Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9L3_LEIBR

TriTrypDb:

LbrM.18.1130 , LBRM2903_180019800

Length:

748

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9L3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	424	426	PF00675	0.491
CLV_NRD_NRD_1	448	450	PF00675	0.499
CLV_NRD_NRD_1	595	597	PF00675	0.556
CLV_PCSK_FUR_1	528	532	PF00082	0.470
CLV_PCSK_KEX2_1	530	532	PF00082	0.487
CLV_PCSK_KEX2_1	595	597	PF00082	0.556
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.487
CLV_PCSK_SKI1_1	420	424	PF00082	0.580
CLV_PCSK_SKI1_1	425	429	PF00082	0.528
CLV_PCSK_SKI1_1	6	10	PF00082	0.616
DEG_APCC_KENBOX_2	322	326	PF00400	0.525
DOC_CDC14_PxL_1	467	475	PF14671	0.482
DOC_CKS1_1	175	180	PF01111	0.530
DOC_CKS1_1	691	696	PF01111	0.665
DOC_CYCLIN_RxL_1	457	469	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	605	608	PF00134	0.567
DOC_MAPK_gen_1	449	458	PF00069	0.464
DOC_MAPK_MEF2A_6	203	212	PF00069	0.522
DOC_PP2B_LxvP_1	401	404	PF13499	0.456
DOC_PP2B_LxvP_1	605	608	PF13499	0.567
DOC_PP2B_LxvP_1	650	653	PF13499	0.516
DOC_PP2B_PxIxI_1	44	50	PF00149	0.700
DOC_PP4_FxxP_1	164	167	PF00568	0.601
DOC_PP4_FxxP_1	246	249	PF00568	0.502
DOC_PP4_FxxP_1	633	636	PF00568	0.642
DOC_PP4_FxxP_1	707	710	PF00568	0.510
DOC_USP7_MATH_1	185	189	PF00917	0.667
DOC_USP7_MATH_1	237	241	PF00917	0.559
DOC_USP7_MATH_1	29	33	PF00917	0.528
DOC_USP7_MATH_1	412	416	PF00917	0.359
DOC_USP7_MATH_1	559	563	PF00917	0.613
DOC_USP7_MATH_1	578	582	PF00917	0.538
DOC_USP7_MATH_1	66	70	PF00917	0.604
DOC_USP7_MATH_1	715	719	PF00917	0.657
DOC_USP7_MATH_1	742	746	PF00917	0.531
DOC_USP7_MATH_1	83	87	PF00917	0.530
DOC_USP7_MATH_2	489	495	PF00917	0.359
DOC_WW_Pin1_4	123	128	PF00397	0.658
DOC_WW_Pin1_4	163	168	PF00397	0.629
DOC_WW_Pin1_4	174	179	PF00397	0.544
DOC_WW_Pin1_4	245	250	PF00397	0.623
DOC_WW_Pin1_4	263	268	PF00397	0.667
DOC_WW_Pin1_4	300	305	PF00397	0.714
DOC_WW_Pin1_4	335	340	PF00397	0.695
DOC_WW_Pin1_4	41	46	PF00397	0.692
DOC_WW_Pin1_4	594	599	PF00397	0.548
DOC_WW_Pin1_4	626	631	PF00397	0.610
DOC_WW_Pin1_4	644	649	PF00397	0.602
DOC_WW_Pin1_4	658	663	PF00397	0.631
DOC_WW_Pin1_4	690	695	PF00397	0.700
DOC_WW_Pin1_4	740	745	PF00397	0.533
LIG_14-3-3_CanoR_1	107	111	PF00244	0.673
LIG_14-3-3_CanoR_1	283	287	PF00244	0.568
LIG_14-3-3_CanoR_1	39	45	PF00244	0.554
LIG_14-3-3_CanoR_1	411	417	PF00244	0.370
LIG_14-3-3_CanoR_1	425	430	PF00244	0.330
LIG_14-3-3_CanoR_1	463	468	PF00244	0.315
LIG_BRCT_BRCA1_1	119	123	PF00533	0.684
LIG_BRCT_BRCA1_1	59	63	PF00533	0.542
LIG_BRCT_BRCA1_2	59	65	PF00533	0.543
LIG_CSL_BTD_1	738	741	PF09270	0.534
LIG_EH1_1	205	213	PF00400	0.520
LIG_eIF4E_1	686	692	PF01652	0.679
LIG_FHA_1	200	206	PF00498	0.533
LIG_FHA_1	223	229	PF00498	0.528
LIG_FHA_1	237	243	PF00498	0.725
LIG_FHA_1	509	515	PF00498	0.518
LIG_FHA_1	627	633	PF00498	0.516
LIG_FHA_1	640	646	PF00498	0.492
LIG_FHA_1	700	706	PF00498	0.516
LIG_FHA_1	77	83	PF00498	0.640
LIG_FHA_2	157	163	PF00498	0.547
LIG_FHA_2	270	276	PF00498	0.566
LIG_FHA_2	312	318	PF00498	0.519
LIG_HP1_1	670	674	PF01393	0.674
LIG_LIR_Apic_2	162	167	PF02991	0.533
LIG_LIR_Apic_2	172	178	PF02991	0.512
LIG_LIR_Apic_2	244	249	PF02991	0.506
LIG_LIR_Apic_2	631	636	PF02991	0.651
LIG_LIR_Apic_2	736	742	PF02991	0.528
LIG_LIR_Gen_1	120	128	PF02991	0.567
LIG_LIR_Gen_1	394	405	PF02991	0.458
LIG_LIR_Nem_3	120	124	PF02991	0.583
LIG_LIR_Nem_3	394	400	PF02991	0.587
LIG_LIR_Nem_3	469	473	PF02991	0.475
LIG_LIR_Nem_3	642	646	PF02991	0.526
LIG_LYPXL_yS_3	470	473	PF13949	0.588
LIG_LYPXL_yS_3	643	646	PF13949	0.682
LIG_MYND_1	603	607	PF01753	0.564
LIG_MYND_1	644	648	PF01753	0.598
LIG_PDZ_Class_1	743	748	PF00595	0.535
LIG_SH2_GRB2like	521	524	PF00017	0.590
LIG_SH2_PTP2	671	674	PF00017	0.673
LIG_SH2_SRC	364	367	PF00017	0.544
LIG_SH2_SRC	686	689	PF00017	0.654
LIG_SH2_STAP1	393	397	PF00017	0.484
LIG_SH2_STAT5	200	203	PF00017	0.568
LIG_SH2_STAT5	245	248	PF00017	0.558
LIG_SH2_STAT5	521	524	PF00017	0.476
LIG_SH2_STAT5	671	674	PF00017	0.673
LIG_SH2_STAT5	686	689	PF00017	0.524
LIG_SH3_1	601	607	PF00018	0.515
LIG_SH3_3	121	127	PF00018	0.502
LIG_SH3_3	192	198	PF00018	0.645
LIG_SH3_3	301	307	PF00018	0.711
LIG_SH3_3	330	336	PF00018	0.560
LIG_SH3_3	351	357	PF00018	0.550
LIG_SH3_3	39	45	PF00018	0.636
LIG_SH3_3	468	474	PF00018	0.596
LIG_SH3_3	478	484	PF00018	0.461
LIG_SH3_3	558	564	PF00018	0.531
LIG_SH3_3	601	607	PF00018	0.584
LIG_SH3_3	656	662	PF00018	0.685
LIG_SH3_3	735	741	PF00018	0.526
LIG_SUMO_SIM_anti_2	329	336	PF11976	0.536
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.625
LIG_TRAF2_1	384	387	PF00917	0.536
LIG_WRC_WIRS_1	286	291	PF05994	0.545
MOD_CDK_SPK_2	300	305	PF00069	0.717
MOD_CDK_SPxxK_3	335	342	PF00069	0.566
MOD_CDK_SPxxK_3	594	601	PF00069	0.533
MOD_CK1_1	106	112	PF00069	0.609
MOD_CK1_1	12	18	PF00069	0.626
MOD_CK1_1	126	132	PF00069	0.456
MOD_CK1_1	146	152	PF00069	0.742
MOD_CK1_1	157	163	PF00069	0.552
MOD_CK1_1	166	172	PF00069	0.557
MOD_CK1_1	180	186	PF00069	0.528
MOD_CK1_1	217	223	PF00069	0.782
MOD_CK1_1	224	230	PF00069	0.690
MOD_CK1_1	244	250	PF00069	0.754
MOD_CK1_1	260	266	PF00069	0.636
MOD_CK1_1	276	282	PF00069	0.507
MOD_CK1_1	318	324	PF00069	0.577
MOD_CK1_1	40	46	PF00069	0.666
MOD_CK1_1	452	458	PF00069	0.454
MOD_CK1_1	466	472	PF00069	0.338
MOD_CK1_1	48	54	PF00069	0.642
MOD_CK1_1	64	70	PF00069	0.615
MOD_CK1_1	651	657	PF00069	0.662
MOD_CK1_1	661	667	PF00069	0.567
MOD_CK1_1	78	84	PF00069	0.581
MOD_CK2_1	269	275	PF00069	0.578
MOD_CK2_1	318	324	PF00069	0.530
MOD_CK2_1	392	398	PF00069	0.406
MOD_Cter_Amidation	528	531	PF01082	0.480
MOD_GlcNHglycan	100	103	PF01048	0.533
MOD_GlcNHglycan	110	113	PF01048	0.540
MOD_GlcNHglycan	128	131	PF01048	0.575
MOD_GlcNHglycan	132	135	PF01048	0.663
MOD_GlcNHglycan	179	182	PF01048	0.717
MOD_GlcNHglycan	187	190	PF01048	0.671
MOD_GlcNHglycan	216	219	PF01048	0.663
MOD_GlcNHglycan	262	265	PF01048	0.706
MOD_GlcNHglycan	274	278	PF01048	0.616
MOD_GlcNHglycan	289	292	PF01048	0.556
MOD_GlcNHglycan	31	34	PF01048	0.576
MOD_GlcNHglycan	317	320	PF01048	0.678
MOD_GlcNHglycan	365	369	PF01048	0.722
MOD_GlcNHglycan	382	385	PF01048	0.467
MOD_GlcNHglycan	39	42	PF01048	0.604
MOD_GlcNHglycan	50	53	PF01048	0.505
MOD_GlcNHglycan	573	576	PF01048	0.659
MOD_GlcNHglycan	586	589	PF01048	0.662
MOD_GlcNHglycan	59	62	PF01048	0.511
MOD_GlcNHglycan	676	679	PF01048	0.623
MOD_GlcNHglycan	721	724	PF01048	0.633
MOD_GlcNHglycan	85	88	PF01048	0.589
MOD_GSK3_1	106	113	PF00069	0.642
MOD_GSK3_1	12	19	PF00069	0.621
MOD_GSK3_1	126	133	PF00069	0.461
MOD_GSK3_1	145	152	PF00069	0.715
MOD_GSK3_1	162	169	PF00069	0.610
MOD_GSK3_1	214	221	PF00069	0.682
MOD_GSK3_1	222	229	PF00069	0.602
MOD_GSK3_1	237	244	PF00069	0.748
MOD_GSK3_1	245	252	PF00069	0.672
MOD_GSK3_1	256	263	PF00069	0.676
MOD_GSK3_1	269	276	PF00069	0.720
MOD_GSK3_1	278	285	PF00069	0.705
MOD_GSK3_1	29	36	PF00069	0.489
MOD_GSK3_1	311	318	PF00069	0.546
MOD_GSK3_1	37	44	PF00069	0.638
MOD_GSK3_1	372	379	PF00069	0.672
MOD_GSK3_1	388	395	PF00069	0.465
MOD_GSK3_1	399	406	PF00069	0.376
MOD_GSK3_1	412	419	PF00069	0.387
MOD_GSK3_1	487	494	PF00069	0.446
MOD_GSK3_1	498	505	PF00069	0.488
MOD_GSK3_1	508	515	PF00069	0.510
MOD_GSK3_1	57	64	PF00069	0.520
MOD_GSK3_1	624	631	PF00069	0.587
MOD_GSK3_1	644	651	PF00069	0.638
MOD_GSK3_1	65	72	PF00069	0.548
MOD_GSK3_1	715	722	PF00069	0.628
MOD_GSK3_1	74	81	PF00069	0.568
MOD_GSK3_1	83	90	PF00069	0.526
MOD_GSK3_1	94	101	PF00069	0.558
MOD_N-GLC_1	144	149	PF02516	0.712
MOD_N-GLC_1	150	155	PF02516	0.611
MOD_N-GLC_1	157	162	PF02516	0.532
MOD_N-GLC_1	256	261	PF02516	0.722
MOD_N-GLC_1	380	385	PF02516	0.515
MOD_N-GLC_1	463	468	PF02516	0.332
MOD_N-GLC_1	61	66	PF02516	0.542
MOD_N-GLC_2	360	362	PF02516	0.550
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	110	115	PF00069	0.664
MOD_NEK2_1	278	283	PF00069	0.775
MOD_NEK2_1	28	33	PF00069	0.671
MOD_NEK2_1	315	320	PF00069	0.551
MOD_NEK2_1	416	421	PF00069	0.630
MOD_NEK2_1	674	679	PF00069	0.723
MOD_NEK2_1	699	704	PF00069	0.659
MOD_NEK2_1	719	724	PF00069	0.588
MOD_NEK2_1	734	739	PF00069	0.647
MOD_NEK2_1	74	79	PF00069	0.688
MOD_PIKK_1	150	156	PF00454	0.652
MOD_PIKK_1	403	409	PF00454	0.488
MOD_PIKK_1	693	699	PF00454	0.636
MOD_PKA_1	425	431	PF00069	0.363
MOD_PKA_1	449	455	PF00069	0.481
MOD_PKA_2	106	112	PF00069	0.672
MOD_PKA_2	143	149	PF00069	0.554
MOD_PKA_2	282	288	PF00069	0.568
MOD_PKA_2	410	416	PF00069	0.354
MOD_PKA_2	452	458	PF00069	0.454
MOD_PKA_2	501	507	PF00069	0.497
MOD_Plk_1	157	163	PF00069	0.571
MOD_Plk_1	273	279	PF00069	0.562
MOD_Plk_1	463	469	PF00069	0.375
MOD_Plk_1	477	483	PF00069	0.470
MOD_Plk_1	734	740	PF00069	0.522
MOD_Plk_4	166	172	PF00069	0.675
MOD_Plk_4	196	202	PF00069	0.535
MOD_Plk_4	241	247	PF00069	0.713
MOD_Plk_4	282	288	PF00069	0.701
MOD_Plk_4	388	394	PF00069	0.499
MOD_Plk_4	477	483	PF00069	0.480
MOD_Plk_4	628	634	PF00069	0.743
MOD_Plk_4	682	688	PF00069	0.668
MOD_Plk_4	734	740	PF00069	0.522
MOD_Plk_4	9	15	PF00069	0.488
MOD_ProDKin_1	123	129	PF00069	0.659
MOD_ProDKin_1	163	169	PF00069	0.630
MOD_ProDKin_1	174	180	PF00069	0.541
MOD_ProDKin_1	245	251	PF00069	0.624
MOD_ProDKin_1	263	269	PF00069	0.670
MOD_ProDKin_1	300	306	PF00069	0.713
MOD_ProDKin_1	335	341	PF00069	0.696
MOD_ProDKin_1	41	47	PF00069	0.696
MOD_ProDKin_1	594	600	PF00069	0.546
MOD_ProDKin_1	626	632	PF00069	0.607
MOD_ProDKin_1	644	650	PF00069	0.604
MOD_ProDKin_1	658	664	PF00069	0.631
MOD_ProDKin_1	690	696	PF00069	0.700
MOD_ProDKin_1	740	746	PF00069	0.531
MOD_SUMO_rev_2	541	551	PF00179	0.651
MOD_SUMO_rev_2	86	96	PF00179	0.532
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.522
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.683
TRG_ENDOCYTIC_2	470	473	PF00928	0.588
TRG_ENDOCYTIC_2	643	646	PF00928	0.682
TRG_ENDOCYTIC_2	671	674	PF00928	0.673
TRG_ENDOCYTIC_2	731	734	PF00928	0.514
TRG_ER_diArg_1	594	596	PF00400	0.546
TRG_ER_FFAT_2	7	19	PF00635	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID50	Leishmania donovani	64%	98%
A4HY05	Leishmania infantum	64%	98%
E9ARR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	98%
Q4QDQ5	Leishmania major	64%	100%