LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H9M7_LEIBR
TriTrypDb:
LbrM.18.1270 , LBRM2903_180018200 * , LBRM2903_180018300 *
Length:
202

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9M7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9M7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 154 156 PF00675 0.482
CLV_NRD_NRD_1 171 173 PF00675 0.548
CLV_PCSK_KEX2_1 153 155 PF00082 0.496
DEG_Nend_UBRbox_2 1 3 PF02207 0.446
DOC_CDC14_PxL_1 28 36 PF14671 0.360
DOC_MAPK_DCC_7 189 197 PF00069 0.560
DOC_MAPK_gen_1 153 161 PF00069 0.432
DOC_MAPK_gen_1 162 170 PF00069 0.450
DOC_MAPK_MEF2A_6 162 170 PF00069 0.365
DOC_PP1_RVXF_1 91 98 PF00149 0.439
DOC_PP2B_LxvP_1 185 188 PF13499 0.599
DOC_PP4_FxxP_1 4 7 PF00568 0.422
DOC_USP7_MATH_1 30 34 PF00917 0.372
DOC_USP7_MATH_1 77 81 PF00917 0.369
LIG_deltaCOP1_diTrp_1 100 105 PF00928 0.351
LIG_LIR_Apic_2 2 7 PF02991 0.428
LIG_MYND_1 190 194 PF01753 0.446
LIG_Pex14_2 145 149 PF04695 0.476
LIG_Pex14_2 24 28 PF04695 0.448
LIG_PTB_Apo_2 145 152 PF02174 0.582
LIG_SH2_GRB2like 120 123 PF00017 0.439
LIG_SH2_GRB2like 146 149 PF00017 0.485
LIG_SH2_NCK_1 120 124 PF00017 0.445
LIG_SH2_SRC 120 123 PF00017 0.439
LIG_SH2_STAT5 96 99 PF00017 0.452
LIG_SUMO_SIM_par_1 157 163 PF11976 0.501
LIG_TRAF2_1 33 36 PF00917 0.484
MOD_CK2_1 30 36 PF00069 0.477
MOD_GlcNHglycan 79 82 PF01048 0.404
MOD_N-GLC_1 147 152 PF02516 0.470
MOD_NEK2_1 110 115 PF00069 0.361
MOD_NEK2_2 69 74 PF00069 0.449
MOD_Plk_1 147 153 PF00069 0.465
MOD_Plk_1 180 186 PF00069 0.632
MOD_Plk_1 69 75 PF00069 0.334
MOD_Plk_4 79 85 PF00069 0.376
TRG_ENDOCYTIC_2 146 149 PF00928 0.485
TRG_ER_diArg_1 152 155 PF00400 0.502
TRG_Pf-PMV_PEXEL_1 53 57 PF00026 0.449

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMB7 Leptomonas seymouri 87% 100%
A0A0S4JNP2 Bodo saltans 76% 100%
A0A1X0P7B0 Trypanosomatidae 81% 97%
A0A3Q8IA15 Leishmania donovani 96% 100%
A4HXZ1 Leishmania infantum 96% 100%
D0A5B7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 83% 98%
E9ARQ4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QDS5 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS