RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H9M5_LEIBR

TriTrypDb:

LbrM.18.1250 , LBRM2903_180018000

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4H9M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9M5

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0061630	ubiquitin protein ligase activity	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.538
CLV_NRD_NRD_1	221	223	PF00675	0.406
CLV_PCSK_KEX2_1	149	151	PF00082	0.326
CLV_PCSK_KEX2_1	190	192	PF00082	0.572
CLV_PCSK_KEX2_1	220	222	PF00082	0.437
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.572
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.455
CLV_PCSK_SKI1_1	149	153	PF00082	0.490
DOC_MAPK_gen_1	149	157	PF00069	0.533
DOC_MAPK_MEF2A_6	149	157	PF00069	0.454

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI8	Leptomonas seymouri	73%	90%
A0A0S4JNW6	Bodo saltans	34%	87%
A0A1X0P805	Trypanosomatidae	61%	90%
A0A3S7WV37	Leishmania donovani	79%	91%
A0A422P0Q0	Trypanosoma rangeli	55%	94%
A4HXY9	Leishmania infantum	79%	91%
D0A5B8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ARQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	92%
Q4QDS7	Leishmania major	80%	100%
V5BNN3	Trypanosoma cruzi	54%	94%

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