Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9N9_LEIBR

TriTrypDb:

LbrM.18.1390 , LBRM2903_180020000 , LBRM2903_180020100

Length:

962

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9N9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.582
CLV_C14_Caspase3-7	311	315	PF00656	0.632
CLV_NRD_NRD_1	106	108	PF00675	0.638
CLV_NRD_NRD_1	209	211	PF00675	0.496
CLV_NRD_NRD_1	227	229	PF00675	0.704
CLV_NRD_NRD_1	242	244	PF00675	0.647
CLV_NRD_NRD_1	651	653	PF00675	0.624
CLV_NRD_NRD_1	773	775	PF00675	0.591
CLV_NRD_NRD_1	789	791	PF00675	0.427
CLV_NRD_NRD_1	803	805	PF00675	0.605
CLV_NRD_NRD_1	810	812	PF00675	0.580
CLV_PCSK_FUR_1	294	298	PF00082	0.629
CLV_PCSK_KEX2_1	106	108	PF00082	0.633
CLV_PCSK_KEX2_1	209	211	PF00082	0.517
CLV_PCSK_KEX2_1	227	229	PF00082	0.691
CLV_PCSK_KEX2_1	242	244	PF00082	0.647
CLV_PCSK_KEX2_1	296	298	PF00082	0.627
CLV_PCSK_KEX2_1	651	653	PF00082	0.498
CLV_PCSK_KEX2_1	773	775	PF00082	0.566
CLV_PCSK_KEX2_1	789	791	PF00082	0.449
CLV_PCSK_KEX2_1	803	805	PF00082	0.603
CLV_PCSK_KEX2_1	821	823	PF00082	0.468
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.627
CLV_PCSK_PC1ET2_1	821	823	PF00082	0.545
CLV_PCSK_SKI1_1	106	110	PF00082	0.575
CLV_PCSK_SKI1_1	194	198	PF00082	0.523
CLV_PCSK_SKI1_1	258	262	PF00082	0.562
CLV_PCSK_SKI1_1	602	606	PF00082	0.693
CLV_PCSK_SKI1_1	752	756	PF00082	0.630
CLV_PCSK_SKI1_1	790	794	PF00082	0.586
CLV_PCSK_SKI1_1	822	826	PF00082	0.611
CLV_Separin_Metazoa	800	804	PF03568	0.579
DEG_APCC_KENBOX_2	851	855	PF00400	0.753
DEG_SCF_FBW7_1	75	80	PF00400	0.658
DEG_SPOP_SBC_1	950	954	PF00917	0.700
DOC_CDC14_PxL_1	775	783	PF14671	0.497
DOC_CYCLIN_RxL_1	367	379	PF00134	0.390
DOC_MAPK_DCC_7	232	241	PF00069	0.671
DOC_MAPK_gen_1	188	197	PF00069	0.607
DOC_MAPK_HePTP_8	229	241	PF00069	0.673
DOC_MAPK_MEF2A_6	232	241	PF00069	0.671
DOC_MIT_MIM_1	205	214	PF04212	0.619
DOC_MIT_MIM_1	769	778	PF04212	0.542
DOC_PP4_FxxP_1	19	22	PF00568	0.649
DOC_PP4_MxPP_1	75	78	PF00568	0.529
DOC_USP7_MATH_1	14	18	PF00917	0.725
DOC_USP7_MATH_1	147	151	PF00917	0.626
DOC_USP7_MATH_1	280	284	PF00917	0.594
DOC_USP7_MATH_1	326	330	PF00917	0.583
DOC_USP7_MATH_1	48	52	PF00917	0.583
DOC_USP7_MATH_1	78	82	PF00917	0.627
DOC_USP7_MATH_1	879	883	PF00917	0.738
DOC_USP7_MATH_1	885	889	PF00917	0.749
DOC_USP7_MATH_1	910	914	PF00917	0.793
DOC_USP7_MATH_1	949	953	PF00917	0.701
DOC_WW_Pin1_4	18	23	PF00397	0.650
DOC_WW_Pin1_4	73	78	PF00397	0.553
DOC_WW_Pin1_4	891	896	PF00397	0.751
DOC_WW_Pin1_4	908	913	PF00397	0.787
DOC_WW_Pin1_4	920	925	PF00397	0.700
DOC_WW_Pin1_4	953	958	PF00397	0.668
LIG_14-3-3_CanoR_1	133	141	PF00244	0.434
LIG_14-3-3_CanoR_1	154	160	PF00244	0.535
LIG_14-3-3_CanoR_1	258	264	PF00244	0.506
LIG_14-3-3_CanoR_1	281	285	PF00244	0.576
LIG_14-3-3_CanoR_1	355	362	PF00244	0.677
LIG_14-3-3_CanoR_1	677	682	PF00244	0.563
LIG_14-3-3_CanoR_1	718	726	PF00244	0.609
LIG_14-3-3_CanoR_1	901	909	PF00244	0.712
LIG_14-3-3_CanoR_1	914	924	PF00244	0.533
LIG_14-3-3_CanoR_1	951	957	PF00244	0.739
LIG_Actin_WH2_1	281	298	PF00022	0.342
LIG_Actin_WH2_2	768	784	PF00022	0.505
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BIR_III_2	13	17	PF00653	0.748
LIG_BRCT_BRCA1_1	100	104	PF00533	0.633
LIG_BRCT_BRCA1_1	525	529	PF00533	0.371
LIG_FAT_LD_1	256	264	PF03623	0.621
LIG_FHA_1	236	242	PF00498	0.561
LIG_FHA_1	376	382	PF00498	0.534
LIG_FHA_1	401	407	PF00498	0.553
LIG_FHA_1	74	80	PF00498	0.714
LIG_FHA_1	797	803	PF00498	0.498
LIG_FHA_2	155	161	PF00498	0.495
LIG_FHA_2	169	175	PF00498	0.473
LIG_FHA_2	252	258	PF00498	0.558
LIG_FHA_2	259	265	PF00498	0.563
LIG_FHA_2	287	293	PF00498	0.456
LIG_FHA_2	299	305	PF00498	0.475
LIG_FHA_2	455	461	PF00498	0.509
LIG_FHA_2	476	482	PF00498	0.562
LIG_FHA_2	505	511	PF00498	0.448
LIG_FHA_2	534	540	PF00498	0.659
LIG_FHA_2	565	571	PF00498	0.504
LIG_FHA_2	684	690	PF00498	0.392
LIG_GBD_Chelix_1	255	263	PF00786	0.592
LIG_HCF-1_HBM_1	366	369	PF13415	0.615
LIG_LIR_Apic_2	17	22	PF02991	0.648
LIG_LIR_Gen_1	333	341	PF02991	0.473
LIG_LIR_Gen_1	735	743	PF02991	0.489
LIG_LIR_Gen_1	827	837	PF02991	0.616
LIG_LIR_Gen_1	855	866	PF02991	0.735
LIG_LIR_Nem_3	306	312	PF02991	0.600
LIG_LIR_Nem_3	333	338	PF02991	0.461
LIG_LIR_Nem_3	735	740	PF02991	0.468
LIG_LIR_Nem_3	827	833	PF02991	0.570
LIG_LIR_Nem_3	855	861	PF02991	0.735
LIG_NRP_CendR_1	959	962	PF00754	0.627
LIG_REV1ctd_RIR_1	868	878	PF16727	0.504
LIG_RPA_C_Fungi	276	288	PF08784	0.494
LIG_RPA_C_Fungi	568	580	PF08784	0.471
LIG_SH2_CRK	148	152	PF00017	0.624
LIG_SH2_CRK	678	682	PF00017	0.572
LIG_SH2_CRK	737	741	PF00017	0.575
LIG_SH2_SRC	66	69	PF00017	0.755
LIG_SH2_STAP1	155	159	PF00017	0.560
LIG_SH2_STAT5	148	151	PF00017	0.598
LIG_SH2_STAT5	369	372	PF00017	0.591
LIG_SH2_STAT5	678	681	PF00017	0.343
LIG_SH2_STAT5	96	99	PF00017	0.672
LIG_SH3_2	957	962	PF14604	0.685
LIG_SH3_3	20	26	PF00018	0.624
LIG_SH3_3	889	895	PF00018	0.790
LIG_SH3_3	954	960	PF00018	0.656
LIG_SUMO_SIM_par_1	322	330	PF11976	0.578
LIG_TRAF2_1	171	174	PF00917	0.607
LIG_TRAF2_1	363	366	PF00917	0.645
LIG_TRAF2_1	507	510	PF00917	0.495
LIG_TRAF2_1	572	575	PF00917	0.467
LIG_TRAF2_1	795	798	PF00917	0.512
MOD_CDC14_SPxK_1	911	914	PF00782	0.749
MOD_CDC14_SPxK_1	956	959	PF00782	0.715
MOD_CDK_SPxK_1	908	914	PF00069	0.770
MOD_CDK_SPxK_1	953	959	PF00069	0.722
MOD_CDK_SPxxK_3	18	25	PF00069	0.675
MOD_CK1_1	262	268	PF00069	0.598
MOD_CK1_1	270	276	PF00069	0.642
MOD_CK1_1	283	289	PF00069	0.458
MOD_CK1_1	431	437	PF00069	0.595
MOD_CK1_1	564	570	PF00069	0.562
MOD_CK1_1	904	910	PF00069	0.785
MOD_CK1_1	952	958	PF00069	0.696
MOD_CK2_1	154	160	PF00069	0.482
MOD_CK2_1	168	174	PF00069	0.434
MOD_CK2_1	258	264	PF00069	0.568
MOD_CK2_1	266	272	PF00069	0.608
MOD_CK2_1	360	366	PF00069	0.598
MOD_CK2_1	454	460	PF00069	0.551
MOD_CK2_1	504	510	PF00069	0.443
MOD_CK2_1	533	539	PF00069	0.608
MOD_CK2_1	683	689	PF00069	0.471
MOD_CK2_1	847	853	PF00069	0.720
MOD_CK2_1	869	875	PF00069	0.758
MOD_GlcNHglycan	285	288	PF01048	0.473
MOD_GlcNHglycan	409	412	PF01048	0.567
MOD_GlcNHglycan	434	437	PF01048	0.584
MOD_GlcNHglycan	638	641	PF01048	0.627
MOD_GlcNHglycan	80	83	PF01048	0.563
MOD_GlcNHglycan	836	840	PF01048	0.607
MOD_GlcNHglycan	849	852	PF01048	0.573
MOD_GlcNHglycan	853	857	PF01048	0.524
MOD_GlcNHglycan	881	884	PF01048	0.756
MOD_GlcNHglycan	888	891	PF01048	0.811
MOD_GlcNHglycan	903	906	PF01048	0.724
MOD_GSK3_1	14	21	PF00069	0.766
MOD_GSK3_1	149	156	PF00069	0.556
MOD_GSK3_1	160	167	PF00069	0.472
MOD_GSK3_1	258	265	PF00069	0.531
MOD_GSK3_1	266	273	PF00069	0.563
MOD_GSK3_1	279	286	PF00069	0.460
MOD_GSK3_1	34	41	PF00069	0.745
MOD_GSK3_1	354	361	PF00069	0.666
MOD_GSK3_1	427	434	PF00069	0.634
MOD_GSK3_1	500	507	PF00069	0.447
MOD_GSK3_1	636	643	PF00069	0.647
MOD_GSK3_1	73	80	PF00069	0.640
MOD_GSK3_1	904	911	PF00069	0.783
MOD_GSK3_1	912	919	PF00069	0.770
MOD_GSK3_1	949	956	PF00069	0.572
MOD_N-GLC_1	4	9	PF02516	0.488
MOD_N-GLC_1	932	937	PF02516	0.761
MOD_NEK2_1	127	132	PF00069	0.486
MOD_NEK2_1	134	139	PF00069	0.521
MOD_NEK2_1	248	253	PF00069	0.621
MOD_NEK2_1	354	359	PF00069	0.645
MOD_NEK2_1	387	392	PF00069	0.601
MOD_NEK2_1	454	459	PF00069	0.596
MOD_NEK2_1	472	477	PF00069	0.542
MOD_NEK2_1	508	513	PF00069	0.539
MOD_NEK2_1	85	90	PF00069	0.720
MOD_NEK2_1	861	866	PF00069	0.729
MOD_NEK2_1	878	883	PF00069	0.735
MOD_PIKK_1	178	184	PF00454	0.382
MOD_PIKK_1	270	276	PF00454	0.668
MOD_PIKK_1	317	323	PF00454	0.587
MOD_PIKK_1	34	40	PF00454	0.752
MOD_PIKK_1	354	360	PF00454	0.626
MOD_PIKK_1	387	393	PF00454	0.570
MOD_PIKK_1	400	406	PF00454	0.574
MOD_PIKK_1	428	434	PF00454	0.564
MOD_PIKK_1	472	478	PF00454	0.592
MOD_PIKK_1	564	570	PF00454	0.490
MOD_PIKK_1	717	723	PF00454	0.614
MOD_PIKK_1	916	922	PF00454	0.659
MOD_PK_1	4	10	PF00069	0.482
MOD_PKA_2	132	138	PF00069	0.460
MOD_PKA_2	153	159	PF00069	0.599
MOD_PKA_2	24	30	PF00069	0.766
MOD_PKA_2	280	286	PF00069	0.571
MOD_PKA_2	317	323	PF00069	0.641
MOD_PKA_2	354	360	PF00069	0.688
MOD_PKA_2	580	586	PF00069	0.763
MOD_PKA_2	676	682	PF00069	0.403
MOD_PKA_2	717	723	PF00069	0.536
MOD_PKA_2	861	867	PF00069	0.729
MOD_PKA_2	950	956	PF00069	0.760
MOD_Plk_1	165	171	PF00069	0.413
MOD_Plk_1	230	236	PF00069	0.575
MOD_Plk_1	298	304	PF00069	0.415
MOD_Plk_1	4	10	PF00069	0.656
MOD_Plk_1	400	406	PF00069	0.405
MOD_Plk_1	602	608	PF00069	0.608
MOD_Plk_1	98	104	PF00069	0.645
MOD_Plk_4	14	20	PF00069	0.742
MOD_Plk_4	251	257	PF00069	0.389
MOD_Plk_4	280	286	PF00069	0.507
MOD_Plk_4	336	342	PF00069	0.593
MOD_Plk_4	389	395	PF00069	0.583
MOD_Plk_4	4	10	PF00069	0.687
MOD_Plk_4	662	668	PF00069	0.488
MOD_ProDKin_1	18	24	PF00069	0.652
MOD_ProDKin_1	73	79	PF00069	0.554
MOD_ProDKin_1	891	897	PF00069	0.751
MOD_ProDKin_1	908	914	PF00069	0.792
MOD_ProDKin_1	920	926	PF00069	0.701
MOD_ProDKin_1	953	959	PF00069	0.666
MOD_SUMO_for_1	123	126	PF00179	0.599
MOD_SUMO_for_1	795	798	PF00179	0.582
MOD_SUMO_rev_2	215	225	PF00179	0.629
MOD_SUMO_rev_2	350	354	PF00179	0.638
MOD_SUMO_rev_2	466	475	PF00179	0.594
MOD_SUMO_rev_2	697	702	PF00179	0.539
MOD_SUMO_rev_2	749	754	PF00179	0.564
TRG_DiLeu_BaEn_1	401	406	PF01217	0.571
TRG_DiLeu_BaEn_1	735	740	PF01217	0.552
TRG_DiLeu_BaEn_1	797	802	PF01217	0.616
TRG_DiLeu_BaEn_2	318	324	PF01217	0.611
TRG_DiLeu_BaEn_4	560	566	PF01217	0.663
TRG_DiLeu_BaEn_4	697	703	PF01217	0.512
TRG_DiLeu_BaEn_4	749	755	PF01217	0.589
TRG_DiLeu_BaEn_4	797	803	PF01217	0.529
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.641
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.619
TRG_ENDOCYTIC_2	148	151	PF00928	0.582
TRG_ENDOCYTIC_2	678	681	PF00928	0.575
TRG_ENDOCYTIC_2	737	740	PF00928	0.469
TRG_ENDOCYTIC_2	858	861	PF00928	0.736
TRG_ER_diArg_1	106	108	PF00400	0.635
TRG_ER_diArg_1	209	211	PF00400	0.521
TRG_ER_diArg_1	227	229	PF00400	0.546
TRG_ER_diArg_1	241	243	PF00400	0.604
TRG_ER_diArg_1	702	705	PF00400	0.481
TRG_ER_diArg_1	773	776	PF00400	0.615
TRG_ER_diArg_1	802	804	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	692	696	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	773	777	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKJ3	Leptomonas seymouri	61%	98%
A0A0S4JNT6	Bodo saltans	29%	100%
A0A1X0P823	Trypanosomatidae	37%	100%
A0A3Q8IJT0	Leishmania donovani	81%	100%
A0A422NIX4	Trypanosoma rangeli	34%	100%
A4HY07	Leishmania infantum	81%	100%
D0A592	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ARS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QDQ3	Leishmania major	81%	100%
V5BJ58	Trypanosoma cruzi	34%	100%