Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family), putative

Species:

Leishmania braziliensis

UniProt:

A4H9N0_LEIBR

TriTrypDb:

LbrM.18.1300 , LBRM2903_180018600

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H9N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9N0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0022607	cellular component assembly	4	5
GO:0033108	mitochondrial respiratory chain complex assembly	6	5
GO:0034552	respiratory chain complex II assembly	6	5
GO:0034553	mitochondrial respiratory chain complex II assembly	7	5
GO:0043933	protein-containing complex organization	4	5
GO:0065003	protein-containing complex assembly	5	5
GO:0071840	cellular component organization or biogenesis	2	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.493
CLV_NRD_NRD_1	107	109	PF00675	0.544
CLV_NRD_NRD_1	180	182	PF00675	0.507
CLV_NRD_NRD_1	270	272	PF00675	0.684
CLV_NRD_NRD_1	308	310	PF00675	0.550
CLV_NRD_NRD_1	336	338	PF00675	0.431
CLV_NRD_NRD_1	354	356	PF00675	0.310
CLV_NRD_NRD_1	369	371	PF00675	0.310
CLV_NRD_NRD_1	49	51	PF00675	0.482
CLV_PCSK_FUR_1	125	129	PF00082	0.638
CLV_PCSK_KEX2_1	127	129	PF00082	0.578
CLV_PCSK_KEX2_1	180	182	PF00082	0.507
CLV_PCSK_KEX2_1	269	271	PF00082	0.682
CLV_PCSK_KEX2_1	308	310	PF00082	0.550
CLV_PCSK_KEX2_1	336	338	PF00082	0.431
CLV_PCSK_KEX2_1	369	371	PF00082	0.310
CLV_PCSK_KEX2_1	49	51	PF00082	0.482
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.647
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.310
CLV_PCSK_PC7_1	45	51	PF00082	0.481
CLV_PCSK_SKI1_1	26	30	PF00082	0.459
CLV_PCSK_SKI1_1	285	289	PF00082	0.636
CLV_PCSK_SKI1_1	321	325	PF00082	0.310
CLV_PCSK_SKI1_1	70	74	PF00082	0.349
DEG_APCC_DBOX_1	320	328	PF00400	0.310
DEG_Nend_Nbox_1	1	3	PF02207	0.473
DOC_CDC14_PxL_1	14	22	PF14671	0.440
DOC_CYCLIN_RxL_1	67	75	PF00134	0.341
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.523
DOC_MAPK_gen_1	145	153	PF00069	0.550
DOC_MAPK_gen_1	308	316	PF00069	0.342
DOC_MAPK_gen_1	355	361	PF00069	0.275
DOC_MAPK_MEF2A_6	308	316	PF00069	0.338
DOC_PP1_RVXF_1	358	364	PF00149	0.310
DOC_USP7_MATH_1	229	233	PF00917	0.649
DOC_USP7_MATH_1	242	246	PF00917	0.509
DOC_USP7_MATH_1	248	252	PF00917	0.592
DOC_USP7_MATH_1	307	311	PF00917	0.461
DOC_USP7_MATH_1	55	59	PF00917	0.482
DOC_USP7_UBL2_3	127	131	PF12436	0.652
DOC_USP7_UBL2_3	356	360	PF12436	0.310
DOC_WW_Pin1_4	171	176	PF00397	0.539
DOC_WW_Pin1_4	232	237	PF00397	0.593
DOC_WW_Pin1_4	243	248	PF00397	0.627
DOC_WW_Pin1_4	293	298	PF00397	0.699
DOC_WW_Pin1_4	303	308	PF00397	0.616
LIG_14-3-3_CanoR_1	285	293	PF00244	0.599
LIG_14-3-3_CanoR_1	7	14	PF00244	0.451
LIG_14-3-3_CanoR_1	70	80	PF00244	0.352
LIG_Actin_WH2_2	310	327	PF00022	0.307
LIG_BRCT_BRCA1_1	61	65	PF00533	0.383
LIG_DCNL_PONY_1	1	4	PF03556	0.471
LIG_FHA_1	148	154	PF00498	0.404
LIG_FHA_1	183	189	PF00498	0.581
LIG_FHA_1	233	239	PF00498	0.512
LIG_FHA_1	77	83	PF00498	0.345
LIG_LIR_Gen_1	62	73	PF02991	0.397
LIG_LIR_Gen_1	79	86	PF02991	0.333
LIG_LIR_Nem_3	220	224	PF02991	0.496
LIG_LIR_Nem_3	62	68	PF02991	0.409
LIG_LIR_Nem_3	79	84	PF02991	0.333
LIG_MYND_1	18	22	PF01753	0.434
LIG_PCNA_yPIPBox_3	308	320	PF02747	0.419
LIG_Pex14_1	363	367	PF04695	0.310
LIG_RPA_C_Fungi	332	344	PF08784	0.383
LIG_SH2_CRK	221	225	PF00017	0.493
LIG_SH2_STAT3	152	155	PF00017	0.523
LIG_SH2_STAT3	347	350	PF00017	0.342
LIG_SH2_STAT5	152	155	PF00017	0.553
LIG_SH2_STAT5	342	345	PF00017	0.310
LIG_SH2_STAT5	93	96	PF00017	0.448
LIG_SH3_1	159	165	PF00018	0.481
LIG_SH3_1	241	247	PF00018	0.474
LIG_SH3_2	162	167	PF14604	0.483
LIG_SH3_2	175	180	PF14604	0.475
LIG_SH3_3	159	165	PF00018	0.536
LIG_SH3_3	172	178	PF00018	0.573
LIG_SH3_3	241	247	PF00018	0.558
LIG_SUMO_SIM_anti_2	64	71	PF11976	0.403
LIG_TRAF2_1	257	260	PF00917	0.637
LIG_UBA3_1	358	364	PF00899	0.245
LIG_WRC_WIRS_1	81	86	PF05994	0.329
MOD_CDC14_SPxK_1	306	309	PF00782	0.555
MOD_CDK_SPK_2	303	308	PF00069	0.590
MOD_CDK_SPxK_1	303	309	PF00069	0.705
MOD_CDK_SPxxK_3	232	239	PF00069	0.567
MOD_CK1_1	103	109	PF00069	0.436
MOD_CK1_1	179	185	PF00069	0.613
MOD_CK1_1	196	202	PF00069	0.468
MOD_CK1_1	232	238	PF00069	0.703
MOD_CK1_1	296	302	PF00069	0.569
MOD_GlcNHglycan	195	198	PF01048	0.516
MOD_GlcNHglycan	227	230	PF01048	0.643
MOD_GlcNHglycan	252	255	PF01048	0.665
MOD_GlcNHglycan	277	280	PF01048	0.584
MOD_GlcNHglycan	309	312	PF01048	0.494
MOD_GlcNHglycan	339	342	PF01048	0.445
MOD_GlcNHglycan	36	39	PF01048	0.557
MOD_GSK3_1	192	199	PF00069	0.564
MOD_GSK3_1	225	232	PF00069	0.640
MOD_GSK3_1	271	278	PF00069	0.482
MOD_GSK3_1	28	35	PF00069	0.534
MOD_GSK3_1	293	300	PF00069	0.669
MOD_GSK3_1	303	310	PF00069	0.466
MOD_GSK3_1	315	322	PF00069	0.301
MOD_GSK3_1	51	58	PF00069	0.468
MOD_GSK3_1	68	75	PF00069	0.353
MOD_GSK3_1	76	83	PF00069	0.429
MOD_GSK3_1	84	91	PF00069	0.399
MOD_GSK3_1	99	106	PF00069	0.422
MOD_N-GLC_1	182	187	PF02516	0.488
MOD_N-GLC_1	337	342	PF02516	0.238
MOD_N-GLC_1	365	370	PF02516	0.261
MOD_NEK2_1	118	123	PF00069	0.513
MOD_NEK2_1	249	254	PF00069	0.501
MOD_NEK2_1	365	370	PF00069	0.283
MOD_NEK2_1	72	77	PF00069	0.427
MOD_NEK2_1	80	85	PF00069	0.331
MOD_NEK2_2	147	152	PF00069	0.382
MOD_PKA_1	100	106	PF00069	0.447
MOD_PKA_1	280	286	PF00069	0.503
MOD_PKA_2	121	127	PF00069	0.533
MOD_PKA_2	147	153	PF00069	0.388
MOD_PKA_2	179	185	PF00069	0.493
MOD_PKA_2	307	313	PF00069	0.541
MOD_PKA_2	6	12	PF00069	0.452
MOD_PKB_1	269	277	PF00069	0.433
MOD_Plk_1	258	264	PF00069	0.678
MOD_Plk_1	325	331	PF00069	0.389
MOD_Plk_1	337	343	PF00069	0.248
MOD_Plk_4	147	153	PF00069	0.453
MOD_Plk_4	315	321	PF00069	0.310
MOD_Plk_4	61	67	PF00069	0.374
MOD_Plk_4	76	82	PF00069	0.322
MOD_Plk_4	88	94	PF00069	0.398
MOD_ProDKin_1	171	177	PF00069	0.539
MOD_ProDKin_1	232	238	PF00069	0.591
MOD_ProDKin_1	243	249	PF00069	0.630
MOD_ProDKin_1	293	299	PF00069	0.697
MOD_ProDKin_1	303	309	PF00069	0.606
MOD_SUMO_for_1	359	362	PF00179	0.275
MOD_SUMO_rev_2	96	102	PF00179	0.455
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.443
TRG_ENDOCYTIC_2	221	224	PF00928	0.495
TRG_ENDOCYTIC_2	320	323	PF00928	0.310
TRG_ER_diArg_1	238	241	PF00400	0.487
TRG_ER_diArg_1	268	271	PF00400	0.682
TRG_ER_diArg_1	307	309	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U5	Leptomonas seymouri	47%	100%
A0A3Q8IJR9	Leishmania donovani	67%	100%
A4HXZ4	Leishmania infantum	67%	100%
E9ARQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QDS2	Leishmania major	70%	97%