Putative calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C2, putative

Species:

Leishmania braziliensis

UniProt:

A4H9L6_LEIBR

TriTrypDb:

LbrM.18.1160

Length:

758

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4H9L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9L6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0019538	protein metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004175	endopeptidase activity	4	10
GO:0004197	cysteine-type endopeptidase activity	5	10
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	10
GO:0008233	peptidase activity	3	10
GO:0008234	cysteine-type peptidase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.361
CLV_NRD_NRD_1	367	369	PF00675	0.237
CLV_NRD_NRD_1	44	46	PF00675	0.449
CLV_NRD_NRD_1	562	564	PF00675	0.365
CLV_PCSK_KEX2_1	188	190	PF00082	0.304
CLV_PCSK_KEX2_1	367	369	PF00082	0.330
CLV_PCSK_KEX2_1	44	46	PF00082	0.444
CLV_PCSK_KEX2_1	561	563	PF00082	0.386
CLV_PCSK_KEX2_1	642	644	PF00082	0.478
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.304
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.282
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.449
CLV_PCSK_SKI1_1	199	203	PF00082	0.349
CLV_PCSK_SKI1_1	22	26	PF00082	0.367
CLV_PCSK_SKI1_1	242	246	PF00082	0.498
CLV_PCSK_SKI1_1	271	275	PF00082	0.303
CLV_PCSK_SKI1_1	442	446	PF00082	0.530
CLV_PCSK_SKI1_1	477	481	PF00082	0.342
CLV_PCSK_SKI1_1	48	52	PF00082	0.425
CLV_PCSK_SKI1_1	73	77	PF00082	0.486
DEG_APCC_DBOX_1	21	29	PF00400	0.296
DEG_APCC_DBOX_1	47	55	PF00400	0.351
DEG_MDM2_SWIB_1	631	639	PF02201	0.375
DEG_SPOP_SBC_1	370	374	PF00917	0.377
DEG_SPOP_SBC_1	752	756	PF00917	0.299
DOC_AGCK_PIF_1	202	207	PF00069	0.254
DOC_ANK_TNKS_1	286	293	PF00023	0.377
DOC_CYCLIN_RxL_1	19	29	PF00134	0.295
DOC_CYCLIN_RxL_1	268	276	PF00134	0.325
DOC_CYCLIN_yClb1_LxF_4	260	266	PF00134	0.382
DOC_MAPK_gen_1	44	53	PF00069	0.497
DOC_MAPK_MEF2A_6	277	285	PF00069	0.222
DOC_MAPK_MEF2A_6	658	666	PF00069	0.323
DOC_PIKK_1	55	63	PF02985	0.438
DOC_PP2B_LxvP_1	435	438	PF13499	0.377
DOC_PP4_FxxP_1	212	215	PF00568	0.530
DOC_PP4_FxxP_1	723	726	PF00568	0.400
DOC_USP7_MATH_1	512	516	PF00917	0.355
DOC_USP7_MATH_1	718	722	PF00917	0.410
DOC_USP7_UBL2_3	331	335	PF12436	0.432
DOC_WW_Pin1_4	243	248	PF00397	0.525
DOC_WW_Pin1_4	319	324	PF00397	0.564
DOC_WW_Pin1_4	366	371	PF00397	0.433
DOC_WW_Pin1_4	524	529	PF00397	0.496
DOC_WW_Pin1_4	670	675	PF00397	0.561
LIG_14-3-3_CanoR_1	148	156	PF00244	0.571
LIG_14-3-3_CanoR_1	223	228	PF00244	0.305
LIG_14-3-3_CanoR_1	368	378	PF00244	0.517
LIG_14-3-3_CanoR_1	608	617	PF00244	0.499
LIG_14-3-3_CanoR_1	643	651	PF00244	0.459
LIG_14-3-3_CanoR_1	658	663	PF00244	0.493
LIG_14-3-3_CanoR_1	751	758	PF00244	0.531
LIG_Actin_WH2_2	132	150	PF00022	0.324
LIG_APCC_ABBA_1	286	291	PF00400	0.479
LIG_APCC_ABBA_1	482	487	PF00400	0.370
LIG_APCC_ABBA_1	739	744	PF00400	0.230
LIG_BIR_II_1	1	5	PF00653	0.422
LIG_BRCT_BRCA1_1	371	375	PF00533	0.515
LIG_BRCT_BRCA1_1	507	511	PF00533	0.315
LIG_BRCT_BRCA1_1	574	578	PF00533	0.480
LIG_BRCT_BRCA1_1	627	631	PF00533	0.532
LIG_BRCT_BRCA1_1	672	676	PF00533	0.626
LIG_BRCT_BRCA1_2	507	513	PF00533	0.288
LIG_DLG_GKlike_1	658	666	PF00625	0.260
LIG_EH1_1	127	135	PF00400	0.383
LIG_eIF4E_1	124	130	PF01652	0.266
LIG_eIF4E_1	342	348	PF01652	0.377
LIG_FHA_1	150	156	PF00498	0.487
LIG_FHA_1	157	163	PF00498	0.533
LIG_FHA_1	185	191	PF00498	0.377
LIG_FHA_1	257	263	PF00498	0.303
LIG_FHA_1	438	444	PF00498	0.543
LIG_FHA_1	453	459	PF00498	0.431
LIG_FHA_1	657	663	PF00498	0.464
LIG_FHA_1	686	692	PF00498	0.565
LIG_FHA_1	704	710	PF00498	0.431
LIG_FHA_1	752	758	PF00498	0.606
LIG_FHA_2	357	363	PF00498	0.569
LIG_FHA_2	371	377	PF00498	0.414
LIG_FHA_2	394	400	PF00498	0.465
LIG_FHA_2	492	498	PF00498	0.459
LIG_FHA_2	698	704	PF00498	0.405
LIG_Integrin_isoDGR_2	309	311	PF01839	0.177
LIG_LIR_Apic_2	210	215	PF02991	0.501
LIG_LIR_Apic_2	276	281	PF02991	0.186
LIG_LIR_Apic_2	720	726	PF02991	0.407
LIG_LIR_Gen_1	200	209	PF02991	0.365
LIG_LIR_Gen_1	322	333	PF02991	0.484
LIG_LIR_Gen_1	350	355	PF02991	0.405
LIG_LIR_Gen_1	372	381	PF02991	0.497
LIG_LIR_Gen_1	426	437	PF02991	0.469
LIG_LIR_Gen_1	467	475	PF02991	0.377
LIG_LIR_Gen_1	476	485	PF02991	0.361
LIG_LIR_Gen_1	502	512	PF02991	0.249
LIG_LIR_Gen_1	632	641	PF02991	0.410
LIG_LIR_Gen_1	8	16	PF02991	0.471
LIG_LIR_Nem_3	196	201	PF02991	0.423
LIG_LIR_Nem_3	225	230	PF02991	0.439
LIG_LIR_Nem_3	322	328	PF02991	0.451
LIG_LIR_Nem_3	350	354	PF02991	0.410
LIG_LIR_Nem_3	372	378	PF02991	0.456
LIG_LIR_Nem_3	426	432	PF02991	0.497
LIG_LIR_Nem_3	449	453	PF02991	0.473
LIG_LIR_Nem_3	467	471	PF02991	0.372
LIG_LIR_Nem_3	476	482	PF02991	0.360
LIG_LIR_Nem_3	502	507	PF02991	0.376
LIG_LIR_Nem_3	632	638	PF02991	0.565
LIG_LIR_Nem_3	8	12	PF02991	0.350
LIG_LRP6_Inhibitor_1	100	106	PF00058	0.342
LIG_NRBOX	342	348	PF00104	0.377
LIG_PCNA_yPIPBox_3	106	119	PF02747	0.374
LIG_PDZ_Class_1	753	758	PF00595	0.314
LIG_Pex14_2	464	468	PF04695	0.438
LIG_Pex14_2	471	475	PF04695	0.418
LIG_Pex14_2	479	483	PF04695	0.414
LIG_Pex14_2	631	635	PF04695	0.358
LIG_RPA_C_Fungi	136	148	PF08784	0.351
LIG_SH2_CRK	198	202	PF00017	0.413
LIG_SH2_CRK	227	231	PF00017	0.556
LIG_SH2_CRK	266	270	PF00017	0.468
LIG_SH2_CRK	325	329	PF00017	0.338
LIG_SH2_CRK	340	344	PF00017	0.190
LIG_SH2_CRK	391	395	PF00017	0.186
LIG_SH2_CRK	550	554	PF00017	0.288
LIG_SH2_GRB2like	307	310	PF00017	0.186
LIG_SH2_PTP2	351	354	PF00017	0.246
LIG_SH2_PTP2	429	432	PF00017	0.207
LIG_SH2_SRC	124	127	PF00017	0.369
LIG_SH2_SRC	307	310	PF00017	0.186
LIG_SH2_SRC	391	394	PF00017	0.186
LIG_SH2_STAP1	325	329	PF00017	0.469
LIG_SH2_STAP1	446	450	PF00017	0.501
LIG_SH2_STAP1	737	741	PF00017	0.343
LIG_SH2_STAT3	251	254	PF00017	0.396
LIG_SH2_STAT5	124	127	PF00017	0.516
LIG_SH2_STAT5	128	131	PF00017	0.474
LIG_SH2_STAT5	227	230	PF00017	0.478
LIG_SH2_STAT5	284	287	PF00017	0.393
LIG_SH2_STAT5	307	310	PF00017	0.287
LIG_SH2_STAT5	342	345	PF00017	0.309
LIG_SH2_STAT5	351	354	PF00017	0.246
LIG_SH2_STAT5	41	44	PF00017	0.426
LIG_SH2_STAT5	429	432	PF00017	0.392
LIG_SH2_STAT5	727	730	PF00017	0.424
LIG_SH2_STAT5	9	12	PF00017	0.413
LIG_SH3_3	115	121	PF00018	0.266
LIG_SH3_3	671	677	PF00018	0.506
LIG_SUMO_SIM_anti_2	131	138	PF11976	0.371
LIG_SUMO_SIM_anti_2	350	356	PF11976	0.373
LIG_SUMO_SIM_anti_2	659	664	PF11976	0.515
LIG_SUMO_SIM_par_1	131	138	PF11976	0.371
LIG_SUMO_SIM_par_1	525	532	PF11976	0.361
LIG_SUMO_SIM_par_1	624	630	PF11976	0.445
LIG_SUMO_SIM_par_1	661	667	PF11976	0.378
LIG_TRAF2_1	700	703	PF00917	0.467
LIG_TRFH_1	587	591	PF08558	0.436
LIG_TYR_ITIM	548	553	PF00017	0.317
LIG_TYR_ITSM	194	201	PF00017	0.416
LIG_WRC_WIRS_1	709	714	PF05994	0.504
MOD_CK1_1	146	152	PF00069	0.575
MOD_CK1_1	175	181	PF00069	0.525
MOD_CK1_1	184	190	PF00069	0.432
MOD_CK1_1	197	203	PF00069	0.441
MOD_CK1_1	246	252	PF00069	0.432
MOD_CK1_1	319	325	PF00069	0.327
MOD_CK1_1	369	375	PF00069	0.369
MOD_CK1_1	506	512	PF00069	0.347
MOD_CK1_1	667	673	PF00069	0.495
MOD_CK1_1	85	91	PF00069	0.367
MOD_CK2_1	180	186	PF00069	0.581
MOD_CK2_1	356	362	PF00069	0.454
MOD_CK2_1	377	383	PF00069	0.259
MOD_CK2_1	393	399	PF00069	0.323
MOD_CK2_1	491	497	PF00069	0.392
MOD_CK2_1	697	703	PF00069	0.499
MOD_Cter_Amidation	169	172	PF01082	0.376
MOD_GlcNHglycan	177	180	PF01048	0.517
MOD_GlcNHglycan	36	40	PF01048	0.557
MOD_GlcNHglycan	404	408	PF01048	0.436
MOD_GlcNHglycan	536	539	PF01048	0.606
MOD_GlcNHglycan	611	614	PF01048	0.264
MOD_GlcNHglycan	617	620	PF01048	0.386
MOD_GlcNHglycan	631	634	PF01048	0.393
MOD_GlcNHglycan	98	101	PF01048	0.413
MOD_GSK3_1	1	8	PF00069	0.457
MOD_GSK3_1	110	117	PF00069	0.489
MOD_GSK3_1	120	127	PF00069	0.360
MOD_GSK3_1	143	150	PF00069	0.542
MOD_GSK3_1	180	187	PF00069	0.507
MOD_GSK3_1	193	200	PF00069	0.409
MOD_GSK3_1	315	322	PF00069	0.260
MOD_GSK3_1	366	373	PF00069	0.461
MOD_GSK3_1	412	419	PF00069	0.277
MOD_GSK3_1	499	506	PF00069	0.330
MOD_GSK3_1	529	536	PF00069	0.477
MOD_GSK3_1	598	605	PF00069	0.351
MOD_GSK3_1	625	632	PF00069	0.526
MOD_GSK3_1	708	715	PF00069	0.470
MOD_GSK3_1	747	754	PF00069	0.566
MOD_GSK3_1	81	88	PF00069	0.474
MOD_N-GLC_1	513	518	PF02516	0.320
MOD_N-GLC_1	564	569	PF02516	0.304
MOD_N-GLC_1	615	620	PF02516	0.300
MOD_N-GLC_1	683	688	PF02516	0.297
MOD_N-GLC_2	255	257	PF02516	0.497
MOD_NEK2_1	1	6	PF00069	0.346
MOD_NEK2_1	147	152	PF00069	0.571
MOD_NEK2_1	156	161	PF00069	0.589
MOD_NEK2_1	180	185	PF00069	0.526
MOD_NEK2_1	194	199	PF00069	0.508
MOD_NEK2_1	256	261	PF00069	0.254
MOD_NEK2_1	269	274	PF00069	0.441
MOD_NEK2_1	35	40	PF00069	0.348
MOD_NEK2_1	403	408	PF00069	0.333
MOD_NEK2_1	505	510	PF00069	0.379
MOD_NEK2_1	533	538	PF00069	0.389
MOD_NEK2_1	595	600	PF00069	0.293
MOD_NEK2_1	629	634	PF00069	0.454
MOD_NEK2_1	664	669	PF00069	0.527
MOD_NEK2_1	712	717	PF00069	0.384
MOD_NEK2_1	747	752	PF00069	0.414
MOD_NEK2_1	82	87	PF00069	0.429
MOD_NEK2_2	228	233	PF00069	0.375
MOD_NEK2_2	718	723	PF00069	0.490
MOD_NEK2_2	737	742	PF00069	0.195
MOD_PIKK_1	1	7	PF00454	0.341
MOD_PIKK_1	506	512	PF00454	0.345
MOD_PIKK_1	538	544	PF00454	0.304
MOD_PIKK_1	664	670	PF00454	0.377
MOD_PIKK_1	697	703	PF00454	0.469
MOD_PKA_1	642	648	PF00069	0.412
MOD_PKA_2	147	153	PF00069	0.533
MOD_PKA_2	222	228	PF00069	0.386
MOD_PKA_2	609	615	PF00069	0.428
MOD_PKA_2	642	648	PF00069	0.473
MOD_Plk_1	172	178	PF00069	0.576
MOD_Plk_1	203	209	PF00069	0.446
MOD_Plk_1	513	519	PF00069	0.271
MOD_Plk_1	656	662	PF00069	0.357
MOD_Plk_1	737	743	PF00069	0.408
MOD_Plk_4	114	120	PF00069	0.460
MOD_Plk_4	124	130	PF00069	0.415
MOD_Plk_4	197	203	PF00069	0.405
MOD_Plk_4	228	234	PF00069	0.351
MOD_Plk_4	269	275	PF00069	0.387
MOD_Plk_4	5	11	PF00069	0.437
MOD_Plk_4	513	519	PF00069	0.315
MOD_Plk_4	529	535	PF00069	0.245
MOD_Plk_4	622	628	PF00069	0.379
MOD_Plk_4	634	640	PF00069	0.488
MOD_Plk_4	708	714	PF00069	0.422
MOD_Plk_4	718	724	PF00069	0.372
MOD_Plk_4	737	743	PF00069	0.198
MOD_ProDKin_1	243	249	PF00069	0.529
MOD_ProDKin_1	319	325	PF00069	0.447
MOD_ProDKin_1	366	372	PF00069	0.265
MOD_ProDKin_1	524	530	PF00069	0.491
MOD_ProDKin_1	670	676	PF00069	0.551
MOD_SUMO_rev_2	183	190	PF00179	0.424
MOD_SUMO_rev_2	69	78	PF00179	0.336
TRG_DiLeu_BaEn_1	111	116	PF01217	0.449
TRG_DiLeu_BaEn_1	476	481	PF01217	0.358
TRG_DiLeu_BaEn_1	720	725	PF01217	0.397
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.314
TRG_ENDOCYTIC_2	198	201	PF00928	0.431
TRG_ENDOCYTIC_2	227	230	PF00928	0.537
TRG_ENDOCYTIC_2	266	269	PF00928	0.420
TRG_ENDOCYTIC_2	325	328	PF00928	0.338
TRG_ENDOCYTIC_2	340	343	PF00928	0.190
TRG_ENDOCYTIC_2	351	354	PF00928	0.246
TRG_ENDOCYTIC_2	429	432	PF00928	0.285
TRG_ENDOCYTIC_2	550	553	PF00928	0.337
TRG_ENDOCYTIC_2	9	12	PF00928	0.351
TRG_ER_diArg_1	366	368	PF00400	0.231
TRG_ER_diArg_1	43	45	PF00400	0.345
TRG_ER_diArg_1	562	564	PF00400	0.368
TRG_ER_diArg_1	607	610	PF00400	0.353
TRG_ER_diArg_1	649	652	PF00400	0.373
TRG_NES_CRM1_1	59	74	PF08389	0.275
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF13	Leptomonas seymouri	48%	100%
A0A1X0P7A0	Trypanosomatidae	27%	100%
A0A3Q8IB60	Leishmania donovani	72%	99%
A0A3R7KWU1	Trypanosoma rangeli	28%	100%
A4HXY0	Leishmania infantum	72%	99%
D0A5C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4QDT6	Leishmania major	72%	100%