Der GTPase-activating protein YihI

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9K6_LEIBR

TriTrypDb:

LbrM.18.1040 , LBRM2903_180016100

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9K6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.709
CLV_NRD_NRD_1	102	104	PF00675	0.527
CLV_NRD_NRD_1	111	113	PF00675	0.462
CLV_NRD_NRD_1	13	15	PF00675	0.581
CLV_NRD_NRD_1	4	6	PF00675	0.586
CLV_NRD_NRD_1	41	43	PF00675	0.658
CLV_NRD_NRD_1	96	98	PF00675	0.478
CLV_PCSK_FUR_1	100	104	PF00082	0.626
CLV_PCSK_KEX2_1	102	104	PF00082	0.551
CLV_PCSK_KEX2_1	111	113	PF00082	0.514
CLV_PCSK_KEX2_1	141	143	PF00082	0.594
CLV_PCSK_KEX2_1	4	6	PF00082	0.602
CLV_PCSK_KEX2_1	41	43	PF00082	0.677
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.594
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.677
CLV_PCSK_SKI1_1	119	123	PF00082	0.513
CLV_PCSK_SKI1_1	16	20	PF00082	0.537
CLV_PCSK_SKI1_1	5	9	PF00082	0.639
CLV_PCSK_SKI1_1	75	79	PF00082	0.480
CLV_PCSK_SKI1_1	84	88	PF00082	0.435
DOC_MAPK_gen_1	11	20	PF00069	0.558
DOC_USP7_UBL2_3	15	19	PF12436	0.623
DOC_USP7_UBL2_3	37	41	PF12436	0.683
DOC_USP7_UBL2_3	71	75	PF12436	0.603
LIG_14-3-3_CanoR_1	42	49	PF00244	0.630
LIG_FHA_1	150	156	PF00498	0.391
LIG_FHA_2	132	138	PF00498	0.549
LIG_FHA_2	22	28	PF00498	0.507
LIG_LIR_Gen_1	163	172	PF02991	0.578
LIG_LIR_Nem_3	163	169	PF02991	0.575
LIG_LRP6_Inhibitor_1	96	102	PF00058	0.383
LIG_SH2_STAT3	117	120	PF00017	0.461
LIG_SH2_STAT5	117	120	PF00017	0.461
MOD_CK1_1	131	137	PF00069	0.615
MOD_CK2_1	131	137	PF00069	0.544
MOD_CK2_1	22	28	PF00069	0.629
MOD_Cter_Amidation	39	42	PF01082	0.657
MOD_GlcNHglycan	27	31	PF01048	0.673
MOD_GSK3_1	18	25	PF00069	0.608
MOD_NEK2_1	18	23	PF00069	0.519
MOD_PK_1	22	28	PF00069	0.643
MOD_PKA_1	22	28	PF00069	0.658
MOD_PKA_1	41	47	PF00069	0.632
MOD_PKA_2	41	47	PF00069	0.618
MOD_SUMO_for_1	107	110	PF00179	0.462
MOD_SUMO_for_1	121	124	PF00179	0.461
MOD_SUMO_rev_2	137	143	PF00179	0.566
TRG_DiLeu_BaEn_1	139	144	PF01217	0.570
TRG_DiLeu_LyEn_5	139	144	PF01217	0.599
TRG_ER_diArg_1	100	103	PF00400	0.525
TRG_ER_diArg_1	4	6	PF00400	0.601
TRG_ER_diArg_1	48	51	PF00400	0.663
TRG_NLS_Bipartite_1	4	20	PF00514	0.607
TRG_NLS_Bipartite_1	57	74	PF00514	0.559
TRG_NLS_MonoCore_2	13	18	PF00514	0.623
TRG_NLS_MonoExtC_3	14	19	PF00514	0.595
TRG_NLS_MonoExtN_4	11	18	PF00514	0.597
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9L1	Leptomonas seymouri	71%	98%
A0A0S4JFM3	Bodo saltans	39%	100%
A0A1X0P6Y6	Trypanosomatidae	44%	100%
A0A3S7WUY3	Leishmania donovani	85%	100%
A4HXX1	Leishmania infantum	85%	100%
C9ZZT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ARN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QDU4	Leishmania major	83%	99%
V5B6M9	Trypanosoma cruzi	44%	100%