Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9K5_LEIBR

TriTrypDb:

LbrM.18.1030 , LBRM2903_180015800

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9K5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.553
CLV_NRD_NRD_1	180	182	PF00675	0.668
CLV_NRD_NRD_1	439	441	PF00675	0.596
CLV_PCSK_FUR_1	437	441	PF00082	0.678
CLV_PCSK_KEX2_1	185	187	PF00082	0.718
CLV_PCSK_KEX2_1	354	356	PF00082	0.480
CLV_PCSK_KEX2_1	430	432	PF00082	0.678
CLV_PCSK_KEX2_1	437	439	PF00082	0.630
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.761
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.442
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.652
CLV_PCSK_PC7_1	181	187	PF00082	0.782
CLV_PCSK_PC7_1	433	439	PF00082	0.658
CLV_PCSK_SKI1_1	181	185	PF00082	0.692
CLV_PCSK_SKI1_1	289	293	PF00082	0.539
CLV_PCSK_SKI1_1	302	306	PF00082	0.481
CLV_Separin_Metazoa	280	284	PF03568	0.384
DEG_Nend_UBRbox_4	1	3	PF02207	0.520
DEG_SPOP_SBC_1	24	28	PF00917	0.522
DOC_CKS1_1	75	80	PF01111	0.525
DOC_MAPK_RevD_3	340	355	PF00069	0.356
DOC_PP1_RVXF_1	108	115	PF00149	0.646
DOC_USP7_MATH_1	100	104	PF00917	0.547
DOC_USP7_MATH_1	133	137	PF00917	0.504
DOC_USP7_MATH_1	222	226	PF00917	0.700
DOC_USP7_MATH_1	24	28	PF00917	0.636
DOC_USP7_MATH_1	275	279	PF00917	0.630
DOC_USP7_MATH_1	4	8	PF00917	0.575
DOC_WW_Pin1_4	220	225	PF00397	0.668
DOC_WW_Pin1_4	233	238	PF00397	0.511
DOC_WW_Pin1_4	271	276	PF00397	0.664
DOC_WW_Pin1_4	322	327	PF00397	0.562
DOC_WW_Pin1_4	379	384	PF00397	0.574
DOC_WW_Pin1_4	451	456	PF00397	0.542
DOC_WW_Pin1_4	47	52	PF00397	0.515
DOC_WW_Pin1_4	74	79	PF00397	0.525
DOC_WW_Pin1_4	89	94	PF00397	0.531
LIG_14-3-3_CanoR_1	110	115	PF00244	0.502
LIG_14-3-3_CanoR_1	117	121	PF00244	0.494
LIG_14-3-3_CanoR_1	122	127	PF00244	0.520
LIG_14-3-3_CanoR_1	186	190	PF00244	0.589
LIG_14-3-3_CanoR_1	262	271	PF00244	0.564
LIG_14-3-3_CanoR_1	355	359	PF00244	0.648
LIG_14-3-3_CanoR_1	398	403	PF00244	0.477
LIG_14-3-3_CanoR_1	431	436	PF00244	0.612
LIG_BRCT_BRCA1_1	241	245	PF00533	0.797
LIG_CSL_BTD_1	257	260	PF09270	0.540
LIG_CtBP_PxDLS_1	54	58	PF00389	0.523
LIG_EVH1_2	93	97	PF00568	0.499
LIG_FHA_1	133	139	PF00498	0.687
LIG_FHA_1	185	191	PF00498	0.582
LIG_FHA_1	201	207	PF00498	0.719
LIG_FHA_1	380	386	PF00498	0.540
LIG_FHA_1	85	91	PF00498	0.606
LIG_FHA_2	239	245	PF00498	0.527
LIG_FHA_2	325	331	PF00498	0.556
LIG_FHA_2	410	416	PF00498	0.541
LIG_LIR_Nem_3	408	414	PF02991	0.470
LIG_MAD2	333	341	PF02301	0.324
LIG_MYND_1	20	24	PF01753	0.526
LIG_MYND_1	227	231	PF01753	0.536
LIG_NRBOX	189	195	PF00104	0.481
LIG_PDZ_Class_3	467	472	PF00595	0.670
LIG_Pex14_1	459	463	PF04695	0.497
LIG_SH2_NCK_1	414	418	PF00017	0.689
LIG_SH2_SRC	463	466	PF00017	0.470
LIG_SH2_STAT3	141	144	PF00017	0.534
LIG_SH2_STAT3	65	68	PF00017	0.573
LIG_SH2_STAT5	239	242	PF00017	0.693
LIG_SH2_STAT5	463	466	PF00017	0.510
LIG_SH3_3	18	24	PF00018	0.523
LIG_SH3_3	221	227	PF00018	0.781
LIG_SH3_3	248	254	PF00018	0.733
LIG_SH3_3	332	338	PF00018	0.508
LIG_SH3_3	46	52	PF00018	0.511
LIG_SH3_3	83	89	PF00018	0.511
LIG_SH3_3	90	96	PF00018	0.496
LIG_TRAF2_1	327	330	PF00917	0.576
LIG_WW_1	95	98	PF00397	0.510
MOD_CDK_SPK_2	451	456	PF00069	0.621
MOD_CK1_1	25	31	PF00069	0.507
MOD_CK1_1	84	90	PF00069	0.534
MOD_CK2_1	185	191	PF00069	0.747
MOD_CK2_1	198	204	PF00069	0.549
MOD_CK2_1	238	244	PF00069	0.793
MOD_CK2_1	324	330	PF00069	0.566
MOD_CK2_1	407	413	PF00069	0.546
MOD_Cter_Amidation	352	355	PF01082	0.414
MOD_Cter_Amidation	428	431	PF01082	0.623
MOD_Cter_Amidation	435	438	PF01082	0.493
MOD_GlcNHglycan	114	117	PF01048	0.650
MOD_GlcNHglycan	200	203	PF01048	0.716
MOD_GlcNHglycan	210	213	PF01048	0.597
MOD_GlcNHglycan	217	220	PF01048	0.535
MOD_GlcNHglycan	246	249	PF01048	0.593
MOD_GlcNHglycan	264	267	PF01048	0.638
MOD_GlcNHglycan	277	280	PF01048	0.514
MOD_GlcNHglycan	28	31	PF01048	0.497
MOD_GSK3_1	112	119	PF00069	0.701
MOD_GSK3_1	200	207	PF00069	0.662
MOD_GSK3_1	22	29	PF00069	0.523
MOD_GSK3_1	240	247	PF00069	0.764
MOD_GSK3_1	271	278	PF00069	0.469
MOD_GSK3_1	354	361	PF00069	0.600
MOD_GSK3_1	80	87	PF00069	0.578
MOD_GSK3_1	98	105	PF00069	0.595
MOD_N-GLC_2	104	106	PF02516	0.509
MOD_NEK2_1	112	117	PF00069	0.712
MOD_NEK2_1	139	144	PF00069	0.705
MOD_NEK2_1	184	189	PF00069	0.635
MOD_NEK2_1	215	220	PF00069	0.708
MOD_NEK2_1	377	382	PF00069	0.461
MOD_PIKK_1	133	139	PF00454	0.503
MOD_PIKK_1	140	146	PF00454	0.651
MOD_PIKK_1	172	178	PF00454	0.825
MOD_PIKK_1	324	330	PF00454	0.667
MOD_PK_1	122	128	PF00069	0.500
MOD_PK_1	431	437	PF00069	0.609
MOD_PKA_1	185	191	PF00069	0.747
MOD_PKA_1	354	360	PF00069	0.432
MOD_PKA_2	116	122	PF00069	0.701
MOD_PKA_2	154	160	PF00069	0.777
MOD_PKA_2	185	191	PF00069	0.688
MOD_PKA_2	354	360	PF00069	0.656
MOD_Plk_1	329	335	PF00069	0.370
MOD_Plk_1	407	413	PF00069	0.408
MOD_Plk_2-3	200	206	PF00069	0.667
MOD_Plk_4	116	122	PF00069	0.734
MOD_Plk_4	154	160	PF00069	0.824
MOD_Plk_4	185	191	PF00069	0.599
MOD_ProDKin_1	220	226	PF00069	0.668
MOD_ProDKin_1	233	239	PF00069	0.512
MOD_ProDKin_1	271	277	PF00069	0.656
MOD_ProDKin_1	322	328	PF00069	0.567
MOD_ProDKin_1	379	385	PF00069	0.577
MOD_ProDKin_1	451	457	PF00069	0.535
MOD_ProDKin_1	47	53	PF00069	0.516
MOD_ProDKin_1	74	80	PF00069	0.525
MOD_ProDKin_1	89	95	PF00069	0.530
MOD_SUMO_for_1	373	376	PF00179	0.513
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.521
TRG_ER_diArg_1	437	440	PF00400	0.650
TRG_NLS_MonoExtN_4	428	434	PF00514	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I846	Leptomonas seymouri	53%	100%
A0A3Q8ID30	Leishmania donovani	75%	100%
A4HXW8	Leishmania infantum	76%	100%
E9ARN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QDU7	Leishmania major	77%	100%