Putative vacuolar protein sorting complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar protein sorting-associated protein 16 homolog, putative

Species:

Leishmania braziliensis

UniProt:

A4H9L7_LEIBR

TriTrypDb:

LbrM.18.1170 , LBRM2903_180017200

Length:

924

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0012505	endomembrane system	2	9
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005768	endosome	7	1
GO:0030897	HOPS complex	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A4H9L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9L7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0006996	organelle organization	4	10
GO:0007033	vacuole organization	5	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016043	cellular component organization	3	10
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0042144	vacuole fusion, non-autophagic	7	1
GO:0048284	organelle fusion	5	1
GO:0097576	vacuole fusion	6	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.480
CLV_C14_Caspase3-7	829	833	PF00656	0.463
CLV_NRD_NRD_1	275	277	PF00675	0.422
CLV_NRD_NRD_1	4	6	PF00675	0.560
CLV_PCSK_KEX2_1	275	277	PF00082	0.422
CLV_PCSK_KEX2_1	4	6	PF00082	0.585
CLV_PCSK_KEX2_1	429	431	PF00082	0.323
CLV_PCSK_KEX2_1	455	457	PF00082	0.412
CLV_PCSK_KEX2_1	595	597	PF00082	0.422
CLV_PCSK_KEX2_1	707	709	PF00082	0.395
CLV_PCSK_KEX2_1	84	86	PF00082	0.416
CLV_PCSK_KEX2_1	844	846	PF00082	0.422
CLV_PCSK_KEX2_1	880	882	PF00082	0.314
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.323
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.487
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.422
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.395
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.192
CLV_PCSK_PC1ET2_1	844	846	PF00082	0.422
CLV_PCSK_PC1ET2_1	880	882	PF00082	0.422
CLV_PCSK_SKI1_1	157	161	PF00082	0.422
CLV_PCSK_SKI1_1	201	205	PF00082	0.249
CLV_PCSK_SKI1_1	218	222	PF00082	0.398
CLV_PCSK_SKI1_1	354	358	PF00082	0.302
CLV_PCSK_SKI1_1	429	433	PF00082	0.422
CLV_PCSK_SKI1_1	541	545	PF00082	0.470
CLV_PCSK_SKI1_1	775	779	PF00082	0.416
CLV_PCSK_SKI1_1	790	794	PF00082	0.387
CLV_PCSK_SKI1_1	802	806	PF00082	0.337
CLV_PCSK_SKI1_1	828	832	PF00082	0.399
DEG_APCC_DBOX_1	351	359	PF00400	0.464
DEG_APCC_DBOX_1	86	94	PF00400	0.211
DEG_SCF_FBW7_1	205	212	PF00400	0.211
DOC_CYCLIN_RxL_1	167	179	PF00134	0.367
DOC_CYCLIN_RxL_1	215	224	PF00134	0.211
DOC_MAPK_DCC_7	460	470	PF00069	0.556
DOC_MAPK_gen_1	275	281	PF00069	0.211
DOC_MAPK_gen_1	352	360	PF00069	0.211
DOC_MAPK_gen_1	455	465	PF00069	0.497
DOC_MAPK_gen_1	84	90	PF00069	0.192
DOC_MAPK_gen_1	9	19	PF00069	0.330
DOC_MAPK_MEF2A_6	103	112	PF00069	0.404
DOC_PP1_RVXF_1	248	255	PF00149	0.379
DOC_PP1_RVXF_1	352	358	PF00149	0.211
DOC_PP2B_LxvP_1	174	177	PF13499	0.379
DOC_PP2B_LxvP_1	231	234	PF13499	0.464
DOC_PP4_FxxP_1	793	796	PF00568	0.422
DOC_USP7_MATH_1	127	131	PF00917	0.381
DOC_USP7_MATH_1	138	142	PF00917	0.383
DOC_USP7_MATH_1	191	195	PF00917	0.224
DOC_USP7_MATH_1	209	213	PF00917	0.390
DOC_USP7_MATH_1	223	227	PF00917	0.233
DOC_USP7_MATH_1	504	508	PF00917	0.515
DOC_USP7_MATH_1	522	526	PF00917	0.334
DOC_USP7_MATH_1	621	625	PF00917	0.428
DOC_USP7_MATH_1	702	706	PF00917	0.514
DOC_USP7_UBL2_3	197	201	PF12436	0.211
DOC_USP7_UBL2_3	537	541	PF12436	0.534
DOC_USP7_UBL2_3	892	896	PF12436	0.323
DOC_WW_Pin1_4	205	210	PF00397	0.459
DOC_WW_Pin1_4	243	248	PF00397	0.323
DOC_WW_Pin1_4	56	61	PF00397	0.342
DOC_WW_Pin1_4	710	715	PF00397	0.636
DOC_WW_Pin1_4	721	726	PF00397	0.629
DOC_WW_Pin1_4	77	82	PF00397	0.318
LIG_14-3-3_CanoR_1	181	190	PF00244	0.466
LIG_14-3-3_CanoR_1	275	281	PF00244	0.397
LIG_14-3-3_CanoR_1	367	372	PF00244	0.373
LIG_14-3-3_CanoR_1	439	445	PF00244	0.420
LIG_14-3-3_CanoR_1	488	492	PF00244	0.526
LIG_14-3-3_CanoR_1	523	527	PF00244	0.558
LIG_14-3-3_CanoR_1	617	625	PF00244	0.211
LIG_14-3-3_CanoR_1	782	786	PF00244	0.445
LIG_14-3-3_CanoR_1	788	796	PF00244	0.381
LIG_Actin_WH2_2	580	597	PF00022	0.422
LIG_BRCT_BRCA1_1	211	215	PF00533	0.464
LIG_BRCT_BRCA1_1	264	268	PF00533	0.238
LIG_BRCT_BRCA1_1	446	450	PF00533	0.440
LIG_BRCT_BRCA1_1	869	873	PF00533	0.464
LIG_Clathr_ClatBox_1	189	193	PF01394	0.466
LIG_Clathr_ClatBox_1	319	323	PF01394	0.347
LIG_Clathr_ClatBox_1	511	515	PF01394	0.274
LIG_FHA_1	112	118	PF00498	0.379
LIG_FHA_1	184	190	PF00498	0.464
LIG_FHA_1	19	25	PF00498	0.285
LIG_FHA_1	198	204	PF00498	0.216
LIG_FHA_1	563	569	PF00498	0.298
LIG_FHA_1	580	586	PF00498	0.181
LIG_FHA_1	606	612	PF00498	0.327
LIG_FHA_1	629	635	PF00498	0.478
LIG_FHA_1	8	14	PF00498	0.430
LIG_FHA_1	836	842	PF00498	0.453
LIG_FHA_1	913	919	PF00498	0.567
LIG_FHA_2	138	144	PF00498	0.420
LIG_FHA_2	150	156	PF00498	0.358
LIG_FHA_2	168	174	PF00498	0.313
LIG_FHA_2	381	387	PF00498	0.421
LIG_FHA_2	628	634	PF00498	0.440
LIG_FHA_2	827	833	PF00498	0.422
LIG_FHA_2	859	865	PF00498	0.464
LIG_GBD_Chelix_1	535	543	PF00786	0.504
LIG_LIR_Apic_2	791	796	PF02991	0.351
LIG_LIR_Apic_2	842	846	PF02991	0.422
LIG_LIR_Gen_1	114	122	PF02991	0.464
LIG_LIR_Gen_1	143	153	PF02991	0.464
LIG_LIR_Gen_1	15	24	PF02991	0.327
LIG_LIR_Gen_1	226	235	PF02991	0.433
LIG_LIR_Gen_1	265	274	PF02991	0.319
LIG_LIR_Gen_1	383	392	PF02991	0.380
LIG_LIR_Gen_1	440	449	PF02991	0.427
LIG_LIR_Gen_1	547	555	PF02991	0.423
LIG_LIR_Gen_1	604	614	PF02991	0.347
LIG_LIR_Gen_1	685	693	PF02991	0.479
LIG_LIR_Gen_1	739	750	PF02991	0.356
LIG_LIR_Gen_1	811	820	PF02991	0.379
LIG_LIR_Nem_3	114	119	PF02991	0.387
LIG_LIR_Nem_3	143	149	PF02991	0.464
LIG_LIR_Nem_3	15	19	PF02991	0.309
LIG_LIR_Nem_3	202	207	PF02991	0.356
LIG_LIR_Nem_3	226	231	PF02991	0.433
LIG_LIR_Nem_3	265	271	PF02991	0.319
LIG_LIR_Nem_3	383	387	PF02991	0.380
LIG_LIR_Nem_3	440	444	PF02991	0.393
LIG_LIR_Nem_3	49	54	PF02991	0.446
LIG_LIR_Nem_3	547	551	PF02991	0.415
LIG_LIR_Nem_3	685	691	PF02991	0.488
LIG_LIR_Nem_3	720	726	PF02991	0.587
LIG_LIR_Nem_3	739	745	PF02991	0.356
LIG_LIR_Nem_3	759	763	PF02991	0.134
LIG_LIR_Nem_3	811	817	PF02991	0.364
LIG_LIR_Nem_3	864	868	PF02991	0.323
LIG_LIR_Nem_3	906	912	PF02991	0.484
LIG_LIR_Nem_3	919	923	PF02991	0.573
LIG_MAD2	239	247	PF02301	0.464
LIG_Pex14_2	437	441	PF04695	0.323
LIG_Pex14_2	920	924	PF04695	0.601
LIG_PTB_Apo_2	110	117	PF02174	0.476
LIG_SH2_CRK	51	55	PF00017	0.447
LIG_SH2_CRK	763	767	PF00017	0.464
LIG_SH2_CRK	843	847	PF00017	0.422
LIG_SH2_GRB2like	33	36	PF00017	0.211
LIG_SH2_PTP2	638	641	PF00017	0.492
LIG_SH2_STAP1	33	37	PF00017	0.361
LIG_SH2_STAP1	384	388	PF00017	0.379
LIG_SH2_STAT5	122	125	PF00017	0.473
LIG_SH2_STAT5	169	172	PF00017	0.367
LIG_SH2_STAT5	207	210	PF00017	0.295
LIG_SH2_STAT5	297	300	PF00017	0.330
LIG_SH2_STAT5	638	641	PF00017	0.460
LIG_SH2_STAT5	662	665	PF00017	0.370
LIG_SH2_STAT5	668	671	PF00017	0.339
LIG_SH2_STAT5	808	811	PF00017	0.387
LIG_SH2_STAT5	852	855	PF00017	0.334
LIG_SH2_STAT5	866	869	PF00017	0.323
LIG_SH3_3	126	132	PF00018	0.312
LIG_SH3_3	319	325	PF00018	0.379
LIG_Sin3_3	146	153	PF02671	0.464
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.347
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.453
LIG_SUMO_SIM_anti_2	269	275	PF11976	0.397
LIG_SUMO_SIM_par_1	108	114	PF11976	0.347
LIG_SUMO_SIM_par_1	188	194	PF11976	0.464
LIG_SUMO_SIM_par_1	510	515	PF11976	0.504
LIG_SUMO_SIM_par_1	53	59	PF11976	0.256
LIG_SUMO_SIM_par_1	567	572	PF11976	0.412
LIG_SUMO_SIM_par_1	582	589	PF11976	0.307
LIG_SxIP_EBH_1	849	858	PF03271	0.464
LIG_TYR_ITIM	636	641	PF00017	0.492
LIG_UBA3_1	887	896	PF00899	0.323
LIG_WRC_WIRS_1	281	286	PF05994	0.211
LIG_WRC_WIRS_1	548	553	PF05994	0.211
MOD_CDK_SPK_2	56	61	PF00069	0.211
MOD_CDK_SPK_2	710	715	PF00069	0.632
MOD_CDK_SPxxK_3	243	250	PF00069	0.379
MOD_CDK_SPxxK_3	77	84	PF00069	0.211
MOD_CK1_1	15	21	PF00069	0.211
MOD_CK1_1	211	217	PF00069	0.456
MOD_CK1_1	224	230	PF00069	0.211
MOD_CK1_1	246	252	PF00069	0.328
MOD_CK1_1	260	266	PF00069	0.399
MOD_CK1_1	269	275	PF00069	0.386
MOD_CK1_1	370	376	PF00069	0.436
MOD_CK1_1	547	553	PF00069	0.211
MOD_CK1_1	682	688	PF00069	0.616
MOD_CK1_1	713	719	PF00069	0.617
MOD_CK1_1	821	827	PF00069	0.367
MOD_CK2_1	149	155	PF00069	0.420
MOD_CK2_1	167	173	PF00069	0.313
MOD_CK2_1	224	230	PF00069	0.444
MOD_CK2_1	380	386	PF00069	0.422
MOD_CK2_1	547	553	PF00069	0.318
MOD_CK2_1	583	589	PF00069	0.399
MOD_CK2_1	63	69	PF00069	0.332
MOD_CK2_1	733	739	PF00069	0.438
MOD_CK2_1	858	864	PF00069	0.433
MOD_GlcNHglycan	265	268	PF01048	0.476
MOD_GlcNHglycan	391	395	PF01048	0.391
MOD_GlcNHglycan	404	407	PF01048	0.415
MOD_GlcNHglycan	446	450	PF01048	0.512
MOD_GlcNHglycan	48	51	PF01048	0.234
MOD_GlcNHglycan	684	687	PF01048	0.642
MOD_GlcNHglycan	728	731	PF01048	0.534
MOD_GlcNHglycan	768	771	PF01048	0.422
MOD_GlcNHglycan	805	808	PF01048	0.357
MOD_GlcNHglycan	818	823	PF01048	0.410
MOD_GSK3_1	172	179	PF00069	0.464
MOD_GSK3_1	205	212	PF00069	0.385
MOD_GSK3_1	257	264	PF00069	0.381
MOD_GSK3_1	386	393	PF00069	0.395
MOD_GSK3_1	440	447	PF00069	0.379
MOD_GSK3_1	575	582	PF00069	0.413
MOD_GSK3_1	617	624	PF00069	0.317
MOD_GSK3_1	64	71	PF00069	0.337
MOD_GSK3_1	713	720	PF00069	0.611
MOD_GSK3_1	766	773	PF00069	0.323
MOD_GSK3_1	8	15	PF00069	0.367
MOD_GSK3_1	818	825	PF00069	0.405
MOD_GSK3_1	835	842	PF00069	0.283
MOD_GSK3_1	908	915	PF00069	0.434
MOD_N-GLC_1	224	229	PF02516	0.438
MOD_N-GLC_1	63	68	PF02516	0.332
MOD_N-GLC_2	121	123	PF02516	0.476
MOD_N-GLC_2	328	330	PF02516	0.442
MOD_NEK2_1	149	154	PF00069	0.427
MOD_NEK2_1	183	188	PF00069	0.385
MOD_NEK2_1	221	226	PF00069	0.464
MOD_NEK2_1	257	262	PF00069	0.389
MOD_NEK2_1	285	290	PF00069	0.391
MOD_NEK2_1	41	46	PF00069	0.211
MOD_NEK2_1	437	442	PF00069	0.391
MOD_NEK2_1	444	449	PF00069	0.427
MOD_NEK2_1	583	588	PF00069	0.422
MOD_NEK2_1	605	610	PF00069	0.323
MOD_NEK2_1	7	12	PF00069	0.402
MOD_NEK2_1	766	771	PF00069	0.323
MOD_NEK2_1	912	917	PF00069	0.506
MOD_NEK2_2	522	527	PF00069	0.606
MOD_NEK2_2	770	775	PF00069	0.422
MOD_PIKK_1	575	581	PF00454	0.471
MOD_PIKK_1	642	648	PF00454	0.372
MOD_PIKK_1	677	683	PF00454	0.624
MOD_PIKK_1	713	719	PF00454	0.465
MOD_PIKK_1	751	757	PF00454	0.417
MOD_PIKK_1	886	892	PF00454	0.352
MOD_PIKK_1	910	916	PF00454	0.576
MOD_PK_1	367	373	PF00069	0.268
MOD_PKA_2	274	280	PF00069	0.395
MOD_PKA_2	402	408	PF00069	0.211
MOD_PKA_2	487	493	PF00069	0.542
MOD_PKA_2	522	528	PF00069	0.604
MOD_PKA_2	562	568	PF00069	0.360
MOD_PKA_2	616	622	PF00069	0.379
MOD_PKA_2	781	787	PF00069	0.420
MOD_PKA_2	8	14	PF00069	0.400
MOD_PKB_1	615	623	PF00069	0.211
MOD_Plk_1	167	173	PF00069	0.464
MOD_Plk_1	224	230	PF00069	0.438
MOD_Plk_1	269	275	PF00069	0.323
MOD_Plk_1	277	283	PF00069	0.323
MOD_Plk_1	390	396	PF00069	0.379
MOD_Plk_1	41	47	PF00069	0.211
MOD_Plk_1	445	451	PF00069	0.552
MOD_Plk_1	68	74	PF00069	0.211
MOD_Plk_1	751	757	PF00069	0.389
MOD_Plk_2-3	684	690	PF00069	0.523
MOD_Plk_4	12	18	PF00069	0.509
MOD_Plk_4	211	217	PF00069	0.327
MOD_Plk_4	224	230	PF00069	0.311
MOD_Plk_4	257	263	PF00069	0.347
MOD_Plk_4	269	275	PF00069	0.328
MOD_Plk_4	280	286	PF00069	0.383
MOD_Plk_4	313	319	PF00069	0.356
MOD_Plk_4	41	47	PF00069	0.430
MOD_Plk_4	579	585	PF00069	0.318
MOD_Plk_4	664	670	PF00069	0.311
MOD_Plk_4	68	74	PF00069	0.285
MOD_Plk_4	733	739	PF00069	0.565
MOD_Plk_4	826	832	PF00069	0.362
MOD_ProDKin_1	205	211	PF00069	0.459
MOD_ProDKin_1	243	249	PF00069	0.323
MOD_ProDKin_1	56	62	PF00069	0.342
MOD_ProDKin_1	710	716	PF00069	0.642
MOD_ProDKin_1	721	727	PF00069	0.624
MOD_ProDKin_1	77	83	PF00069	0.318
MOD_SUMO_for_1	857	860	PF00179	0.464
MOD_SUMO_rev_2	151	159	PF00179	0.453
MOD_SUMO_rev_2	193	203	PF00179	0.211
MOD_SUMO_rev_2	503	512	PF00179	0.503
MOD_SUMO_rev_2	687	697	PF00179	0.467
TRG_DiLeu_BaEn_1	752	757	PF01217	0.323
TRG_DiLeu_BaEn_2	352	358	PF01217	0.464
TRG_DiLeu_BaEn_2	68	74	PF01217	0.211
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.422
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.508
TRG_ENDOCYTIC_2	384	387	PF00928	0.379
TRG_ENDOCYTIC_2	51	54	PF00928	0.446
TRG_ENDOCYTIC_2	638	641	PF00928	0.460
TRG_ENDOCYTIC_2	662	665	PF00928	0.433
TRG_ENDOCYTIC_2	763	766	PF00928	0.464
TRG_ENDOCYTIC_2	865	868	PF00928	0.347
TRG_ER_diArg_1	274	276	PF00400	0.422
TRG_ER_diArg_1	456	459	PF00400	0.417
TRG_ER_diArg_1	614	617	PF00400	0.417
TRG_ER_diArg_1	85	88	PF00400	0.192
TRG_NES_CRM1_1	182	196	PF08389	0.464
TRG_NES_CRM1_1	503	515	PF08389	0.286
TRG_NLS_MonoCore_2	83	88	PF00514	0.192
TRG_NLS_MonoExtN_4	81	88	PF00514	0.192
TRG_Pf-PMV_PEXEL_1	741	746	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	903	907	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I839	Leptomonas seymouri	70%	100%
A0A1X0P477	Trypanosomatidae	23%	92%
A0A1X0P6Z7	Trypanosomatidae	39%	100%
A0A3S7WUZ3	Leishmania donovani	88%	100%
A0A422P0I7	Trypanosoma rangeli	38%	100%
A4HXY1	Leishmania infantum	88%	100%
D0A5C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ARP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q11182	Caenorhabditis elegans	22%	100%
Q4QDT5	Leishmania major	88%	100%
Q55C58	Dictyostelium discoideum	25%	100%
Q5E9L7	Bos taurus	26%	100%
Q920Q4	Mus musculus	25%	100%
Q93VQ0	Arabidopsis thaliana	26%	100%
Q9H269	Homo sapiens	26%	100%
Q9UT38	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
V5BGG7	Trypanosoma cruzi	23%	92%