Cytochrome c oxidase assembly protein COX11, mitochondrial

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9P2_LEIBR

TriTrypDb:

LbrM.18.1420 , LBRM2903_180020400

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H9P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9P2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.615
CLV_NRD_NRD_1	177	179	PF00675	0.677
CLV_NRD_NRD_1	36	38	PF00675	0.543
CLV_PCSK_KEX2_1	164	166	PF00082	0.525
CLV_PCSK_KEX2_1	35	37	PF00082	0.560
CLV_PCSK_PC7_1	32	38	PF00082	0.553
CLV_PCSK_SKI1_1	38	42	PF00082	0.385
CLV_PCSK_SKI1_1	70	74	PF00082	0.396
DEG_APCC_DBOX_1	182	190	PF00400	0.364
DEG_Nend_Nbox_1	1	3	PF02207	0.576
DOC_MAPK_gen_1	32	42	PF00069	0.677
DOC_MAPK_gen_1	75	83	PF00069	0.592
DOC_MAPK_MEF2A_6	35	44	PF00069	0.731
DOC_MAPK_MEF2A_6	82	90	PF00069	0.532
DOC_PP1_RVXF_1	73	80	PF00149	0.668
DOC_PP2B_LxvP_1	65	68	PF13499	0.674
DOC_USP7_MATH_1	68	72	PF00917	0.578
DOC_WW_Pin1_4	111	116	PF00397	0.391
DOC_WW_Pin1_4	181	186	PF00397	0.413
LIG_14-3-3_CanoR_1	129	136	PF00244	0.330
LIG_14-3-3_CanoR_1	248	254	PF00244	0.726
LIG_14-3-3_CanoR_1	37	43	PF00244	0.684
LIG_14-3-3_CanoR_1	55	62	PF00244	0.648
LIG_14-3-3_CanoR_1	70	79	PF00244	0.510
LIG_Actin_WH2_2	65	80	PF00022	0.495
LIG_FHA_1	120	126	PF00498	0.365
LIG_FHA_1	136	142	PF00498	0.261
LIG_FHA_1	39	45	PF00498	0.648
LIG_LIR_Gen_1	120	128	PF02991	0.360
LIG_LIR_Gen_1	235	245	PF02991	0.769
LIG_LIR_Gen_1	59	69	PF02991	0.617
LIG_LIR_Gen_1	93	103	PF02991	0.410
LIG_LIR_Nem_3	59	65	PF02991	0.577
LIG_LIR_Nem_3	93	98	PF02991	0.410
LIG_PDZ_Class_1	249	254	PF00595	0.726
LIG_Pex14_2	91	95	PF04695	0.350
LIG_SH2_CRK	62	66	PF00017	0.667
LIG_SH2_NCK_1	130	134	PF00017	0.370
LIG_SH2_STAP1	121	125	PF00017	0.436
LIG_SH2_STAP1	130	134	PF00017	0.370
LIG_SH2_STAP1	62	66	PF00017	0.612
LIG_SH2_STAT5	103	106	PF00017	0.459
LIG_SH2_STAT5	121	124	PF00017	0.287
LIG_SH2_STAT5	191	194	PF00017	0.375
LIG_SH2_STAT5	2	5	PF00017	0.739
LIG_SH3_1	179	185	PF00018	0.474
LIG_SH3_3	179	185	PF00018	0.446
LIG_SUMO_SIM_par_1	214	222	PF11976	0.699
LIG_TRAF2_1	185	188	PF00917	0.440
LIG_ULM_U2AF65_1	164	169	PF00076	0.266
MOD_CK1_1	7	13	PF00069	0.629
MOD_CK2_1	181	187	PF00069	0.415
MOD_CK2_1	227	233	PF00069	0.727
MOD_CK2_1	68	74	PF00069	0.499
MOD_GlcNHglycan	228	232	PF01048	0.531
MOD_GlcNHglycan	92	95	PF01048	0.341
MOD_GSK3_1	38	45	PF00069	0.649
MOD_N-GLC_1	226	231	PF02516	0.364
MOD_PIKK_1	246	252	PF00454	0.758
MOD_PKA_2	128	134	PF00069	0.326
MOD_PKA_2	31	37	PF00069	0.670
MOD_PKA_2	4	10	PF00069	0.614
MOD_Plk_1	119	125	PF00069	0.302
MOD_Plk_4	119	125	PF00069	0.351
MOD_Plk_4	201	207	PF00069	0.234
MOD_ProDKin_1	111	117	PF00069	0.385
MOD_ProDKin_1	181	187	PF00069	0.413
MOD_SUMO_for_1	141	144	PF00179	0.465
TRG_DiLeu_BaEn_2	232	238	PF01217	0.589
TRG_DiLeu_BaEn_4	187	193	PF01217	0.451
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.699
TRG_ENDOCYTIC_2	121	124	PF00928	0.398
TRG_ENDOCYTIC_2	130	133	PF00928	0.340
TRG_ENDOCYTIC_2	196	199	PF00928	0.345
TRG_ENDOCYTIC_2	62	65	PF00928	0.575
TRG_ENDOCYTIC_2	66	69	PF00928	0.576
TRG_ER_diArg_1	35	37	PF00400	0.726
TRG_NES_CRM1_1	148	161	PF08389	0.444
TRG_NES_CRM1_1	190	201	PF08389	0.209
TRG_NLS_MonoExtC_3	164	170	PF00514	0.270
TRG_NLS_MonoExtN_4	164	169	PF00514	0.266
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JNI9	Bodo saltans	32%	71%
A0A1X0P730	Trypanosomatidae	47%	72%
A0A3Q8IB53	Leishmania donovani	80%	98%
A4HY09	Leishmania infantum	80%	98%
D0A587	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	73%
E9ARS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4QDQ0	Leishmania major	80%	100%
V5BEH9	Trypanosoma cruzi	46%	90%