ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4H9M0_LEIBR

TriTrypDb:

LbrM.18.1200 , LBRM2903_180017500

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0000502	proteasome complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2

Expansion

Sequence features

A4H9M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9M0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.416
CLV_C14_Caspase3-7	56	60	PF00656	0.481
CLV_NRD_NRD_1	161	163	PF00675	0.450
CLV_NRD_NRD_1	225	227	PF00675	0.414
CLV_PCSK_KEX2_1	225	227	PF00082	0.318
CLV_PCSK_SKI1_1	115	119	PF00082	0.489
CLV_PCSK_SKI1_1	120	124	PF00082	0.501
CLV_PCSK_SKI1_1	162	166	PF00082	0.579
CLV_PCSK_SKI1_1	211	215	PF00082	0.360
CLV_PCSK_SKI1_1	289	293	PF00082	0.433
CLV_PCSK_SKI1_1	63	67	PF00082	0.277
DEG_APCC_DBOX_1	203	211	PF00400	0.337
DEG_SCF_FBW7_1	97	103	PF00400	0.256
DOC_CKS1_1	97	102	PF01111	0.500
DOC_CYCLIN_RxL_1	206	216	PF00134	0.449
DOC_MAPK_MEF2A_6	8	16	PF00069	0.497
DOC_USP7_MATH_1	154	158	PF00917	0.703
DOC_USP7_MATH_1	30	34	PF00917	0.415
DOC_WW_Pin1_4	175	180	PF00397	0.603
DOC_WW_Pin1_4	193	198	PF00397	0.227
DOC_WW_Pin1_4	85	90	PF00397	0.463
DOC_WW_Pin1_4	96	101	PF00397	0.334
LIG_14-3-3_CanoR_1	120	129	PF00244	0.405
LIG_14-3-3_CanoR_1	162	172	PF00244	0.453
LIG_14-3-3_CanoR_1	225	235	PF00244	0.353
LIG_BIR_III_2	176	180	PF00653	0.499
LIG_BIR_III_4	191	195	PF00653	0.501
LIG_BRCT_BRCA1_1	273	277	PF00533	0.473
LIG_BRCT_BRCA1_1	30	34	PF00533	0.415
LIG_FHA_1	194	200	PF00498	0.358
LIG_FHA_2	261	267	PF00498	0.486
LIG_FHA_2	40	46	PF00498	0.480
LIG_FHA_2	90	96	PF00498	0.540
LIG_LIR_Gen_1	263	269	PF02991	0.471
LIG_LIR_Nem_3	123	128	PF02991	0.451
LIG_LIR_Nem_3	263	267	PF02991	0.274
LIG_PCNA_APIM_2	287	293	PF02747	0.419
LIG_PCNA_yPIPBox_3	233	246	PF02747	0.388
LIG_PCNA_yPIPBox_3	284	298	PF02747	0.389
LIG_SH2_CRK	86	90	PF00017	0.489
LIG_SH2_STAT5	290	293	PF00017	0.391
LIG_SH3_3	104	110	PF00018	0.356
LIG_SH3_3	166	172	PF00018	0.519
LIG_SUMO_SIM_anti_2	9	17	PF11976	0.333
MOD_CK2_1	118	124	PF00069	0.525
MOD_CK2_1	245	251	PF00069	0.465
MOD_CK2_1	29	35	PF00069	0.612
MOD_CK2_1	39	45	PF00069	0.627
MOD_CK2_1	89	95	PF00069	0.534
MOD_GlcNHglycan	146	149	PF01048	0.750
MOD_GlcNHglycan	182	185	PF01048	0.484
MOD_GlcNHglycan	215	218	PF01048	0.221
MOD_GlcNHglycan	228	231	PF01048	0.151
MOD_GlcNHglycan	273	276	PF01048	0.459
MOD_GSK3_1	186	193	PF00069	0.302
MOD_GSK3_1	39	46	PF00069	0.665
MOD_GSK3_1	85	92	PF00069	0.458
MOD_GSK3_1	96	103	PF00069	0.339
MOD_N-GLC_1	143	148	PF02516	0.747
MOD_N-GLC_1	253	258	PF02516	0.469
MOD_NEK2_1	118	123	PF00069	0.441
MOD_NEK2_1	213	218	PF00069	0.287
MOD_NEK2_1	245	250	PF00069	0.425
MOD_PKA_1	252	258	PF00069	0.472
MOD_PKA_2	7	13	PF00069	0.464
MOD_Plk_1	118	124	PF00069	0.525
MOD_ProDKin_1	175	181	PF00069	0.596
MOD_ProDKin_1	193	199	PF00069	0.161
MOD_ProDKin_1	85	91	PF00069	0.461
MOD_ProDKin_1	96	102	PF00069	0.330
MOD_SUMO_rev_2	156	165	PF00179	0.705
MOD_SUMO_rev_2	248	255	PF00179	0.296
MOD_SUMO_rev_2	299	308	PF00179	0.445
TRG_DiLeu_BaEn_2	240	246	PF01217	0.449
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.337
TRG_ENDOCYTIC_2	278	281	PF00928	0.376
TRG_NES_CRM1_1	13	26	PF08389	0.292
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U8	Leptomonas seymouri	57%	100%
A0A0S4KHT8	Bodo saltans	32%	100%
A0A1X0P783	Trypanosomatidae	42%	97%
A0A3S7WV17	Leishmania donovani	82%	100%
A0A3S7X3U4	Leishmania donovani	24%	76%
A0A422P0K3	Trypanosoma rangeli	45%	100%
A4HXY4	Leishmania infantum	82%	100%
A4I610	Leishmania infantum	24%	76%
D0A5C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ARP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B1A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	76%
Q4Q6W3	Leishmania major	24%	76%
Q4QDT2	Leishmania major	82%	100%
Q8Q0U0	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	25%	86%
V5BJ76	Trypanosoma cruzi	47%	100%