Dynein light chain roadblock

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Outer arm dynein light chain 7

Species:

Leishmania braziliensis

UniProt:

A4H9K8_LEIBR

TriTrypDb:

LbrM.18.1070 , LBRM2903_180016500

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005868	cytoplasmic dynein complex	4	11
GO:0005874	microtubule	6	11
GO:0005875	microtubule associated complex	2	11
GO:0030286	dynein complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:1902494	catalytic complex	2	11
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4H9K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9K8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0045505	dynein intermediate chain binding	3	11
GO:0003774	cytoskeletal motor activity	1	1
GO:0003777	microtubule motor activity	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	15	17	PF00082	0.319
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.319
CLV_PCSK_SKI1_1	15	19	PF00082	0.240
CLV_PCSK_SKI1_1	24	28	PF00082	0.240
CLV_PCSK_SKI1_1	63	67	PF00082	0.376
CLV_PCSK_SKI1_1	94	98	PF00082	0.240
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.316
DOC_MAPK_gen_1	21	29	PF00069	0.347
DOC_MAPK_gen_1	81	89	PF00069	0.240
DOC_USP7_UBL2_3	107	111	PF12436	0.574
LIG_14-3-3_CanoR_1	16	23	PF00244	0.319
LIG_14-3-3_CanoR_1	37	47	PF00244	0.266
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_FHA_2	80	86	PF00498	0.159
LIG_IRF3_LxIS_1	54	61	PF10401	0.159
LIG_LIR_Gen_1	92	103	PF02991	0.240
LIG_LIR_Nem_3	92	98	PF02991	0.240
LIG_SH2_CRK	51	55	PF00017	0.240
LIG_SH2_CRK	95	99	PF00017	0.372
LIG_SH2_STAP1	51	55	PF00017	0.259
LIG_SUMO_SIM_par_1	56	61	PF11976	0.190
LIG_SUMO_SIM_par_1	96	102	PF11976	0.398
LIG_TYR_ITIM	49	54	PF00017	0.240
LIG_UBA3_1	54	63	PF00899	0.240
MOD_CK1_1	61	67	PF00069	0.316
MOD_CK2_1	36	42	PF00069	0.245
MOD_GlcNHglycan	5	8	PF01048	0.548
MOD_GlcNHglycan	60	63	PF01048	0.335
MOD_NEK2_1	1	6	PF00069	0.435
MOD_NEK2_1	58	63	PF00069	0.287
MOD_PKA_1	15	21	PF00069	0.319
MOD_PKA_2	15	21	PF00069	0.319
MOD_PKA_2	36	42	PF00069	0.240
MOD_Plk_4	61	67	PF00069	0.316
MOD_SUMO_rev_2	86	96	PF00179	0.240
TRG_ENDOCYTIC_2	51	54	PF00928	0.240
TRG_ENDOCYTIC_2	95	98	PF00928	0.252
TRG_ER_diArg_1	78	81	PF00400	0.240
TRG_Pf-PMV_PEXEL_1	45	50	PF00026	0.240

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V1	Leptomonas seymouri	86%	100%
A0A0N1HUN3	Leptomonas seymouri	37%	100%
A0A0S4JND4	Bodo saltans	32%	100%
A0A0S4KIT1	Bodo saltans	35%	100%
A0A1X0NII5	Trypanosomatidae	27%	97%
A0A1X0P773	Trypanosomatidae	59%	97%
A0A3Q8IJB4	Leishmania donovani	35%	94%
A0A3Q8IJQ7	Leishmania donovani	88%	100%
A0A422NF11	Trypanosoma rangeli	33%	96%
A0A422P0L4	Trypanosoma rangeli	63%	97%
A4HKZ6	Leishmania braziliensis	25%	89%
A4HMJ5	Leishmania braziliensis	37%	100%
A4HXX4	Leishmania infantum	88%	100%
A4IB75	Leishmania infantum	35%	94%
C9ZMI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
C9ZWI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
C9ZZS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	95%
D0AAN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AEZ6	Leishmania major	34%	100%
E9ARN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B3D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	88%
E9B652	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	75%
P62627	Mus musculus	40%	100%
P62628	Rattus norvegicus	40%	100%
Q32P85	Bos taurus	45%	100%
Q3T140	Bos taurus	40%	100%
Q4QDU1	Leishmania major	87%	100%
Q8TF09	Homo sapiens	45%	100%
Q9DAJ5	Mus musculus	44%	100%
Q9NP97	Homo sapiens	39%	100%
V5B5T5	Trypanosoma cruzi	31%	100%
V5BM74	Trypanosoma cruzi	62%	97%