Mitochondrial carrier protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9N5_LEIBR

TriTrypDb:

LbrM.18.1350 , LBRM2903_180019200

Length:

316

Annotations

LeishMANIAdb annotations

Homologous to animal mitochondrial 2-oxoglutarate/malate carriers.. For some reason, these genes duplicated in Leishmaniidae and other pathogenic lineages.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Show entries

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	4
GO:0005737	cytoplasm	2	4
GO:0005739	mitochondrion	5	4
GO:0016020	membrane	2	20
GO:0020023	kinetoplast	2	4
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

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Expansion

Sequence features

A4H9N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9N5

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	4
GO:0006817	phosphate ion transport	7	4
GO:0006820	monoatomic anion transport	5	4
GO:0006835	dicarboxylic acid transport	7	4
GO:0008272	sulfate transport	5	4
GO:0009987	cellular process	1	4
GO:0015698	inorganic anion transport	6	4
GO:0015709	thiosulfate transport	5	4
GO:0015711	organic anion transport	5	4

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	4
GO:0005310	dicarboxylic acid transmembrane transporter activity	5	4
GO:0005342	organic acid transmembrane transporter activity	3	4
GO:0008509	monoatomic anion transmembrane transporter activity	4	4
GO:0008514	organic anion transmembrane transporter activity	5	4
GO:0015075	monoatomic ion transmembrane transporter activity	3	4
GO:0015103	inorganic anion transmembrane transporter activity	4	4
GO:0015116	sulfate transmembrane transporter activity	4	4
GO:0015117	thiosulfate transmembrane transporter activity	4	4
GO:0015131	oxaloacetate transmembrane transporter activity	6	4

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.326
CLV_PCSK_KEX2_1	206	208	PF00082	0.414
CLV_PCSK_KEX2_1	64	66	PF00082	0.385
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.457
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.385
CLV_PCSK_SKI1_1	160	164	PF00082	0.320
CLV_PCSK_SKI1_1	265	269	PF00082	0.519
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.301
DOC_MAPK_MEF2A_6	10	18	PF00069	0.669
DOC_PP4_FxxP_1	35	38	PF00568	0.317

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W6	Leptomonas seymouri	25%	93%
A0A0N1PCE4	Leptomonas seymouri	74%	100%
A0A0S4JNY1	Bodo saltans	48%	88%
A0A1X0P7C0	Trypanosomatidae	56%	100%
A0A3Q8IB24	Leishmania donovani	85%	100%
A0A3Q8IEB7	Leishmania donovani	81%	100%
A0A3R7KWT0	Trypanosoma rangeli	58%	100%
A0A3S5H742	Leishmania donovani	85%	100%
A0A3S5H7M7	Leishmania donovani	25%	93%
A0JN87	Bos taurus	21%	100%

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