Ethanolamine-phosphate cytidylyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cholinephosphate cytidylyltransferase A, putative

Species:

Leishmania braziliensis

UniProt:

A4H9L4_LEIBR

TriTrypDb:

LbrM.18.1140 , LBRM2903_180019700

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4H9L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9L4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006646	phosphatidylethanolamine biosynthetic process	6	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046337	phosphatidylethanolamine metabolic process	6	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0070567	cytidylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	385	387	PF00675	0.317
CLV_NRD_NRD_1	574	576	PF00675	0.535
CLV_PCSK_KEX2_1	196	198	PF00082	0.348
CLV_PCSK_KEX2_1	332	334	PF00082	0.310
CLV_PCSK_KEX2_1	385	387	PF00082	0.317
CLV_PCSK_KEX2_1	476	478	PF00082	0.276
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.315
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.325
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.276
CLV_PCSK_SKI1_1	134	138	PF00082	0.737
CLV_PCSK_SKI1_1	199	203	PF00082	0.332
CLV_PCSK_SKI1_1	300	304	PF00082	0.573
CLV_PCSK_SKI1_1	433	437	PF00082	0.306
CLV_PCSK_SKI1_1	47	51	PF00082	0.536
DEG_APCC_DBOX_1	299	307	PF00400	0.411
DEG_APCC_DBOX_1	46	54	PF00400	0.263
DEG_SCF_FBW7_1	547	554	PF00400	0.639
DOC_CKS1_1	428	433	PF01111	0.629
DOC_CKS1_1	527	532	PF01111	0.640
DOC_CKS1_1	548	553	PF01111	0.648
DOC_CYCLIN_RxL_1	44	52	PF00134	0.417
DOC_MAPK_gen_1	329	339	PF00069	0.558
DOC_MAPK_gen_1	385	393	PF00069	0.560
DOC_MAPK_HePTP_8	233	245	PF00069	0.337
DOC_MAPK_MEF2A_6	217	224	PF00069	0.449
DOC_MAPK_MEF2A_6	236	245	PF00069	0.337
DOC_MAPK_MEF2A_6	300	307	PF00069	0.394
DOC_MAPK_MEF2A_6	333	342	PF00069	0.477
DOC_MAPK_MEF2A_6	36	45	PF00069	0.395
DOC_MAPK_MEF2A_6	457	466	PF00069	0.537
DOC_MAPK_NFAT4_5	217	225	PF00069	0.449
DOC_MAPK_RevD_3	370	386	PF00069	0.379
DOC_PP1_SILK_1	541	546	PF00149	0.522
DOC_PP2B_LxvP_1	153	156	PF13499	0.516
DOC_PP2B_LxvP_1	424	427	PF13499	0.536
DOC_PP2B_LxvP_1	53	56	PF13499	0.429
DOC_USP7_MATH_1	146	150	PF00917	0.525
DOC_USP7_UBL2_3	262	266	PF12436	0.670
DOC_USP7_UBL2_3	331	335	PF12436	0.577
DOC_WW_Pin1_4	427	432	PF00397	0.627
DOC_WW_Pin1_4	500	505	PF00397	0.476
DOC_WW_Pin1_4	526	531	PF00397	0.562
DOC_WW_Pin1_4	547	552	PF00397	0.646
LIG_14-3-3_CanoR_1	154	164	PF00244	0.515
LIG_14-3-3_CanoR_1	168	178	PF00244	0.356
LIG_14-3-3_CanoR_1	197	204	PF00244	0.530
LIG_14-3-3_CanoR_1	21	30	PF00244	0.426
LIG_14-3-3_CanoR_1	210	216	PF00244	0.479
LIG_14-3-3_CanoR_1	47	56	PF00244	0.365
LIG_14-3-3_CanoR_1	494	501	PF00244	0.461
LIG_14-3-3_CanoR_1	563	570	PF00244	0.616
LIG_14-3-3_CanoR_1	575	582	PF00244	0.664
LIG_Actin_WH2_2	91	106	PF00022	0.521
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_BRCT_BRCA1_1	7	11	PF00533	0.359
LIG_Clathr_ClatBox_1	372	376	PF01394	0.344
LIG_EH1_1	282	290	PF00400	0.449
LIG_EH1_1	411	419	PF00400	0.522
LIG_eIF4E_1	334	340	PF01652	0.581
LIG_eIF4E_1	412	418	PF01652	0.549
LIG_eIF4E_1	515	521	PF01652	0.400
LIG_FHA_1	156	162	PF00498	0.499
LIG_FHA_1	170	176	PF00498	0.242
LIG_FHA_1	240	246	PF00498	0.358
LIG_FHA_1	314	320	PF00498	0.395
LIG_FHA_1	548	554	PF00498	0.560
LIG_FHA_1	577	583	PF00498	0.595
LIG_FHA_2	10	16	PF00498	0.341
LIG_FHA_2	221	227	PF00498	0.363
LIG_FHA_2	480	486	PF00498	0.476
LIG_FHA_2	527	533	PF00498	0.623
LIG_IRF3_LxIS_1	178	184	PF10401	0.451
LIG_LIR_Apic_2	474	478	PF02991	0.562
LIG_LIR_Apic_2	525	530	PF02991	0.477
LIG_LIR_Apic_2	532	538	PF02991	0.538
LIG_LIR_Gen_1	158	164	PF02991	0.502
LIG_LIR_Gen_1	206	216	PF02991	0.487
LIG_LIR_Gen_1	280	291	PF02991	0.358
LIG_LIR_Gen_1	321	330	PF02991	0.365
LIG_LIR_LC3C_4	316	319	PF02991	0.449
LIG_LIR_Nem_3	158	163	PF02991	0.497
LIG_LIR_Nem_3	206	211	PF02991	0.495
LIG_LIR_Nem_3	235	241	PF02991	0.284
LIG_LIR_Nem_3	280	286	PF02991	0.357
LIG_LIR_Nem_3	321	325	PF02991	0.403
LIG_LIR_Nem_3	35	41	PF02991	0.371
LIG_LIR_Nem_3	356	361	PF02991	0.430
LIG_LIR_Nem_3	531	537	PF02991	0.549
LIG_LIR_Nem_3	76	80	PF02991	0.398
LIG_NRBOX	175	181	PF00104	0.363
LIG_NRBOX	283	289	PF00104	0.475
LIG_NRBOX	395	401	PF00104	0.635
LIG_NRBOX	60	66	PF00104	0.396
LIG_Pex14_2	38	42	PF04695	0.369
LIG_PTB_Apo_2	264	271	PF02174	0.664
LIG_PTB_Apo_2	72	79	PF02174	0.443
LIG_PTB_Phospho_1	264	270	PF10480	0.663
LIG_PTB_Phospho_1	72	78	PF10480	0.435
LIG_SH2_CRK	314	318	PF00017	0.343
LIG_SH2_CRK	334	338	PF00017	0.587
LIG_SH2_CRK	358	362	PF00017	0.324
LIG_SH2_CRK	475	479	PF00017	0.562
LIG_SH2_CRK	527	531	PF00017	0.501
LIG_SH2_CRK	535	539	PF00017	0.504
LIG_SH2_CRK	71	75	PF00017	0.322
LIG_SH2_GRB2like	515	518	PF00017	0.562
LIG_SH2_NCK_1	527	531	PF00017	0.476
LIG_SH2_SRC	412	415	PF00017	0.535
LIG_SH2_STAP1	422	426	PF00017	0.530
LIG_SH2_STAT5	160	163	PF00017	0.504
LIG_SH2_STAT5	238	241	PF00017	0.363
LIG_SH2_STAT5	270	273	PF00017	0.590
LIG_SH2_STAT5	274	277	PF00017	0.560
LIG_SH2_STAT5	351	354	PF00017	0.632
LIG_SH2_STAT5	378	381	PF00017	0.560
LIG_SH2_STAT5	412	415	PF00017	0.510
LIG_SH2_STAT5	495	498	PF00017	0.562
LIG_SH3_1	545	551	PF00018	0.629
LIG_SH3_3	149	155	PF00018	0.363
LIG_SH3_3	34	40	PF00018	0.359
LIG_SH3_3	498	504	PF00018	0.501
LIG_SH3_3	545	551	PF00018	0.640
LIG_SH3_5	156	160	PF00018	0.538
LIG_SUMO_SIM_anti_2	174	180	PF11976	0.453
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.420
LIG_SUMO_SIM_par_1	178	184	PF11976	0.362
LIG_SUMO_SIM_par_1	244	250	PF11976	0.449
LIG_SUMO_SIM_par_1	315	321	PF11976	0.364
LIG_SUMO_SIM_par_1	371	376	PF11976	0.384
LIG_SUMO_SIM_par_1	416	421	PF11976	0.514
LIG_TRAF2_1	12	15	PF00917	0.449
LIG_TRAF2_1	482	485	PF00917	0.473
LIG_TRFH_1	350	354	PF08558	0.413
LIG_TYR_ITIM	312	317	PF00017	0.475
LIG_TYR_ITIM	513	518	PF00017	0.562
LIG_UBA3_1	302	309	PF00899	0.435
LIG_UBA3_1	327	335	PF00899	0.569
LIG_WRC_WIRS_1	319	324	PF05994	0.344
MOD_CDK_SPxK_1	427	433	PF00069	0.629
MOD_CK1_1	200	206	PF00069	0.556
MOD_CK1_1	279	285	PF00069	0.328
MOD_CK1_1	32	38	PF00069	0.357
MOD_CK1_1	503	509	PF00069	0.487
MOD_CK1_1	566	572	PF00069	0.667
MOD_CK1_1	577	583	PF00069	0.655
MOD_CK2_1	220	226	PF00069	0.363
MOD_CK2_1	479	485	PF00069	0.461
MOD_CK2_1	9	15	PF00069	0.350
MOD_GlcNHglycan	122	125	PF01048	0.755
MOD_GlcNHglycan	142	145	PF01048	0.718
MOD_GlcNHglycan	148	151	PF01048	0.707
MOD_GlcNHglycan	199	202	PF01048	0.333
MOD_GSK3_1	140	147	PF00069	0.514
MOD_GSK3_1	206	213	PF00069	0.537
MOD_GSK3_1	21	28	PF00069	0.410
MOD_GSK3_1	402	409	PF00069	0.531
MOD_GSK3_1	5	12	PF00069	0.373
MOD_GSK3_1	526	533	PF00069	0.623
MOD_GSK3_1	543	550	PF00069	0.453
MOD_GSK3_1	553	560	PF00069	0.545
MOD_N-GLC_1	255	260	PF02516	0.419
MOD_NEK2_1	181	186	PF00069	0.393
MOD_NEK2_1	220	225	PF00069	0.336
MOD_NEK2_1	239	244	PF00069	0.342
MOD_NEK2_1	420	425	PF00069	0.525
MOD_NEK2_1	5	10	PF00069	0.455
MOD_NEK2_1	64	69	PF00069	0.312
MOD_NEK2_1	73	78	PF00069	0.326
MOD_PIKK_1	353	359	PF00454	0.475
MOD_PKA_2	276	282	PF00069	0.476
MOD_PKA_2	43	49	PF00069	0.397
MOD_PKA_2	574	580	PF00069	0.720
MOD_PKB_1	197	205	PF00069	0.604
MOD_PKB_1	561	569	PF00069	0.597
MOD_Plk_1	113	119	PF00069	0.567
MOD_Plk_1	166	172	PF00069	0.447
MOD_Plk_1	279	285	PF00069	0.343
MOD_Plk_1	418	424	PF00069	0.518
MOD_Plk_1	5	11	PF00069	0.375
MOD_Plk_1	566	572	PF00069	0.700
MOD_Plk_4	113	119	PF00069	0.567
MOD_Plk_4	171	177	PF00069	0.320
MOD_Plk_4	220	226	PF00069	0.335
MOD_Plk_4	247	253	PF00069	0.342
MOD_Plk_4	279	285	PF00069	0.362
MOD_Plk_4	29	35	PF00069	0.376
MOD_Plk_4	313	319	PF00069	0.351
MOD_Plk_4	359	365	PF00069	0.339
MOD_Plk_4	395	401	PF00069	0.530
MOD_Plk_4	406	412	PF00069	0.512
MOD_Plk_4	5	11	PF00069	0.375
MOD_Plk_4	530	536	PF00069	0.566
MOD_Plk_4	553	559	PF00069	0.541
MOD_Plk_4	73	79	PF00069	0.427
MOD_ProDKin_1	427	433	PF00069	0.629
MOD_ProDKin_1	500	506	PF00069	0.476
MOD_ProDKin_1	526	532	PF00069	0.562
MOD_ProDKin_1	547	553	PF00069	0.642
MOD_SUMO_rev_2	568	577	PF00179	0.721
MOD_SUMO_rev_2	87	97	PF00179	0.428
TRG_DiLeu_BaEn_1	14	19	PF01217	0.444
TRG_DiLeu_BaEn_1	280	285	PF01217	0.363
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.476
TRG_ENDOCYTIC_2	160	163	PF00928	0.485
TRG_ENDOCYTIC_2	238	241	PF00928	0.344
TRG_ENDOCYTIC_2	314	317	PF00928	0.364
TRG_ENDOCYTIC_2	334	337	PF00928	0.638
TRG_ENDOCYTIC_2	358	361	PF00928	0.313
TRG_ENDOCYTIC_2	515	518	PF00928	0.559
TRG_ENDOCYTIC_2	534	537	PF00928	0.443
TRG_ENDOCYTIC_2	71	74	PF00928	0.305
TRG_ENDOCYTIC_2	77	80	PF00928	0.373
TRG_ER_diArg_1	385	387	PF00400	0.518
TRG_ER_diLys_1	581	586	PF00400	0.615
TRG_NLS_MonoExtC_3	330	335	PF00514	0.512
TRG_NLS_MonoExtN_4	329	336	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	47	52	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I259	Leptomonas seymouri	79%	100%
A0A0S4JNN5	Bodo saltans	45%	100%
A0A1X0P717	Trypanosomatidae	61%	100%
A0A3Q8IA23	Leishmania donovani	92%	99%
A0A422P0J5	Trypanosoma rangeli	60%	100%
A4HY04	Leishmania infantum	92%	99%
D0A5A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ARR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4QDQ6	Leishmania major	89%	100%
V5BEI8	Trypanosoma cruzi	59%	100%