Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9Q0_LEIBR

TriTrypDb:

LbrM.18.1500 , LBRM2903_180021200

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H9Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Q0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.421
CLV_PCSK_KEX2_1	12	14	PF00082	0.452
CLV_PCSK_KEX2_1	5	7	PF00082	0.438
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.366
CLV_PCSK_SKI1_1	27	31	PF00082	0.447
CLV_PCSK_SKI1_1	96	100	PF00082	0.363
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DOC_CDC14_PxL_1	81	89	PF14671	0.579
DOC_CKS1_1	233	238	PF01111	0.489
DOC_MAPK_gen_1	12	18	PF00069	0.671
DOC_PP4_FxxP_1	133	136	PF00568	0.572
DOC_PP4_FxxP_1	197	200	PF00568	0.621
DOC_PP4_FxxP_1	233	236	PF00568	0.539
DOC_PP4_FxxP_1	262	265	PF00568	0.494
DOC_PP4_MxPP_1	168	171	PF00568	0.660
DOC_USP7_MATH_1	72	76	PF00917	0.723
DOC_USP7_MATH_1	92	96	PF00917	0.571
DOC_USP7_MATH_2	191	197	PF00917	0.664
DOC_WW_Pin1_4	155	160	PF00397	0.672
DOC_WW_Pin1_4	205	210	PF00397	0.587
DOC_WW_Pin1_4	232	237	PF00397	0.541
DOC_WW_Pin1_4	63	68	PF00397	0.781
LIG_14-3-3_CanoR_1	86	92	PF00244	0.591
LIG_APCC_ABBA_1	271	276	PF00400	0.499
LIG_BRCT_BRCA1_1	229	233	PF00533	0.554
LIG_DCNL_PONY_1	1	4	PF03556	0.553
LIG_FHA_1	122	128	PF00498	0.565
LIG_FHA_1	176	182	PF00498	0.752
LIG_FHA_1	233	239	PF00498	0.487
LIG_FHA_1	97	103	PF00498	0.537
LIG_FHA_2	20	26	PF00498	0.558
LIG_IBAR_NPY_1	118	120	PF08397	0.456
LIG_LIR_Apic_2	115	119	PF02991	0.537
LIG_LIR_Apic_2	195	200	PF02991	0.612
LIG_LIR_Apic_2	230	236	PF02991	0.550
LIG_LIR_Apic_2	261	265	PF02991	0.497
LIG_LIR_Gen_1	221	226	PF02991	0.604
LIG_LIR_Gen_1	280	291	PF02991	0.529
LIG_LIR_Gen_1	303	310	PF02991	0.493
LIG_LIR_Nem_3	137	142	PF02991	0.652
LIG_LIR_Nem_3	195	201	PF02991	0.606
LIG_LIR_Nem_3	221	225	PF02991	0.604
LIG_LIR_Nem_3	256	262	PF02991	0.585
LIG_LIR_Nem_3	280	286	PF02991	0.509
LIG_PCNA_yPIPBox_3	17	30	PF02747	0.560
LIG_Pex14_1	332	336	PF04695	0.355
LIG_Pex14_2	197	201	PF04695	0.602
LIG_Pex14_2	262	266	PF04695	0.494
LIG_REV1ctd_RIR_1	136	144	PF16727	0.639
LIG_RPA_C_Fungi	1	13	PF08784	0.429
LIG_SH2_CRK	116	120	PF00017	0.289
LIG_SH2_GRB2like	116	119	PF00017	0.462
LIG_SH2_NCK_1	120	124	PF00017	0.478
LIG_SH2_SRC	322	325	PF00017	0.410
LIG_SH2_STAP1	165	169	PF00017	0.569
LIG_SH2_STAT5	120	123	PF00017	0.311
LIG_SH2_STAT5	322	325	PF00017	0.410
LIG_SH2_STAT5	89	92	PF00017	0.528
LIG_SUMO_SIM_anti_2	124	129	PF11976	0.454
LIG_SxIP_EBH_1	70	80	PF03271	0.413
LIG_TYR_ITIM	334	339	PF00017	0.355
LIG_WRC_WIRS_1	194	199	PF05994	0.582
LIG_WRC_WIRS_1	259	264	PF05994	0.373
LIG_WW_3	169	173	PF00397	0.552
MOD_CK1_1	19	25	PF00069	0.652
MOD_CK1_1	33	39	PF00069	0.736
MOD_CK1_1	66	72	PF00069	0.618
MOD_CK2_1	299	305	PF00069	0.433
MOD_GlcNHglycan	160	163	PF01048	0.693
MOD_GlcNHglycan	344	347	PF01048	0.545
MOD_GlcNHglycan	55	58	PF01048	0.713
MOD_GlcNHglycan	68	71	PF01048	0.675
MOD_GSK3_1	108	115	PF00069	0.315
MOD_GSK3_1	205	212	PF00069	0.529
MOD_GSK3_1	92	99	PF00069	0.427
MOD_NEK2_1	175	180	PF00069	0.628
MOD_NEK2_1	258	263	PF00069	0.466
MOD_NEK2_1	30	35	PF00069	0.682
MOD_NEK2_1	87	92	PF00069	0.526
MOD_NEK2_2	227	232	PF00069	0.472
MOD_PIKK_1	19	25	PF00454	0.441
MOD_PK_1	94	100	PF00069	0.497
MOD_PKA_2	87	93	PF00069	0.532
MOD_Plk_1	121	127	PF00069	0.539
MOD_Plk_4	123	129	PF00069	0.368
MOD_Plk_4	148	154	PF00069	0.501
MOD_Plk_4	164	170	PF00069	0.539
MOD_Plk_4	193	199	PF00069	0.586
MOD_Plk_4	209	215	PF00069	0.488
MOD_Plk_4	287	293	PF00069	0.421
MOD_ProDKin_1	155	161	PF00069	0.603
MOD_ProDKin_1	205	211	PF00069	0.482
MOD_ProDKin_1	232	238	PF00069	0.421
MOD_ProDKin_1	63	69	PF00069	0.753
TRG_ENDOCYTIC_2	120	123	PF00928	0.340
TRG_ENDOCYTIC_2	165	168	PF00928	0.589
TRG_ENDOCYTIC_2	222	225	PF00928	0.523
TRG_ENDOCYTIC_2	259	262	PF00928	0.410
TRG_ENDOCYTIC_2	336	339	PF00928	0.525
TRG_ER_diArg_1	4	6	PF00400	0.529
TRG_ER_diArg_1	85	88	PF00400	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX40	Leptomonas seymouri	74%	97%
A0A0S4JJX8	Bodo saltans	50%	100%
A0A1X0P7D7	Trypanosomatidae	63%	100%
A0A3S7WV34	Leishmania donovani	80%	100%
A4HY17	Leishmania infantum	80%	100%
D0A568	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ART1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QDP2	Leishmania major	78%	100%
V5BJ52	Trypanosoma cruzi	67%	100%