LeishMANIAdb
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Putative heat shock protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative heat shock protein
Gene product:
heat shock protein 110, putative
Species:
Leishmania braziliensis
UniProt:
A4H9P0_LEIBR
TriTrypDb:
LbrM.18.1400 , LBRM2903_180020200 *
Length:
821

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 2
Pissara et al. yes yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0043226 organelle 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4H9P0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9P0

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0044183 protein folding chaperone 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140657 ATP-dependent activity 1 12
GO:0140662 ATP-dependent protein folding chaperone 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 159 161 PF00675 0.336
CLV_NRD_NRD_1 585 587 PF00675 0.492
CLV_NRD_NRD_1 663 665 PF00675 0.554
CLV_NRD_NRD_1 83 85 PF00675 0.221
CLV_PCSK_KEX2_1 159 161 PF00082 0.351
CLV_PCSK_KEX2_1 267 269 PF00082 0.305
CLV_PCSK_KEX2_1 32 34 PF00082 0.296
CLV_PCSK_KEX2_1 663 665 PF00082 0.490
CLV_PCSK_KEX2_1 68 70 PF00082 0.319
CLV_PCSK_PC1ET2_1 267 269 PF00082 0.305
CLV_PCSK_PC1ET2_1 32 34 PF00082 0.311
CLV_PCSK_PC1ET2_1 68 70 PF00082 0.296
CLV_PCSK_SKI1_1 281 285 PF00082 0.296
CLV_PCSK_SKI1_1 396 400 PF00082 0.440
CLV_PCSK_SKI1_1 431 435 PF00082 0.407
CLV_PCSK_SKI1_1 554 558 PF00082 0.599
CLV_PCSK_SKI1_1 768 772 PF00082 0.490
CLV_PCSK_SKI1_1 84 88 PF00082 0.290
CLV_PCSK_SKI1_1 98 102 PF00082 0.279
DEG_APCC_DBOX_1 267 275 PF00400 0.311
DEG_APCC_KENBOX_2 542 546 PF00400 0.801
DOC_CDC14_PxL_1 403 411 PF14671 0.477
DOC_CYCLIN_RxL_1 278 285 PF00134 0.296
DOC_MAPK_gen_1 256 263 PF00069 0.299
DOC_MAPK_gen_1 267 273 PF00069 0.291
DOC_MAPK_gen_1 444 450 PF00069 0.520
DOC_MAPK_gen_1 557 566 PF00069 0.449
DOC_MAPK_gen_1 678 687 PF00069 0.496
DOC_MAPK_MEF2A_6 560 568 PF00069 0.432
DOC_MAPK_MEF2A_6 74 82 PF00069 0.217
DOC_PP1_RVXF_1 700 707 PF00149 0.525
DOC_PP1_RVXF_1 96 102 PF00149 0.245
DOC_USP7_MATH_1 286 290 PF00917 0.364
DOC_USP7_MATH_1 438 442 PF00917 0.516
DOC_USP7_MATH_1 451 455 PF00917 0.436
DOC_USP7_MATH_1 488 492 PF00917 0.438
DOC_USP7_MATH_1 674 678 PF00917 0.314
DOC_USP7_UBL2_3 554 558 PF12436 0.527
DOC_USP7_UBL2_3 768 772 PF12436 0.555
DOC_WW_Pin1_4 387 392 PF00397 0.296
DOC_WW_Pin1_4 416 421 PF00397 0.604
LIG_14-3-3_CanoR_1 124 129 PF00244 0.364
LIG_14-3-3_CanoR_1 191 196 PF00244 0.334
LIG_14-3-3_CanoR_1 309 313 PF00244 0.323
LIG_14-3-3_CanoR_1 418 424 PF00244 0.502
LIG_14-3-3_CanoR_1 449 459 PF00244 0.441
LIG_14-3-3_CanoR_1 663 669 PF00244 0.438
LIG_14-3-3_CanoR_1 98 104 PF00244 0.428
LIG_Actin_WH2_2 182 198 PF00022 0.440
LIG_BIR_II_1 1 5 PF00653 0.311
LIG_BRCT_BRCA1_1 389 393 PF00533 0.296
LIG_BRCT_BRCA1_1 421 425 PF00533 0.503
LIG_Clathr_ClatBox_1 297 301 PF01394 0.355
LIG_Clathr_ClatBox_1 509 513 PF01394 0.282
LIG_FHA_1 12 18 PF00498 0.296
LIG_FHA_1 213 219 PF00498 0.329
LIG_FHA_1 25 31 PF00498 0.311
LIG_FHA_1 33 39 PF00498 0.330
LIG_FHA_1 403 409 PF00498 0.338
LIG_FHA_1 61 67 PF00498 0.311
LIG_FHA_1 86 92 PF00498 0.318
LIG_FHA_2 196 202 PF00498 0.383
LIG_FHA_2 655 661 PF00498 0.525
LIG_FHA_2 712 718 PF00498 0.449
LIG_FHA_2 751 757 PF00498 0.420
LIG_Integrin_isoDGR_2 96 98 PF01839 0.325
LIG_LIR_Gen_1 339 347 PF02991 0.330
LIG_LIR_Nem_3 186 190 PF02991 0.298
LIG_LIR_Nem_3 242 248 PF02991 0.357
LIG_LIR_Nem_3 339 344 PF02991 0.418
LIG_LIR_Nem_3 405 409 PF02991 0.425
LIG_LIR_Nem_3 655 661 PF02991 0.569
LIG_LIR_Nem_3 7 11 PF02991 0.305
LIG_LYPXL_yS_3 406 409 PF13949 0.471
LIG_NRBOX 279 285 PF00104 0.311
LIG_PCNA_TLS_4 606 613 PF02747 0.361
LIG_Pex14_2 4 8 PF04695 0.311
LIG_SH2_GRB2like 128 131 PF00017 0.296
LIG_SH2_GRB2like 464 467 PF00017 0.490
LIG_SH2_NCK_1 629 633 PF00017 0.455
LIG_SH2_SRC 478 481 PF00017 0.522
LIG_SH2_SRC 650 653 PF00017 0.425
LIG_SH2_STAP1 629 633 PF00017 0.308
LIG_SH2_STAP1 661 665 PF00017 0.467
LIG_SH2_STAT3 113 116 PF00017 0.296
LIG_SH2_STAT5 105 108 PF00017 0.341
LIG_SH2_STAT5 128 131 PF00017 0.296
LIG_SH2_STAT5 154 157 PF00017 0.296
LIG_SH2_STAT5 245 248 PF00017 0.407
LIG_SH2_STAT5 282 285 PF00017 0.311
LIG_SH2_STAT5 478 481 PF00017 0.410
LIG_SH2_STAT5 56 59 PF00017 0.339
LIG_SH2_STAT5 612 615 PF00017 0.375
LIG_SH3_1 772 778 PF00018 0.548
LIG_SH3_2 552 557 PF14604 0.709
LIG_SH3_3 299 305 PF00018 0.390
LIG_SH3_3 401 407 PF00018 0.350
LIG_SH3_3 414 420 PF00018 0.434
LIG_SH3_3 421 427 PF00018 0.377
LIG_SH3_3 445 451 PF00018 0.506
LIG_SH3_3 549 555 PF00018 0.630
LIG_SH3_3 564 570 PF00018 0.488
LIG_SH3_3 770 776 PF00018 0.548
LIG_SH3_4 554 561 PF00018 0.641
LIG_SUMO_SIM_par_1 13 18 PF11976 0.311
LIG_SUMO_SIM_par_1 507 513 PF11976 0.400
LIG_TRAF2_1 588 591 PF00917 0.481
LIG_TRAF2_1 714 717 PF00917 0.478
LIG_TRAF2_1 778 781 PF00917 0.570
LIG_TRAF2_1 802 805 PF00917 0.737
LIG_WRC_WIRS_1 304 309 PF05994 0.219
LIG_WRC_WIRS_1 38 43 PF05994 0.311
MOD_CDK_SPK_2 387 392 PF00069 0.311
MOD_CK1_1 375 381 PF00069 0.469
MOD_CK1_1 419 425 PF00069 0.481
MOD_CK2_1 191 197 PF00069 0.334
MOD_CK2_1 28 34 PF00069 0.296
MOD_CK2_1 654 660 PF00069 0.465
MOD_CK2_1 711 717 PF00069 0.467
MOD_CK2_1 750 756 PF00069 0.528
MOD_CK2_1 757 763 PF00069 0.501
MOD_Cter_Amidation 707 710 PF01082 0.595
MOD_GlcNHglycan 182 185 PF01048 0.512
MOD_GlcNHglycan 284 287 PF01048 0.296
MOD_GlcNHglycan 288 291 PF01048 0.296
MOD_GlcNHglycan 333 336 PF01048 0.247
MOD_GlcNHglycan 453 456 PF01048 0.541
MOD_GlcNHglycan 759 762 PF01048 0.374
MOD_GSK3_1 11 18 PF00069 0.313
MOD_GSK3_1 191 198 PF00069 0.363
MOD_GSK3_1 24 31 PF00069 0.311
MOD_GSK3_1 250 257 PF00069 0.217
MOD_GSK3_1 282 289 PF00069 0.467
MOD_GSK3_1 33 40 PF00069 0.334
MOD_GSK3_1 368 375 PF00069 0.338
MOD_GSK3_1 398 405 PF00069 0.287
MOD_GSK3_1 85 92 PF00069 0.325
MOD_N-GLC_1 11 16 PF02516 0.311
MOD_N-GLC_1 177 182 PF02516 0.296
MOD_N-GLC_1 237 242 PF02516 0.325
MOD_N-GLC_1 286 291 PF02516 0.418
MOD_N-GLC_1 372 377 PF02516 0.302
MOD_N-GLC_1 89 94 PF02516 0.450
MOD_N-GLC_2 104 106 PF02516 0.311
MOD_NEK2_1 11 16 PF00069 0.212
MOD_NEK2_1 146 151 PF00069 0.424
MOD_NEK2_1 331 336 PF00069 0.357
MOD_NEK2_1 99 104 PF00069 0.458
MOD_NEK2_2 60 65 PF00069 0.330
MOD_PIKK_1 742 748 PF00454 0.515
MOD_PKA_1 32 38 PF00069 0.296
MOD_PKA_1 757 763 PF00069 0.485
MOD_PKA_2 308 314 PF00069 0.330
MOD_PKA_2 32 38 PF00069 0.296
MOD_PKA_2 594 600 PF00069 0.486
MOD_Plk_1 11 17 PF00069 0.337
MOD_Plk_1 33 39 PF00069 0.307
MOD_Plk_1 653 659 PF00069 0.484
MOD_Plk_2-3 308 314 PF00069 0.440
MOD_Plk_2-3 340 346 PF00069 0.364
MOD_Plk_2-3 654 660 PF00069 0.484
MOD_Plk_2-3 711 717 PF00069 0.511
MOD_Plk_4 172 178 PF00069 0.301
MOD_Plk_4 34 40 PF00069 0.301
MOD_Plk_4 578 584 PF00069 0.476
MOD_Plk_4 60 66 PF00069 0.312
MOD_Plk_4 608 614 PF00069 0.374
MOD_Plk_4 745 751 PF00069 0.436
MOD_ProDKin_1 387 393 PF00069 0.296
MOD_ProDKin_1 416 422 PF00069 0.599
MOD_SUMO_for_1 778 781 PF00179 0.570
MOD_SUMO_rev_2 102 112 PF00179 0.440
MOD_SUMO_rev_2 253 257 PF00179 0.360
MOD_SUMO_rev_2 262 269 PF00179 0.381
MOD_SUMO_rev_2 751 760 PF00179 0.578
MOD_SUMO_rev_2 77 87 PF00179 0.440
MOD_SUMO_rev_2 805 812 PF00179 0.733
TRG_DiLeu_BaEn_1 157 162 PF01217 0.296
TRG_DiLeu_BaLyEn_6 269 274 PF01217 0.270
TRG_ENDOCYTIC_2 187 190 PF00928 0.296
TRG_ENDOCYTIC_2 248 251 PF00928 0.322
TRG_ENDOCYTIC_2 406 409 PF00928 0.471
TRG_ER_diArg_1 159 161 PF00400 0.350
TRG_ER_diArg_1 268 271 PF00400 0.376
TRG_ER_diArg_1 498 501 PF00400 0.398
TRG_ER_diArg_1 600 603 PF00400 0.523
TRG_ER_diArg_1 616 619 PF00400 0.314
TRG_ER_diArg_1 663 665 PF00400 0.543
TRG_ER_diArg_1 679 682 PF00400 0.362
TRG_ER_diArg_1 692 695 PF00400 0.517
TRG_Pf-PMV_PEXEL_1 159 164 PF00026 0.297
TRG_Pf-PMV_PEXEL_1 357 361 PF00026 0.468
TRG_Pf-PMV_PEXEL_1 46 50 PF00026 0.319
TRG_Pf-PMV_PEXEL_1 669 673 PF00026 0.420

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDD3 Leptomonas seymouri 76% 98%
A0A0S4JJU2 Bodo saltans 24% 100%
A0A0S4JRV7 Bodo saltans 52% 99%
A0A1X0P8H2 Trypanosomatidae 57% 99%
A0A3R7L0X2 Trypanosoma rangeli 56% 99%
A0A3S5H744 Leishmania donovani 83% 100%
A0A3S5H808 Leishmania donovani 25% 100%
A0A3S7X203 Leishmania donovani 25% 100%
A0A422P1B1 Trypanosoma rangeli 26% 100%
A4HGY5 Leishmania braziliensis 26% 100%
A4HND7 Leishmania braziliensis 26% 100%
A4I417 Leishmania infantum 25% 100%
A4IC10 Leishmania infantum 25% 100%
A7HZ39 Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) 25% 100%
C9ZYJ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
D0A590 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9AFU8 Leishmania major 25% 100%
E9AGQ5 Leishmania infantum 83% 100%
E9ARS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9B0A4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B700 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
F4HQD4 Arabidopsis thaliana 31% 99%
F4JMJ1 Arabidopsis thaliana 23% 95%
O59838 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 100%
O74225 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 32% 100%
O88600 Rattus norvegicus 29% 98%
O97125 Drosophila melanogaster 25% 100%
P32589 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
P32590 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P34932 Homo sapiens 29% 98%
P36415 Dictyostelium discoideum 24% 100%
P36604 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
P41827 Anopheles albimanus 26% 100%
P48722 Mus musculus 29% 98%
P91902 Ceratitis capitata 25% 100%
Q01233 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 100%
Q05036 Caenorhabditis elegans 31% 100%
Q0IIM3 Bos taurus 28% 96%
Q10265 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
Q2TFN9 Canis lupus familiaris 29% 98%
Q4Q7Y0 Leishmania major 26% 100%
Q4QDQ2 Leishmania major 83% 100%
Q5R606 Pongo abelii 29% 96%
Q5RDM4 Pongo abelii 29% 98%
Q61316 Mus musculus 29% 98%
Q6FJI3 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 30% 100%
Q6TMK3 Dictyostelium discoideum 32% 100%
Q74ZJ0 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 30% 100%
Q875P5 Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) 29% 100%
Q875V0 Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630) 29% 100%
Q92598 Homo sapiens 29% 96%
Q94738 Mesocentrotus franciscanus 34% 93%
Q96VB9 Candida albicans (strain SC5314 / ATCC MYA-2876) 30% 100%
Q9S7C0 Arabidopsis thaliana 31% 99%
Q9SAB1 Arabidopsis thaliana 29% 100%
V5DFF3 Trypanosoma cruzi 58% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS