Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9P9_LEIBR

TriTrypDb:

LbrM.18.1490 , LBRM2903_180021100

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	2
GO:0005929	cilium	4	2
GO:0030286	dynein complex	3	2
GO:0030990	intraciliary transport particle	2	1
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2
GO:1902494	catalytic complex	2	2
GO:0005840	ribosome	5	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H9P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9P9

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0006810	transport	3	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045503	dynein light chain binding	3	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.652
CLV_C14_Caspase3-7	331	335	PF00656	0.688
CLV_NRD_NRD_1	149	151	PF00675	0.587
CLV_NRD_NRD_1	161	163	PF00675	0.489
CLV_NRD_NRD_1	171	173	PF00675	0.471
CLV_NRD_NRD_1	239	241	PF00675	0.456
CLV_NRD_NRD_1	32	34	PF00675	0.521
CLV_NRD_NRD_1	324	326	PF00675	0.612
CLV_NRD_NRD_1	574	576	PF00675	0.492
CLV_NRD_NRD_1	809	811	PF00675	0.557
CLV_NRD_NRD_1	87	89	PF00675	0.623
CLV_PCSK_KEX2_1	151	153	PF00082	0.584
CLV_PCSK_KEX2_1	163	165	PF00082	0.485
CLV_PCSK_KEX2_1	170	172	PF00082	0.415
CLV_PCSK_KEX2_1	239	241	PF00082	0.456
CLV_PCSK_KEX2_1	32	34	PF00082	0.547
CLV_PCSK_KEX2_1	324	326	PF00082	0.613
CLV_PCSK_KEX2_1	39	41	PF00082	0.596
CLV_PCSK_KEX2_1	600	602	PF00082	0.553
CLV_PCSK_KEX2_1	809	811	PF00082	0.557
CLV_PCSK_KEX2_1	86	88	PF00082	0.694
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.647
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.608
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.598
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.553
CLV_PCSK_PC7_1	159	165	PF00082	0.492
CLV_PCSK_PC7_1	167	173	PF00082	0.437
CLV_PCSK_PC7_1	35	41	PF00082	0.637
CLV_PCSK_PC7_1	82	88	PF00082	0.477
CLV_PCSK_SKI1_1	318	322	PF00082	0.603
CLV_PCSK_SKI1_1	326	330	PF00082	0.614
CLV_PCSK_SKI1_1	379	383	PF00082	0.455
CLV_PCSK_SKI1_1	538	542	PF00082	0.403
DEG_APCC_DBOX_1	149	157	PF00400	0.374
DEG_SPOP_SBC_1	421	425	PF00917	0.493
DOC_MAPK_gen_1	432	442	PF00069	0.401
DOC_MAPK_HePTP_8	761	773	PF00069	0.374
DOC_MAPK_MEF2A_6	435	444	PF00069	0.392
DOC_MAPK_MEF2A_6	467	476	PF00069	0.222
DOC_MAPK_MEF2A_6	764	773	PF00069	0.319
DOC_PP1_RVXF_1	238	245	PF00149	0.552
DOC_PP1_RVXF_1	536	542	PF00149	0.356
DOC_PP2B_LxvP_1	686	689	PF13499	0.444
DOC_PP4_FxxP_1	541	544	PF00568	0.338
DOC_USP7_MATH_1	3	7	PF00917	0.767
DOC_USP7_MATH_1	407	411	PF00917	0.528
DOC_USP7_MATH_1	416	420	PF00917	0.522
DOC_USP7_MATH_1	421	425	PF00917	0.433
DOC_USP7_MATH_1	501	505	PF00917	0.299
DOC_USP7_MATH_1	514	518	PF00917	0.229
DOC_USP7_MATH_1	615	619	PF00917	0.539
DOC_USP7_MATH_1	647	651	PF00917	0.636
DOC_USP7_MATH_1	702	706	PF00917	0.363
DOC_USP7_MATH_1	709	713	PF00917	0.432
DOC_USP7_MATH_1	71	75	PF00917	0.559
DOC_USP7_MATH_1	719	723	PF00917	0.488
DOC_USP7_MATH_2	603	609	PF00917	0.555
DOC_USP7_UBL2_3	99	103	PF12436	0.748
DOC_WW_Pin1_4	102	107	PF00397	0.606
DOC_WW_Pin1_4	206	211	PF00397	0.657
DOC_WW_Pin1_4	395	400	PF00397	0.391
DOC_WW_Pin1_4	462	467	PF00397	0.443
DOC_WW_Pin1_4	482	487	PF00397	0.368
DOC_WW_Pin1_4	499	504	PF00397	0.349
DOC_WW_Pin1_4	65	70	PF00397	0.661
DOC_WW_Pin1_4	700	705	PF00397	0.551
DOC_WW_Pin1_4	773	778	PF00397	0.404
DOC_WW_Pin1_4	809	814	PF00397	0.353
LIG_14-3-3_CanoR_1	234	242	PF00244	0.443
LIG_14-3-3_CanoR_1	379	389	PF00244	0.403
LIG_14-3-3_CanoR_1	488	496	PF00244	0.434
LIG_14-3-3_CanoR_1	528	536	PF00244	0.361
LIG_14-3-3_CanoR_1	814	820	PF00244	0.502
LIG_14-3-3_CanoR_1	864	874	PF00244	0.530
LIG_Actin_WH2_2	316	332	PF00022	0.544
LIG_Actin_WH2_2	848	866	PF00022	0.515
LIG_BIR_II_1	1	5	PF00653	0.480
LIG_BRCT_BRCA1_1	132	136	PF00533	0.613
LIG_BRCT_BRCA1_1	418	422	PF00533	0.428
LIG_Clathr_ClatBox_1	241	245	PF01394	0.380
LIG_Clathr_ClatBox_1	583	587	PF01394	0.301
LIG_FHA_1	367	373	PF00498	0.604
LIG_FHA_1	380	386	PF00498	0.401
LIG_FHA_1	711	717	PF00498	0.412
LIG_FHA_1	754	760	PF00498	0.418
LIG_FHA_1	768	774	PF00498	0.274
LIG_FHA_1	810	816	PF00498	0.382
LIG_FHA_2	188	194	PF00498	0.485
LIG_FHA_2	210	216	PF00498	0.661
LIG_FHA_2	26	32	PF00498	0.511
LIG_FHA_2	288	294	PF00498	0.635
LIG_FHA_2	572	578	PF00498	0.559
LIG_FHA_2	818	824	PF00498	0.482
LIG_FHA_2	826	832	PF00498	0.334
LIG_FXI_DFP_1	241	245	PF00024	0.496
LIG_LIR_Gen_1	469	477	PF02991	0.309
LIG_LIR_Gen_1	577	586	PF02991	0.578
LIG_LIR_Gen_1	724	734	PF02991	0.590
LIG_LIR_Nem_3	258	263	PF02991	0.442
LIG_LIR_Nem_3	317	323	PF02991	0.604
LIG_LIR_Nem_3	423	429	PF02991	0.260
LIG_LIR_Nem_3	469	474	PF02991	0.347
LIG_LIR_Nem_3	577	583	PF02991	0.616
LIG_LIR_Nem_3	724	729	PF02991	0.584
LIG_LIR_Nem_3	744	750	PF02991	0.380
LIG_NRBOX	471	477	PF00104	0.358
LIG_PCNA_yPIPBox_3	432	443	PF02747	0.412
LIG_PDZ_Wminus1_1	873	875	PF00595	0.392
LIG_PTAP_UEV_1	13	18	PF05743	0.518
LIG_REV1ctd_RIR_1	318	329	PF16727	0.607
LIG_SH2_NCK_1	718	722	PF00017	0.628
LIG_SH2_SRC	752	755	PF00017	0.338
LIG_SH2_SRC	760	763	PF00017	0.391
LIG_SH2_STAP1	260	264	PF00017	0.413
LIG_SH2_STAP1	536	540	PF00017	0.483
LIG_SH2_STAP1	580	584	PF00017	0.478
LIG_SH2_STAP1	666	670	PF00017	0.362
LIG_SH2_STAT3	224	227	PF00017	0.429
LIG_SH2_STAT5	263	266	PF00017	0.431
LIG_SH2_STAT5	426	429	PF00017	0.377
LIG_SH2_STAT5	760	763	PF00017	0.371
LIG_SH3_3	11	17	PF00018	0.651
LIG_SH3_3	274	280	PF00018	0.500
LIG_SH3_3	443	449	PF00018	0.406
LIG_SH3_3	500	506	PF00018	0.323
LIG_SH3_3	729	735	PF00018	0.414
LIG_SH3_3	739	745	PF00018	0.357
LIG_SH3_4	99	106	PF00018	0.476
LIG_SUMO_SIM_anti_2	469	476	PF11976	0.314
LIG_SUMO_SIM_par_1	387	394	PF11976	0.343
LIG_SUMO_SIM_par_1	473	479	PF11976	0.385
LIG_TRAF2_1	144	147	PF00917	0.568
LIG_TRAF2_1	28	31	PF00917	0.522
LIG_TRAF2_1	280	283	PF00917	0.524
LIG_TRAF2_1	312	315	PF00917	0.623
LIG_TRAF2_1	74	77	PF00917	0.636
LIG_TRFH_1	626	630	PF08558	0.448
LIG_TYR_ITAM	577	597	PF00017	0.429
LIG_TYR_ITIM	738	743	PF00017	0.307
LIG_WRC_WIRS_1	426	431	PF05994	0.259
LIG_WRC_WIRS_1	468	473	PF05994	0.515
MOD_CDC14_SPxK_1	502	505	PF00782	0.351
MOD_CDK_SPK_2	462	467	PF00069	0.286
MOD_CDK_SPK_2	65	70	PF00069	0.533
MOD_CDK_SPK_2	809	814	PF00069	0.389
MOD_CDK_SPxK_1	482	488	PF00069	0.358
MOD_CDK_SPxK_1	499	505	PF00069	0.232
MOD_CDK_SPxxK_3	65	72	PF00069	0.593
MOD_CK1_1	129	135	PF00069	0.432
MOD_CK1_1	18	24	PF00069	0.645
MOD_CK1_1	209	215	PF00069	0.613
MOD_CK1_1	424	430	PF00069	0.354
MOD_CK1_1	494	500	PF00069	0.359
MOD_CK1_1	545	551	PF00069	0.360
MOD_CK1_1	632	638	PF00069	0.508
MOD_CK1_1	639	645	PF00069	0.561
MOD_CK1_1	679	685	PF00069	0.482
MOD_CK1_1	710	716	PF00069	0.587
MOD_CK1_1	833	839	PF00069	0.330
MOD_CK2_1	23	29	PF00069	0.548
MOD_CK2_1	287	293	PF00069	0.636
MOD_CK2_1	571	577	PF00069	0.619
MOD_CK2_1	71	77	PF00069	0.622
MOD_CK2_1	831	837	PF00069	0.475
MOD_CMANNOS	789	792	PF00535	0.288
MOD_Cter_Amidation	365	368	PF01082	0.507
MOD_GlcNHglycan	17	20	PF01048	0.727
MOD_GlcNHglycan	197	200	PF01048	0.721
MOD_GlcNHglycan	245	249	PF01048	0.595
MOD_GlcNHglycan	257	260	PF01048	0.582
MOD_GlcNHglycan	330	333	PF01048	0.594
MOD_GlcNHglycan	399	402	PF01048	0.707
MOD_GlcNHglycan	493	496	PF01048	0.444
MOD_GlcNHglycan	531	534	PF01048	0.530
MOD_GlcNHglycan	58	61	PF01048	0.736
MOD_GlcNHglycan	607	610	PF01048	0.654
MOD_GlcNHglycan	631	634	PF01048	0.502
MOD_GlcNHglycan	649	652	PF01048	0.717
MOD_GlcNHglycan	666	669	PF01048	0.604
MOD_GlcNHglycan	783	786	PF01048	0.364
MOD_GlcNHglycan	795	799	PF01048	0.358
MOD_GSK3_1	126	133	PF00069	0.558
MOD_GSK3_1	3	10	PF00069	0.664
MOD_GSK3_1	393	400	PF00069	0.465
MOD_GSK3_1	407	414	PF00069	0.557
MOD_GSK3_1	416	423	PF00069	0.392
MOD_GSK3_1	510	517	PF00069	0.363
MOD_GSK3_1	567	574	PF00069	0.535
MOD_GSK3_1	582	589	PF00069	0.276
MOD_GSK3_1	61	68	PF00069	0.763
MOD_GSK3_1	617	624	PF00069	0.642
MOD_GSK3_1	632	639	PF00069	0.487
MOD_GSK3_1	643	650	PF00069	0.553
MOD_GSK3_1	662	669	PF00069	0.655
MOD_GSK3_1	707	714	PF00069	0.548
MOD_GSK3_1	809	816	PF00069	0.418
MOD_GSK3_1	817	824	PF00069	0.421
MOD_N-GLC_1	394	399	PF02516	0.574
MOD_N-GLC_1	567	572	PF02516	0.602
MOD_NEK2_1	1	6	PF00069	0.493
MOD_NEK2_1	244	249	PF00069	0.635
MOD_NEK2_1	286	291	PF00069	0.421
MOD_NEK2_1	328	333	PF00069	0.602
MOD_NEK2_1	380	385	PF00069	0.430
MOD_NEK2_1	422	427	PF00069	0.341
MOD_NEK2_1	476	481	PF00069	0.381
MOD_NEK2_1	529	534	PF00069	0.417
MOD_NEK2_1	586	591	PF00069	0.435
MOD_NEK2_1	738	743	PF00069	0.223
MOD_NEK2_1	815	820	PF00069	0.353
MOD_NEK2_2	617	622	PF00069	0.588
MOD_OFUCOSY	493	498	PF10250	0.376
MOD_PIKK_1	18	24	PF00454	0.497
MOD_PIKK_1	287	293	PF00454	0.636
MOD_PIKK_1	299	305	PF00454	0.571
MOD_PIKK_1	679	685	PF00454	0.456
MOD_PIKK_1	817	823	PF00454	0.401
MOD_PK_1	152	158	PF00069	0.370
MOD_PKA_2	233	239	PF00069	0.429
MOD_PKA_2	299	305	PF00069	0.387
MOD_PKA_2	431	437	PF00069	0.406
MOD_PKA_2	693	699	PF00069	0.516
MOD_PKA_2	781	787	PF00069	0.307
MOD_PKA_2	813	819	PF00069	0.497
MOD_PKB_1	150	158	PF00069	0.527
MOD_Plk_1	640	646	PF00069	0.358
MOD_Plk_4	467	473	PF00069	0.352
MOD_Plk_4	666	672	PF00069	0.465
MOD_Plk_4	702	708	PF00069	0.394
MOD_Plk_4	738	744	PF00069	0.439
MOD_ProDKin_1	102	108	PF00069	0.601
MOD_ProDKin_1	206	212	PF00069	0.653
MOD_ProDKin_1	395	401	PF00069	0.394
MOD_ProDKin_1	462	468	PF00069	0.432
MOD_ProDKin_1	482	488	PF00069	0.365
MOD_ProDKin_1	499	505	PF00069	0.352
MOD_ProDKin_1	65	71	PF00069	0.661
MOD_ProDKin_1	700	706	PF00069	0.545
MOD_ProDKin_1	773	779	PF00069	0.403
MOD_ProDKin_1	809	815	PF00069	0.352
MOD_SUMO_rev_2	135	144	PF00179	0.626
MOD_SUMO_rev_2	146	153	PF00179	0.482
MOD_SUMO_rev_2	184	190	PF00179	0.570
MOD_SUMO_rev_2	31	41	PF00179	0.526
TRG_DiLeu_BaEn_1	110	115	PF01217	0.414
TRG_DiLeu_BaEn_4	168	174	PF01217	0.522
TRG_ENDOCYTIC_2	426	429	PF00928	0.265
TRG_ENDOCYTIC_2	536	539	PF00928	0.380
TRG_ENDOCYTIC_2	580	583	PF00928	0.494
TRG_ENDOCYTIC_2	594	597	PF00928	0.415
TRG_ENDOCYTIC_2	740	743	PF00928	0.313
TRG_ER_diArg_1	150	153	PF00400	0.595
TRG_ER_diArg_1	161	164	PF00400	0.463
TRG_ER_diArg_1	170	172	PF00400	0.316
TRG_ER_diArg_1	238	240	PF00400	0.445
TRG_ER_diArg_1	297	300	PF00400	0.572
TRG_ER_diArg_1	32	35	PF00400	0.518
TRG_ER_diArg_1	323	325	PF00400	0.613
TRG_ER_diArg_1	435	438	PF00400	0.391
TRG_ER_diArg_1	86	88	PF00400	0.707
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED2	Leptomonas seymouri	58%	99%
A0A0S4JR75	Bodo saltans	34%	99%
A0A1X0P8I2	Trypanosomatidae	41%	98%
A0A3Q8ID60	Leishmania donovani	77%	96%
A0A3R7KCG9	Trypanosoma rangeli	41%	99%
A4HY16	Leishmania infantum	76%	96%
D0A574	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	94%
E9ART0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	97%
Q4QDP3	Leishmania major	76%	100%
Q8C761	Mus musculus	24%	88%
Q8WVS4	Homo sapiens	25%	82%
V5BNK6	Trypanosoma cruzi	42%	100%