Homologous to animal mitochondrial 2-oxoglutarate/malate carriers.. For some reason, these genes duplicated in Leishmaniidae and other pathogenic lineages.. Localization: Mitochondrial (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 19 |
| NetGPI | no | yes: 0, no: 19 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 20 |
| GO:0110165 | cellular anatomical entity | 1 | 20 |
| GO:0005654 | nucleoplasm | 2 | 4 |
| GO:0005737 | cytoplasm | 2 | 4 |
| GO:0005739 | mitochondrion | 5 | 4 |
| GO:0020023 | kinetoplast | 2 | 4 |
| GO:0032838 | plasma membrane bounded cell projection cytoplasm | 4 | 4 |
| GO:0043226 | organelle | 2 | 4 |
| GO:0043227 | membrane-bounded organelle | 3 | 4 |
| GO:0043229 | intracellular organelle | 3 | 4 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 4 |
| GO:0097014 | ciliary plasm | 5 | 4 |
| GO:0099568 | cytoplasmic region | 3 | 4 |
Related structures:
AlphaFold database: A4H9N6
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006810 | transport | 3 | 4 |
| GO:0006811 | monoatomic ion transport | 4 | 4 |
| GO:0006817 | phosphate ion transport | 7 | 4 |
| GO:0006820 | monoatomic anion transport | 5 | 4 |
| GO:0006835 | dicarboxylic acid transport | 7 | 4 |
| GO:0008272 | sulfate transport | 5 | 4 |
| GO:0009987 | cellular process | 1 | 4 |
| GO:0015698 | inorganic anion transport | 6 | 4 |
| GO:0015709 | thiosulfate transport | 5 | 4 |
| GO:0015711 | organic anion transport | 5 | 4 |
| GO:0015729 | oxaloacetate transport | 6 | 4 |
| GO:0015740 | C4-dicarboxylate transport | 8 | 4 |
| GO:0015743 | malate transport | 6 | 4 |
| GO:0015744 | succinate transport | 6 | 4 |
| GO:0015849 | organic acid transport | 5 | 4 |
| GO:0034220 | monoatomic ion transmembrane transport | 3 | 4 |
| GO:0035435 | phosphate ion transmembrane transport | 6 | 4 |
| GO:0046942 | carboxylic acid transport | 6 | 4 |
| GO:0051179 | localization | 1 | 4 |
| GO:0051234 | establishment of localization | 2 | 4 |
| GO:0055085 | transmembrane transport | 2 | 4 |
| GO:0071422 | succinate transmembrane transport | 5 | 4 |
| GO:0071423 | malate transmembrane transport | 5 | 4 |
| GO:0071702 | organic substance transport | 4 | 4 |
| GO:0072348 | sulfur compound transport | 4 | 4 |
| GO:0098656 | monoatomic anion transmembrane transport | 4 | 4 |
| GO:0098660 | inorganic ion transmembrane transport | 4 | 4 |
| GO:0098661 | inorganic anion transmembrane transport | 5 | 4 |
| GO:1903825 | organic acid transmembrane transport | 3 | 4 |
| GO:1905039 | carboxylic acid transmembrane transport | 4 | 4 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005215 | transporter activity | 1 | 4 |
| GO:0005310 | dicarboxylic acid transmembrane transporter activity | 5 | 4 |
| GO:0005342 | organic acid transmembrane transporter activity | 3 | 4 |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 4 | 4 |
| GO:0008514 | organic anion transmembrane transporter activity | 5 | 4 |
| GO:0015075 | monoatomic ion transmembrane transporter activity | 3 | 4 |
| GO:0015103 | inorganic anion transmembrane transporter activity | 4 | 4 |
| GO:0015116 | sulfate transmembrane transporter activity | 4 | 4 |
| GO:0015117 | thiosulfate transmembrane transporter activity | 4 | 4 |
| GO:0015131 | oxaloacetate transmembrane transporter activity | 6 | 4 |
| GO:0015140 | malate transmembrane transporter activity | 6 | 4 |
| GO:0015141 | succinate transmembrane transporter activity | 6 | 4 |
| GO:0015291 | secondary active transmembrane transporter activity | 4 | 4 |
| GO:0015297 | antiporter activity | 5 | 4 |
| GO:0015318 | inorganic molecular entity transmembrane transporter activity | 3 | 4 |
| GO:0015556 | C4-dicarboxylate transmembrane transporter activity | 6 | 4 |
| GO:0022804 | active transmembrane transporter activity | 3 | 4 |
| GO:0022857 | transmembrane transporter activity | 2 | 4 |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 4 | 4 |
| GO:1901682 | sulfur compound transmembrane transporter activity | 3 | 4 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 54 | 58 | PF00656 | 0.363 |
| CLV_NRD_NRD_1 | 307 | 309 | PF00675 | 0.313 |
| CLV_PCSK_FUR_1 | 305 | 309 | PF00082 | 0.338 |
| CLV_PCSK_KEX2_1 | 206 | 208 | PF00082 | 0.395 |
| CLV_PCSK_KEX2_1 | 307 | 309 | PF00082 | 0.324 |
| CLV_PCSK_KEX2_1 | 64 | 66 | PF00082 | 0.393 |
| CLV_PCSK_PC1ET2_1 | 206 | 208 | PF00082 | 0.436 |
| CLV_PCSK_PC1ET2_1 | 64 | 66 | PF00082 | 0.393 |
| CLV_PCSK_SKI1_1 | 160 | 164 | PF00082 | 0.318 |
| CLV_PCSK_SKI1_1 | 265 | 269 | PF00082 | 0.527 |
| DOC_CYCLIN_yCln2_LP_2 | 133 | 139 | PF00134 | 0.317 |
| DOC_MAPK_MEF2A_6 | 10 | 18 | PF00069 | 0.711 |
| DOC_PP4_FxxP_1 | 35 | 38 | PF00568 | 0.333 |
| DOC_PP4_MxPP_1 | 48 | 51 | PF00568 | 0.235 |
| DOC_USP7_MATH_1 | 122 | 126 | PF00917 | 0.369 |
| DOC_USP7_MATH_1 | 177 | 181 | PF00917 | 0.437 |
| DOC_USP7_MATH_1 | 51 | 55 | PF00917 | 0.311 |
| DOC_USP7_UBL2_3 | 60 | 64 | PF12436 | 0.278 |
| DOC_WW_Pin1_4 | 132 | 137 | PF00397 | 0.276 |
| DOC_WW_Pin1_4 | 206 | 211 | PF00397 | 0.608 |
| LIG_14-3-3_CanoR_1 | 152 | 156 | PF00244 | 0.547 |
| LIG_14-3-3_CanoR_1 | 239 | 248 | PF00244 | 0.359 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.690 |
| LIG_FHA_1 | 112 | 118 | PF00498 | 0.193 |
| LIG_FHA_1 | 51 | 57 | PF00498 | 0.360 |
| LIG_FHA_1 | 81 | 87 | PF00498 | 0.321 |
| LIG_FHA_2 | 113 | 119 | PF00498 | 0.294 |
| LIG_LIR_Nem_3 | 173 | 178 | PF02991 | 0.514 |
| LIG_LIR_Nem_3 | 224 | 230 | PF02991 | 0.308 |
| LIG_LIR_Nem_3 | 277 | 282 | PF02991 | 0.250 |
| LIG_NRP_CendR_1 | 307 | 310 | PF00754 | 0.341 |
| LIG_Pex14_2 | 27 | 31 | PF04695 | 0.344 |
| LIG_Pex14_2 | 35 | 39 | PF04695 | 0.318 |
| LIG_Rb_pABgroove_1 | 270 | 278 | PF01858 | 0.292 |
| LIG_SH2_CRK | 228 | 232 | PF00017 | 0.299 |
| LIG_SH2_CRK | 68 | 72 | PF00017 | 0.332 |
| LIG_SH2_NCK_1 | 228 | 232 | PF00017 | 0.299 |
| LIG_SH2_STAP1 | 276 | 280 | PF00017 | 0.274 |
| LIG_SH2_STAT5 | 279 | 282 | PF00017 | 0.342 |
| LIG_SH2_STAT5 | 299 | 302 | PF00017 | 0.404 |
| LIG_SH2_STAT5 | 68 | 71 | PF00017 | 0.383 |
| LIG_SH3_3 | 11 | 17 | PF00018 | 0.645 |
| LIG_SH3_3 | 202 | 208 | PF00018 | 0.582 |
| LIG_SH3_3 | 228 | 234 | PF00018 | 0.406 |
| LIG_TYR_ITIM | 226 | 231 | PF00017 | 0.299 |
| LIG_WRC_WIRS_1 | 129 | 134 | PF05994 | 0.376 |
| LIG_WW_2 | 14 | 17 | PF00397 | 0.685 |
| MOD_CK1_1 | 131 | 137 | PF00069 | 0.310 |
| MOD_CK1_1 | 221 | 227 | PF00069 | 0.324 |
| MOD_CK1_1 | 229 | 235 | PF00069 | 0.329 |
| MOD_CK2_1 | 132 | 138 | PF00069 | 0.353 |
| MOD_GlcNHglycan | 107 | 110 | PF01048 | 0.665 |
| MOD_GlcNHglycan | 124 | 127 | PF01048 | 0.209 |
| MOD_GlcNHglycan | 172 | 175 | PF01048 | 0.315 |
| MOD_GlcNHglycan | 24 | 27 | PF01048 | 0.221 |
| MOD_GlcNHglycan | 242 | 245 | PF01048 | 0.487 |
| MOD_GlcNHglycan | 6 | 9 | PF01048 | 0.595 |
| MOD_GlcNHglycan | 72 | 75 | PF01048 | 0.487 |
| MOD_GSK3_1 | 128 | 135 | PF00069 | 0.318 |
| MOD_GSK3_1 | 18 | 25 | PF00069 | 0.446 |
| MOD_GSK3_1 | 195 | 202 | PF00069 | 0.587 |
| MOD_GSK3_1 | 51 | 58 | PF00069 | 0.339 |
| MOD_GSK3_1 | 66 | 73 | PF00069 | 0.319 |
| MOD_NEK2_1 | 143 | 148 | PF00069 | 0.469 |
| MOD_NEK2_1 | 156 | 161 | PF00069 | 0.469 |
| MOD_NEK2_1 | 18 | 23 | PF00069 | 0.449 |
| MOD_NEK2_1 | 199 | 204 | PF00069 | 0.469 |
| MOD_NEK2_1 | 226 | 231 | PF00069 | 0.376 |
| MOD_NEK2_1 | 275 | 280 | PF00069 | 0.316 |
| MOD_NEK2_1 | 59 | 64 | PF00069 | 0.337 |
| MOD_PIKK_1 | 51 | 57 | PF00454 | 0.282 |
| MOD_PKA_2 | 151 | 157 | PF00069 | 0.563 |
| MOD_PKA_2 | 240 | 246 | PF00069 | 0.279 |
| MOD_Plk_4 | 112 | 118 | PF00069 | 0.235 |
| MOD_Plk_4 | 128 | 134 | PF00069 | 0.338 |
| MOD_Plk_4 | 151 | 157 | PF00069 | 0.511 |
| MOD_Plk_4 | 195 | 201 | PF00069 | 0.490 |
| MOD_Plk_4 | 218 | 224 | PF00069 | 0.367 |
| MOD_Plk_4 | 226 | 232 | PF00069 | 0.379 |
| MOD_Plk_4 | 275 | 281 | PF00069 | 0.283 |
| MOD_Plk_4 | 287 | 293 | PF00069 | 0.314 |
| MOD_Plk_4 | 42 | 48 | PF00069 | 0.280 |
| MOD_ProDKin_1 | 132 | 138 | PF00069 | 0.276 |
| MOD_ProDKin_1 | 206 | 212 | PF00069 | 0.606 |
| MOD_SUMO_for_1 | 267 | 270 | PF00179 | 0.359 |
| TRG_ENDOCYTIC_2 | 228 | 231 | PF00928 | 0.299 |
| TRG_ENDOCYTIC_2 | 68 | 71 | PF00928 | 0.332 |
| TRG_ENDOCYTIC_2 | 89 | 92 | PF00928 | 0.274 |
| TRG_ER_diArg_1 | 239 | 242 | PF00400 | 0.280 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P8W6 | Leptomonas seymouri | 25% | 91% |
| A0A0N1PCE4 | Leptomonas seymouri | 74% | 100% |
| A0A0S4JNY1 | Bodo saltans | 48% | 86% |
| A0A1X0P7C0 | Trypanosomatidae | 59% | 98% |
| A0A3Q8IB24 | Leishmania donovani | 82% | 100% |
| A0A3Q8IEB7 | Leishmania donovani | 82% | 100% |
| A0A3R7KWT0 | Trypanosoma rangeli | 60% | 100% |
| A0A3S5H742 | Leishmania donovani | 82% | 98% |
| A0A3S5H7M7 | Leishmania donovani | 27% | 92% |
| A0PC02 | Ochotona dauurica | 22% | 100% |
| A1CIF6 | Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) | 23% | 93% |
| A1CWA4 | Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) | 22% | 94% |
| A2ADF7 | Mus musculus | 22% | 97% |
| A3KPP4 | Danio rerio | 27% | 100% |
| A4H9N5 | Leishmania braziliensis | 97% | 100% |
| A4H9X7 | Leishmania braziliensis | 25% | 97% |
| A4H9X8 | Leishmania braziliensis | 25% | 97% |
| A4HI60 | Leishmania braziliensis | 26% | 92% |
| A4HXZ9 | Leishmania infantum | 82% | 98% |
| A4HY01 | Leishmania infantum | 82% | 100% |
| A4I5D6 | Leishmania infantum | 27% | 92% |
| A5DX39 | Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) | 23% | 100% |
| B0G143 | Dictyostelium discoideum | 25% | 100% |
| B0Y4J4 | Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) | 23% | 97% |
| D0A5A6 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 55% | 100% |
| E9ARR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 80% | 97% |
| E9ARR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 80% | 100% |
| E9ARX1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 98% |
| E9ARX2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 98% |
| E9B0N4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 92% |
| F1R4U0 | Danio rerio | 23% | 98% |
| F1RFX9 | Sus scrofa | 26% | 93% |
| F4HT41 | Arabidopsis thaliana | 24% | 90% |
| G5EE96 | Caenorhabditis elegans | 25% | 100% |
| K3VFR5 | Fusarium pseudograminearum (strain CS3096) | 28% | 100% |
| O13844 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 24% | 100% |
| O77792 | Bos taurus | 26% | 100% |
| O81845 | Arabidopsis thaliana | 25% | 100% |
| O89035 | Rattus norvegicus | 26% | 100% |
| O95258 | Homo sapiens | 25% | 95% |
| O95847 | Homo sapiens | 25% | 96% |
| O97562 | Sus scrofa | 27% | 100% |
| O97649 | Sus scrofa | 26% | 100% |
| P04575 | Mesocricetus auratus | 22% | 100% |
| P04633 | Rattus norvegicus | 23% | 100% |
| P0C582 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 25% | 94% |
| P10861 | Bos taurus | 23% | 100% |
| P12242 | Mus musculus | 21% | 100% |
| P14271 | Oryctolagus cuniculus | 25% | 100% |
| P22292 | Bos taurus | 27% | 99% |
| P25874 | Homo sapiens | 24% | 100% |
| P32089 | Rattus norvegicus | 21% | 100% |
| P32332 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 20% | 96% |
| P33303 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 21% | 96% |
| P38152 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 21% | 100% |
| P53007 | Homo sapiens | 21% | 100% |
| P55851 | Homo sapiens | 27% | 100% |
| P55916 | Homo sapiens | 26% | 99% |
| P56499 | Rattus norvegicus | 28% | 100% |
| P56500 | Rattus norvegicus | 28% | 100% |
| P56501 | Mus musculus | 29% | 100% |
| P70406 | Mus musculus | 28% | 100% |
| P79110 | Bos taurus | 23% | 100% |
| P90992 | Caenorhabditis elegans | 26% | 100% |
| P97700 | Rattus norvegicus | 26% | 99% |
| Q02978 | Homo sapiens | 27% | 99% |
| Q06143 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 24% | 100% |
| Q18P97 | Suncus murinus | 23% | 100% |
| Q27257 | Caenorhabditis elegans | 26% | 99% |
| Q3SZI5 | Bos taurus | 28% | 100% |
| Q3SZK0 | Bos taurus | 26% | 100% |
| Q4Q7J8 | Leishmania major | 26% | 100% |
| Q4QDK0 | Leishmania major | 24% | 98% |
| Q4QDQ9 | Leishmania major | 83% | 100% |
| Q4QDR2 | Leishmania major | 83% | 100% |
| Q4QDR4 | Leishmania major | 83% | 100% |
| Q4QDR6 | Leishmania major | 83% | 100% |
| Q4WQC5 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 23% | 97% |
| Q54BM3 | Dictyostelium discoideum | 22% | 100% |
| Q54FE6 | Dictyostelium discoideum | 29% | 100% |
| Q54MZ4 | Dictyostelium discoideum | 23% | 71% |
| Q54PY7 | Dictyostelium discoideum | 24% | 97% |
| Q5PQM9 | Rattus norvegicus | 22% | 100% |
| Q5R5A8 | Pongo abelii | 27% | 100% |
| Q5RFB7 | Pongo abelii | 21% | 100% |
| Q5SVS4 | Homo sapiens | 21% | 100% |
| Q5SWT3 | Mus musculus | 22% | 100% |
| Q5U3V7 | Danio rerio | 24% | 90% |
| Q5XGI1 | Xenopus tropicalis | 21% | 100% |
| Q5XIF9 | Rattus norvegicus | 25% | 97% |
| Q6DG32 | Danio rerio | 24% | 100% |
| Q6FTN2 | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | 25% | 100% |
| Q6GQ22 | Xenopus laevis | 20% | 100% |
| Q6PGY3 | Danio rerio | 23% | 86% |
| Q6PIV7 | Homo sapiens | 23% | 100% |
| Q7K566 | Drosophila melanogaster | 23% | 100% |
| Q8BZ09 | Mus musculus | 21% | 100% |
| Q8HXE3 | Macaca fascicularis | 21% | 100% |
| Q8JZU2 | Mus musculus | 22% | 100% |
| Q8K404 | Dicrostonyx groenlandicus | 22% | 100% |
| Q94AG6 | Arabidopsis thaliana | 23% | 95% |
| Q99JD3 | Rattus norvegicus | 21% | 100% |
| Q9BQT8 | Homo sapiens | 21% | 100% |
| Q9C5M0 | Arabidopsis thaliana | 22% | 100% |
| Q9CR58 | Mus musculus | 21% | 100% |
| Q9CR62 | Mus musculus | 27% | 99% |
| Q9ER18 | Phodopus sungorus | 22% | 100% |
| Q9FY68 | Arabidopsis thaliana | 22% | 92% |
| Q9GMZ1 | Canis lupus familiaris | 25% | 100% |
| Q9N2I9 | Canis lupus familiaris | 25% | 100% |
| Q9N2J1 | Canis lupus familiaris | 28% | 100% |
| Q9QZD8 | Mus musculus | 24% | 100% |
| Q9SB52 | Arabidopsis thaliana | 27% | 99% |
| Q9SJY5 | Arabidopsis thaliana | 25% | 99% |
| Q9UBX3 | Homo sapiens | 26% | 100% |
| Q9UTN1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 22% | 97% |
| Q9VMK1 | Drosophila melanogaster | 25% | 93% |
| Q9W720 | Danio rerio | 27% | 100% |
| Q9W725 | Cyprinus carpio | 26% | 100% |
| Q9XI74 | Arabidopsis thaliana | 27% | 100% |
| Q9Z2B2 | Mus musculus | 25% | 95% |
| Q9ZWG1 | Arabidopsis thaliana | 24% | 100% |
| V5BNM4 | Trypanosoma cruzi | 59% | 95% |
| W5PSH7 | Ovis aries | 23% | 100% |