AN1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AN1-like zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4H9M2_LEIBR

TriTrypDb:

LbrM.18.1220 , LBRM2903_180017700

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9M2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.706
CLV_NRD_NRD_1	102	104	PF00675	0.725
CLV_NRD_NRD_1	111	113	PF00675	0.669
CLV_NRD_NRD_1	337	339	PF00675	0.544
CLV_PCSK_KEX2_1	102	104	PF00082	0.725
CLV_PCSK_KEX2_1	111	113	PF00082	0.669
CLV_PCSK_KEX2_1	33	35	PF00082	0.360
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.475
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.360
CLV_PCSK_SKI1_1	189	193	PF00082	0.417
CLV_PCSK_SKI1_1	250	254	PF00082	0.421
CLV_PCSK_SKI1_1	314	318	PF00082	0.488
CLV_PCSK_SKI1_1	339	343	PF00082	0.599
CLV_PCSK_SKI1_1	63	67	PF00082	0.460
DEG_Nend_UBRbox_3	1	3	PF02207	0.525
DOC_MAPK_MEF2A_6	291	300	PF00069	0.641
DOC_PP1_RVXF_1	312	319	PF00149	0.451
DOC_PP4_FxxP_1	219	222	PF00568	0.474
DOC_PP4_FxxP_1	318	321	PF00568	0.479
DOC_USP7_MATH_1	118	122	PF00917	0.437
DOC_USP7_MATH_1	159	163	PF00917	0.619
DOC_USP7_MATH_1	239	243	PF00917	0.346
DOC_USP7_MATH_1	26	30	PF00917	0.334
DOC_USP7_UBL2_3	200	204	PF12436	0.601
DOC_WW_Pin1_4	164	169	PF00397	0.574
DOC_WW_Pin1_4	175	180	PF00397	0.562
DOC_WW_Pin1_4	194	199	PF00397	0.476
DOC_WW_Pin1_4	265	270	PF00397	0.470
DOC_WW_Pin1_4	304	309	PF00397	0.566
DOC_WW_Pin1_4	317	322	PF00397	0.546
LIG_14-3-3_CanoR_1	161	165	PF00244	0.622
LIG_14-3-3_CanoR_1	189	194	PF00244	0.405
LIG_14-3-3_CanoR_1	27	35	PF00244	0.235
LIG_APCC_ABBA_1	284	289	PF00400	0.624
LIG_CaM_IQ_9	330	345	PF13499	0.368
LIG_FHA_1	139	145	PF00498	0.425
LIG_FHA_1	212	218	PF00498	0.375
LIG_FHA_1	281	287	PF00498	0.533
LIG_FHA_1	55	61	PF00498	0.295
LIG_FHA_2	17	23	PF00498	0.300
LIG_FHA_2	257	263	PF00498	0.540
LIG_LIR_Gen_1	242	252	PF02991	0.430
LIG_LIR_Nem_3	235	240	PF02991	0.451
LIG_LIR_Nem_3	242	246	PF02991	0.361
LIG_NRBOX	252	258	PF00104	0.459
LIG_SH2_CRK	294	298	PF00017	0.577
LIG_SH2_NCK_1	96	100	PF00017	0.452
LIG_SH2_STAT3	69	72	PF00017	0.473
LIG_SH3_3	173	179	PF00018	0.737
LIG_SH3_3	279	285	PF00018	0.443
LIG_SH3_3	293	299	PF00018	0.485
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.360
LIG_SUMO_SIM_par_1	63	68	PF11976	0.306
LIG_TRAF2_2	70	75	PF00917	0.508
LIG_WRC_WIRS_1	240	245	PF05994	0.339
LIG_WW_2	296	299	PF00397	0.439
MOD_CDK_SPxK_1	194	200	PF00069	0.527
MOD_CDK_SPxxK_3	265	272	PF00069	0.469
MOD_CK1_1	166	172	PF00069	0.600
MOD_CK1_1	346	352	PF00069	0.517
MOD_CK1_1	95	101	PF00069	0.578
MOD_CK2_1	164	170	PF00069	0.665
MOD_Cter_Amidation	109	112	PF01082	0.676
MOD_GlcNHglycan	115	118	PF01048	0.604
MOD_GlcNHglycan	228	231	PF01048	0.537
MOD_GlcNHglycan	92	95	PF01048	0.610
MOD_GlcNHglycan	97	100	PF01048	0.608
MOD_GSK3_1	159	166	PF00069	0.559
MOD_GSK3_1	203	210	PF00069	0.570
MOD_GSK3_1	34	41	PF00069	0.356
MOD_GSK3_1	341	348	PF00069	0.687
MOD_GSK3_1	90	97	PF00069	0.444
MOD_LATS_1	32	38	PF00433	0.295
MOD_NEK2_1	113	118	PF00069	0.500
MOD_NEK2_1	226	231	PF00069	0.628
MOD_NEK2_1	256	261	PF00069	0.436
MOD_NEK2_1	280	285	PF00069	0.523
MOD_NEK2_1	342	347	PF00069	0.465
MOD_NEK2_1	90	95	PF00069	0.567
MOD_PIKK_1	347	353	PF00454	0.601
MOD_PK_1	183	189	PF00069	0.568
MOD_PKA_2	160	166	PF00069	0.666
MOD_PKA_2	26	32	PF00069	0.383
MOD_Plk_2-3	16	22	PF00069	0.411
MOD_Plk_4	221	227	PF00069	0.533
MOD_Plk_4	239	245	PF00069	0.314
MOD_Plk_4	299	305	PF00069	0.622
MOD_ProDKin_1	164	170	PF00069	0.579
MOD_ProDKin_1	175	181	PF00069	0.558
MOD_ProDKin_1	194	200	PF00069	0.482
MOD_ProDKin_1	265	271	PF00069	0.462
MOD_ProDKin_1	304	310	PF00069	0.560
MOD_ProDKin_1	317	323	PF00069	0.559
MOD_SUMO_rev_2	331	341	PF00179	0.465
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.436
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.498
TRG_ER_diArg_1	111	113	PF00400	0.673
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X2	Leptomonas seymouri	65%	99%
A0A0S4KFT8	Bodo saltans	30%	100%
A0A1X0P6Y8	Trypanosomatidae	30%	100%
A0A3S5ISH4	Trypanosoma rangeli	31%	100%
A0A3S7WV04	Leishmania donovani	79%	100%
A4HXY6	Leishmania infantum	79%	100%
D0A5C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ARP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QDT0	Leishmania major	79%	100%
V5AZ68	Trypanosoma cruzi	34%	100%