Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9Q4_LEIBR

TriTrypDb:

LbrM.18.1540 , LBRM2903_180021600

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Q4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.639
CLV_C14_Caspase3-7	242	246	PF00656	0.541
CLV_C14_Caspase3-7	416	420	PF00656	0.514
CLV_C14_Caspase3-7	56	60	PF00656	0.405
CLV_C14_Caspase3-7	612	616	PF00656	0.523
CLV_C14_Caspase3-7	819	823	PF00656	0.479
CLV_NRD_NRD_1	29	31	PF00675	0.689
CLV_NRD_NRD_1	475	477	PF00675	0.556
CLV_NRD_NRD_1	632	634	PF00675	0.425
CLV_NRD_NRD_1	691	693	PF00675	0.482
CLV_NRD_NRD_1	832	834	PF00675	0.435
CLV_PCSK_FUR_1	26	30	PF00082	0.674
CLV_PCSK_FUR_1	473	477	PF00082	0.740
CLV_PCSK_KEX2_1	25	27	PF00082	0.719
CLV_PCSK_KEX2_1	28	30	PF00082	0.685
CLV_PCSK_KEX2_1	475	477	PF00082	0.556
CLV_PCSK_KEX2_1	691	693	PF00082	0.482
CLV_PCSK_KEX2_1	831	833	PF00082	0.412
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.719
CLV_PCSK_SKI1_1	102	106	PF00082	0.515
CLV_PCSK_SKI1_1	29	33	PF00082	0.615
CLV_PCSK_SKI1_1	476	480	PF00082	0.565
CLV_PCSK_SKI1_1	485	489	PF00082	0.575
CLV_PCSK_SKI1_1	768	772	PF00082	0.451
CLV_PCSK_SKI1_1	800	804	PF00082	0.481
CLV_PCSK_SKI1_1	833	837	PF00082	0.494
DEG_APCC_DBOX_1	27	35	PF00400	0.629
DEG_Nend_UBRbox_1	1	4	PF02207	0.531
DEG_SPOP_SBC_1	609	613	PF00917	0.647
DEG_SPOP_SBC_1	628	632	PF00917	0.387
DOC_CKS1_1	306	311	PF01111	0.500
DOC_CKS1_1	325	330	PF01111	0.418
DOC_CKS1_1	39	44	PF01111	0.587
DOC_CYCLIN_RxL_1	473	486	PF00134	0.636
DOC_CYCLIN_RxL_1	762	774	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	291	297	PF00134	0.680
DOC_MAPK_gen_1	661	670	PF00069	0.406
DOC_MAPK_gen_1	831	839	PF00069	0.486
DOC_MAPK_JIP1_4	664	670	PF00069	0.481
DOC_MAPK_MEF2A_6	379	388	PF00069	0.525
DOC_PP2B_LxvP_1	626	629	PF13499	0.451
DOC_PP4_FxxP_1	342	345	PF00568	0.388
DOC_USP7_MATH_1	10	14	PF00917	0.598
DOC_USP7_MATH_1	109	113	PF00917	0.607
DOC_USP7_MATH_1	136	140	PF00917	0.721
DOC_USP7_MATH_1	162	166	PF00917	0.654
DOC_USP7_MATH_1	171	175	PF00917	0.581
DOC_USP7_MATH_1	24	28	PF00917	0.762
DOC_USP7_MATH_1	283	287	PF00917	0.520
DOC_USP7_MATH_1	361	365	PF00917	0.480
DOC_USP7_MATH_1	422	426	PF00917	0.704
DOC_USP7_MATH_1	477	481	PF00917	0.572
DOC_USP7_MATH_1	516	520	PF00917	0.652
DOC_USP7_MATH_1	539	543	PF00917	0.589
DOC_USP7_MATH_1	610	614	PF00917	0.632
DOC_USP7_MATH_1	629	633	PF00917	0.387
DOC_USP7_MATH_1	728	732	PF00917	0.570
DOC_USP7_MATH_1	835	839	PF00917	0.531
DOC_WW_Pin1_4	141	146	PF00397	0.702
DOC_WW_Pin1_4	29	34	PF00397	0.676
DOC_WW_Pin1_4	305	310	PF00397	0.507
DOC_WW_Pin1_4	324	329	PF00397	0.426
DOC_WW_Pin1_4	38	43	PF00397	0.636
DOC_WW_Pin1_4	420	425	PF00397	0.636
DOC_WW_Pin1_4	496	501	PF00397	0.602
DOC_WW_Pin1_4	508	513	PF00397	0.632
DOC_WW_Pin1_4	6	11	PF00397	0.560
DOC_WW_Pin1_4	616	621	PF00397	0.625
DOC_WW_Pin1_4	640	645	PF00397	0.435
DOC_WW_Pin1_4	675	680	PF00397	0.501
DOC_WW_Pin1_4	71	76	PF00397	0.388
DOC_WW_Pin1_4	778	783	PF00397	0.467
LIG_14-3-3_CanoR_1	362	366	PF00244	0.537
LIG_14-3-3_CanoR_1	476	482	PF00244	0.567
LIG_14-3-3_CanoR_1	485	491	PF00244	0.578
LIG_14-3-3_CanoR_1	495	503	PF00244	0.608
LIG_14-3-3_CanoR_1	508	512	PF00244	0.738
LIG_14-3-3_CanoR_1	602	610	PF00244	0.536
LIG_14-3-3_CanoR_1	627	637	PF00244	0.454
LIG_14-3-3_CanoR_1	82	86	PF00244	0.504
LIG_Actin_WH2_2	342	359	PF00022	0.437
LIG_BIR_III_2	187	191	PF00653	0.652
LIG_BIR_III_2	421	425	PF00653	0.702
LIG_BIR_III_2	561	565	PF00653	0.327
LIG_CSL_BTD_1	142	145	PF09270	0.518
LIG_deltaCOP1_diTrp_1	561	566	PF00928	0.339
LIG_DLG_GKlike_1	682	690	PF00625	0.501
LIG_FHA_1	120	126	PF00498	0.458
LIG_FHA_1	192	198	PF00498	0.676
LIG_FHA_1	276	282	PF00498	0.679
LIG_FHA_1	339	345	PF00498	0.381
LIG_FHA_1	543	549	PF00498	0.600
LIG_FHA_1	645	651	PF00498	0.438
LIG_FHA_1	782	788	PF00498	0.489
LIG_FHA_1	93	99	PF00498	0.415
LIG_FHA_2	201	207	PF00498	0.547
LIG_FHA_2	409	415	PF00498	0.552
LIG_FHA_2	421	427	PF00498	0.625
LIG_FHA_2	54	60	PF00498	0.580
LIG_FHA_2	610	616	PF00498	0.800
LIG_FHA_2	756	762	PF00498	0.312
LIG_LIR_Apic_2	172	178	PF02991	0.670
LIG_LIR_Apic_2	268	274	PF02991	0.639
LIG_LIR_Apic_2	341	345	PF02991	0.391
LIG_LIR_Gen_1	112	121	PF02991	0.352
LIG_LIR_Gen_1	59	70	PF02991	0.342
LIG_LIR_Nem_3	112	117	PF02991	0.335
LIG_LIR_Nem_3	238	244	PF02991	0.594
LIG_LIR_Nem_3	341	346	PF02991	0.390
LIG_LIR_Nem_3	486	490	PF02991	0.485
LIG_LIR_Nem_3	547	553	PF02991	0.486
LIG_LIR_Nem_3	576	581	PF02991	0.406
LIG_LIR_Nem_3	59	65	PF02991	0.346
LIG_LYPXL_yS_3	550	553	PF13949	0.485
LIG_MYND_1	38	42	PF01753	0.549
LIG_MYND_1	590	594	PF01753	0.518
LIG_PDZ_Class_2	834	839	PF00595	0.595
LIG_Rb_pABgroove_1	265	273	PF01858	0.638
LIG_SH2_CRK	271	275	PF00017	0.641
LIG_SH2_NCK_1	108	112	PF00017	0.499
LIG_SH2_NCK_1	271	275	PF00017	0.641
LIG_SH2_PTP2	114	117	PF00017	0.322
LIG_SH2_PTP2	175	178	PF00017	0.644
LIG_SH2_PTP2	578	581	PF00017	0.383
LIG_SH2_SRC	175	178	PF00017	0.555
LIG_SH2_STAP1	182	186	PF00017	0.485
LIG_SH2_STAT5	114	117	PF00017	0.322
LIG_SH2_STAT5	175	178	PF00017	0.621
LIG_SH2_STAT5	334	337	PF00017	0.387
LIG_SH2_STAT5	375	378	PF00017	0.398
LIG_SH2_STAT5	578	581	PF00017	0.383
LIG_SH2_STAT5	588	591	PF00017	0.439
LIG_SH3_1	271	277	PF00018	0.584
LIG_SH3_1	300	306	PF00018	0.482
LIG_SH3_3	173	179	PF00018	0.592
LIG_SH3_3	271	277	PF00018	0.594
LIG_SH3_3	300	306	PF00018	0.612
LIG_SH3_3	31	37	PF00018	0.692
LIG_SH3_3	399	405	PF00018	0.386
LIG_SH3_3	471	477	PF00018	0.535
LIG_SH3_5	178	182	PF00018	0.667
LIG_SUMO_SIM_anti_2	740	745	PF11976	0.455
LIG_SUMO_SIM_anti_2	77	82	PF11976	0.368
LIG_SUMO_SIM_par_1	191	196	PF11976	0.665
LIG_SUMO_SIM_par_1	536	542	PF11976	0.478
LIG_TRAF2_1	345	348	PF00917	0.494
LIG_TRAF2_1	681	684	PF00917	0.593
LIG_TRAF2_1	699	702	PF00917	0.333
LIG_TRAF2_2	328	333	PF00917	0.478
LIG_TRFH_1	640	644	PF08558	0.429
LIG_TYR_ITIM	239	244	PF00017	0.593
LIG_TYR_ITIM	548	553	PF00017	0.485
LIG_WRC_WIRS_1	339	344	PF05994	0.379
MOD_CDC14_SPxK_1	511	514	PF00782	0.544
MOD_CDK_SPxK_1	29	35	PF00069	0.570
MOD_CDK_SPxK_1	508	514	PF00069	0.544
MOD_CDK_SPxxK_3	675	682	PF00069	0.494
MOD_CK1_1	141	147	PF00069	0.542
MOD_CK1_1	165	171	PF00069	0.539
MOD_CK1_1	223	229	PF00069	0.510
MOD_CK1_1	304	310	PF00069	0.438
MOD_CK1_1	364	370	PF00069	0.408
MOD_CK1_1	425	431	PF00069	0.547
MOD_CK1_1	43	49	PF00069	0.630
MOD_CK1_1	462	468	PF00069	0.560
MOD_CK1_1	486	492	PF00069	0.582
MOD_CK1_1	519	525	PF00069	0.679
MOD_CK1_1	526	532	PF00069	0.569
MOD_CK1_1	542	548	PF00069	0.523
MOD_CK1_1	6	12	PF00069	0.717
MOD_CK1_1	781	787	PF00069	0.509
MOD_CK1_1	818	824	PF00069	0.474
MOD_CK2_1	10	16	PF00069	0.654
MOD_CK2_1	193	199	PF00069	0.519
MOD_CK2_1	200	206	PF00069	0.528
MOD_CK2_1	408	414	PF00069	0.541
MOD_CK2_1	420	426	PF00069	0.620
MOD_CK2_1	696	702	PF00069	0.449
MOD_CK2_1	81	87	PF00069	0.366
MOD_CMANNOS	563	566	PF00535	0.398
MOD_DYRK1A_RPxSP_1	305	309	PF00069	0.507
MOD_GlcNHglycan	134	137	PF01048	0.496
MOD_GlcNHglycan	164	167	PF01048	0.488
MOD_GlcNHglycan	211	214	PF01048	0.710
MOD_GlcNHglycan	241	244	PF01048	0.531
MOD_GlcNHglycan	247	250	PF01048	0.602
MOD_GlcNHglycan	426	430	PF01048	0.655
MOD_GlcNHglycan	446	449	PF01048	0.676
MOD_GlcNHglycan	454	457	PF01048	0.598
MOD_GlcNHglycan	490	493	PF01048	0.527
MOD_GlcNHglycan	62	65	PF01048	0.339
MOD_GlcNHglycan	693	696	PF01048	0.493
MOD_GlcNHglycan	698	701	PF01048	0.461
MOD_GlcNHglycan	730	733	PF01048	0.674
MOD_GlcNHglycan	748	751	PF01048	0.290
MOD_GSK3_1	115	122	PF00069	0.503
MOD_GSK3_1	132	139	PF00069	0.489
MOD_GSK3_1	161	168	PF00069	0.500
MOD_GSK3_1	20	27	PF00069	0.571
MOD_GSK3_1	301	308	PF00069	0.511
MOD_GSK3_1	360	367	PF00069	0.467
MOD_GSK3_1	446	453	PF00069	0.604
MOD_GSK3_1	459	466	PF00069	0.681
MOD_GSK3_1	486	493	PF00069	0.531
MOD_GSK3_1	519	526	PF00069	0.664
MOD_GSK3_1	538	545	PF00069	0.537
MOD_GSK3_1	6	13	PF00069	0.588
MOD_GSK3_1	604	611	PF00069	0.586
MOD_GSK3_1	640	647	PF00069	0.401
MOD_GSK3_1	81	88	PF00069	0.369
MOD_N-GLC_1	526	531	PF02516	0.538
MOD_NEK2_1	250	255	PF00069	0.511
MOD_NEK2_1	490	495	PF00069	0.516
MOD_NEK2_1	507	512	PF00069	0.611
MOD_NEK2_1	650	655	PF00069	0.544
MOD_NEK2_1	668	673	PF00069	0.289
MOD_NEK2_1	737	742	PF00069	0.415
MOD_NEK2_1	771	776	PF00069	0.544
MOD_NEK2_1	81	86	PF00069	0.522
MOD_NEK2_1	93	98	PF00069	0.431
MOD_NEK2_2	10	15	PF00069	0.509
MOD_NEK2_2	361	366	PF00069	0.473
MOD_NEK2_2	483	488	PF00069	0.485
MOD_NEK2_2	53	58	PF00069	0.437
MOD_PIKK_1	250	256	PF00454	0.676
MOD_PIKK_1	554	560	PF00454	0.446
MOD_PIKK_1	771	777	PF00454	0.549
MOD_PIKK_1	93	99	PF00454	0.385
MOD_PK_1	156	162	PF00069	0.648
MOD_PKA_1	691	697	PF00069	0.522
MOD_PKA_2	301	307	PF00069	0.568
MOD_PKA_2	349	355	PF00069	0.442
MOD_PKA_2	361	367	PF00069	0.464
MOD_PKA_2	408	414	PF00069	0.469
MOD_PKA_2	450	456	PF00069	0.560
MOD_PKA_2	494	500	PF00069	0.546
MOD_PKA_2	507	513	PF00069	0.712
MOD_PKA_2	522	528	PF00069	0.537
MOD_PKA_2	601	607	PF00069	0.500
MOD_PKA_2	691	697	PF00069	0.522
MOD_PKA_2	81	87	PF00069	0.529
MOD_Plk_1	119	125	PF00069	0.523
MOD_Plk_1	156	162	PF00069	0.648
MOD_Plk_1	182	188	PF00069	0.487
MOD_Plk_1	526	532	PF00069	0.534
MOD_Plk_1	604	610	PF00069	0.642
MOD_Plk_1	650	656	PF00069	0.534
MOD_Plk_1	682	688	PF00069	0.501
MOD_Plk_2-3	202	208	PF00069	0.553
MOD_Plk_4	10	16	PF00069	0.510
MOD_Plk_4	138	144	PF00069	0.608
MOD_Plk_4	156	162	PF00069	0.471
MOD_Plk_4	171	177	PF00069	0.776
MOD_Plk_4	338	344	PF00069	0.377
MOD_Plk_4	477	483	PF00069	0.592
MOD_Plk_4	574	580	PF00069	0.487
MOD_Plk_4	621	627	PF00069	0.411
MOD_Plk_4	650	656	PF00069	0.534
MOD_Plk_4	739	745	PF00069	0.385
MOD_Plk_4	755	761	PF00069	0.397
MOD_ProDKin_1	141	147	PF00069	0.708
MOD_ProDKin_1	29	35	PF00069	0.678
MOD_ProDKin_1	305	311	PF00069	0.505
MOD_ProDKin_1	324	330	PF00069	0.427
MOD_ProDKin_1	38	44	PF00069	0.634
MOD_ProDKin_1	420	426	PF00069	0.639
MOD_ProDKin_1	496	502	PF00069	0.605
MOD_ProDKin_1	508	514	PF00069	0.634
MOD_ProDKin_1	6	12	PF00069	0.561
MOD_ProDKin_1	616	622	PF00069	0.623
MOD_ProDKin_1	640	646	PF00069	0.430
MOD_ProDKin_1	675	681	PF00069	0.494
MOD_ProDKin_1	71	77	PF00069	0.385
MOD_ProDKin_1	778	784	PF00069	0.468
MOD_SUMO_rev_2	378	384	PF00179	0.532
TRG_DiLeu_BaEn_2	797	803	PF01217	0.404
TRG_DiLeu_BaEn_3	701	707	PF01217	0.338
TRG_DiLeu_BaEn_4	683	689	PF01217	0.498
TRG_ENDOCYTIC_2	114	117	PF00928	0.322
TRG_ENDOCYTIC_2	241	244	PF00928	0.596
TRG_ENDOCYTIC_2	373	376	PF00928	0.475
TRG_ENDOCYTIC_2	550	553	PF00928	0.485
TRG_ENDOCYTIC_2	578	581	PF00928	0.383
TRG_ER_diArg_1	26	29	PF00400	0.694
TRG_ER_diArg_1	472	475	PF00400	0.540
TRG_ER_diArg_1	635	638	PF00400	0.396
TRG_ER_diArg_1	690	692	PF00400	0.462
TRG_ER_diArg_1	830	833	PF00400	0.398
TRG_NLS_MonoExtC_3	24	29	PF00514	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U0	Leptomonas seymouri	44%	76%
A0A3S7WV44	Leishmania donovani	77%	80%
A4HY20	Leishmania infantum	77%	80%
E9ART4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	74%
Q4QDN9	Leishmania major	76%	100%