Putative chaperone protein DNAj

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania braziliensis

UniProt:

A4H9Q3_LEIBR

TriTrypDb:

LbrM.18.1530 , LBRM2903_180021500

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Q3

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	10
GO:0006448	regulation of translational elongation	7	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009889	regulation of biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0010468	regulation of gene expression	5	10
GO:0010556	regulation of macromolecule biosynthetic process	5	10
GO:0010608	post-transcriptional regulation of gene expression	6	10
GO:0017182	peptidyl-diphthamide metabolic process	7	10
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018202	peptidyl-histidine modification	6	10
GO:0019222	regulation of metabolic process	3	10
GO:0019538	protein metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031326	regulation of cellular biosynthetic process	5	10
GO:0034248	regulation of amide metabolic process	5	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0051171	regulation of nitrogen compound metabolic process	4	10
GO:0051246	regulation of protein metabolic process	5	10
GO:0060255	regulation of macromolecule metabolic process	4	10
GO:0065007	biological regulation	1	10
GO:0071704	organic substance metabolic process	2	10
GO:0080090	regulation of primary metabolic process	4	10
GO:1900247	regulation of cytoplasmic translational elongation	8	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	10
GO:0002097	tRNA wobble base modification	7	1
GO:0002098	tRNA wobble uridine modification	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0008033	tRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.344
CLV_PCSK_KEX2_1	35	37	PF00082	0.327
CLV_PCSK_PC7_1	31	37	PF00082	0.324
CLV_PCSK_SKI1_1	31	35	PF00082	0.310
CLV_PCSK_SKI1_1	36	40	PF00082	0.310
DEG_SPOP_SBC_1	162	166	PF00917	0.430
DOC_USP7_MATH_1	152	156	PF00917	0.704
DOC_USP7_MATH_1	162	166	PF00917	0.517
DOC_USP7_MATH_1	56	60	PF00917	0.400
DOC_USP7_MATH_1	92	96	PF00917	0.545
DOC_USP7_UBL2_3	45	49	PF12436	0.202
DOC_WW_Pin1_4	11	16	PF00397	0.424
DOC_WW_Pin1_4	19	24	PF00397	0.202
DOC_WW_Pin1_4	50	55	PF00397	0.333
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_EVH1_2	67	71	PF00568	0.202
LIG_FHA_1	106	112	PF00498	0.428
LIG_FHA_1	143	149	PF00498	0.526
LIG_FHA_1	165	171	PF00498	0.338
LIG_FHA_2	24	30	PF00498	0.316
LIG_FHA_2	39	45	PF00498	0.299
LIG_KLC1_Yacidic_2	107	112	PF13176	0.291
LIG_LIR_Gen_1	112	120	PF02991	0.484
LIG_LIR_Gen_1	14	23	PF02991	0.353
LIG_LIR_LC3C_4	176	181	PF02991	0.449
LIG_LIR_Nem_3	11	16	PF02991	0.414
LIG_LIR_Nem_3	112	118	PF02991	0.451
LIG_LIR_Nem_3	70	74	PF02991	0.355
LIG_PCNA_PIPBox_1	1	10	PF02747	0.370
LIG_PDZ_Class_2	180	185	PF00595	0.422
LIG_REV1ctd_RIR_1	69	79	PF16727	0.202
LIG_SH2_CRK	16	20	PF00017	0.232
LIG_SH2_STAP1	143	147	PF00017	0.498
LIG_SH2_STAT5	110	113	PF00017	0.516
LIG_SH2_STAT5	168	171	PF00017	0.461
LIG_SH3_1	146	152	PF00018	0.369
LIG_SH3_3	146	152	PF00018	0.621
MOD_CK1_1	164	170	PF00069	0.548
MOD_CK1_1	55	61	PF00069	0.305
MOD_CK2_1	6	12	PF00069	0.544
MOD_GlcNHglycan	1	4	PF01048	0.680
MOD_GlcNHglycan	154	157	PF01048	0.702
MOD_GlcNHglycan	23	26	PF01048	0.353
MOD_GlcNHglycan	54	57	PF01048	0.379
MOD_GSK3_1	162	169	PF00069	0.568
MOD_GSK3_1	19	26	PF00069	0.307
MOD_GSK3_1	48	55	PF00069	0.387
MOD_GSK3_1	58	65	PF00069	0.328
MOD_N-GLC_1	56	61	PF02516	0.226
MOD_NEK2_1	142	147	PF00069	0.415
MOD_OFUCOSY	172	177	PF10250	0.452
MOD_Plk_1	113	119	PF00069	0.393
MOD_Plk_4	105	111	PF00069	0.503
MOD_Plk_4	175	181	PF00069	0.377
MOD_Plk_4	67	73	PF00069	0.324
MOD_ProDKin_1	11	17	PF00069	0.425
MOD_ProDKin_1	19	25	PF00069	0.202
MOD_ProDKin_1	50	56	PF00069	0.333
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.290
TRG_ENDOCYTIC_2	16	19	PF00928	0.310
TRG_ER_diArg_1	34	36	PF00400	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKZ1	Leptomonas seymouri	52%	100%
A0A0S4JNU9	Bodo saltans	39%	100%
A0A1X0P737	Trypanosomatidae	39%	100%
A0A3S7WV53	Leishmania donovani	67%	100%
A0A422NIQ2	Trypanosoma rangeli	40%	100%
A4HY19	Leishmania infantum	66%	100%
D0A566	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ART3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q0VBY7	Bos taurus	25%	100%
Q4QDP0	Leishmania major	66%	100%
Q54CI5	Dictyostelium discoideum	29%	100%
Q6P3W2	Homo sapiens	27%	100%