EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania braziliensis

UniProt:

A4H9P7_LEIBR

TriTrypDb:

LbrM.18.1470 , LBRM2903_180020900

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9P7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.494
CLV_NRD_NRD_1	198	200	PF00675	0.478
CLV_NRD_NRD_1	206	208	PF00675	0.405
CLV_NRD_NRD_1	59	61	PF00675	0.636
CLV_NRD_NRD_1	68	70	PF00675	0.655
CLV_PCSK_KEX2_1	198	200	PF00082	0.496
CLV_PCSK_KEX2_1	68	70	PF00082	0.613
CLV_PCSK_SKI1_1	131	135	PF00082	0.351
CLV_PCSK_SKI1_1	166	170	PF00082	0.333
CLV_PCSK_SKI1_1	218	222	PF00082	0.430
CLV_PCSK_SKI1_1	32	36	PF00082	0.506
DOC_CKS1_1	41	46	PF01111	0.447
DOC_MAPK_gen_1	198	206	PF00069	0.475
DOC_USP7_MATH_1	36	40	PF00917	0.547
DOC_USP7_MATH_1	94	98	PF00917	0.551
DOC_WW_Pin1_4	40	45	PF00397	0.436
LIG_14-3-3_CanoR_1	20	28	PF00244	0.437
LIG_14-3-3_CanoR_1	218	227	PF00244	0.425
LIG_14-3-3_CanoR_1	82	90	PF00244	0.495
LIG_eIF4E_1	142	148	PF01652	0.403
LIG_FHA_1	142	148	PF00498	0.403
LIG_FHA_1	174	180	PF00498	0.444
LIG_FHA_1	41	47	PF00498	0.533
LIG_FHA_2	152	158	PF00498	0.399
LIG_LIR_Gen_1	111	120	PF02991	0.270
LIG_LIR_Gen_1	145	155	PF02991	0.395
LIG_LIR_Gen_1	160	170	PF02991	0.396
LIG_LIR_Gen_1	73	83	PF02991	0.641
LIG_LIR_Nem_3	111	116	PF02991	0.280
LIG_LIR_Nem_3	12	16	PF02991	0.482
LIG_LIR_Nem_3	129	133	PF02991	0.297
LIG_LIR_Nem_3	145	151	PF02991	0.376
LIG_LIR_Nem_3	160	165	PF02991	0.391
LIG_LIR_Nem_3	221	227	PF02991	0.541
LIG_LIR_Nem_3	73	78	PF02991	0.635
LIG_LYPXL_yS_3	224	227	PF13949	0.539
LIG_Pex14_2	148	152	PF04695	0.377
LIG_SH2_SRC	50	53	PF00017	0.439
LIG_SH2_STAT5	178	181	PF00017	0.529
LIG_SH2_STAT5	211	214	PF00017	0.462
LIG_SH2_STAT5	50	53	PF00017	0.401
LIG_SH2_STAT5	83	86	PF00017	0.682
LIG_SH3_3	38	44	PF00018	0.538
LIG_TRAF2_1	104	107	PF00917	0.761
LIG_UBA3_1	200	208	PF00899	0.402
LIG_WRC_WIRS_1	127	132	PF05994	0.287
MOD_CK2_1	151	157	PF00069	0.316
MOD_GlcNHglycan	38	41	PF01048	0.564
MOD_GlcNHglycan	79	82	PF01048	0.606
MOD_GSK3_1	36	43	PF00069	0.608
MOD_GSK3_1	77	84	PF00069	0.710
MOD_NEK2_1	28	33	PF00069	0.535
MOD_NEK2_2	126	131	PF00069	0.297
MOD_NEK2_2	161	166	PF00069	0.299
MOD_NMyristoyl	1	7	PF02799	0.643
MOD_PIKK_1	218	224	PF00454	0.402
MOD_PIKK_1	94	100	PF00454	0.489
MOD_PKA_2	19	25	PF00069	0.461
MOD_PKA_2	3	9	PF00069	0.682
MOD_PKA_2	81	87	PF00069	0.585
MOD_Plk_2-3	19	25	PF00069	0.510
MOD_Plk_4	70	76	PF00069	0.639
MOD_ProDKin_1	40	46	PF00069	0.436
MOD_SUMO_rev_2	164	171	PF00179	0.512
TRG_DiLeu_BaEn_1	196	201	PF01217	0.424
TRG_DiLeu_BaEn_1	215	220	PF01217	0.455
TRG_DiLeu_BaEn_3	23	29	PF01217	0.453
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.535
TRG_DiLeu_LyEn_5	215	220	PF01217	0.455
TRG_ENDOCYTIC_2	113	116	PF00928	0.279
TRG_ENDOCYTIC_2	13	16	PF00928	0.474
TRG_ENDOCYTIC_2	211	214	PF00928	0.491
TRG_ENDOCYTIC_2	224	227	PF00928	0.539
TRG_ER_diArg_1	198	200	PF00400	0.509
TRG_ER_diLys_1	230	235	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC76	Leptomonas seymouri	73%	100%
A0A0S4JR21	Bodo saltans	38%	92%
A0A1X0P714	Trypanosomatidae	53%	100%
A0A3Q8IEC5	Leishmania donovani	84%	100%
A0A422NIP8	Trypanosoma rangeli	54%	100%
A4HY14	Leishmania infantum	84%	100%
D0A578	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ARS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QDP5	Leishmania major	83%	99%