GPI mannosyltransferase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

gpi mannosyltransferase 2

Species:

Leishmania braziliensis

UniProt:

A4H9K3_LEIBR

TriTrypDb:

LbrM.18.1010 , LBRM2903_180015900

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	7
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0031501	mannosyltransferase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4H9K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9K3

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	7
GO:0006505	GPI anchor metabolic process	6	7
GO:0006506	GPI anchor biosynthetic process	6	7
GO:0006629	lipid metabolic process	3	7
GO:0006643	membrane lipid metabolic process	4	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006661	phosphatidylinositol biosynthetic process	6	7
GO:0006664	glycolipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009247	glycolipid biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019637	organophosphate metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046467	membrane lipid biosynthetic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1903509	liposaccharide metabolic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0000009	alpha-1,6-mannosyltransferase activity	6	7
GO:0000030	mannosyltransferase activity	5	7
GO:0003824	catalytic activity	1	7
GO:0004376	glycolipid mannosyltransferase activity	6	7
GO:0016740	transferase activity	2	7
GO:0016757	glycosyltransferase activity	3	7
GO:0016758	hexosyltransferase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.571
CLV_NRD_NRD_1	164	166	PF00675	0.276
CLV_NRD_NRD_1	259	261	PF00675	0.276
CLV_PCSK_FUR_1	257	261	PF00082	0.304
CLV_PCSK_KEX2_1	164	166	PF00082	0.276
CLV_PCSK_KEX2_1	187	189	PF00082	0.433
CLV_PCSK_KEX2_1	257	259	PF00082	0.340
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.436
CLV_PCSK_SKI1_1	164	168	PF00082	0.333
CLV_PCSK_SKI1_1	184	188	PF00082	0.434
CLV_PCSK_SKI1_1	373	377	PF00082	0.461
CLV_PCSK_SKI1_1	50	54	PF00082	0.393
CLV_PCSK_SKI1_1	511	515	PF00082	0.476
CLV_PCSK_SKI1_1	584	588	PF00082	0.266
DEG_APCC_DBOX_1	474	482	PF00400	0.633
DEG_APCC_DBOX_1	49	57	PF00400	0.314
DEG_ODPH_VHL_1	134	146	PF01847	0.238
DEG_SCF_FBW7_2	189	196	PF00400	0.723
DEG_SPOP_SBC_1	325	329	PF00917	0.624
DOC_CDC14_PxL_1	117	125	PF14671	0.314
DOC_CDC14_PxL_1	365	373	PF14671	0.601
DOC_CKS1_1	270	275	PF01111	0.314
DOC_CKS1_1	319	324	PF01111	0.605
DOC_CYCLIN_yCln2_LP_2	420	426	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	428	434	PF00134	0.308
DOC_CYCLIN_yCln2_LP_2	559	565	PF00134	0.314
DOC_MAPK_gen_1	164	171	PF00069	0.476
DOC_MAPK_gen_1	538	545	PF00069	0.316
DOC_MAPK_MEF2A_6	480	489	PF00069	0.488
DOC_PP2B_LxvP_1	235	238	PF13499	0.611
DOC_PP2B_LxvP_1	338	341	PF13499	0.734
DOC_PP2B_LxvP_1	428	431	PF13499	0.233
DOC_PP2B_LxvP_1	474	477	PF13499	0.657
DOC_PP2B_LxvP_1	559	562	PF13499	0.314
DOC_PP4_FxxP_1	171	174	PF00568	0.476
DOC_PP4_FxxP_1	68	71	PF00568	0.537
DOC_USP7_MATH_1	10	14	PF00917	0.288
DOC_USP7_MATH_1	377	381	PF00917	0.640
DOC_USP7_MATH_1	436	440	PF00917	0.609
DOC_USP7_MATH_1	443	447	PF00917	0.582
DOC_USP7_MATH_1	548	552	PF00917	0.224
DOC_USP7_MATH_1	71	75	PF00917	0.504
DOC_WW_Pin1_4	189	194	PF00397	0.761
DOC_WW_Pin1_4	269	274	PF00397	0.314
DOC_WW_Pin1_4	318	323	PF00397	0.667
DOC_WW_Pin1_4	373	378	PF00397	0.685
DOC_WW_Pin1_4	585	590	PF00397	0.440
LIG_14-3-3_CanoR_1	14	20	PF00244	0.272
LIG_14-3-3_CanoR_1	182	189	PF00244	0.673
LIG_14-3-3_CanoR_1	311	316	PF00244	0.664
LIG_14-3-3_CanoR_1	584	589	PF00244	0.475
LIG_14-3-3_CanoR_1	595	603	PF00244	0.403
LIG_14-3-3_CanoR_1	654	659	PF00244	0.418
LIG_14-3-3_CanoR_1	88	92	PF00244	0.533
LIG_Actin_WH2_2	569	586	PF00022	0.241
LIG_APCC_ABBA_1	279	284	PF00400	0.329
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BRCT_BRCA1_1	410	414	PF00533	0.276
LIG_BRCT_BRCA1_1	550	554	PF00533	0.224
LIG_BRCT_BRCA1_1	73	77	PF00533	0.503
LIG_CaM_NSCaTE_8	541	548	PF13499	0.333
LIG_DLG_GKlike_1	311	319	PF00625	0.621
LIG_FHA_1	129	135	PF00498	0.279
LIG_FHA_1	229	235	PF00498	0.645
LIG_FHA_1	276	282	PF00498	0.301
LIG_FHA_1	350	356	PF00498	0.669
LIG_FHA_1	38	44	PF00498	0.333
LIG_FHA_1	654	660	PF00498	0.421
LIG_FHA_2	231	237	PF00498	0.553
LIG_FHA_2	245	251	PF00498	0.581
LIG_FHA_2	318	324	PF00498	0.601
LIG_FHA_2	34	40	PF00498	0.375
LIG_FHA_2	77	83	PF00498	0.559
LIG_GBD_Chelix_1	158	166	PF00786	0.233
LIG_GBD_Chelix_1	397	405	PF00786	0.393
LIG_GBD_Chelix_1	48	56	PF00786	0.393
LIG_GBD_Chelix_1	617	625	PF00786	0.241
LIG_LIR_Apic_2	170	174	PF02991	0.476
LIG_LIR_Gen_1	198	209	PF02991	0.601
LIG_LIR_Gen_1	27	34	PF02991	0.343
LIG_LIR_Gen_1	284	295	PF02991	0.241
LIG_LIR_Gen_1	86	96	PF02991	0.476
LIG_LIR_Nem_3	27	31	PF02991	0.361
LIG_LIR_Nem_3	284	290	PF02991	0.241
LIG_LIR_Nem_3	291	296	PF02991	0.221
LIG_LIR_Nem_3	415	419	PF02991	0.299
LIG_LIR_Nem_3	544	549	PF02991	0.383
LIG_LIR_Nem_3	551	557	PF02991	0.315
LIG_LIR_Nem_3	86	92	PF02991	0.476
LIG_LYPXL_S_1	532	536	PF13949	0.476
LIG_LYPXL_yS_3	533	536	PF13949	0.276
LIG_MYND_1	472	476	PF01753	0.663
LIG_NRBOX	616	622	PF00104	0.289
LIG_NRBOX	642	648	PF00104	0.314
LIG_PCNA_PIPBox_1	309	318	PF02747	0.670
LIG_Pex14_1	387	391	PF04695	0.598
LIG_RPA_C_Fungi	254	266	PF08784	0.393
LIG_RPA_C_Fungi	9	21	PF08784	0.241
LIG_SH2_NCK_1	549	553	PF00017	0.241
LIG_SH2_PTP2	147	150	PF00017	0.393
LIG_SH2_SRC	84	87	PF00017	0.501
LIG_SH2_STAP1	282	286	PF00017	0.314
LIG_SH2_STAP1	434	438	PF00017	0.343
LIG_SH2_STAT3	434	437	PF00017	0.382
LIG_SH2_STAT5	108	111	PF00017	0.314
LIG_SH2_STAT5	147	150	PF00017	0.478
LIG_SH2_STAT5	282	285	PF00017	0.330
LIG_SH2_STAT5	296	299	PF00017	0.314
LIG_SH2_STAT5	315	318	PF00017	0.515
LIG_SH2_STAT5	33	36	PF00017	0.356
LIG_SH2_STAT5	501	504	PF00017	0.314
LIG_SH2_STAT5	506	509	PF00017	0.314
LIG_SH2_STAT5	549	552	PF00017	0.314
LIG_SH2_STAT5	575	578	PF00017	0.304
LIG_SH2_STAT6	508	512	PF00017	0.264
LIG_SH3_1	337	343	PF00018	0.666
LIG_SH3_3	112	118	PF00018	0.317
LIG_SH3_3	16	22	PF00018	0.428
LIG_SH3_3	267	273	PF00018	0.241
LIG_SH3_3	337	343	PF00018	0.666
LIG_SH3_3	363	369	PF00018	0.492
LIG_SH3_3	494	500	PF00018	0.403
LIG_SUMO_SIM_anti_2	660	666	PF11976	0.304
LIG_SUMO_SIM_par_1	120	126	PF11976	0.241
LIG_SUMO_SIM_par_1	244	250	PF11976	0.385
LIG_SUMO_SIM_par_1	277	285	PF11976	0.249
LIG_SUMO_SIM_par_1	488	493	PF11976	0.314
LIG_SUMO_SIM_par_1	561	567	PF11976	0.393
LIG_SxIP_EBH_1	362	371	PF03271	0.647
LIG_TRAF2_1	79	82	PF00917	0.422
LIG_TRFH_1	574	578	PF08558	0.241
LIG_WRC_WIRS_1	168	173	PF05994	0.314
MOD_CK1_1	195	201	PF00069	0.599
MOD_CK1_1	314	320	PF00069	0.506
MOD_CK1_1	35	41	PF00069	0.325
MOD_CK1_1	390	396	PF00069	0.241
MOD_CK1_1	408	414	PF00069	0.186
MOD_CK1_1	544	550	PF00069	0.393
MOD_CK1_1	657	663	PF00069	0.301
MOD_CK2_1	188	194	PF00069	0.690
MOD_CK2_1	213	219	PF00069	0.540
MOD_CK2_1	244	250	PF00069	0.508
MOD_CK2_1	390	396	PF00069	0.314
MOD_CK2_1	76	82	PF00069	0.433
MOD_GlcNHglycan	184	187	PF01048	0.529
MOD_GlcNHglycan	379	382	PF01048	0.512
MOD_GlcNHglycan	438	441	PF01048	0.532
MOD_GlcNHglycan	445	448	PF01048	0.474
MOD_GlcNHglycan	451	454	PF01048	0.458
MOD_GlcNHglycan	546	549	PF01048	0.393
MOD_GlcNHglycan	550	553	PF01048	0.351
MOD_GlcNHglycan	589	592	PF01048	0.254
MOD_GSK3_1	188	195	PF00069	0.607
MOD_GSK3_1	210	217	PF00069	0.654
MOD_GSK3_1	311	318	PF00069	0.683
MOD_GSK3_1	33	40	PF00069	0.454
MOD_GSK3_1	373	380	PF00069	0.607
MOD_GSK3_1	387	394	PF00069	0.506
MOD_GSK3_1	4	11	PF00069	0.248
MOD_GSK3_1	401	408	PF00069	0.302
MOD_GSK3_1	544	551	PF00069	0.353
MOD_GSK3_1	653	660	PF00069	0.305
MOD_N-GLC_1	151	156	PF02516	0.233
MOD_N-GLC_1	373	378	PF02516	0.503
MOD_N-GLC_1	517	522	PF02516	0.241
MOD_NEK2_1	15	20	PF00069	0.194
MOD_NEK2_1	230	235	PF00069	0.420
MOD_NEK2_1	275	280	PF00069	0.249
MOD_NEK2_1	4	9	PF00069	0.503
MOD_NEK2_1	401	406	PF00069	0.328
MOD_NEK2_1	449	454	PF00069	0.415
MOD_NEK2_1	57	62	PF00069	0.369
MOD_NEK2_1	608	613	PF00069	0.430
MOD_NEK2_1	623	628	PF00069	0.228
MOD_NEK2_1	646	651	PF00069	0.460
MOD_NEK2_2	282	287	PF00069	0.314
MOD_NEK2_2	288	293	PF00069	0.314
MOD_NEK2_2	541	546	PF00069	0.393
MOD_PIKK_1	594	600	PF00454	0.241
MOD_PIKK_1	646	652	PF00454	0.277
MOD_PKA_1	164	170	PF00069	0.393
MOD_PKA_1	187	193	PF00069	0.536
MOD_PKA_2	164	170	PF00069	0.393
MOD_PKA_2	187	193	PF00069	0.667
MOD_PKA_2	594	600	PF00069	0.304
MOD_PKA_2	609	615	PF00069	0.257
MOD_PKA_2	653	659	PF00069	0.314
MOD_PKA_2	87	93	PF00069	0.393
MOD_Plk_1	210	216	PF00069	0.549
MOD_Plk_1	218	224	PF00069	0.422
MOD_Plk_1	381	387	PF00069	0.463
MOD_Plk_4	15	21	PF00069	0.241
MOD_Plk_4	164	170	PF00069	0.327
MOD_Plk_4	230	236	PF00069	0.497
MOD_Plk_4	282	288	PF00069	0.320
MOD_Plk_4	311	317	PF00069	0.581
MOD_Plk_4	367	373	PF00069	0.706
MOD_Plk_4	387	393	PF00069	0.408
MOD_Plk_4	541	547	PF00069	0.314
MOD_Plk_4	564	570	PF00069	0.311
MOD_Plk_4	623	629	PF00069	0.393
MOD_Plk_4	654	660	PF00069	0.287
MOD_Plk_4	71	77	PF00069	0.416
MOD_ProDKin_1	189	195	PF00069	0.714
MOD_ProDKin_1	269	275	PF00069	0.314
MOD_ProDKin_1	318	324	PF00069	0.585
MOD_ProDKin_1	373	379	PF00069	0.604
MOD_ProDKin_1	585	591	PF00069	0.263
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.334
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.393
TRG_ENDOCYTIC_2	147	150	PF00928	0.314
TRG_ENDOCYTIC_2	201	204	PF00928	0.510
TRG_ENDOCYTIC_2	224	227	PF00928	0.403
TRG_ENDOCYTIC_2	23	26	PF00928	0.424
TRG_ENDOCYTIC_2	501	504	PF00928	0.314
TRG_ENDOCYTIC_2	509	512	PF00928	0.314
TRG_ENDOCYTIC_2	533	536	PF00928	0.314
TRG_ENDOCYTIC_2	644	647	PF00928	0.314
TRG_ER_diArg_1	163	165	PF00400	0.314
TRG_ER_diArg_1	256	259	PF00400	0.415
TRG_NES_CRM1_1	479	493	PF08389	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL0	Leptomonas seymouri	51%	99%
A0A3S7WV16	Leishmania donovani	75%	97%
A4HXW9	Leishmania infantum	75%	97%
E9ARN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QDU6	Leishmania major	74%	100%