Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9M4_LEIBR

TriTrypDb:

LbrM.18.1240 , LBRM2903_180017900

Length:

1024

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9M4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.632
CLV_C14_Caspase3-7	207	211	PF00656	0.565
CLV_C14_Caspase3-7	577	581	PF00656	0.574
CLV_NRD_NRD_1	1011	1013	PF00675	0.735
CLV_NRD_NRD_1	139	141	PF00675	0.538
CLV_NRD_NRD_1	34	36	PF00675	0.700
CLV_NRD_NRD_1	445	447	PF00675	0.577
CLV_NRD_NRD_1	456	458	PF00675	0.489
CLV_NRD_NRD_1	495	497	PF00675	0.404
CLV_NRD_NRD_1	565	567	PF00675	0.663
CLV_NRD_NRD_1	711	713	PF00675	0.508
CLV_NRD_NRD_1	742	744	PF00675	0.685
CLV_PCSK_FUR_1	454	458	PF00082	0.634
CLV_PCSK_FUR_1	736	740	PF00082	0.672
CLV_PCSK_KEX2_1	1011	1013	PF00082	0.692
CLV_PCSK_KEX2_1	175	177	PF00082	0.469
CLV_PCSK_KEX2_1	308	310	PF00082	0.672
CLV_PCSK_KEX2_1	34	36	PF00082	0.642
CLV_PCSK_KEX2_1	342	344	PF00082	0.683
CLV_PCSK_KEX2_1	358	360	PF00082	0.494
CLV_PCSK_KEX2_1	438	440	PF00082	0.595
CLV_PCSK_KEX2_1	445	447	PF00082	0.554
CLV_PCSK_KEX2_1	456	458	PF00082	0.481
CLV_PCSK_KEX2_1	495	497	PF00082	0.404
CLV_PCSK_KEX2_1	565	567	PF00082	0.663
CLV_PCSK_KEX2_1	597	599	PF00082	0.583
CLV_PCSK_KEX2_1	711	713	PF00082	0.557
CLV_PCSK_KEX2_1	738	740	PF00082	0.649
CLV_PCSK_KEX2_1	741	743	PF00082	0.692
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.501
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.672
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.678
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.429
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.649
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.610
CLV_PCSK_PC7_1	707	713	PF00082	0.432
CLV_PCSK_PC7_1	736	742	PF00082	0.729
CLV_PCSK_SKI1_1	172	176	PF00082	0.586
CLV_PCSK_SKI1_1	266	270	PF00082	0.606
CLV_PCSK_SKI1_1	358	362	PF00082	0.644
CLV_PCSK_SKI1_1	503	507	PF00082	0.434
CLV_PCSK_SKI1_1	565	569	PF00082	0.614
CLV_PCSK_SKI1_1	627	631	PF00082	0.525
CLV_PCSK_SKI1_1	765	769	PF00082	0.813
CLV_Separin_Metazoa	550	554	PF03568	0.528
CLV_Separin_Metazoa	670	674	PF03568	0.445
CLV_Separin_Metazoa	729	733	PF03568	0.614
DEG_APCC_DBOX_1	265	273	PF00400	0.492
DEG_APCC_DBOX_1	380	388	PF00400	0.660
DEG_APCC_DBOX_1	581	589	PF00400	0.650
DEG_SIAH_1	784	792	PF03145	0.544
DEG_SPOP_SBC_1	425	429	PF00917	0.645
DEG_SPOP_SBC_1	753	757	PF00917	0.766
DEG_SPOP_SBC_1	78	82	PF00917	0.606
DEG_SPOP_SBC_1	880	884	PF00917	0.542
DOC_CKS1_1	70	75	PF01111	0.519
DOC_CYCLIN_RxL_1	117	131	PF00134	0.587
DOC_CYCLIN_RxL_1	826	839	PF00134	0.552
DOC_MAPK_gen_1	658	667	PF00069	0.570
DOC_MAPK_gen_1	826	835	PF00069	0.549
DOC_PP2B_LxvP_1	83	86	PF13499	0.600
DOC_PP4_FxxP_1	58	61	PF00568	0.523
DOC_USP7_MATH_1	264	268	PF00917	0.520
DOC_USP7_MATH_1	39	43	PF00917	0.636
DOC_USP7_MATH_1	426	430	PF00917	0.648
DOC_USP7_MATH_1	476	480	PF00917	0.512
DOC_USP7_MATH_1	59	63	PF00917	0.690
DOC_USP7_MATH_1	745	749	PF00917	0.776
DOC_USP7_MATH_1	78	82	PF00917	0.493
DOC_USP7_MATH_1	785	789	PF00917	0.803
DOC_USP7_MATH_1	885	889	PF00917	0.755
DOC_USP7_MATH_1	958	962	PF00917	0.698
DOC_USP7_MATH_1	966	970	PF00917	0.733
DOC_USP7_UBL2_3	250	254	PF12436	0.632
DOC_WW_Pin1_4	682	687	PF00397	0.554
DOC_WW_Pin1_4	69	74	PF00397	0.553
DOC_WW_Pin1_4	881	886	PF00397	0.696
DOC_WW_Pin1_4	892	897	PF00397	0.629
DOC_WW_Pin1_4	90	95	PF00397	0.633
DOC_WW_Pin1_4	959	964	PF00397	0.715
LIG_14-3-3_CanoR_1	176	184	PF00244	0.495
LIG_14-3-3_CanoR_1	284	292	PF00244	0.729
LIG_14-3-3_CanoR_1	34	40	PF00244	0.549
LIG_14-3-3_CanoR_1	373	379	PF00244	0.562
LIG_14-3-3_CanoR_1	383	388	PF00244	0.635
LIG_14-3-3_CanoR_1	666	674	PF00244	0.496
LIG_14-3-3_CanoR_1	749	754	PF00244	0.703
LIG_14-3-3_CanoR_1	978	983	PF00244	0.697
LIG_Actin_WH2_2	282	299	PF00022	0.710
LIG_Actin_WH2_2	846	864	PF00022	0.474
LIG_CaM_IQ_9	289	305	PF13499	0.705
LIG_Clathr_ClatBox_1	269	273	PF01394	0.527
LIG_FHA_1	1	7	PF00498	0.671
LIG_FHA_1	553	559	PF00498	0.588
LIG_FHA_1	667	673	PF00498	0.496
LIG_FHA_1	700	706	PF00498	0.662
LIG_FHA_1	748	754	PF00498	0.553
LIG_FHA_1	796	802	PF00498	0.697
LIG_FHA_1	872	878	PF00498	0.507
LIG_FHA_1	93	99	PF00498	0.698
LIG_FHA_2	180	186	PF00498	0.644
LIG_FHA_2	219	225	PF00498	0.495
LIG_FHA_2	339	345	PF00498	0.430
LIG_FHA_2	364	370	PF00498	0.586
LIG_FHA_2	375	381	PF00498	0.598
LIG_FHA_2	398	404	PF00498	0.620
LIG_FHA_2	426	432	PF00498	0.562
LIG_FHA_2	435	441	PF00498	0.509
LIG_FHA_2	473	479	PF00498	0.574
LIG_FHA_2	55	61	PF00498	0.535
LIG_FHA_2	603	609	PF00498	0.588
LIG_FHA_2	698	704	PF00498	0.715
LIG_FHA_2	978	984	PF00498	0.699
LIG_Integrin_isoDGR_2	507	509	PF01839	0.391
LIG_LIR_Apic_2	55	61	PF02991	0.552
LIG_LIR_Apic_2	65	71	PF02991	0.710
LIG_LIR_Gen_1	718	727	PF02991	0.570
LIG_LIR_Gen_1	97	104	PF02991	0.559
LIG_LIR_LC3C_4	80	85	PF02991	0.550
LIG_LIR_Nem_3	97	103	PF02991	0.585
LIG_MYND_1	90	94	PF01753	0.510
LIG_NRBOX	852	858	PF00104	0.469
LIG_SH2_CRK	150	154	PF00017	0.516
LIG_SH2_CRK	68	72	PF00017	0.528
LIG_SH2_NCK_1	150	154	PF00017	0.559
LIG_SH2_PTP2	100	103	PF00017	0.594
LIG_SH2_SRC	100	103	PF00017	0.537
LIG_SH2_SRC	66	69	PF00017	0.694
LIG_SH2_STAP1	402	406	PF00017	0.628
LIG_SH2_STAP1	727	731	PF00017	0.611
LIG_SH2_STAT5	100	103	PF00017	0.594
LIG_SH2_STAT5	220	223	PF00017	0.610
LIG_SH2_STAT5	66	69	PF00017	0.751
LIG_SH3_1	741	747	PF00018	0.699
LIG_SH3_1	998	1004	PF00018	0.525
LIG_SH3_2	744	749	PF14604	0.547
LIG_SH3_3	11	17	PF00018	0.608
LIG_SH3_3	45	51	PF00018	0.676
LIG_SH3_3	741	747	PF00018	0.699
LIG_SH3_3	788	794	PF00018	0.751
LIG_SH3_3	874	880	PF00018	0.557
LIG_SH3_3	998	1004	PF00018	0.636
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.526
LIG_SUMO_SIM_par_1	267	276	PF11976	0.393
LIG_SUMO_SIM_par_1	849	855	PF11976	0.480
LIG_TRAF2_1	159	162	PF00917	0.509
LIG_TRAF2_1	255	258	PF00917	0.626
LIG_TRAF2_1	312	315	PF00917	0.699
LIG_TRAF2_1	367	370	PF00917	0.665
LIG_TRAF2_1	448	451	PF00917	0.633
LIG_TRAF2_1	475	478	PF00917	0.517
LIG_TRAF2_1	514	517	PF00917	0.516
LIG_TRAF2_1	726	729	PF00917	0.607
LIG_TRAF2_1	905	908	PF00917	0.474
LIG_TYR_ITIM	98	103	PF00017	0.649
MOD_CDK_SPxK_1	69	75	PF00069	0.522
MOD_CK1_1	271	277	PF00069	0.590
MOD_CK1_1	62	68	PF00069	0.650
MOD_CK1_1	69	75	PF00069	0.669
MOD_CK1_1	699	705	PF00069	0.459
MOD_CK1_1	718	724	PF00069	0.594
MOD_CK1_1	752	758	PF00069	0.715
MOD_CK1_1	77	83	PF00069	0.713
MOD_CK1_1	924	930	PF00069	0.678
MOD_CK1_1	93	99	PF00069	0.609
MOD_CK1_1	961	967	PF00069	0.732
MOD_CK2_1	179	185	PF00069	0.639
MOD_CK2_1	218	224	PF00069	0.494
MOD_CK2_1	363	369	PF00069	0.617
MOD_CK2_1	372	378	PF00069	0.579
MOD_CK2_1	416	422	PF00069	0.611
MOD_CK2_1	425	431	PF00069	0.546
MOD_CK2_1	434	440	PF00069	0.410
MOD_CK2_1	472	478	PF00069	0.538
MOD_CK2_1	510	516	PF00069	0.552
MOD_CK2_1	54	60	PF00069	0.692
MOD_CK2_1	602	608	PF00069	0.589
MOD_CK2_1	723	729	PF00069	0.548
MOD_CK2_1	934	940	PF00069	0.726
MOD_CK2_1	977	983	PF00069	0.700
MOD_GlcNHglycan	1013	1016	PF01048	0.700
MOD_GlcNHglycan	161	166	PF01048	0.572
MOD_GlcNHglycan	265	269	PF01048	0.651
MOD_GlcNHglycan	36	39	PF01048	0.582
MOD_GlcNHglycan	428	431	PF01048	0.557
MOD_GlcNHglycan	511	515	PF01048	0.556
MOD_GlcNHglycan	60	64	PF01048	0.637
MOD_GlcNHglycan	762	765	PF01048	0.645
MOD_GlcNHglycan	781	784	PF01048	0.648
MOD_GlcNHglycan	887	890	PF01048	0.720
MOD_GlcNHglycan	923	926	PF01048	0.680
MOD_GlcNHglycan	940	945	PF01048	0.729
MOD_GlcNHglycan	970	973	PF01048	0.609
MOD_GSK3_1	117	124	PF00069	0.515
MOD_GSK3_1	175	182	PF00069	0.573
MOD_GSK3_1	264	271	PF00069	0.558
MOD_GSK3_1	34	41	PF00069	0.660
MOD_GSK3_1	379	386	PF00069	0.654
MOD_GSK3_1	472	479	PF00069	0.483
MOD_GSK3_1	62	69	PF00069	0.687
MOD_GSK3_1	689	696	PF00069	0.734
MOD_GSK3_1	699	706	PF00069	0.640
MOD_GSK3_1	74	81	PF00069	0.555
MOD_GSK3_1	745	752	PF00069	0.760
MOD_GSK3_1	754	761	PF00069	0.702
MOD_GSK3_1	88	95	PF00069	0.669
MOD_GSK3_1	881	888	PF00069	0.764
MOD_GSK3_1	924	931	PF00069	0.663
MOD_GSK3_1	964	971	PF00069	0.660
MOD_N-GLC_1	501	506	PF02516	0.389
MOD_N-GLC_1	759	764	PF02516	0.796
MOD_NEK2_1	121	126	PF00069	0.515
MOD_NEK2_1	379	384	PF00069	0.610
MOD_NEK2_1	397	402	PF00069	0.353
MOD_NEK2_1	424	429	PF00069	0.569
MOD_NEK2_1	434	439	PF00069	0.520
MOD_NEK2_1	510	515	PF00069	0.547
MOD_NEK2_1	602	607	PF00069	0.586
MOD_NEK2_1	653	658	PF00069	0.496
MOD_NEK2_1	869	874	PF00069	0.550
MOD_PIKK_1	530	536	PF00454	0.497
MOD_PIKK_1	629	635	PF00454	0.549
MOD_PIKK_1	930	936	PF00454	0.735
MOD_PK_1	749	755	PF00069	0.553
MOD_PKA_1	1011	1017	PF00069	0.601
MOD_PKA_1	175	181	PF00069	0.515
MOD_PKA_1	34	40	PF00069	0.607
MOD_PKA_2	1011	1017	PF00069	0.545
MOD_PKA_2	175	181	PF00069	0.513
MOD_PKA_2	33	39	PF00069	0.693
MOD_PKA_2	372	378	PF00069	0.637
MOD_PKA_2	407	413	PF00069	0.561
MOD_PKA_2	552	558	PF00069	0.533
MOD_PKA_2	723	729	PF00069	0.604
MOD_PKA_2	977	983	PF00069	0.683
MOD_PKB_1	381	389	PF00069	0.650
MOD_PKB_1	919	927	PF00069	0.691
MOD_Plk_1	121	127	PF00069	0.514
MOD_Plk_1	179	185	PF00069	0.600
MOD_Plk_1	218	224	PF00069	0.455
MOD_Plk_1	264	270	PF00069	0.621
MOD_Plk_1	379	385	PF00069	0.607
MOD_Plk_1	450	456	PF00069	0.631
MOD_Plk_1	510	516	PF00069	0.569
MOD_Plk_1	718	724	PF00069	0.667
MOD_Plk_1	928	934	PF00069	0.678
MOD_Plk_2-3	846	852	PF00069	0.469
MOD_Plk_4	244	250	PF00069	0.383
MOD_Plk_4	321	327	PF00069	0.517
MOD_Plk_4	383	389	PF00069	0.647
MOD_Plk_4	39	45	PF00069	0.613
MOD_Plk_4	62	68	PF00069	0.582
MOD_Plk_4	79	85	PF00069	0.549
MOD_Plk_4	818	824	PF00069	0.536
MOD_Plk_4	846	852	PF00069	0.469
MOD_ProDKin_1	682	688	PF00069	0.558
MOD_ProDKin_1	69	75	PF00069	0.553
MOD_ProDKin_1	881	887	PF00069	0.695
MOD_ProDKin_1	892	898	PF00069	0.624
MOD_ProDKin_1	90	96	PF00069	0.628
MOD_ProDKin_1	959	965	PF00069	0.718
MOD_SUMO_for_1	829	832	PF00179	0.562
MOD_SUMO_rev_2	478	485	PF00179	0.371
MOD_SUMO_rev_2	500	505	PF00179	0.530
TRG_DiLeu_BaEn_1	393	398	PF01217	0.639
TRG_DiLeu_BaEn_1	412	417	PF01217	0.581
TRG_DiLeu_BaEn_1	846	851	PF01217	0.466
TRG_DiLeu_BaEn_4	130	136	PF01217	0.502
TRG_DiLeu_BaEn_4	450	456	PF01217	0.631
TRG_ENDOCYTIC_2	100	103	PF00928	0.537
TRG_ENDOCYTIC_2	150	153	PF00928	0.460
TRG_ENDOCYTIC_2	171	174	PF00928	0.488
TRG_ENDOCYTIC_2	720	723	PF00928	0.564
TRG_ENDOCYTIC_2	727	730	PF00928	0.520
TRG_ER_diArg_1	1010	1012	PF00400	0.728
TRG_ER_diArg_1	199	202	PF00400	0.552
TRG_ER_diArg_1	33	35	PF00400	0.592
TRG_ER_diArg_1	381	384	PF00400	0.624
TRG_ER_diArg_1	445	447	PF00400	0.598
TRG_ER_diArg_1	454	457	PF00400	0.596
TRG_ER_diArg_1	494	496	PF00400	0.397
TRG_ER_diArg_1	736	739	PF00400	0.646
TRG_ER_diArg_1	740	743	PF00400	0.695
TRG_ER_diArg_1	808	811	PF00400	0.482
TRG_ER_diArg_1	865	868	PF00400	0.607
TRG_ER_diArg_1	919	922	PF00400	0.649
TRG_ER_diArg_1	998	1001	PF00400	0.699
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	359	364	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	445	450	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	732	737	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBB1	Leptomonas seymouri	57%	87%
A0A3R7MU41	Trypanosoma rangeli	37%	100%
A0A3S5H739	Leishmania donovani	83%	100%
A4HXY8	Leishmania infantum	83%	100%
D0A5B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ARQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QDS8	Leishmania major	82%	100%
V5BEK2	Trypanosoma cruzi	36%	100%