Proline--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prolyl-tRNA synthetase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9N1_LEIBR

TriTrypDb:

LbrM.18.1310 , LBRM2903_180018800

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H9N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9N1

PDB structure(s): 5xil_A

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	16
GO:0006139	nucleobase-containing compound metabolic process	3	16
GO:0006399	tRNA metabolic process	7	16
GO:0006418	tRNA aminoacylation for protein translation	6	16
GO:0006433	prolyl-tRNA aminoacylation	7	16
GO:0006520	amino acid metabolic process	3	16
GO:0006725	cellular aromatic compound metabolic process	3	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016070	RNA metabolic process	5	16
GO:0019752	carboxylic acid metabolic process	5	16
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0034660	ncRNA metabolic process	6	16
GO:0043038	amino acid activation	4	16
GO:0043039	tRNA aminoacylation	5	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043436	oxoacid metabolic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044281	small molecule metabolic process	2	16
GO:0046483	heterocycle metabolic process	3	16
GO:0071704	organic substance metabolic process	2	16
GO:0090304	nucleic acid metabolic process	4	16
GO:1901360	organic cyclic compound metabolic process	3	16
GO:1901564	organonitrogen compound metabolic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0002161	aminoacyl-tRNA editing activity	5	15
GO:0003824	catalytic activity	1	16
GO:0004812	aminoacyl-tRNA ligase activity	4	16
GO:0004827	proline-tRNA ligase activity	5	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0016874	ligase activity	2	16
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0052689	carboxylic ester hydrolase activity	4	15
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140098	catalytic activity, acting on RNA	3	16
GO:0140101	catalytic activity, acting on a tRNA	4	16
GO:0140640	catalytic activity, acting on a nucleic acid	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	541	545	PF00656	0.521
CLV_NRD_NRD_1	216	218	PF00675	0.461
CLV_NRD_NRD_1	405	407	PF00675	0.397
CLV_NRD_NRD_1	636	638	PF00675	0.358
CLV_NRD_NRD_1	655	657	PF00675	0.256
CLV_PCSK_KEX2_1	192	194	PF00082	0.568
CLV_PCSK_KEX2_1	216	218	PF00082	0.461
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.568
CLV_PCSK_SKI1_1	120	124	PF00082	0.327
CLV_PCSK_SKI1_1	13	17	PF00082	0.520
CLV_PCSK_SKI1_1	362	366	PF00082	0.310
CLV_PCSK_SKI1_1	381	385	PF00082	0.310
CLV_PCSK_SKI1_1	517	521	PF00082	0.240
CLV_PCSK_SKI1_1	53	57	PF00082	0.321
CLV_PCSK_SKI1_1	707	711	PF00082	0.341
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.416
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.362
DOC_MAPK_gen_1	329	339	PF00069	0.510
DOC_MAPK_JIP1_4	120	126	PF00069	0.496
DOC_MAPK_MEF2A_6	332	341	PF00069	0.502
DOC_MAPK_MEF2A_6	475	483	PF00069	0.535
DOC_MAPK_MEF2A_6	558	566	PF00069	0.510
DOC_MAPK_RevD_3	45	61	PF00069	0.497
DOC_PP1_RVXF_1	165	172	PF00149	0.494
DOC_PP1_RVXF_1	85	92	PF00149	0.535
DOC_PP2B_LxvP_1	21	24	PF13499	0.521
DOC_PP2B_LxvP_1	398	401	PF13499	0.510
DOC_PP2B_LxvP_1	685	688	PF13499	0.501
DOC_PP4_FxxP_1	352	355	PF00568	0.510
DOC_PP4_FxxP_1	453	456	PF00568	0.510
DOC_PP4_FxxP_1	689	692	PF00568	0.510
DOC_USP7_MATH_1	203	207	PF00917	0.601
DOC_USP7_MATH_1	414	418	PF00917	0.425
DOC_USP7_MATH_1	572	576	PF00917	0.617
DOC_USP7_MATH_1	585	589	PF00917	0.537
DOC_USP7_MATH_1	660	664	PF00917	0.510
DOC_USP7_MATH_1	69	73	PF00917	0.571
DOC_USP7_MATH_1	694	698	PF00917	0.425
DOC_USP7_UBL2_3	703	707	PF12436	0.563
DOC_WW_Pin1_4	106	111	PF00397	0.521
DOC_WW_Pin1_4	197	202	PF00397	0.626
DOC_WW_Pin1_4	353	358	PF00397	0.521
DOC_WW_Pin1_4	544	549	PF00397	0.510
DOC_WW_Pin1_4	592	597	PF00397	0.582
LIG_14-3-3_CanoR_1	120	125	PF00244	0.550
LIG_14-3-3_CanoR_1	316	325	PF00244	0.510
LIG_14-3-3_CanoR_1	404	413	PF00244	0.570
LIG_14-3-3_CanoR_1	495	505	PF00244	0.397
LIG_14-3-3_CanoR_1	581	589	PF00244	0.527
LIG_14-3-3_CanoR_1	622	632	PF00244	0.548
LIG_Actin_WH2_2	63	80	PF00022	0.551
LIG_APCC_ABBA_1	155	160	PF00400	0.254
LIG_APCC_ABBA_1	481	486	PF00400	0.444
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_deltaCOP1_diTrp_1	363	373	PF00928	0.521
LIG_deltaCOP1_diTrp_1	627	631	PF00928	0.397
LIG_FHA_1	121	127	PF00498	0.576
LIG_FHA_1	132	138	PF00498	0.497
LIG_FHA_1	145	151	PF00498	0.542
LIG_FHA_1	354	360	PF00498	0.521
LIG_FHA_1	417	423	PF00498	0.510
LIG_FHA_1	472	478	PF00498	0.510
LIG_FHA_1	497	503	PF00498	0.481
LIG_FHA_1	50	56	PF00498	0.525
LIG_FHA_1	618	624	PF00498	0.475
LIG_FHA_1	682	688	PF00498	0.542
LIG_FHA_1	708	714	PF00498	0.595
LIG_FHA_1	84	90	PF00498	0.563
LIG_FHA_2	228	234	PF00498	0.389
LIG_FHA_2	305	311	PF00498	0.522
LIG_FHA_2	31	37	PF00498	0.521
LIG_FHA_2	406	412	PF00498	0.507
LIG_FHA_2	418	424	PF00498	0.517
LIG_FHA_2	510	516	PF00498	0.511
LIG_FHA_2	71	77	PF00498	0.597
LIG_LIR_Apic_2	351	355	PF02991	0.510
LIG_LIR_Apic_2	450	456	PF02991	0.539
LIG_LIR_Gen_1	151	159	PF02991	0.569
LIG_LIR_Gen_1	222	232	PF02991	0.437
LIG_LIR_Gen_1	388	398	PF02991	0.521
LIG_LIR_Gen_1	626	635	PF02991	0.362
LIG_LIR_Gen_1	710	719	PF02991	0.572
LIG_LIR_LC3C_4	573	578	PF02991	0.425
LIG_LIR_Nem_3	109	114	PF02991	0.568
LIG_LIR_Nem_3	151	155	PF02991	0.569
LIG_LIR_Nem_3	222	228	PF02991	0.431
LIG_LIR_Nem_3	236	240	PF02991	0.393
LIG_LIR_Nem_3	272	278	PF02991	0.441
LIG_LIR_Nem_3	321	327	PF02991	0.510
LIG_LIR_Nem_3	388	393	PF02991	0.521
LIG_LIR_Nem_3	626	631	PF02991	0.362
LIG_LIR_Nem_3	710	715	PF02991	0.572
LIG_Pex14_2	445	449	PF04695	0.510
LIG_SH2_CRK	390	394	PF00017	0.510
LIG_SH2_NCK_1	390	394	PF00017	0.521
LIG_SH2_PTP2	225	228	PF00017	0.458
LIG_SH2_SRC	225	228	PF00017	0.458
LIG_SH2_STAP1	146	150	PF00017	0.508
LIG_SH2_STAP1	164	168	PF00017	0.428
LIG_SH2_STAP1	327	331	PF00017	0.510
LIG_SH2_STAP1	390	394	PF00017	0.512
LIG_SH2_STAP1	418	422	PF00017	0.510
LIG_SH2_STAT5	146	149	PF00017	0.496
LIG_SH2_STAT5	158	161	PF00017	0.406
LIG_SH2_STAT5	225	228	PF00017	0.415
LIG_SH2_STAT5	244	247	PF00017	0.299
LIG_SH2_STAT5	252	255	PF00017	0.389
LIG_SH2_STAT5	274	277	PF00017	0.423
LIG_SH2_STAT5	418	421	PF00017	0.510
LIG_SH3_3	319	325	PF00018	0.510
LIG_SH3_3	488	494	PF00018	0.423
LIG_SUMO_SIM_anti_2	35	43	PF11976	0.496
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.571
LIG_SUMO_SIM_anti_2	498	505	PF11976	0.482
LIG_SUMO_SIM_anti_2	99	105	PF11976	0.581
LIG_SUMO_SIM_par_1	122	129	PF11976	0.592
LIG_SUMO_SIM_par_1	382	388	PF11976	0.571
LIG_TRAF2_1	33	36	PF00917	0.549
LIG_TRAF2_1	512	515	PF00917	0.553
LIG_TRAF2_1	659	662	PF00917	0.509
LIG_TYR_ITIM	235	240	PF00017	0.432
LIG_WRC_WIRS_1	422	427	PF05994	0.612
LIG_WW_3	492	496	PF00397	0.421
MOD_CDK_SPxxK_3	353	360	PF00069	0.521
MOD_CDK_SPxxK_3	544	551	PF00069	0.510
MOD_CK1_1	206	212	PF00069	0.621
MOD_CK1_1	353	359	PF00069	0.515
MOD_CK1_1	417	423	PF00069	0.425
MOD_CK1_1	72	78	PF00069	0.563
MOD_CK2_1	227	233	PF00069	0.395
MOD_CK2_1	279	285	PF00069	0.522
MOD_CK2_1	30	36	PF00069	0.528
MOD_CK2_1	304	310	PF00069	0.503
MOD_CK2_1	405	411	PF00069	0.449
MOD_CK2_1	417	423	PF00069	0.517
MOD_CK2_1	509	515	PF00069	0.511
MOD_CK2_1	656	662	PF00069	0.510
MOD_CK2_1	687	693	PF00069	0.425
MOD_CK2_1	70	76	PF00069	0.514
MOD_Cter_Amidation	404	407	PF01082	0.321
MOD_GlcNHglycan	174	177	PF01048	0.610
MOD_GlcNHglycan	205	208	PF01048	0.681
MOD_GlcNHglycan	221	224	PF01048	0.322
MOD_GlcNHglycan	239	243	PF01048	0.282
MOD_GlcNHglycan	658	661	PF01048	0.305
MOD_GSK3_1	126	133	PF00069	0.597
MOD_GSK3_1	144	151	PF00069	0.395
MOD_GSK3_1	414	421	PF00069	0.537
MOD_GSK3_1	45	52	PF00069	0.462
MOD_GSK3_1	466	473	PF00069	0.510
MOD_GSK3_1	506	513	PF00069	0.535
MOD_GSK3_1	65	72	PF00069	0.524
MOD_GSK3_1	656	663	PF00069	0.510
MOD_GSK3_1	703	710	PF00069	0.597
MOD_N-GLC_1	114	119	PF02516	0.325
MOD_N-GLC_1	219	224	PF02516	0.498
MOD_N-GLC_1	544	549	PF02516	0.310
MOD_N-GLC_1	81	86	PF02516	0.207
MOD_NEK2_1	125	130	PF00069	0.505
MOD_NEK2_1	277	282	PF00069	0.496
MOD_NEK2_1	45	50	PF00069	0.525
MOD_NEK2_1	520	525	PF00069	0.614
MOD_NEK2_1	56	61	PF00069	0.515
MOD_NEK2_1	70	75	PF00069	0.493
MOD_NEK2_2	51	56	PF00069	0.496
MOD_PIKK_1	131	137	PF00454	0.614
MOD_PIKK_1	496	502	PF00454	0.531
MOD_PIKK_1	687	693	PF00454	0.425
MOD_PKA_1	656	662	PF00069	0.510
MOD_PKA_2	315	321	PF00069	0.510
MOD_PKA_2	405	411	PF00069	0.597
MOD_PKA_2	580	586	PF00069	0.535
MOD_PKA_2	623	629	PF00069	0.558
MOD_Plk_1	126	132	PF00069	0.550
MOD_Plk_1	219	225	PF00069	0.476
MOD_Plk_1	459	465	PF00069	0.551
MOD_Plk_1	572	578	PF00069	0.612
MOD_Plk_2-3	30	36	PF00069	0.535
MOD_Plk_4	318	324	PF00069	0.521
MOD_Plk_4	421	427	PF00069	0.535
MOD_Plk_4	459	465	PF00069	0.524
MOD_Plk_4	51	57	PF00069	0.496
MOD_Plk_4	708	714	PF00069	0.588
MOD_ProDKin_1	106	112	PF00069	0.521
MOD_ProDKin_1	197	203	PF00069	0.626
MOD_ProDKin_1	353	359	PF00069	0.521
MOD_ProDKin_1	544	550	PF00069	0.510
MOD_ProDKin_1	592	598	PF00069	0.582
MOD_SUMO_for_1	374	377	PF00179	0.597
MOD_SUMO_rev_2	5	15	PF00179	0.359
MOD_SUMO_rev_2	72	80	PF00179	0.571
TRG_DiLeu_BaEn_1	36	41	PF01217	0.478
TRG_DiLeu_BaEn_2	626	632	PF01217	0.483
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.425
TRG_ENDOCYTIC_2	166	169	PF00928	0.398
TRG_ENDOCYTIC_2	225	228	PF00928	0.400
TRG_ENDOCYTIC_2	237	240	PF00928	0.446
TRG_ENDOCYTIC_2	274	277	PF00928	0.423
TRG_ENDOCYTIC_2	390	393	PF00928	0.510
TRG_ENDOCYTIC_2	394	397	PF00928	0.510
TRG_ER_diArg_1	359	362	PF00400	0.510
TRG_ER_diArg_1	403	406	PF00400	0.603
TRG_ER_diArg_1	622	625	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	525	530	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY85	Leptomonas seymouri	82%	100%
A0A0S4JN58	Bodo saltans	56%	88%
A0A1X0P793	Trypanosomatidae	62%	89%
A0A3R7KPX0	Trypanosoma rangeli	64%	84%
A0A3S7WV15	Leishmania donovani	81%	99%
A0A3S7WV32	Leishmania donovani	89%	99%
A0M4Z3	Gramella forsetii (strain KT0803)	35%	100%
A3MV50	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	30%	100%
A4HXZ5	Leishmania infantum	89%	89%
A4HY00	Leishmania infantum	81%	100%
A4YI09	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	30%	100%
A5FA31	Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101)	35%	100%
A5UU62	Roseiflexus sp. (strain RS-1)	40%	100%
A6L5I2	Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154)	37%	100%
A6LAP3	Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)	35%	100%
A7NKX0	Roseiflexus castenholzii (strain DSM 13941 / HLO8)	41%	100%
A8MC04	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	31%	100%
A8MLB3	Alkaliphilus oremlandii (strain OhILAs)	41%	100%
A9W9Q2	Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)	40%	100%
B0R3A3	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	39%	100%
B2A5T8	Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)	42%	100%
B2RJG1	Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)	37%	100%
B2UL92	Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)	36%	100%
B3EP23	Chlorobium phaeobacteroides (strain BS1)	40%	100%
B3ER64	Amoebophilus asiaticus (strain 5a2)	37%	100%
B3QPX3	Chlorobaculum parvum (strain DSM 263 / NCIMB 8327)	39%	100%
B4S9D5	Prosthecochloris aestuarii (strain DSM 271 / SK 413)	39%	100%
B4SG51	Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)	38%	100%
B7J1X2	Borreliella burgdorferi (strain ZS7)	36%	100%
B8G3V5	Chloroflexus aggregans (strain MD-66 / DSM 9485)	39%	100%
B8ZRT2	Mycobacterium leprae (strain Br4923)	40%	100%
B9LC55	Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)	40%	100%
B9LUM0	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	39%	100%
D0A5B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	89%
E9ARQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
E9ARQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O51363	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	36%	100%
O58734	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	34%	100%
O60155	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
P38708	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
Q0SNA5	Borreliella afzelii (strain PKo)	35%	100%
Q18CD7	Clostridioides difficile (strain 630)	41%	100%
Q1J0W2	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	36%	100%
Q2ILX2	Anaeromyxobacter dehalogenans (strain 2CP-C)	40%	100%
Q2W136	Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)	36%	100%
Q3ASP3	Chlorobium chlorochromatii (strain CaD3)	38%	100%
Q3IS99	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	39%	100%
Q46G28	Methanosarcina barkeri (strain Fusaro / DSM 804)	33%	100%
Q4A5S0	Mycoplasmopsis synoviae (strain 53)	34%	100%
Q4J8L4	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	30%	100%
Q4QDS0	Leishmania major	80%	100%
Q4QDS1	Leishmania major	87%	100%
Q5JF49	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	32%	100%
Q5LCF0	Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)	36%	100%
Q5V5H0	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	37%	100%
Q64TJ6	Bacteroides fragilis (strain YCH46)	36%	100%
Q661L6	Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi)	36%	100%
Q67PA6	Symbiobacterium thermophilum (strain T / IAM 14863)	41%	100%
Q6MIW2	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	35%	100%
Q7MVS7	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	36%	100%
Q81Z76	Bacillus anthracis	40%	100%
Q8A988	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	36%	100%
Q8I5R7	Plasmodium falciparum (isolate 3D7)	39%	96%
Q8KCD1	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	39%	100%
Q8PYZ1	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	32%	100%
Q8SSD7	Encephalitozoon cuniculi (strain GB-M1)	48%	100%
Q8TJA2	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	34%	100%
Q971B5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	29%	100%
Q9FYR6	Arabidopsis thaliana	38%	100%
Q9HS52	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	39%	100%
Q9L4Q8	Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / CCUG 9281 / NCIMB 10654 / HF)	40%	100%
Q9M1R2	Arabidopsis thaliana	53%	100%
Q9RUW4	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	35%	100%
Q9V022	Pyrococcus abyssi (strain GE5 / Orsay)	33%	100%
Q9Y9G0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	32%	100%
Q9Z5I7	Mycobacterium leprae (strain TN)	40%	100%
V5AZ66	Trypanosoma cruzi	64%	89%