SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9N2_LEIBR

TriTrypDb:

LbrM.18.1320 , LBRM2903_180018900

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9N2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.530
CLV_C14_Caspase3-7	366	370	PF00656	0.473
CLV_C14_Caspase3-7	447	451	PF00656	0.506
CLV_C14_Caspase3-7	486	490	PF00656	0.595
CLV_C14_Caspase3-7	510	514	PF00656	0.510
CLV_MEL_PAP_1	613	619	PF00089	0.417
CLV_NRD_NRD_1	515	517	PF00675	0.562
CLV_NRD_NRD_1	567	569	PF00675	0.663
CLV_NRD_NRD_1	615	617	PF00675	0.491
CLV_PCSK_KEX2_1	5	7	PF00082	0.601
CLV_PCSK_KEX2_1	515	517	PF00082	0.642
CLV_PCSK_KEX2_1	567	569	PF00082	0.603
CLV_PCSK_KEX2_1	615	617	PF00082	0.491
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.488
CLV_PCSK_PC7_1	511	517	PF00082	0.646
CLV_PCSK_SKI1_1	497	501	PF00082	0.499
CLV_PCSK_SKI1_1	533	537	PF00082	0.541
CLV_PCSK_SKI1_1	60	64	PF00082	0.570
CLV_Separin_Metazoa	530	534	PF03568	0.562
DEG_APCC_DBOX_1	188	196	PF00400	0.454
DEG_Nend_UBRbox_1	1	4	PF02207	0.622
DEG_SPOP_SBC_1	158	162	PF00917	0.521
DEG_SPOP_SBC_1	180	184	PF00917	0.578
DOC_CKS1_1	113	118	PF01111	0.521
DOC_CKS1_1	131	136	PF01111	0.506
DOC_CKS1_1	577	582	PF01111	0.545
DOC_CYCLIN_RxL_1	200	210	PF00134	0.316
DOC_CYCLIN_RxL_1	322	332	PF00134	0.506
DOC_CYCLIN_RxL_1	530	540	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	461	467	PF00134	0.463
DOC_MAPK_gen_1	189	197	PF00069	0.437
DOC_MAPK_gen_1	5	13	PF00069	0.530
DOC_PP1_RVXF_1	201	208	PF00149	0.320
DOC_PP1_RVXF_1	77	84	PF00149	0.559
DOC_PP2B_LxvP_1	120	123	PF13499	0.701
DOC_PP2B_LxvP_1	215	218	PF13499	0.308
DOC_PP4_FxxP_1	275	278	PF00568	0.463
DOC_PP4_FxxP_1	500	503	PF00568	0.496
DOC_PP4_FxxP_1	592	595	PF00568	0.536
DOC_USP7_MATH_1	123	127	PF00917	0.711
DOC_USP7_MATH_1	159	163	PF00917	0.556
DOC_USP7_MATH_1	164	168	PF00917	0.674
DOC_USP7_MATH_1	174	178	PF00917	0.599
DOC_USP7_MATH_1	354	358	PF00917	0.421
DOC_USP7_MATH_1	485	489	PF00917	0.585
DOC_USP7_MATH_1	561	565	PF00917	0.509
DOC_USP7_UBL2_3	101	105	PF12436	0.447
DOC_WW_Pin1_4	112	117	PF00397	0.594
DOC_WW_Pin1_4	130	135	PF00397	0.543
DOC_WW_Pin1_4	207	212	PF00397	0.395
DOC_WW_Pin1_4	213	218	PF00397	0.406
DOC_WW_Pin1_4	221	226	PF00397	0.549
DOC_WW_Pin1_4	305	310	PF00397	0.491
DOC_WW_Pin1_4	367	372	PF00397	0.463
DOC_WW_Pin1_4	425	430	PF00397	0.463
DOC_WW_Pin1_4	47	52	PF00397	0.520
DOC_WW_Pin1_4	576	581	PF00397	0.686
LIG_14-3-3_CanoR_1	18	24	PF00244	0.571
LIG_14-3-3_CanoR_1	243	248	PF00244	0.461
LIG_14-3-3_CanoR_1	25	33	PF00244	0.461
LIG_14-3-3_CanoR_1	412	422	PF00244	0.506
LIG_14-3-3_CanoR_1	6	12	PF00244	0.574
LIG_14-3-3_CanoR_1	620	624	PF00244	0.593
LIG_APCC_ABBA_1	535	540	PF00400	0.496
LIG_BRCT_BRCA1_1	117	121	PF00533	0.497
LIG_BRCT_BRCA1_1	181	185	PF00533	0.542
LIG_BRCT_BRCA1_1	620	624	PF00533	0.593
LIG_FHA_1	131	137	PF00498	0.747
LIG_FHA_1	254	260	PF00498	0.489
LIG_FHA_1	268	274	PF00498	0.424
LIG_FHA_1	280	286	PF00498	0.473
LIG_FHA_1	330	336	PF00498	0.519
LIG_FHA_1	413	419	PF00498	0.517
LIG_FHA_1	608	614	PF00498	0.415
LIG_FHA_2	137	143	PF00498	0.536
LIG_FHA_2	29	35	PF00498	0.447
LIG_FHA_2	329	335	PF00498	0.517
LIG_FHA_2	71	77	PF00498	0.590
LIG_LIR_Apic_2	184	190	PF02991	0.441
LIG_LIR_Gen_1	182	192	PF02991	0.479
LIG_LIR_Gen_1	210	220	PF02991	0.320
LIG_LIR_Gen_1	287	296	PF02991	0.509
LIG_LIR_Nem_3	182	188	PF02991	0.490
LIG_LIR_Nem_3	210	215	PF02991	0.306
LIG_LIR_Nem_3	287	292	PF02991	0.509
LIG_LIR_Nem_3	459	465	PF02991	0.536
LIG_LIR_Nem_3	621	627	PF02991	0.605
LIG_LYPXL_SIV_4	491	499	PF13949	0.473
LIG_MYND_1	134	138	PF01753	0.558
LIG_NRBOX	448	454	PF00104	0.517
LIG_PTB_Apo_2	201	208	PF02174	0.402
LIG_PTB_Apo_2	429	436	PF02174	0.506
LIG_PTB_Phospho_1	429	435	PF10480	0.506
LIG_SH2_CRK	27	31	PF00017	0.443
LIG_SH2_NCK_1	27	31	PF00017	0.583
LIG_SH2_NCK_1	435	439	PF00017	0.463
LIG_SH2_NCK_1	484	488	PF00017	0.489
LIG_SH2_PTP2	465	468	PF00017	0.506
LIG_SH2_SRC	465	468	PF00017	0.517
LIG_SH2_STAP1	313	317	PF00017	0.506
LIG_SH2_STAP1	401	405	PF00017	0.463
LIG_SH2_STAT3	600	603	PF00017	0.531
LIG_SH2_STAT5	27	30	PF00017	0.439
LIG_SH2_STAT5	316	319	PF00017	0.468
LIG_SH2_STAT5	391	394	PF00017	0.516
LIG_SH2_STAT5	435	438	PF00017	0.463
LIG_SH2_STAT5	465	468	PF00017	0.463
LIG_SH3_3	110	116	PF00018	0.692
LIG_SH3_3	27	33	PF00018	0.469
LIG_SH3_3	303	309	PF00018	0.517
LIG_SH3_3	348	354	PF00018	0.557
LIG_SH3_3	365	371	PF00018	0.422
LIG_SH3_3	574	580	PF00018	0.561
LIG_SH3_3	65	71	PF00018	0.612
LIG_SH3_5	387	391	PF00018	0.484
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.429
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.434
LIG_SUMO_SIM_par_1	539	547	PF11976	0.434
LIG_SUMO_SIM_par_1	609	614	PF11976	0.463
LIG_TRAF2_1	246	249	PF00917	0.504
LIG_TRAF2_1	73	76	PF00917	0.589
LIG_TYR_ITSM	285	292	PF00017	0.517
LIG_UBA3_1	418	424	PF00899	0.506
LIG_WRC_WIRS_1	285	290	PF05994	0.506
LIG_WRC_WIRS_1	375	380	PF05994	0.506
MOD_CDC14_SPxK_1	50	53	PF00782	0.513
MOD_CDK_SPxK_1	47	53	PF00069	0.518
MOD_CDK_SPxxK_3	576	583	PF00069	0.550
MOD_CK1_1	125	131	PF00069	0.733
MOD_CK1_1	162	168	PF00069	0.625
MOD_CK1_1	179	185	PF00069	0.532
MOD_CK1_1	19	25	PF00069	0.423
MOD_CK1_1	228	234	PF00069	0.530
MOD_CK1_1	267	273	PF00069	0.463
MOD_CK1_1	374	380	PF00069	0.506
MOD_CK1_1	410	416	PF00069	0.401
MOD_CK2_1	243	249	PF00069	0.507
MOD_CK2_1	28	34	PF00069	0.445
MOD_CK2_1	394	400	PF00069	0.463
MOD_CK2_1	70	76	PF00069	0.604
MOD_Cter_Amidation	3	6	PF01082	0.468
MOD_GlcNHglycan	105	108	PF01048	0.484
MOD_GlcNHglycan	161	164	PF01048	0.725
MOD_GlcNHglycan	166	169	PF01048	0.761
MOD_GlcNHglycan	171	174	PF01048	0.713
MOD_GlcNHglycan	199	202	PF01048	0.575
MOD_GlcNHglycan	227	230	PF01048	0.672
MOD_GlcNHglycan	232	236	PF01048	0.713
MOD_GlcNHglycan	300	303	PF01048	0.316
MOD_GlcNHglycan	356	359	PF01048	0.268
MOD_GlcNHglycan	485	488	PF01048	0.560
MOD_GlcNHglycan	518	521	PF01048	0.667
MOD_GlcNHglycan	551	554	PF01048	0.580
MOD_GlcNHglycan	559	562	PF01048	0.481
MOD_GlcNHglycan	600	603	PF01048	0.457
MOD_GSK3_1	122	129	PF00069	0.663
MOD_GSK3_1	158	165	PF00069	0.555
MOD_GSK3_1	174	181	PF00069	0.571
MOD_GSK3_1	221	228	PF00069	0.657
MOD_GSK3_1	317	324	PF00069	0.506
MOD_GSK3_1	339	346	PF00069	0.508
MOD_GSK3_1	367	374	PF00069	0.517
MOD_GSK3_1	403	410	PF00069	0.463
MOD_GSK3_1	557	564	PF00069	0.559
MOD_N-GLC_1	425	430	PF02516	0.263
MOD_NEK2_1	127	132	PF00069	0.612
MOD_NEK2_1	264	269	PF00069	0.483
MOD_NEK2_1	317	322	PF00069	0.463
MOD_NEK2_1	407	412	PF00069	0.463
MOD_NEK2_1	544	549	PF00069	0.603
MOD_NEK2_1	619	624	PF00069	0.589
MOD_NEK2_1	7	12	PF00069	0.541
MOD_NEK2_2	284	289	PF00069	0.506
MOD_PIKK_1	127	133	PF00454	0.715
MOD_PIKK_1	345	351	PF00454	0.473
MOD_PIKK_1	561	567	PF00454	0.585
MOD_PKA_2	339	345	PF00069	0.500
MOD_PKA_2	394	400	PF00069	0.477
MOD_PKA_2	619	625	PF00069	0.592
MOD_Plk_1	248	254	PF00069	0.445
MOD_Plk_1	439	445	PF00069	0.506
MOD_Plk_1	478	484	PF00069	0.463
MOD_Plk_4	115	121	PF00069	0.579
MOD_Plk_4	181	187	PF00069	0.521
MOD_Plk_4	312	318	PF00069	0.506
MOD_Plk_4	371	377	PF00069	0.500
MOD_Plk_4	403	409	PF00069	0.497
MOD_Plk_4	414	420	PF00069	0.463
MOD_Plk_4	502	508	PF00069	0.504
MOD_Plk_4	582	588	PF00069	0.509
MOD_Plk_4	607	613	PF00069	0.498
MOD_Plk_4	619	625	PF00069	0.637
MOD_Plk_4	7	13	PF00069	0.552
MOD_ProDKin_1	112	118	PF00069	0.594
MOD_ProDKin_1	130	136	PF00069	0.545
MOD_ProDKin_1	207	213	PF00069	0.392
MOD_ProDKin_1	221	227	PF00069	0.556
MOD_ProDKin_1	305	311	PF00069	0.491
MOD_ProDKin_1	367	373	PF00069	0.463
MOD_ProDKin_1	425	431	PF00069	0.463
MOD_ProDKin_1	47	53	PF00069	0.523
MOD_ProDKin_1	576	582	PF00069	0.679
MOD_SUMO_rev_2	576	585	PF00179	0.543
TRG_DiLeu_BaEn_1	37	42	PF01217	0.497
TRG_DiLeu_BaEn_1	607	612	PF01217	0.548
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.466
TRG_ENDOCYTIC_2	27	30	PF00928	0.467
TRG_ENDOCYTIC_2	289	292	PF00928	0.604
TRG_ENDOCYTIC_2	434	437	PF00928	0.463
TRG_ENDOCYTIC_2	465	468	PF00928	0.506
TRG_ER_diArg_1	188	191	PF00400	0.464
TRG_ER_diArg_1	392	395	PF00400	0.506
TRG_ER_diArg_1	566	568	PF00400	0.606
TRG_ER_diArg_1	615	617	PF00400	0.491
TRG_NES_CRM1_1	21	34	PF08389	0.426
TRG_NES_CRM1_1	603	614	PF08389	0.405
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJT8	Leptomonas seymouri	54%	99%
A0A3S5H741	Leishmania donovani	79%	100%
A4HXZ6	Leishmania infantum	79%	100%
D0A5B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ARR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QDR9	Leishmania major	78%	99%