Zinc_finger_protein_family_member_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9L2_LEIBR

TriTrypDb:

LbrM.18.1120 , LBRM2903_180019900

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9L2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.597
CLV_NRD_NRD_1	252	254	PF00675	0.724
CLV_NRD_NRD_1	386	388	PF00675	0.414
CLV_NRD_NRD_1	432	434	PF00675	0.602
CLV_NRD_NRD_1	475	477	PF00675	0.679
CLV_NRD_NRD_1	488	490	PF00675	0.698
CLV_PCSK_FUR_1	472	476	PF00082	0.574
CLV_PCSK_KEX2_1	252	254	PF00082	0.724
CLV_PCSK_KEX2_1	386	388	PF00082	0.414
CLV_PCSK_KEX2_1	429	431	PF00082	0.597
CLV_PCSK_KEX2_1	434	436	PF00082	0.632
CLV_PCSK_KEX2_1	474	476	PF00082	0.642
CLV_PCSK_KEX2_1	488	490	PF00082	0.685
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.578
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.613
CLV_PCSK_PC7_1	430	436	PF00082	0.592
CLV_PCSK_SKI1_1	299	303	PF00082	0.388
CLV_PCSK_SKI1_1	376	380	PF00082	0.559
DEG_Kelch_Keap1_1	463	468	PF01344	0.572
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DEG_SCF_FBW7_1	178	185	PF00400	0.562
DEG_SCF_FBW7_1	553	559	PF00400	0.658
DOC_CKS1_1	553	558	PF01111	0.547
DOC_PP2B_LxvP_1	580	583	PF13499	0.496
DOC_PP4_FxxP_1	13	16	PF00568	0.591
DOC_PP4_FxxP_1	22	25	PF00568	0.601
DOC_USP7_MATH_1	116	120	PF00917	0.570
DOC_USP7_MATH_1	151	155	PF00917	0.576
DOC_USP7_MATH_1	18	22	PF00917	0.713
DOC_USP7_MATH_1	183	187	PF00917	0.561
DOC_USP7_MATH_1	315	319	PF00917	0.560
DOC_WW_Pin1_4	178	183	PF00397	0.772
DOC_WW_Pin1_4	205	210	PF00397	0.660
DOC_WW_Pin1_4	215	220	PF00397	0.657
DOC_WW_Pin1_4	227	232	PF00397	0.572
DOC_WW_Pin1_4	476	481	PF00397	0.713
DOC_WW_Pin1_4	490	495	PF00397	0.647
DOC_WW_Pin1_4	518	523	PF00397	0.649
DOC_WW_Pin1_4	552	557	PF00397	0.674
DOC_WW_Pin1_4	560	565	PF00397	0.650
DOC_WW_Pin1_4	600	605	PF00397	0.549
LIG_14-3-3_CanoR_1	175	183	PF00244	0.559
LIG_14-3-3_CanoR_1	488	497	PF00244	0.671
LIG_14-3-3_CanoR_1	525	535	PF00244	0.608
LIG_14-3-3_CanoR_1	57	61	PF00244	0.625
LIG_14-3-3_CanoR_1	584	592	PF00244	0.568
LIG_BIR_III_4	65	69	PF00653	0.574
LIG_BRCT_BRCA1_1	318	322	PF00533	0.539
LIG_BRCT_BRCA1_1	9	13	PF00533	0.564
LIG_FHA_1	266	272	PF00498	0.459
LIG_FHA_1	282	288	PF00498	0.551
LIG_FHA_1	296	302	PF00498	0.295
LIG_FHA_2	249	255	PF00498	0.645
LIG_FHA_2	256	262	PF00498	0.509
LIG_FHA_2	328	334	PF00498	0.424
LIG_FHA_2	519	525	PF00498	0.671
LIG_LIR_Apic_2	10	16	PF02991	0.579
LIG_LIR_Apic_2	20	25	PF02991	0.599
LIG_LIR_Apic_2	218	223	PF02991	0.549
LIG_LIR_Gen_1	258	267	PF02991	0.426
LIG_LIR_Gen_1	3	13	PF02991	0.570
LIG_LIR_Gen_1	326	337	PF02991	0.417
LIG_LIR_Gen_1	59	69	PF02991	0.592
LIG_LIR_Nem_3	164	169	PF02991	0.543
LIG_LIR_Nem_3	258	263	PF02991	0.568
LIG_LIR_Nem_3	273	279	PF02991	0.385
LIG_LIR_Nem_3	3	9	PF02991	0.573
LIG_LIR_Nem_3	326	332	PF02991	0.426
LIG_LIR_Nem_3	59	64	PF02991	0.607
LIG_LIR_Nem_3	87	91	PF02991	0.591
LIG_LYPXL_yS_3	351	354	PF13949	0.415
LIG_NRBOX	575	581	PF00104	0.625
LIG_PCNA_yPIPBox_3	252	263	PF02747	0.572
LIG_Pex14_2	272	276	PF04695	0.396
LIG_PTB_Apo_2	82	89	PF02174	0.525
LIG_SH2_CRK	220	224	PF00017	0.558
LIG_SH2_CRK	280	284	PF00017	0.381
LIG_SH2_GRB2like	400	403	PF00017	0.417
LIG_SH2_NCK_1	220	224	PF00017	0.558
LIG_SH2_NCK_1	280	284	PF00017	0.381
LIG_SH2_NCK_1	6	10	PF00017	0.573
LIG_SH2_NCK_1	61	65	PF00017	0.717
LIG_SH2_SRC	220	223	PF00017	0.558
LIG_SH2_SRC	400	403	PF00017	0.417
LIG_SH2_SRC	6	9	PF00017	0.577
LIG_SH2_STAP1	99	103	PF00017	0.744
LIG_SH2_STAT5	133	136	PF00017	0.597
LIG_SH2_STAT5	167	170	PF00017	0.663
LIG_SH2_STAT5	329	332	PF00017	0.426
LIG_SH2_STAT5	341	344	PF00017	0.477
LIG_SH2_STAT5	581	584	PF00017	0.518
LIG_SH3_3	268	274	PF00018	0.390
LIG_SH3_3	285	291	PF00018	0.403
LIG_SH3_3	349	355	PF00018	0.439
LIG_SH3_3	359	365	PF00018	0.460
LIG_SH3_3	40	46	PF00018	0.822
LIG_SH3_3	588	594	PF00018	0.513
LIG_SH3_3	598	604	PF00018	0.549
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.559
LIG_SUMO_SIM_anti_2	369	375	PF11976	0.394
LIG_SUMO_SIM_par_1	230	235	PF11976	0.554
LIG_SUMO_SIM_par_1	267	273	PF11976	0.519
LIG_SUMO_SIM_par_1	369	375	PF11976	0.335
LIG_TYR_ITSM	57	64	PF00017	0.728
LIG_WRC_WIRS_1	19	24	PF05994	0.522
MOD_CDK_SPK_2	600	605	PF00069	0.549
MOD_CDK_SPxxK_3	518	525	PF00069	0.567
MOD_CK1_1	171	177	PF00069	0.746
MOD_CK1_1	248	254	PF00069	0.738
MOD_CK1_1	446	452	PF00069	0.718
MOD_CK1_1	462	468	PF00069	0.560
MOD_CK1_1	478	484	PF00069	0.640
MOD_CK1_1	493	499	PF00069	0.591
MOD_CK1_1	502	508	PF00069	0.668
MOD_CK1_1	515	521	PF00069	0.699
MOD_CK1_1	572	578	PF00069	0.552
MOD_CK1_1	587	593	PF00069	0.523
MOD_CK2_1	248	254	PF00069	0.654
MOD_CK2_1	255	261	PF00069	0.518
MOD_CK2_1	327	333	PF00069	0.415
MOD_CK2_1	462	468	PF00069	0.592
MOD_CK2_1	518	524	PF00069	0.670
MOD_GlcNHglycan	136	139	PF01048	0.610
MOD_GlcNHglycan	144	147	PF01048	0.730
MOD_GlcNHglycan	201	204	PF01048	0.592
MOD_GlcNHglycan	227	230	PF01048	0.611
MOD_GlcNHglycan	242	245	PF01048	0.752
MOD_GlcNHglycan	401	405	PF01048	0.492
MOD_GlcNHglycan	407	410	PF01048	0.574
MOD_GlcNHglycan	439	442	PF01048	0.563
MOD_GlcNHglycan	450	453	PF01048	0.603
MOD_GlcNHglycan	462	465	PF01048	0.654
MOD_GlcNHglycan	468	472	PF01048	0.675
MOD_GlcNHglycan	529	532	PF01048	0.576
MOD_GlcNHglycan	65	69	PF01048	0.660
MOD_GlcNHglycan	7	12	PF01048	0.568
MOD_GSK3_1	161	168	PF00069	0.687
MOD_GSK3_1	173	180	PF00069	0.655
MOD_GSK3_1	194	201	PF00069	0.661
MOD_GSK3_1	240	247	PF00069	0.708
MOD_GSK3_1	261	268	PF00069	0.616
MOD_GSK3_1	396	403	PF00069	0.495
MOD_GSK3_1	443	450	PF00069	0.622
MOD_GSK3_1	458	465	PF00069	0.601
MOD_GSK3_1	498	505	PF00069	0.693
MOD_GSK3_1	510	517	PF00069	0.764
MOD_GSK3_1	548	555	PF00069	0.651
MOD_GSK3_1	556	563	PF00069	0.640
MOD_GSK3_1	566	573	PF00069	0.481
MOD_N-GLC_1	171	176	PF02516	0.744
MOD_N-GLC_1	245	250	PF02516	0.558
MOD_N-GLC_1	295	300	PF02516	0.441
MOD_N-GLC_1	327	332	PF02516	0.509
MOD_N-GLC_1	458	463	PF02516	0.604
MOD_N-GLC_1	499	504	PF02516	0.676
MOD_N-GLC_1	505	510	PF02516	0.640
MOD_N-GLC_1	515	520	PF02516	0.600
MOD_N-GLC_1	527	532	PF02516	0.688
MOD_N-GLC_1	84	89	PF02516	0.527
MOD_NEK2_1	134	139	PF00069	0.721
MOD_NEK2_1	199	204	PF00069	0.738
MOD_NEK2_1	295	300	PF00069	0.441
MOD_NEK2_1	316	321	PF00069	0.543
MOD_NEK2_1	36	41	PF00069	0.633
MOD_NEK2_1	510	515	PF00069	0.619
MOD_NEK2_1	527	532	PF00069	0.761
MOD_NEK2_1	558	563	PF00069	0.548
MOD_NEK2_1	570	575	PF00069	0.542
MOD_NEK2_2	56	61	PF00069	0.732
MOD_OFUCOSY	314	320	PF10250	0.538
MOD_PIKK_1	149	155	PF00454	0.766
MOD_PIKK_1	537	543	PF00454	0.542
MOD_PIKK_1	548	554	PF00454	0.491
MOD_PIKK_1	570	576	PF00454	0.650
MOD_PKA_1	475	481	PF00069	0.616
MOD_PKA_1	488	494	PF00069	0.670
MOD_PKA_2	174	180	PF00069	0.602
MOD_PKA_2	475	481	PF00069	0.725
MOD_PKA_2	488	494	PF00069	0.667
MOD_PKA_2	56	62	PF00069	0.730
MOD_Plk_1	245	251	PF00069	0.544
MOD_Plk_1	295	301	PF00069	0.433
MOD_Plk_1	505	511	PF00069	0.677
MOD_Plk_1	587	593	PF00069	0.625
MOD_Plk_1	84	90	PF00069	0.524
MOD_Plk_4	162	168	PF00069	0.745
MOD_Plk_4	255	261	PF00069	0.521
MOD_Plk_4	366	372	PF00069	0.364
MOD_Plk_4	390	396	PF00069	0.383
MOD_Plk_4	505	511	PF00069	0.804
MOD_Plk_4	56	62	PF00069	0.762
MOD_Plk_4	575	581	PF00069	0.507
MOD_Plk_4	587	593	PF00069	0.507
MOD_Plk_4	92	98	PF00069	0.593
MOD_ProDKin_1	178	184	PF00069	0.772
MOD_ProDKin_1	205	211	PF00069	0.659
MOD_ProDKin_1	215	221	PF00069	0.659
MOD_ProDKin_1	227	233	PF00069	0.576
MOD_ProDKin_1	476	482	PF00069	0.715
MOD_ProDKin_1	490	496	PF00069	0.648
MOD_ProDKin_1	518	524	PF00069	0.649
MOD_ProDKin_1	552	558	PF00069	0.669
MOD_ProDKin_1	560	566	PF00069	0.642
MOD_SUMO_rev_2	270	279	PF00179	0.397
MOD_SUMO_rev_2	388	393	PF00179	0.429
MOD_SUMO_rev_2	421	431	PF00179	0.554
TRG_DiLeu_BaEn_1	410	415	PF01217	0.348
TRG_ENDOCYTIC_2	260	263	PF00928	0.439
TRG_ENDOCYTIC_2	329	332	PF00928	0.433
TRG_ENDOCYTIC_2	351	354	PF00928	0.415
TRG_ENDOCYTIC_2	6	9	PF00928	0.577
TRG_ENDOCYTIC_2	61	64	PF00928	0.724
TRG_ENDOCYTIC_2	99	102	PF00928	0.742
TRG_ER_diArg_1	432	435	PF00400	0.610
TRG_ER_diArg_1	472	475	PF00400	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV5	Leptomonas seymouri	42%	96%
A0A3S5H743	Leishmania donovani	77%	97%
A4HY06	Leishmania infantum	77%	97%
E9ARR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QDQ4	Leishmania major	76%	100%