Putative pumilio protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9P5_LEIBR

TriTrypDb:

LbrM.18.1450 , LBRM2903_180020700

Length:

849

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9P5

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	438	442	PF00656	0.395
CLV_C14_Caspase3-7	783	787	PF00656	0.727
CLV_MEL_PAP_1	135	141	PF00089	0.532
CLV_NRD_NRD_1	104	106	PF00675	0.602
CLV_NRD_NRD_1	45	47	PF00675	0.602
CLV_NRD_NRD_1	509	511	PF00675	0.395
CLV_NRD_NRD_1	733	735	PF00675	0.728
CLV_NRD_NRD_1	791	793	PF00675	0.587
CLV_NRD_NRD_1	840	842	PF00675	0.564
CLV_PCSK_KEX2_1	103	105	PF00082	0.611
CLV_PCSK_KEX2_1	45	47	PF00082	0.602
CLV_PCSK_KEX2_1	733	735	PF00082	0.728
CLV_PCSK_KEX2_1	840	842	PF00082	0.596
CLV_PCSK_SKI1_1	430	434	PF00082	0.315
CLV_PCSK_SKI1_1	506	510	PF00082	0.419
CLV_PCSK_SKI1_1	96	100	PF00082	0.517
DEG_APCC_DBOX_1	505	513	PF00400	0.397
DEG_COP1_1	147	155	PF00400	0.511
DEG_SIAH_1	659	667	PF03145	0.535
DOC_CKS1_1	410	415	PF01111	0.438
DOC_CKS1_1	657	662	PF01111	0.542
DOC_CKS1_1	684	689	PF01111	0.513
DOC_CKS1_1	699	704	PF01111	0.510
DOC_CKS1_1	715	720	PF01111	0.607
DOC_MAPK_FxFP_2	663	666	PF00069	0.531
DOC_MAPK_gen_1	110	120	PF00069	0.478
DOC_MAPK_gen_1	404	411	PF00069	0.315
DOC_MAPK_gen_1	90	99	PF00069	0.465
DOC_MAPK_MEF2A_6	93	101	PF00069	0.507
DOC_PP1_RVXF_1	302	309	PF00149	0.395
DOC_PP2B_LxvP_1	118	121	PF13499	0.530
DOC_PP2B_LxvP_1	397	400	PF13499	0.315
DOC_PP4_FxxP_1	663	666	PF00568	0.531
DOC_PP4_FxxP_1	699	702	PF00568	0.660
DOC_PP4_FxxP_1	766	769	PF00568	0.561
DOC_SPAK_OSR1_1	406	410	PF12202	0.395
DOC_USP7_MATH_1	119	123	PF00917	0.616
DOC_USP7_MATH_1	126	130	PF00917	0.640
DOC_USP7_MATH_1	582	586	PF00917	0.641
DOC_USP7_MATH_1	666	670	PF00917	0.675
DOC_USP7_MATH_1	760	764	PF00917	0.645
DOC_WW_Pin1_4	409	414	PF00397	0.464
DOC_WW_Pin1_4	609	614	PF00397	0.627
DOC_WW_Pin1_4	656	661	PF00397	0.544
DOC_WW_Pin1_4	683	688	PF00397	0.605
DOC_WW_Pin1_4	698	703	PF00397	0.517
DOC_WW_Pin1_4	714	719	PF00397	0.641
DOC_WW_Pin1_4	736	741	PF00397	0.651
DOC_WW_Pin1_4	756	761	PF00397	0.533
DOC_WW_Pin1_4	765	770	PF00397	0.689
LIG_14-3-3_CanoR_1	125	135	PF00244	0.563
LIG_14-3-3_CanoR_1	78	86	PF00244	0.562
LIG_APCC_ABBA_1	165	170	PF00400	0.471
LIG_APCC_ABBA_1	209	214	PF00400	0.315
LIG_BRCT_BRCA1_1	762	766	PF00533	0.770
LIG_CtBP_PxDLS_1	400	404	PF00389	0.395
LIG_FHA_1	147	153	PF00498	0.599
LIG_FHA_1	260	266	PF00498	0.369
LIG_FHA_1	410	416	PF00498	0.472
LIG_FHA_1	699	705	PF00498	0.593
LIG_FHA_1	722	728	PF00498	0.586
LIG_FHA_1	810	816	PF00498	0.542
LIG_FHA_1	823	829	PF00498	0.508
LIG_FHA_2	21	27	PF00498	0.642
LIG_FHA_2	432	438	PF00498	0.315
LIG_FHA_2	481	487	PF00498	0.428
LIG_FHA_2	684	690	PF00498	0.516
LIG_IBAR_NPY_1	644	646	PF08397	0.548
LIG_Integrin_isoDGR_2	576	578	PF01839	0.576
LIG_Integrin_RGD_1	734	736	PF01839	0.586
LIG_LIR_Apic_2	763	769	PF02991	0.563
LIG_LIR_Gen_1	175	185	PF02991	0.382
LIG_LIR_Gen_1	80	88	PF02991	0.531
LIG_LIR_Nem_3	175	181	PF02991	0.381
LIG_LIR_Nem_3	217	222	PF02991	0.388
LIG_LIR_Nem_3	224	230	PF02991	0.251
LIG_LIR_Nem_3	466	471	PF02991	0.315
LIG_LIR_Nem_3	631	636	PF02991	0.537
LIG_LIR_Nem_3	688	693	PF02991	0.685
LIG_LIR_Nem_3	80	86	PF02991	0.539
LIG_MLH1_MIPbox_1	762	766	PF16413	0.562
LIG_MYND_1	683	687	PF01753	0.518
LIG_PCNA_yPIPBox_3	229	241	PF02747	0.315
LIG_Pex14_2	172	176	PF04695	0.490
LIG_PTB_Apo_2	742	749	PF02174	0.714
LIG_PTB_Phospho_1	742	748	PF10480	0.714
LIG_Rb_pABgroove_1	230	238	PF01858	0.315
LIG_SH2_CRK	178	182	PF00017	0.380
LIG_SH2_CRK	633	637	PF00017	0.556
LIG_SH2_CRK	642	646	PF00017	0.644
LIG_SH2_CRK	715	719	PF00017	0.615
LIG_SH2_CRK	83	87	PF00017	0.528
LIG_SH2_GRB2like	468	471	PF00017	0.315
LIG_SH2_GRB2like	743	746	PF00017	0.717
LIG_SH2_GRB2like	811	814	PF00017	0.535
LIG_SH2_SRC	640	643	PF00017	0.537
LIG_SH2_SRC	743	746	PF00017	0.717
LIG_SH2_STAP1	468	472	PF00017	0.315
LIG_SH2_STAP1	711	715	PF00017	0.688
LIG_SH2_STAP1	79	83	PF00017	0.550
LIG_SH2_STAP1	811	815	PF00017	0.535
LIG_SH2_STAT3	230	233	PF00017	0.315
LIG_SH2_STAT3	272	275	PF00017	0.395
LIG_SH2_STAT3	390	393	PF00017	0.315
LIG_SH2_STAT3	471	474	PF00017	0.394
LIG_SH2_STAT3	675	678	PF00017	0.691
LIG_SH2_STAT3	681	684	PF00017	0.629
LIG_SH2_STAT3	711	714	PF00017	0.788
LIG_SH2_STAT5	168	171	PF00017	0.470
LIG_SH2_STAT5	230	233	PF00017	0.315
LIG_SH2_STAT5	390	393	PF00017	0.315
LIG_SH2_STAT5	459	462	PF00017	0.327
LIG_SH2_STAT5	471	474	PF00017	0.356
LIG_SH2_STAT5	743	746	PF00017	0.717
LIG_SH2_STAT5	79	82	PF00017	0.568
LIG_SH2_STAT5	811	814	PF00017	0.535
LIG_SH3_3	35	41	PF00018	0.592
LIG_SH3_3	527	533	PF00018	0.500
LIG_SH3_3	766	772	PF00018	0.553
LIG_SH3_3	89	95	PF00018	0.541
LIG_SH3_5	174	178	PF00018	0.465
LIG_TRAF2_1	248	251	PF00917	0.517
LIG_TRAF2_1	435	438	PF00917	0.315
LIG_TRAF2_1	73	76	PF00917	0.601
LIG_UBA3_1	257	264	PF00899	0.448
LIG_UBA3_1	443	449	PF00899	0.315
LIG_WRC_WIRS_1	169	174	PF05994	0.492
LIG_WRC_WIRS_1	185	190	PF05994	0.183
MOD_CK1_1	127	133	PF00069	0.784
MOD_CK1_1	273	279	PF00069	0.418
MOD_CK1_1	611	617	PF00069	0.552
MOD_CK1_1	803	809	PF00069	0.634
MOD_CK2_1	20	26	PF00069	0.553
MOD_CK2_1	336	342	PF00069	0.278
MOD_CK2_1	431	437	PF00069	0.315
MOD_CK2_1	480	486	PF00069	0.428
MOD_GlcNHglycan	121	124	PF01048	0.653
MOD_GlcNHglycan	245	249	PF01048	0.399
MOD_GlcNHglycan	31	34	PF01048	0.518
MOD_GlcNHglycan	480	483	PF01048	0.233
MOD_GlcNHglycan	529	533	PF01048	0.582
MOD_GlcNHglycan	545	548	PF01048	0.581
MOD_GlcNHglycan	551	554	PF01048	0.684
MOD_GlcNHglycan	584	587	PF01048	0.622
MOD_GlcNHglycan	630	633	PF01048	0.607
MOD_GlcNHglycan	668	671	PF01048	0.522
MOD_GlcNHglycan	762	765	PF01048	0.684
MOD_GlcNHglycan	796	799	PF01048	0.813
MOD_GlcNHglycan	802	805	PF01048	0.703
MOD_GlcNHglycan	815	818	PF01048	0.537
MOD_GSK3_1	124	131	PF00069	0.786
MOD_GSK3_1	418	425	PF00069	0.315
MOD_GSK3_1	495	502	PF00069	0.429
MOD_GSK3_1	52	59	PF00069	0.602
MOD_GSK3_1	549	556	PF00069	0.668
MOD_GSK3_1	565	572	PF00069	0.569
MOD_GSK3_1	608	615	PF00069	0.669
MOD_GSK3_1	756	763	PF00069	0.657
MOD_GSK3_1	803	810	PF00069	0.761
MOD_GSK3_1	822	829	PF00069	0.598
MOD_N-GLC_1	3	8	PF02516	0.676
MOD_N-GLC_1	499	504	PF02516	0.427
MOD_N-GLC_1	553	558	PF02516	0.773
MOD_N-GLC_1	800	805	PF02516	0.629
MOD_N-GLC_1	807	812	PF02516	0.657
MOD_N-GLC_1	826	831	PF02516	0.533
MOD_NEK2_1	270	275	PF00069	0.395
MOD_NEK2_1	28	33	PF00069	0.668
MOD_NEK2_1	418	423	PF00069	0.315
MOD_NEK2_1	464	469	PF00069	0.427
MOD_NEK2_1	52	57	PF00069	0.581
MOD_NEK2_1	86	91	PF00069	0.522
MOD_NEK2_2	168	173	PF00069	0.484
MOD_PIKK_1	158	164	PF00454	0.508
MOD_PIKK_1	480	486	PF00454	0.395
MOD_PIKK_1	734	740	PF00454	0.604
MOD_PIKK_1	839	845	PF00454	0.593
MOD_PKA_2	124	130	PF00069	0.611
MOD_PKA_2	259	265	PF00069	0.368
MOD_PKA_2	549	555	PF00069	0.770
MOD_PKA_2	77	83	PF00069	0.576
MOD_PKA_2	839	845	PF00069	0.600
MOD_Plk_1	244	250	PF00069	0.371
MOD_Plk_1	270	276	PF00069	0.395
MOD_Plk_1	380	386	PF00069	0.315
MOD_Plk_1	499	505	PF00069	0.421
MOD_Plk_1	785	791	PF00069	0.707
MOD_Plk_1	800	806	PF00069	0.550
MOD_Plk_1	807	813	PF00069	0.521
MOD_Plk_4	499	505	PF00069	0.421
MOD_Plk_4	52	58	PF00069	0.601
MOD_Plk_4	612	618	PF00069	0.714
MOD_ProDKin_1	409	415	PF00069	0.457
MOD_ProDKin_1	609	615	PF00069	0.628
MOD_ProDKin_1	656	662	PF00069	0.541
MOD_ProDKin_1	683	689	PF00069	0.606
MOD_ProDKin_1	698	704	PF00069	0.518
MOD_ProDKin_1	714	720	PF00069	0.642
MOD_ProDKin_1	736	742	PF00069	0.648
MOD_ProDKin_1	756	762	PF00069	0.534
MOD_ProDKin_1	765	771	PF00069	0.684
MOD_SUMO_for_1	240	243	PF00179	0.476
MOD_SUMO_rev_2	441	450	PF00179	0.395
TRG_DiLeu_BaEn_3	438	444	PF01217	0.315
TRG_DiLeu_BaEn_4	217	223	PF01217	0.395
TRG_DiLeu_BaEn_4	81	87	PF01217	0.488
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.315
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.319
TRG_DiLeu_BaLyEn_6	625	630	PF01217	0.530
TRG_ENDOCYTIC_2	178	181	PF00928	0.373
TRG_ENDOCYTIC_2	633	636	PF00928	0.697
TRG_ENDOCYTIC_2	83	86	PF00928	0.533
TRG_ER_diArg_1	103	105	PF00400	0.611
TRG_ER_diArg_1	403	406	PF00400	0.315
TRG_ER_diArg_1	44	46	PF00400	0.584
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.233

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T7	Leptomonas seymouri	54%	98%
A0A3S5H745	Leishmania donovani	77%	95%
A4HY12	Leishmania infantum	77%	95%
E9ARS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	97%
Q4QDP7	Leishmania major	79%	100%