Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9K7_LEIBR

TriTrypDb:

LbrM.18.1060 , LBRM2903_180016400

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	33
GO:0110165	cellular anatomical entity	1	33
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H9K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9K7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006862	nucleotide transport	6	7
GO:0009987	cellular process	1	7
GO:0015748	organophosphate ester transport	5	7
GO:0015931	nucleobase-containing compound transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0055085	transmembrane transport	2	7
GO:0071702	organic substance transport	4	7
GO:0071705	nitrogen compound transport	4	7
GO:0035352	NAD transmembrane transport	4	1
GO:0043132	NAD transport	7	1
GO:1901679	nucleotide transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0051724	NAD transmembrane transporter activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.356
CLV_NRD_NRD_1	399	401	PF00675	0.305
CLV_NRD_NRD_1	409	411	PF00675	0.270
CLV_NRD_NRD_1	79	81	PF00675	0.311
CLV_PCSK_KEX2_1	399	401	PF00082	0.342
CLV_PCSK_KEX2_1	81	83	PF00082	0.299
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.308
CLV_PCSK_SKI1_1	200	204	PF00082	0.264
CLV_PCSK_SKI1_1	393	397	PF00082	0.315
CLV_PCSK_SKI1_1	415	419	PF00082	0.240
CLV_PCSK_SKI1_1	67	71	PF00082	0.316
CLV_PCSK_SKI1_1	81	85	PF00082	0.297
DEG_APCC_DBOX_1	244	252	PF00400	0.567
DOC_CDC14_PxL_1	281	289	PF14671	0.220
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.327
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.399
DOC_MAPK_gen_1	274	281	PF00069	0.253
DOC_PP1_RVXF_1	65	72	PF00149	0.321
DOC_PP2B_LxvP_1	260	263	PF13499	0.430
DOC_PP2B_LxvP_1	51	54	PF13499	0.358
DOC_USP7_MATH_1	158	162	PF00917	0.332
DOC_USP7_MATH_1	170	174	PF00917	0.369
DOC_USP7_MATH_1	18	22	PF00917	0.562
DOC_USP7_MATH_1	307	311	PF00917	0.481
DOC_USP7_MATH_1	423	427	PF00917	0.328
DOC_USP7_UBL2_3	389	393	PF12436	0.591
DOC_WW_Pin1_4	189	194	PF00397	0.335
DOC_WW_Pin1_4	322	327	PF00397	0.329
DOC_WW_Pin1_4	379	384	PF00397	0.580
DOC_WW_Pin1_4	5	10	PF00397	0.595
DOC_WW_Pin1_4	85	90	PF00397	0.634
LIG_14-3-3_CanoR_1	10	16	PF00244	0.494
LIG_14-3-3_CanoR_1	200	208	PF00244	0.468
LIG_14-3-3_CanoR_1	295	303	PF00244	0.466
LIG_14-3-3_CanoR_1	46	54	PF00244	0.279
LIG_BRCT_BRCA1_1	143	147	PF00533	0.234
LIG_Clathr_ClatBox_1	146	150	PF01394	0.392
LIG_FHA_1	10	16	PF00498	0.462
LIG_FHA_1	141	147	PF00498	0.328
LIG_FHA_1	233	239	PF00498	0.603
LIG_FHA_1	276	282	PF00498	0.323
LIG_FHA_1	28	34	PF00498	0.456
LIG_FHA_1	284	290	PF00498	0.303
LIG_FHA_1	342	348	PF00498	0.299
LIG_FHA_1	39	45	PF00498	0.368
LIG_IRF3_LxIS_1	73	79	PF10401	0.500
LIG_LIR_Gen_1	211	221	PF02991	0.558
LIG_LIR_Gen_1	341	351	PF02991	0.177
LIG_LIR_Gen_1	440	448	PF02991	0.337
LIG_LIR_Gen_1	45	54	PF02991	0.344
LIG_LIR_Gen_1	55	64	PF02991	0.300
LIG_LIR_Nem_3	211	217	PF02991	0.558
LIG_LIR_Nem_3	220	224	PF02991	0.532
LIG_LIR_Nem_3	265	271	PF02991	0.331
LIG_LIR_Nem_3	341	346	PF02991	0.299
LIG_LIR_Nem_3	391	395	PF02991	0.524
LIG_LIR_Nem_3	440	444	PF02991	0.248
LIG_LIR_Nem_3	45	51	PF02991	0.339
LIG_LIR_Nem_3	55	59	PF02991	0.276
LIG_LIR_Nem_3	68	74	PF02991	0.373
LIG_NRBOX	135	141	PF00104	0.234
LIG_NRBOX	184	190	PF00104	0.327
LIG_Pex14_1	268	272	PF04695	0.283
LIG_Pex14_1	290	294	PF04695	0.292
LIG_Pex14_2	221	225	PF04695	0.467
LIG_Pex14_2	435	439	PF04695	0.308
LIG_REV1ctd_RIR_1	415	421	PF16727	0.450
LIG_SH2_CRK	214	218	PF00017	0.571
LIG_SH2_CRK	252	256	PF00017	0.307
LIG_SH2_GRB2like	214	217	PF00017	0.586
LIG_SH2_NCK_1	108	112	PF00017	0.457
LIG_SH2_NCK_1	206	210	PF00017	0.637
LIG_SH2_NCK_1	296	300	PF00017	0.357
LIG_SH2_SRC	155	158	PF00017	0.380
LIG_SH2_STAP1	11	15	PF00017	0.371
LIG_SH2_STAP1	174	178	PF00017	0.341
LIG_SH2_STAP1	296	300	PF00017	0.452
LIG_SH2_STAT5	11	14	PF00017	0.584
LIG_SH2_STAT5	145	148	PF00017	0.307
LIG_SH2_STAT5	155	158	PF00017	0.328
LIG_SH2_STAT5	272	275	PF00017	0.295
LIG_SH2_STAT5	280	283	PF00017	0.284
LIG_SH2_STAT5	296	299	PF00017	0.297
LIG_SUMO_SIM_anti_2	184	190	PF11976	0.349
LIG_SUMO_SIM_anti_2	192	198	PF11976	0.326
LIG_SUMO_SIM_anti_2	426	431	PF11976	0.354
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.167
LIG_SUMO_SIM_par_1	187	192	PF11976	0.316
LIG_SUMO_SIM_par_1	285	291	PF11976	0.222
LIG_UBA3_1	146	153	PF00899	0.479
LIG_UBA3_1	434	443	PF00899	0.223
MOD_CDK_SPK_2	5	10	PF00069	0.449
MOD_CK1_1	160	166	PF00069	0.329
MOD_CK1_1	172	178	PF00069	0.332
MOD_CK1_1	207	213	PF00069	0.618
MOD_CK1_1	275	281	PF00069	0.318
MOD_CK1_1	283	289	PF00069	0.331
MOD_CK1_1	341	347	PF00069	0.279
MOD_CK1_1	378	384	PF00069	0.575
MOD_CK2_1	285	291	PF00069	0.256
MOD_GlcNHglycan	105	108	PF01048	0.359
MOD_GlcNHglycan	162	165	PF01048	0.578
MOD_GlcNHglycan	174	177	PF01048	0.488
MOD_GlcNHglycan	19	23	PF01048	0.755
MOD_GlcNHglycan	255	258	PF01048	0.295
MOD_GlcNHglycan	264	267	PF01048	0.235
MOD_GlcNHglycan	282	285	PF01048	0.585
MOD_GlcNHglycan	309	312	PF01048	0.642
MOD_GlcNHglycan	35	38	PF01048	0.659
MOD_GlcNHglycan	377	380	PF01048	0.331
MOD_GlcNHglycan	60	63	PF01048	0.335
MOD_GSK3_1	141	148	PF00069	0.304
MOD_GSK3_1	18	25	PF00069	0.493
MOD_GSK3_1	200	207	PF00069	0.528
MOD_GSK3_1	307	314	PF00069	0.426
MOD_GSK3_1	33	40	PF00069	0.430
MOD_GSK3_1	334	341	PF00069	0.265
MOD_GSK3_1	375	382	PF00069	0.559
MOD_GSK3_1	42	49	PF00069	0.361
MOD_GSK3_1	439	446	PF00069	0.279
MOD_GSK3_1	5	12	PF00069	0.534
MOD_GSK3_1	81	88	PF00069	0.564
MOD_N-GLC_1	423	428	PF02516	0.327
MOD_N-GLC_1	46	51	PF02516	0.540
MOD_NEK2_1	140	145	PF00069	0.362
MOD_NEK2_1	169	174	PF00069	0.362
MOD_NEK2_1	208	213	PF00069	0.573
MOD_NEK2_1	439	444	PF00069	0.229
MOD_NEK2_1	76	81	PF00069	0.478
MOD_NEK2_1	96	101	PF00069	0.407
MOD_PKA_1	81	87	PF00069	0.558
MOD_PKA_2	103	109	PF00069	0.633
MOD_PKA_2	294	300	PF00069	0.471
MOD_PKA_2	81	87	PF00069	0.558
MOD_PKA_2	9	15	PF00069	0.577
MOD_Plk_1	141	147	PF00069	0.351
MOD_Plk_1	423	429	PF00069	0.351
MOD_Plk_4	141	147	PF00069	0.330
MOD_Plk_4	210	216	PF00069	0.597
MOD_Plk_4	275	281	PF00069	0.289
MOD_Plk_4	285	291	PF00069	0.304
MOD_Plk_4	312	318	PF00069	0.350
MOD_Plk_4	334	340	PF00069	0.292
MOD_Plk_4	342	348	PF00069	0.271
MOD_Plk_4	391	397	PF00069	0.450
MOD_Plk_4	52	58	PF00069	0.235
MOD_Plk_4	88	94	PF00069	0.552
MOD_ProDKin_1	189	195	PF00069	0.335
MOD_ProDKin_1	322	328	PF00069	0.328
MOD_ProDKin_1	379	385	PF00069	0.580
MOD_ProDKin_1	5	11	PF00069	0.596
MOD_ProDKin_1	85	91	PF00069	0.635
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.349
TRG_ENDOCYTIC_2	128	131	PF00928	0.467
TRG_ENDOCYTIC_2	214	217	PF00928	0.563
TRG_ENDOCYTIC_2	252	255	PF00928	0.291
TRG_ER_diArg_1	398	400	PF00400	0.477
TRG_ER_diArg_1	80	83	PF00400	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S5	Leptomonas seymouri	23%	100%
A0A0N1IBB8	Leptomonas seymouri	60%	95%
A0A0N1IHK9	Leptomonas seymouri	26%	100%
A0A0S4JF45	Bodo saltans	38%	100%
A0A0S4JH99	Bodo saltans	25%	90%
A0A0S4JIT1	Bodo saltans	23%	100%
A0A1X0NN16	Trypanosomatidae	23%	100%
A0A1X0NQB5	Trypanosomatidae	25%	100%
A0A1X0P6Z0	Trypanosomatidae	45%	100%
A0A3Q8IC78	Leishmania donovani	26%	100%
A0A3Q8IS12	Leishmania donovani	24%	100%
A0A3R7L1P3	Trypanosoma rangeli	25%	100%
A0A3S7WUZ5	Leishmania donovani	84%	100%
A0A422NGL1	Trypanosoma rangeli	25%	100%
A0A422P0Q3	Trypanosoma rangeli	44%	100%
A4H690	Leishmania braziliensis	26%	99%
A4HQI4	Leishmania braziliensis	26%	100%
A4HUL3	Leishmania infantum	26%	100%
A4HXX3	Leishmania infantum	83%	100%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AHZ3	Leishmania infantum	24%	100%
E9ANB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ARN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q094	Leishmania major	24%	89%
Q4QDU2	Leishmania major	81%	98%
Q4QHB2	Leishmania major	25%	94%
V5BTU3	Trypanosoma cruzi	25%	100%
V5DDT9	Trypanosoma cruzi	25%	100%
V5DN72	Trypanosoma cruzi	44%	100%