LeishMANIAdb
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Protein RFT1 homolog

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein RFT1 homolog
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H9M6_LEIBR
TriTrypDb:
LbrM.18.1260 , LBRM2903_180018100
Length:
109

Annotations

LeishMANIAdb annotations

A short 2TM protein that is likely part of some larger complex. Multiple distant relatives exist in kinetoplastid genomes.. Very loosely similar to the V-type proton ATPase subunit F

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4H9M6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9M6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 75 77 PF00675 0.378
CLV_PCSK_KEX2_1 75 77 PF00082 0.378
CLV_PCSK_PC7_1 71 77 PF00082 0.374
CLV_PCSK_SKI1_1 48 52 PF00082 0.477
CLV_PCSK_SKI1_1 81 85 PF00082 0.375
DOC_CYCLIN_yCln2_LP_2 97 100 PF00134 0.683
DOC_MAPK_RevD_3 62 76 PF00069 0.357
DOC_PP1_RVXF_1 29 36 PF00149 0.378
DOC_PP1_RVXF_1 69 75 PF00149 0.535
DOC_PP2B_LxvP_1 96 99 PF13499 0.643
LIG_14-3-3_CanoR_1 26 35 PF00244 0.469
LIG_BRCT_MDC1_1 105 109 PF00533 0.579
LIG_FHA_1 59 65 PF00498 0.349
LIG_LIR_Gen_1 34 40 PF02991 0.396
LIG_LIR_Gen_1 63 73 PF02991 0.357
LIG_LIR_Nem_3 34 38 PF02991 0.353
LIG_LIR_Nem_3 63 68 PF02991 0.342
LIG_Pex14_2 24 28 PF04695 0.357
LIG_RPA_C_Fungi 71 83 PF08784 0.539
LIG_SH2_STAP1 3 7 PF00017 0.560
LIG_SH2_STAP1 60 64 PF00017 0.438
LIG_SH2_STAP1 86 90 PF00017 0.345
LIG_SH2_STAT5 60 63 PF00017 0.436
LIG_SH2_STAT5 73 76 PF00017 0.325
LIG_SUMO_SIM_par_1 36 41 PF11976 0.429
LIG_UBA3_1 23 31 PF00899 0.519
MOD_CK1_1 103 109 PF00069 0.706
MOD_CK1_1 5 11 PF00069 0.363
MOD_GSK3_1 100 107 PF00069 0.642
MOD_GSK3_1 60 67 PF00069 0.336
MOD_NEK2_1 64 69 PF00069 0.357
MOD_NEK2_2 60 65 PF00069 0.357
MOD_Plk_4 60 66 PF00069 0.399
MOD_SUMO_rev_2 41 50 PF00179 0.483
TRG_DiLeu_BaEn_1 92 97 PF01217 0.520
TRG_ER_diArg_1 74 76 PF00400 0.549

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE18 Leptomonas seymouri 84% 100%
A0A1X0P8F4 Trypanosomatidae 63% 100%
A0A3Q8IEA6 Leishmania donovani 90% 100%
A0A3R7P1K9 Trypanosoma rangeli 62% 100%
A4HXZ0 Leishmania infantum 90% 100%
E9ARQ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QDS6 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS