Phosphodiesterase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

cAMP phosphodiesterase A, putative

Species:

Leishmania braziliensis

UniProt:

A4H9L9_LEIBR

TriTrypDb:

LbrM.18.1190 , LBRM2903_180017400

Length:

631

Annotations

LeishMANIAdb annotations

Phosphodiesterase, with probable N-terminal lipidation signal. Not embedded in membrane, like its homologs.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9L9

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	14
GO:0009987	cellular process	1	14
GO:0050789	regulation of biological process	2	14
GO:0050794	regulation of cellular process	3	14
GO:0065007	biological regulation	1	14
GO:0009892	negative regulation of metabolic process	4	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:2000377	regulation of reactive oxygen species metabolic process	5	1
GO:2000378	negative regulation of reactive oxygen species metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	14
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	14
GO:0005488	binding	1	13
GO:0008081	phosphoric diester hydrolase activity	5	14
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	14
GO:0042578	phosphoric ester hydrolase activity	4	14
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.479
CLV_NRD_NRD_1	204	206	PF00675	0.508
CLV_NRD_NRD_1	94	96	PF00675	0.476
CLV_PCSK_FUR_1	175	179	PF00082	0.510
CLV_PCSK_KEX2_1	126	128	PF00082	0.371
CLV_PCSK_KEX2_1	177	179	PF00082	0.529
CLV_PCSK_KEX2_1	408	410	PF00082	0.343
CLV_PCSK_KEX2_1	94	96	PF00082	0.632
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.371
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.552
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.343
CLV_PCSK_SKI1_1	141	145	PF00082	0.550
CLV_PCSK_SKI1_1	178	182	PF00082	0.609
CLV_PCSK_SKI1_1	262	266	PF00082	0.340
CLV_PCSK_SKI1_1	282	286	PF00082	0.488
CLV_PCSK_SKI1_1	453	457	PF00082	0.270
DEG_APCC_DBOX_1	408	416	PF00400	0.341
DEG_APCC_DBOX_1	452	460	PF00400	0.318
DEG_SCF_FBW7_2	596	602	PF00400	0.324
DEG_SPOP_SBC_1	97	101	PF00917	0.670
DOC_CKS1_1	596	601	PF01111	0.324
DOC_CYCLIN_RxL_1	565	575	PF00134	0.376
DOC_MAPK_gen_1	251	261	PF00069	0.470
DOC_MAPK_MEF2A_6	319	327	PF00069	0.346
DOC_PIKK_1	451	459	PF02985	0.376
DOC_PP1_RVXF_1	301	308	PF00149	0.393
DOC_PP2B_LxvP_1	333	336	PF13499	0.322
DOC_PP4_FxxP_1	429	432	PF00568	0.376
DOC_SPAK_OSR1_1	612	616	PF12202	0.421
DOC_USP7_MATH_1	16	20	PF00917	0.470
DOC_USP7_MATH_1	309	313	PF00917	0.360
DOC_USP7_MATH_1	60	64	PF00917	0.577
DOC_USP7_MATH_1	80	84	PF00917	0.245
DOC_USP7_UBL2_3	196	200	PF12436	0.564
DOC_USP7_UBL2_3	285	289	PF12436	0.274
DOC_WW_Pin1_4	267	272	PF00397	0.504
DOC_WW_Pin1_4	275	280	PF00397	0.469
DOC_WW_Pin1_4	572	577	PF00397	0.300
DOC_WW_Pin1_4	595	600	PF00397	0.418
LIG_14-3-3_CanoR_1	127	131	PF00244	0.451
LIG_14-3-3_CanoR_1	163	170	PF00244	0.481
LIG_14-3-3_CanoR_1	315	319	PF00244	0.240
LIG_14-3-3_CanoR_1	409	418	PF00244	0.288
LIG_APCC_ABBA_1	597	602	PF00400	0.299
LIG_BIR_II_1	1	5	PF00653	0.384
LIG_BRCT_BRCA1_1	104	108	PF00533	0.724
LIG_BRCT_BRCA1_1	461	465	PF00533	0.314
LIG_BRCT_BRCA1_1	556	560	PF00533	0.299
LIG_BRCT_BRCA1_1	70	74	PF00533	0.413
LIG_deltaCOP1_diTrp_1	314	321	PF00928	0.330
LIG_deltaCOP1_diTrp_1	69	74	PF00928	0.418
LIG_FHA_1	19	25	PF00498	0.582
LIG_FHA_1	395	401	PF00498	0.283
LIG_FHA_1	44	50	PF00498	0.374
LIG_FHA_1	99	105	PF00498	0.608
LIG_FHA_2	133	139	PF00498	0.461
LIG_FHA_2	250	256	PF00498	0.491
LIG_FHA_2	29	35	PF00498	0.523
LIG_FHA_2	488	494	PF00498	0.272
LIG_FHA_2	519	525	PF00498	0.209
LIG_FHA_2	97	103	PF00498	0.654
LIG_FXI_DFP_1	426	430	PF00024	0.421
LIG_IBAR_NPY_1	382	384	PF08397	0.318
LIG_LIR_Apic_2	266	271	PF02991	0.488
LIG_LIR_Apic_2	428	432	PF02991	0.270
LIG_LIR_Gen_1	255	264	PF02991	0.495
LIG_LIR_Gen_1	330	337	PF02991	0.477
LIG_LIR_Gen_1	347	357	PF02991	0.346
LIG_LIR_Gen_1	39	48	PF02991	0.343
LIG_LIR_Gen_1	462	473	PF02991	0.295
LIG_LIR_Gen_1	598	609	PF02991	0.384
LIG_LIR_Gen_1	69	77	PF02991	0.360
LIG_LIR_Nem_3	105	111	PF02991	0.584
LIG_LIR_Nem_3	255	259	PF02991	0.463
LIG_LIR_Nem_3	317	321	PF02991	0.383
LIG_LIR_Nem_3	330	335	PF02991	0.367
LIG_LIR_Nem_3	347	352	PF02991	0.308
LIG_LIR_Nem_3	39	43	PF02991	0.519
LIG_LIR_Nem_3	598	604	PF02991	0.334
LIG_LIR_Nem_3	69	73	PF02991	0.339
LIG_MLH1_MIPbox_1	70	74	PF16413	0.438
LIG_Pex14_1	70	74	PF04695	0.321
LIG_Pex14_2	357	361	PF04695	0.343
LIG_PTB_Apo_2	467	474	PF02174	0.318
LIG_REV1ctd_RIR_1	71	79	PF16727	0.503
LIG_RPA_C_Fungi	298	310	PF08784	0.258
LIG_SH2_CRK	349	353	PF00017	0.302
LIG_SH2_GRB2like	384	387	PF00017	0.270
LIG_SH2_STAP1	160	164	PF00017	0.490
LIG_SH2_STAT5	142	145	PF00017	0.486
LIG_SH2_STAT5	332	335	PF00017	0.568
LIG_SH2_STAT5	445	448	PF00017	0.376
LIG_SH2_STAT5	48	51	PF00017	0.433
LIG_SH2_STAT5	506	509	PF00017	0.376
LIG_SH2_STAT5	549	552	PF00017	0.268
LIG_SH2_STAT5	595	598	PF00017	0.263
LIG_SH3_3	280	286	PF00018	0.371
LIG_SH3_4	285	292	PF00018	0.278
LIG_Sin3_3	256	263	PF02671	0.358
LIG_SUMO_SIM_anti_2	21	26	PF11976	0.462
LIG_SUMO_SIM_par_1	165	172	PF11976	0.384
LIG_SUMO_SIM_par_1	184	190	PF11976	0.570
LIG_TRAF2_1	122	125	PF00917	0.382
LIG_TRAF2_1	270	273	PF00917	0.298
LIG_TRAF2_1	31	34	PF00917	0.572
LIG_TRAF2_1	480	483	PF00917	0.182
LIG_UBA3_1	260	265	PF00899	0.311
LIG_UBA3_1	527	535	PF00899	0.182
LIG_WRC_WIRS_1	40	45	PF05994	0.287
LIG_WRC_WIRS_1	476	481	PF05994	0.343
MOD_CDK_SPxxK_3	275	282	PF00069	0.438
MOD_CK1_1	297	303	PF00069	0.473
MOD_CK1_1	36	42	PF00069	0.461
MOD_CK1_1	509	515	PF00069	0.450
MOD_CK1_1	518	524	PF00069	0.444
MOD_CK2_1	118	124	PF00069	0.610
MOD_CK2_1	267	273	PF00069	0.411
MOD_CK2_1	28	34	PF00069	0.523
MOD_CK2_1	370	376	PF00069	0.301
MOD_CK2_1	451	457	PF00069	0.262
MOD_CK2_1	460	466	PF00069	0.264
MOD_CK2_1	477	483	PF00069	0.283
MOD_CK2_1	487	493	PF00069	0.294
MOD_CK2_1	96	102	PF00069	0.655
MOD_GlcNHglycan	104	107	PF01048	0.624
MOD_GlcNHglycan	299	302	PF01048	0.522
MOD_GlcNHglycan	327	330	PF01048	0.460
MOD_GlcNHglycan	372	375	PF01048	0.352
MOD_GlcNHglycan	418	421	PF01048	0.435
MOD_GlcNHglycan	82	85	PF01048	0.515
MOD_GSK3_1	16	23	PF00069	0.383
MOD_GSK3_1	263	270	PF00069	0.375
MOD_GSK3_1	336	343	PF00069	0.398
MOD_GSK3_1	39	46	PF00069	0.441
MOD_GSK3_1	441	448	PF00069	0.300
MOD_GSK3_1	495	502	PF00069	0.401
MOD_GSK3_1	516	523	PF00069	0.421
MOD_GSK3_1	56	63	PF00069	0.496
MOD_GSK3_1	581	588	PF00069	0.429
MOD_GSK3_1	624	631	PF00069	0.535
MOD_GSK3_1	96	103	PF00069	0.622
MOD_LATS_1	439	445	PF00433	0.283
MOD_N-GLC_1	190	195	PF02516	0.582
MOD_N-GLC_1	239	244	PF02516	0.690
MOD_N-GLC_1	249	254	PF02516	0.622
MOD_N-GLC_1	410	415	PF02516	0.203
MOD_N-GLC_1	50	55	PF02516	0.288
MOD_NEK2_1	132	137	PF00069	0.344
MOD_NEK2_1	263	268	PF00069	0.349
MOD_NEK2_1	299	304	PF00069	0.472
MOD_NEK2_1	344	349	PF00069	0.235
MOD_NEK2_1	394	399	PF00069	0.259
MOD_NEK2_1	422	427	PF00069	0.378
MOD_NEK2_1	43	48	PF00069	0.314
MOD_NEK2_1	459	464	PF00069	0.346
MOD_NEK2_1	528	533	PF00069	0.197
MOD_NEK2_1	585	590	PF00069	0.392
MOD_NEK2_2	249	254	PF00069	0.600
MOD_NEK2_2	384	389	PF00069	0.270
MOD_NEK2_2	445	450	PF00069	0.318
MOD_NEK2_2	506	511	PF00069	0.236
MOD_PIKK_1	294	300	PF00454	0.545
MOD_PIKK_1	399	405	PF00454	0.425
MOD_PIKK_1	585	591	PF00454	0.397
MOD_PKA_1	126	132	PF00069	0.540
MOD_PKA_2	126	132	PF00069	0.437
MOD_PKA_2	162	168	PF00069	0.491
MOD_PKA_2	314	320	PF00069	0.237
MOD_PKA_2	487	493	PF00069	0.263
MOD_Plk_1	132	138	PF00069	0.366
MOD_Plk_1	239	245	PF00069	0.694
MOD_Plk_1	33	39	PF00069	0.502
MOD_Plk_1	451	457	PF00069	0.297
MOD_Plk_1	68	74	PF00069	0.514
MOD_Plk_2-3	554	560	PF00069	0.313
MOD_Plk_4	10	16	PF00069	0.388
MOD_Plk_4	126	132	PF00069	0.556
MOD_Plk_4	20	26	PF00069	0.411
MOD_Plk_4	340	346	PF00069	0.329
MOD_Plk_4	44	50	PF00069	0.434
MOD_Plk_4	441	447	PF00069	0.316
MOD_Plk_4	460	466	PF00069	0.252
MOD_Plk_4	487	493	PF00069	0.270
MOD_Plk_4	69	75	PF00069	0.395
MOD_ProDKin_1	267	273	PF00069	0.512
MOD_ProDKin_1	275	281	PF00069	0.462
MOD_ProDKin_1	572	578	PF00069	0.300
MOD_ProDKin_1	595	601	PF00069	0.418
MOD_SUMO_rev_2	102	111	PF00179	0.560
MOD_SUMO_rev_2	121	128	PF00179	0.338
MOD_SUMO_rev_2	165	173	PF00179	0.606
MOD_SUMO_rev_2	619	623	PF00179	0.517
TRG_ENDOCYTIC_2	318	321	PF00928	0.353
TRG_ENDOCYTIC_2	332	335	PF00928	0.403
TRG_ENDOCYTIC_2	349	352	PF00928	0.176
TRG_ENDOCYTIC_2	40	43	PF00928	0.524
TRG_NES_CRM1_1	486	499	PF08389	0.196
TRG_NES_CRM1_1	525	538	PF08389	0.258
TRG_NES_CRM1_1	606	620	PF08389	0.324
TRG_NLS_MonoExtC_3	176	182	PF00514	0.320
TRG_NLS_MonoExtN_4	175	181	PF00514	0.320
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	568	573	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG81	Leptomonas seymouri	66%	100%
A0A0S4IZR3	Bodo saltans	23%	95%
A0A0S4KIW5	Bodo saltans	46%	100%
A0A1X0P701	Trypanosomatidae	48%	100%
A0A3Q8IB14	Leishmania donovani	85%	100%
A0A422P0P1	Trypanosoma rangeli	47%	100%
A4HXY3	Leishmania infantum	86%	100%
C9ZL03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	93%
D0A5C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ARP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q6S998	Leishmania major	84%	100%
V5BNN7	Trypanosoma cruzi	45%	100%