Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) family, putative

Species:

Leishmania braziliensis

UniProt:

A4H9N7_LEIBR

TriTrypDb:

LbrM.18.1370 , LBRM2903_180019500

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0000139	Golgi membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4H9N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9N7

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006474	N-terminal protein amino acid acetylation	5	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007059	chromosome segregation	2	5
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	5
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0017196	N-terminal peptidyl-methionine acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0043966	histone H3 acetylation	7	1
GO:0043967	histone H4 acetylation	7	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004596	peptide alpha-N-acetyltransferase activity	8	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0034212	peptide N-acetyltransferase activity	7	7
GO:0004402	histone acetyltransferase activity	4	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.650
CLV_NRD_NRD_1	260	262	PF00675	0.380
CLV_NRD_NRD_1	392	394	PF00675	0.396
CLV_NRD_NRD_1	396	398	PF00675	0.382
CLV_NRD_NRD_1	489	491	PF00675	0.433
CLV_NRD_NRD_1	528	530	PF00675	0.478
CLV_NRD_NRD_1	54	56	PF00675	0.311
CLV_NRD_NRD_1	583	585	PF00675	0.414
CLV_NRD_NRD_1	612	614	PF00675	0.448
CLV_NRD_NRD_1	94	96	PF00675	0.291
CLV_PCSK_FUR_1	526	530	PF00082	0.506
CLV_PCSK_KEX2_1	392	394	PF00082	0.396
CLV_PCSK_KEX2_1	396	398	PF00082	0.382
CLV_PCSK_KEX2_1	526	528	PF00082	0.475
CLV_PCSK_KEX2_1	54	56	PF00082	0.311
CLV_PCSK_KEX2_1	583	585	PF00082	0.414
CLV_PCSK_KEX2_1	612	614	PF00082	0.450
CLV_PCSK_PC7_1	392	398	PF00082	0.362
CLV_PCSK_SKI1_1	102	106	PF00082	0.349
CLV_PCSK_SKI1_1	239	243	PF00082	0.333
CLV_PCSK_SKI1_1	336	340	PF00082	0.346
CLV_PCSK_SKI1_1	431	435	PF00082	0.363
CLV_PCSK_SKI1_1	612	616	PF00082	0.396
DEG_SPOP_SBC_1	34	38	PF00917	0.599
DEG_SPOP_SBC_1	517	521	PF00917	0.651
DOC_CKS1_1	560	565	PF01111	0.683
DOC_MAPK_gen_1	533	540	PF00069	0.623
DOC_MAPK_RevD_3	513	529	PF00069	0.660
DOC_PP1_RVXF_1	41	47	PF00149	0.552
DOC_PP1_RVXF_1	625	631	PF00149	0.647
DOC_PP2B_LxvP_1	567	570	PF13499	0.609
DOC_PP2B_PxIxI_1	505	511	PF00149	0.622
DOC_SPAK_OSR1_1	397	401	PF12202	0.548
DOC_USP7_MATH_1	120	124	PF00917	0.648
DOC_USP7_MATH_1	167	171	PF00917	0.588
DOC_USP7_MATH_1	462	466	PF00917	0.702
DOC_USP7_MATH_1	517	521	PF00917	0.714
DOC_USP7_MATH_1	617	621	PF00917	0.682
DOC_WW_Pin1_4	283	288	PF00397	0.608
DOC_WW_Pin1_4	29	34	PF00397	0.655
DOC_WW_Pin1_4	508	513	PF00397	0.618
DOC_WW_Pin1_4	559	564	PF00397	0.652
DOC_WW_Pin1_4	572	577	PF00397	0.653
DOC_WW_Pin1_4	586	591	PF00397	0.651
LIG_14-3-3_CanoR_1	239	244	PF00244	0.530
LIG_14-3-3_CanoR_1	67	73	PF00244	0.460
LIG_Actin_WH2_2	41	56	PF00022	0.465
LIG_APCC_ABBA_1	427	432	PF00400	0.474
LIG_BIR_III_2	311	315	PF00653	0.630
LIG_BRCT_BRCA1_1	331	335	PF00533	0.644
LIG_CaM_IQ_9	87	102	PF13499	0.509
LIG_eIF4E_1	258	264	PF01652	0.569
LIG_FHA_1	106	112	PF00498	0.560
LIG_FHA_1	188	194	PF00498	0.512
LIG_FHA_1	213	219	PF00498	0.540
LIG_FHA_1	227	233	PF00498	0.617
LIG_FHA_1	35	41	PF00498	0.585
LIG_FHA_1	639	645	PF00498	0.254
LIG_FHA_1	652	658	PF00498	0.328
LIG_FHA_2	147	153	PF00498	0.499
LIG_FHA_2	363	369	PF00498	0.677
LIG_FHA_2	382	388	PF00498	0.653
LIG_FHA_2	474	480	PF00498	0.636
LIG_FHA_2	539	545	PF00498	0.610
LIG_GBD_Chelix_1	192	200	PF00786	0.236
LIG_LIR_Apic_2	585	590	PF02991	0.644
LIG_LIR_Gen_1	654	663	PF02991	0.532
LIG_LIR_Gen_1	71	81	PF02991	0.513
LIG_LIR_Nem_3	238	243	PF02991	0.579
LIG_LIR_Nem_3	254	258	PF02991	0.532
LIG_LIR_Nem_3	332	338	PF02991	0.695
LIG_LIR_Nem_3	592	596	PF02991	0.609
LIG_LIR_Nem_3	609	614	PF02991	0.648
LIG_LIR_Nem_3	654	658	PF02991	0.357
LIG_LIR_Nem_3	71	76	PF02991	0.477
LIG_LYPXL_yS_3	593	596	PF13949	0.611
LIG_NRBOX	262	268	PF00104	0.599
LIG_PCNA_yPIPBox_3	394	408	PF02747	0.540
LIG_RPA_C_Fungi	199	211	PF08784	0.472
LIG_SH2_CRK	655	659	PF00017	0.334
LIG_SH2_NCK_1	545	549	PF00017	0.498
LIG_SH2_SRC	57	60	PF00017	0.284
LIG_SH2_STAP1	251	255	PF00017	0.451
LIG_SH2_STAP1	444	448	PF00017	0.400
LIG_SH2_STAP1	68	72	PF00017	0.388
LIG_SH2_STAP1	73	77	PF00017	0.318
LIG_SH2_STAT3	243	246	PF00017	0.399
LIG_SH2_STAT5	217	220	PF00017	0.351
LIG_SH2_STAT5	243	246	PF00017	0.363
LIG_SH2_STAT5	255	258	PF00017	0.436
LIG_SH2_STAT5	342	345	PF00017	0.511
LIG_SH3_3	126	132	PF00018	0.495
LIG_SH3_3	220	226	PF00018	0.373
LIG_SH3_3	510	516	PF00018	0.727
LIG_SUMO_SIM_par_1	506	511	PF11976	0.517
LIG_SUMO_SIM_par_1	84	90	PF11976	0.278
LIG_TRAF2_1	144	147	PF00917	0.457
LIG_TRAF2_1	156	159	PF00917	0.364
LIG_TRAF2_1	302	305	PF00917	0.557
LIG_TRAF2_1	384	387	PF00917	0.520
LIG_TRAF2_1	89	92	PF00917	0.322
LIG_TYR_ITIM	653	658	PF00017	0.334
LIG_WRC_WIRS_1	218	223	PF05994	0.342
MOD_CDK_SPK_2	586	591	PF00069	0.534
MOD_CK1_1	119	125	PF00069	0.560
MOD_CK1_1	136	142	PF00069	0.560
MOD_CK1_1	16	22	PF00069	0.586
MOD_CK1_1	181	187	PF00069	0.545
MOD_CK1_1	212	218	PF00069	0.416
MOD_CK1_1	322	328	PF00069	0.586
MOD_CK1_1	329	335	PF00069	0.527
MOD_CK1_1	520	526	PF00069	0.598
MOD_CK1_1	586	592	PF00069	0.523
MOD_CK1_1	9	15	PF00069	0.511
MOD_CK2_1	146	152	PF00069	0.360
MOD_CK2_1	29	35	PF00069	0.590
MOD_CK2_1	299	305	PF00069	0.554
MOD_CK2_1	362	368	PF00069	0.488
MOD_CK2_1	381	387	PF00069	0.547
MOD_CK2_1	473	479	PF00069	0.551
MOD_CK2_1	497	503	PF00069	0.539
MOD_CK2_1	68	74	PF00069	0.407
MOD_GlcNHglycan	118	121	PF01048	0.554
MOD_GlcNHglycan	125	128	PF01048	0.534
MOD_GlcNHglycan	288	291	PF01048	0.626
MOD_GlcNHglycan	328	331	PF01048	0.611
MOD_GlcNHglycan	456	461	PF01048	0.552
MOD_GlcNHglycan	464	467	PF01048	0.595
MOD_GSK3_1	116	123	PF00069	0.507
MOD_GSK3_1	13	20	PF00069	0.671
MOD_GSK3_1	177	184	PF00069	0.596
MOD_GSK3_1	24	31	PF00069	0.613
MOD_GSK3_1	299	306	PF00069	0.615
MOD_GSK3_1	321	328	PF00069	0.759
MOD_GSK3_1	34	41	PF00069	0.466
MOD_GSK3_1	358	365	PF00069	0.374
MOD_GSK3_1	452	459	PF00069	0.486
MOD_GSK3_1	462	469	PF00069	0.623
MOD_GSK3_1	5	12	PF00069	0.586
MOD_GSK3_1	516	523	PF00069	0.575
MOD_N-GLC_1	106	111	PF02516	0.430
MOD_N-GLC_1	178	183	PF02516	0.486
MOD_N-GLC_1	24	29	PF02516	0.532
MOD_N-GLC_1	306	311	PF02516	0.567
MOD_NEK2_1	321	326	PF00069	0.533
MOD_NEK2_1	338	343	PF00069	0.414
MOD_NEK2_1	416	421	PF00069	0.537
MOD_NEK2_1	468	473	PF00069	0.614
MOD_NEK2_1	518	523	PF00069	0.560
MOD_NEK2_1	638	643	PF00069	0.221
MOD_NEK2_1	651	656	PF00069	0.221
MOD_NEK2_2	330	335	PF00069	0.551
MOD_PIKK_1	133	139	PF00454	0.450
MOD_PIKK_1	242	248	PF00454	0.403
MOD_PIKK_1	319	325	PF00454	0.655
MOD_PIKK_1	575	581	PF00454	0.503
MOD_PIKK_1	87	93	PF00454	0.348
MOD_PKA_1	583	589	PF00069	0.491
MOD_PKA_1	612	618	PF00069	0.601
MOD_PKA_1	95	101	PF00069	0.345
MOD_PKA_2	583	589	PF00069	0.565
MOD_PKA_2	612	618	PF00069	0.683
MOD_PKB_1	356	364	PF00069	0.377
MOD_Plk_1	146	152	PF00069	0.353
MOD_Plk_1	495	501	PF00069	0.666
MOD_Plk_2-3	381	387	PF00069	0.530
MOD_Plk_2-3	475	481	PF00069	0.476
MOD_Plk_4	187	193	PF00069	0.446
MOD_Plk_4	231	237	PF00069	0.356
MOD_Plk_4	330	336	PF00069	0.565
MOD_Plk_4	338	344	PF00069	0.381
MOD_Plk_4	417	423	PF00069	0.347
MOD_Plk_4	583	589	PF00069	0.555
MOD_Plk_4	68	74	PF00069	0.407
MOD_ProDKin_1	283	289	PF00069	0.503
MOD_ProDKin_1	29	35	PF00069	0.560
MOD_ProDKin_1	508	514	PF00069	0.511
MOD_ProDKin_1	559	565	PF00069	0.562
MOD_ProDKin_1	572	578	PF00069	0.562
MOD_ProDKin_1	586	592	PF00069	0.552
MOD_SUMO_rev_2	254	264	PF00179	0.359
TRG_DiLeu_BaEn_4	609	615	PF01217	0.469
TRG_DiLeu_LyEn_5	503	508	PF01217	0.525
TRG_ENDOCYTIC_2	436	439	PF00928	0.395
TRG_ENDOCYTIC_2	593	596	PF00928	0.502
TRG_ENDOCYTIC_2	655	658	PF00928	0.334
TRG_ENDOCYTIC_2	73	76	PF00928	0.336
TRG_ER_diArg_1	356	359	PF00400	0.480
TRG_ER_diArg_1	391	393	PF00400	0.470
TRG_ER_diArg_1	396	398	PF00400	0.356
TRG_ER_diArg_1	42	45	PF00400	0.443
TRG_ER_diArg_1	525	528	PF00400	0.590
TRG_ER_diArg_1	53	55	PF00400	0.312
TRG_ER_diArg_1	532	535	PF00400	0.594
TRG_ER_diArg_1	582	584	PF00400	0.510
TRG_ER_diArg_1	611	613	PF00400	0.579
TRG_NLS_MonoExtC_3	392	397	PF00514	0.405
TRG_NLS_MonoExtN_4	392	397	PF00514	0.405
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4M7	Leptomonas seymouri	43%	80%
A0A3S7WV24	Leishmania donovani	70%	94%
A4HY02	Leishmania infantum	70%	82%
E9ARR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	95%
Q4QDQ8	Leishmania major	69%	100%