251	PF00082	0.668
CLV_PCSK_KEX2_1	320	322	PF00082	0.395
CLV_PCSK_KEX2_1	344	346	PF00082	0.399
CLV_PCSK_KEX2_1	40	42	PF00082	0.388
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.339
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.388
CLV_PCSK_PC7_1	145	151	PF00082	0.330
CLV_PCSK_SKI1_1	145	149	PF00082	0.338
CLV_PCSK_SKI1_1	161	165	PF00082	0.543
CLV_PCSK_SKI1_1	250	254	PF00082	0.694
CLV_PCSK_SKI1_1	377	381	PF00082	0.549
CLV_PCSK_SKI1_1	40	44	PF00082	0.402
CLV_PCSK_SKI1_1	416	420	PF00082	0.413
DEG_APCC_DBOX_1	336	344	PF00400	0.368
DEG_SPOP_SBC_1	138	142	PF00917	0.302
DEG_SPOP_SBC_1	226	230	PF00917	0.520
DOC_CDC14_PxL_1	203	211	PF14671	0.501
DOC_CYCLIN_RxL_1	247	254	PF00134	0.634
DOC_USP7_MATH_1	12	16	PF00917	0.568
DOC_USP7_MATH_1	214	218	PF00917	0.434
DOC_USP7_MATH_1	225	229	PF00917	0.555
DOC_USP7_MATH_1	238	242	PF00917	0.575
DOC_USP7_MATH_1	314	318	PF00917	0.414
DOC_USP7_MATH_1	362	366	PF00917	0.678
DOC_USP7_MATH_1	58	62	PF00917	0.294
DOC_WW_Pin1_4	164	169	PF00397	0.369
DOC_WW_Pin1_4	242	247	PF00397	0.663
DOC_WW_Pin1_4	251	256	PF00397	0.576
DOC_WW_Pin1_4	44	49	PF00397	0.225
DOC_WW_Pin1_4	6	11	PF00397	0.491
LIG_14-3-3_CanoR_1	137	147	PF00244	0.310
LIG_14-3-3_CanoR_1	161	167	PF00244	0.428
LIG_14-3-3_CanoR_1	249	253	PF00244	0.545
LIG_14-3-3_CanoR_1	285	292	PF00244	0.549
LIG_14-3-3_CanoR_1	299	308	PF00244	0.418
LIG_Actin_WH2_2	329	346	PF00022	0.395
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_Clathr_ClatBox_1	397	401	PF01394	0.453
LIG_FHA_1	279	285	PF00498	0.494
LIG_FHA_1	328	334	PF00498	0.387
LIG_FHA_1	67	73	PF00498	0.309
LIG_FHA_2	149	155	PF00498	0.392
LIG_FHA_2	259	265	PF00498	0.550
LIG_FHA_2	317	323	PF00498	0.384
LIG_FHA_2	370	376	PF00498	0.566
LIG_LIR_Gen_1	151	160	PF02991	0.449
LIG_LIR_Gen_1	310	316	PF02991	0.378
LIG_LIR_Gen_1	95	102	PF02991	0.294
LIG_LIR_Nem_3	151	156	PF02991	0.467
LIG_LIR_Nem_3	196	202	PF02991	0.427
LIG_LIR_Nem_3	310	315	PF02991	0.381
LIG_LIR_Nem_3	47	53	PF02991	0.225
LIG_LIR_Nem_3	95	101	PF02991	0.384
LIG_LYPXL_yS_3	206	209	PF13949	0.496
LIG_NRBOX	175	181	PF00104	0.442
LIG_PCNA_yPIPBox_3	68	78	PF02747	0.231
LIG_PDZ_Class_2	415	420	PF00595	0.564
LIG_Pex14_1	199	203	PF04695	0.487
LIG_Pex14_2	50	54	PF04695	0.312
LIG_REV1ctd_RIR_1	47	55	PF16727	0.312
LIG_SH2_CRK	153	157	PF00017	0.456
LIG_SH2_GRB2like	74	77	PF00017	0.231
LIG_SH2_PTP2	74	77	PF00017	0.231
LIG_SH2_SRC	74	77	PF00017	0.231
LIG_SH2_STAP1	124	128	PF00017	0.337
LIG_SH2_STAP1	162	166	PF00017	0.427
LIG_SH2_STAT3	378	381	PF00017	0.524
LIG_SH2_STAT5	332	335	PF00017	0.444
LIG_SH2_STAT5	339	342	PF00017	0.451
LIG_SH2_STAT5	37	40	PF00017	0.314
LIG_SH2_STAT5	378	381	PF00017	0.379
LIG_SH2_STAT5	53	56	PF00017	0.352
LIG_SH2_STAT5	74	77	PF00017	0.231
LIG_SH3_3	184	190	PF00018	0.367
LIG_SH3_3	264	270	PF00018	0.501
LIG_SH3_3	361	367	PF00018	0.443
LIG_SUMO_SIM_par_1	115	122	PF11976	0.285
LIG_SUMO_SIM_par_1	395	401	PF11976	0.417
LIG_TRAF2_1	261	264	PF00917	0.519
MOD_CDC14_SPxK_1	254	257	PF00782	0.619
MOD_CDK_SPK_2	251	256	PF00069	0.544
MOD_CDK_SPK_2	6	11	PF00069	0.495
MOD_CDK_SPxK_1	251	257	PF00069	0.595
MOD_CDK_SPxxK_3	242	249	PF00069	0.669
MOD_CDK_SPxxK_3	44	51	PF00069	0.225
MOD_CK1_1	167	173	PF00069	0.460
MOD_CK1_1	217	223	PF00069	0.497
MOD_CK1_1	228	234	PF00069	0.579
MOD_CK1_1	365	371	PF00069	0.507
MOD_CK1_1	66	72	PF00069	0.355
MOD_CK2_1	258	264	PF00069	0.539
MOD_CK2_1	369	375	PF00069	0.569
MOD_CK2_1	58	64	PF00069	0.231
MOD_GlcNHglycan	15	18	PF01048	0.514
MOD_GlcNHglycan	216	219	PF01048	0.535
MOD_GlcNHglycan	222	225	PF01048	0.609
MOD_GlcNHglycan	235	239	PF01048	0.596
MOD_GlcNHglycan	240	243	PF01048	0.630
MOD_GlcNHglycan	263	267	PF01048	0.578
MOD_GlcNHglycan	271	274	PF01048	0.588
MOD_GlcNHglycan	301	304	PF01048	0.508
MOD_GlcNHglycan	368	371	PF01048	0.550
MOD_GlcNHglycan	60	63	PF01048	0.502
MOD_GlcNHglycan	78	81	PF01048	0.221
MOD_GlcNHglycan	88	91	PF01048	0.340
MOD_GSK3_1	234	241	PF00069	0.559
MOD_GSK3_1	244	251	PF00069	0.555
MOD_GSK3_1	258	265	PF00069	0.677
MOD_GSK3_1	32	39	PF00069	0.251
MOD_GSK3_1	362	369	PF00069	0.509
MOD_GSK3_1	52	59	PF00069	0.278
MOD_GSK3_1	62	69	PF00069	0.393
MOD_LATS_1	135	141	PF00433	0.437
MOD_N-GLC_1	44	49	PF02516	0.231
MOD_NEK2_1	308	313	PF00069	0.647
MOD_NEK2_1	315	320	PF00069	0.547
MOD_NEK2_1	36	41	PF00069	0.319
MOD_NEK2_1	4	9	PF00069	0.490
MOD_NEK2_1	86	91	PF00069	0.312
MOD_NEK2_1	97	102	PF00069	0.372
MOD_NEK2_2	119	124	PF00069	0.413
MOD_NEK2_2	32	37	PF00069	0.243
MOD_OFUCOSY	354	361	PF10250	0.391
MOD_PIKK_1	167	173	PF00454	0.388
MOD_PIKK_1	244	250	PF00454	0.553
MOD_PKA_2	13	19	PF00069	0.482
MOD_PKA_2	248	254	PF00069	0.614
MOD_PKA_2	284	290	PF00069	0.555
MOD_PKA_2	308	314	PF00069	0.632
MOD_PKB_1	297	305	PF00069	0.509
MOD_Plk_1	234	240	PF00069	0.541
MOD_Plk_1	262	268	PF00069	0.511
MOD_Plk_1	327	333	PF00069	0.384
MOD_Plk_2-3	258	264	PF00069	0.521
MOD_Plk_4	119	125	PF00069	0.338
MOD_Plk_4	32	38	PF00069	0.232
MOD_Plk_4	327	333	PF00069	0.384
MOD_Plk_4	66	72	PF00069	0.312
MOD_Plk_4	97	103	PF00069	0.300
MOD_ProDKin_1	164	170	PF00069	0.364
MOD_ProDKin_1	242	248	PF00069	0.665
MOD_ProDKin_1	251	257	PF00069	0.574
MOD_ProDKin_1	44	50	PF00069	0.225
MOD_ProDKin_1	6	12	PF00069	0.493
MOD_SUMO_for_1	128	131	PF00179	0.376
MOD_SUMO_rev_2	384	392	PF00179	0.537
TRG_DiLeu_BaEn_3	263	269	PF01217	0.508
TRG_ENDOCYTIC_2	153	156	PF00928	0.446
TRG_ENDOCYTIC_2	206	209	PF00928	0.496
TRG_ER_diArg_1	197	199	PF00400	0.436
TRG_ER_diArg_1	200	202	PF00400	0.425
TRG_ER_diArg_1	296	299	PF00400	0.437
TRG_ER_diArg_1	343	345	PF00400	0.426
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	406	411	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZP2	Leptomonas seymouri	44%	99%
A0A3S7WV66	Leishmania donovani	68%	100%
A4HY26	Leishmania infantum	68%	100%
E9ART9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QDN4	Leishmania major	70%	98%