Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9K1_LEIBR

TriTrypDb:

LbrM.18.0990 , LBRM2903_180015600

Length:

893

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.544
CLV_C14_Caspase3-7	208	212	PF00656	0.644
CLV_C14_Caspase3-7	467	471	PF00656	0.571
CLV_C14_Caspase3-7	614	618	PF00656	0.347
CLV_C14_Caspase3-7	90	94	PF00656	0.555
CLV_NRD_NRD_1	176	178	PF00675	0.590
CLV_NRD_NRD_1	282	284	PF00675	0.629
CLV_NRD_NRD_1	316	318	PF00675	0.670
CLV_NRD_NRD_1	48	50	PF00675	0.377
CLV_NRD_NRD_1	505	507	PF00675	0.678
CLV_NRD_NRD_1	685	687	PF00675	0.472
CLV_NRD_NRD_1	696	698	PF00675	0.619
CLV_NRD_NRD_1	73	75	PF00675	0.639
CLV_NRD_NRD_1	788	790	PF00675	0.739
CLV_NRD_NRD_1	889	891	PF00675	0.769
CLV_PCSK_FUR_1	503	507	PF00082	0.539
CLV_PCSK_KEX2_1	124	126	PF00082	0.635
CLV_PCSK_KEX2_1	264	266	PF00082	0.722
CLV_PCSK_KEX2_1	282	284	PF00082	0.585
CLV_PCSK_KEX2_1	316	318	PF00082	0.664
CLV_PCSK_KEX2_1	328	330	PF00082	0.649
CLV_PCSK_KEX2_1	48	50	PF00082	0.377
CLV_PCSK_KEX2_1	505	507	PF00082	0.556
CLV_PCSK_KEX2_1	696	698	PF00082	0.645
CLV_PCSK_KEX2_1	73	75	PF00082	0.639
CLV_PCSK_KEX2_1	788	790	PF00082	0.739
CLV_PCSK_KEX2_1	889	891	PF00082	0.769
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.537
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.722
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.581
CLV_PCSK_SKI1_1	177	181	PF00082	0.637
CLV_PCSK_SKI1_1	187	191	PF00082	0.611
CLV_PCSK_SKI1_1	261	265	PF00082	0.728
CLV_PCSK_SKI1_1	34	38	PF00082	0.572
CLV_PCSK_SKI1_1	525	529	PF00082	0.688
CLV_PCSK_SKI1_1	697	701	PF00082	0.523
CLV_PCSK_SKI1_1	754	758	PF00082	0.432
DEG_APCC_DBOX_1	656	664	PF00400	0.373
DEG_APCC_DBOX_1	696	704	PF00400	0.530
DEG_Nend_UBRbox_2	1	3	PF02207	0.594
DEG_SCF_FBW7_1	148	154	PF00400	0.561
DEG_SPOP_SBC_1	160	164	PF00917	0.609
DEG_SPOP_SBC_1	366	370	PF00917	0.579
DEG_SPOP_SBC_1	471	475	PF00917	0.555
DEG_SPOP_SBC_1	550	554	PF00917	0.632
DOC_CKS1_1	148	153	PF01111	0.560
DOC_CKS1_1	416	421	PF01111	0.548
DOC_CKS1_1	862	867	PF01111	0.578
DOC_MAPK_DCC_7	414	424	PF00069	0.555
DOC_MAPK_gen_1	264	272	PF00069	0.575
DOC_MAPK_gen_1	282	290	PF00069	0.596
DOC_MAPK_gen_1	390	400	PF00069	0.566
DOC_MAPK_gen_1	73	80	PF00069	0.637
DOC_MAPK_MEF2A_6	187	196	PF00069	0.625
DOC_MAPK_MEF2A_6	34	41	PF00069	0.675
DOC_MAPK_NFAT4_5	34	42	PF00069	0.592
DOC_PP1_RVXF_1	695	702	PF00149	0.373
DOC_PP1_RVXF_1	71	78	PF00149	0.462
DOC_PP2B_LxvP_1	290	293	PF13499	0.741
DOC_PP2B_LxvP_1	363	366	PF13499	0.569
DOC_PP4_FxxP_1	231	234	PF00568	0.733
DOC_USP7_MATH_1	151	155	PF00917	0.746
DOC_USP7_MATH_1	160	164	PF00917	0.699
DOC_USP7_MATH_1	185	189	PF00917	0.507
DOC_USP7_MATH_1	22	26	PF00917	0.488
DOC_USP7_MATH_1	366	370	PF00917	0.604
DOC_USP7_MATH_1	388	392	PF00917	0.625
DOC_USP7_MATH_1	4	8	PF00917	0.590
DOC_USP7_MATH_1	445	449	PF00917	0.684
DOC_USP7_MATH_1	491	495	PF00917	0.533
DOC_USP7_MATH_1	540	544	PF00917	0.562
DOC_USP7_MATH_1	550	554	PF00917	0.529
DOC_USP7_MATH_1	576	580	PF00917	0.521
DOC_USP7_MATH_1	591	595	PF00917	0.377
DOC_USP7_MATH_1	625	629	PF00917	0.485
DOC_USP7_MATH_1	672	676	PF00917	0.517
DOC_USP7_MATH_1	752	756	PF00917	0.486
DOC_USP7_MATH_2	429	435	PF00917	0.525
DOC_USP7_MATH_2	518	524	PF00917	0.526
DOC_USP7_UBL2_3	174	178	PF12436	0.562
DOC_USP7_UBL2_3	34	38	PF12436	0.572
DOC_USP7_UBL2_3	669	673	PF12436	0.359
DOC_WW_Pin1_4	147	152	PF00397	0.701
DOC_WW_Pin1_4	156	161	PF00397	0.582
DOC_WW_Pin1_4	288	293	PF00397	0.746
DOC_WW_Pin1_4	295	300	PF00397	0.673
DOC_WW_Pin1_4	380	385	PF00397	0.744
DOC_WW_Pin1_4	401	406	PF00397	0.670
DOC_WW_Pin1_4	415	420	PF00397	0.619
DOC_WW_Pin1_4	425	430	PF00397	0.586
DOC_WW_Pin1_4	514	519	PF00397	0.642
DOC_WW_Pin1_4	776	781	PF00397	0.710
DOC_WW_Pin1_4	809	814	PF00397	0.747
DOC_WW_Pin1_4	861	866	PF00397	0.584
LIG_14-3-3_CanoR_1	187	192	PF00244	0.471
LIG_14-3-3_CanoR_1	458	466	PF00244	0.606
LIG_14-3-3_CanoR_1	49	59	PF00244	0.377
LIG_14-3-3_CanoR_1	696	700	PF00244	0.440
LIG_14-3-3_CanoR_1	733	738	PF00244	0.511
LIG_14-3-3_CanoR_1	767	773	PF00244	0.627
LIG_14-3-3_CanoR_1	809	813	PF00244	0.597
LIG_14-3-3_CanoR_1	853	858	PF00244	0.630
LIG_14-3-3_CanoR_1	889	893	PF00244	0.726
LIG_Actin_WH2_2	23	40	PF00022	0.445
LIG_CaM_IQ_9	678	693	PF13499	0.462
LIG_FHA_1	115	121	PF00498	0.555
LIG_FHA_1	21	27	PF00498	0.542
LIG_FHA_1	225	231	PF00498	0.640
LIG_FHA_1	393	399	PF00498	0.566
LIG_FHA_1	416	422	PF00498	0.634
LIG_FHA_1	533	539	PF00498	0.683
LIG_FHA_1	61	67	PF00498	0.538
LIG_FHA_1	845	851	PF00498	0.727
LIG_FHA_2	515	521	PF00498	0.692
LIG_FHA_2	610	616	PF00498	0.516
LIG_FHA_2	660	666	PF00498	0.370
LIG_LIR_Apic_2	228	234	PF02991	0.569
LIG_LIR_Apic_2	802	808	PF02991	0.657
LIG_LIR_Gen_1	55	66	PF02991	0.552
LIG_LIR_Gen_1	712	722	PF02991	0.382
LIG_LIR_Gen_1	76	82	PF02991	0.496
LIG_LIR_Nem_3	55	61	PF02991	0.533
LIG_LIR_Nem_3	665	670	PF02991	0.458
LIG_LIR_Nem_3	712	717	PF02991	0.382
LIG_LIR_Nem_3	76	80	PF02991	0.485
LIG_MYND_1	309	313	PF01753	0.644
LIG_PDZ_Class_1	888	893	PF00595	0.714
LIG_Pex14_2	132	136	PF04695	0.623
LIG_PTAP_UEV_1	298	303	PF05743	0.734
LIG_SH2_CRK	714	718	PF00017	0.385
LIG_SH2_NCK_1	207	211	PF00017	0.582
LIG_SH2_NCK_1	845	849	PF00017	0.563
LIG_SH2_PTP2	58	61	PF00017	0.522
LIG_SH2_STAP1	670	674	PF00017	0.515
LIG_SH2_STAP1	845	849	PF00017	0.563
LIG_SH2_STAT3	728	731	PF00017	0.583
LIG_SH2_STAT3	763	766	PF00017	0.433
LIG_SH2_STAT5	31	34	PF00017	0.682
LIG_SH2_STAT5	58	61	PF00017	0.522
LIG_SH2_STAT5	857	860	PF00017	0.711
LIG_SH3_1	245	251	PF00018	0.538
LIG_SH3_1	414	420	PF00018	0.708
LIG_SH3_1	480	486	PF00018	0.540
LIG_SH3_2	248	253	PF14604	0.545
LIG_SH3_3	113	119	PF00018	0.798
LIG_SH3_3	245	251	PF00018	0.709
LIG_SH3_3	254	260	PF00018	0.736
LIG_SH3_3	290	296	PF00018	0.743
LIG_SH3_3	299	305	PF00018	0.636
LIG_SH3_3	413	419	PF00018	0.821
LIG_SH3_3	480	486	PF00018	0.698
LIG_SH3_3	56	62	PF00018	0.529
LIG_SH3_3	777	783	PF00018	0.692
LIG_SUMO_SIM_anti_2	188	193	PF11976	0.482
LIG_TRAF2_1	234	237	PF00917	0.713
LIG_TRAF2_1	384	387	PF00917	0.666
LIG_TRAF2_1	662	665	PF00917	0.494
LIG_UBA3_1	595	603	PF00899	0.357
LIG_WW_3	291	295	PF00397	0.741
MOD_CDC14_SPxK_1	291	294	PF00782	0.741
MOD_CDC14_SPxK_1	406	409	PF00782	0.727
MOD_CDK_SPK_2	292	297	PF00069	0.742
MOD_CDK_SPK_2	776	781	PF00069	0.710
MOD_CDK_SPxK_1	288	294	PF00069	0.749
MOD_CDK_SPxK_1	403	409	PF00069	0.722
MOD_CK1_1	130	136	PF00069	0.683
MOD_CK1_1	159	165	PF00069	0.592
MOD_CK1_1	168	174	PF00069	0.550
MOD_CK1_1	295	301	PF00069	0.744
MOD_CK1_1	319	325	PF00069	0.712
MOD_CK1_1	332	338	PF00069	0.581
MOD_CK1_1	472	478	PF00069	0.560
MOD_CK1_1	523	529	PF00069	0.530
MOD_CK1_1	554	560	PF00069	0.558
MOD_CK1_1	732	738	PF00069	0.502
MOD_CK2_1	141	147	PF00069	0.610
MOD_CK2_1	425	431	PF00069	0.542
MOD_CK2_1	514	520	PF00069	0.562
MOD_CK2_1	609	615	PF00069	0.517
MOD_CK2_1	625	631	PF00069	0.513
MOD_CK2_1	659	665	PF00069	0.372
MOD_Cter_Amidation	175	178	PF01082	0.593
MOD_Cter_Amidation	326	329	PF01082	0.681
MOD_DYRK1A_RPxSP_1	809	813	PF00069	0.573
MOD_GlcNHglycan	103	106	PF01048	0.760
MOD_GlcNHglycan	133	136	PF01048	0.625
MOD_GlcNHglycan	138	141	PF01048	0.576
MOD_GlcNHglycan	181	184	PF01048	0.617
MOD_GlcNHglycan	2	5	PF01048	0.784
MOD_GlcNHglycan	207	210	PF01048	0.634
MOD_GlcNHglycan	318	321	PF01048	0.703
MOD_GlcNHglycan	359	362	PF01048	0.563
MOD_GlcNHglycan	431	436	PF01048	0.549
MOD_GlcNHglycan	475	478	PF01048	0.704
MOD_GlcNHglycan	528	531	PF01048	0.549
MOD_GlcNHglycan	578	581	PF01048	0.537
MOD_GlcNHglycan	6	9	PF01048	0.790
MOD_GlcNHglycan	674	677	PF01048	0.517
MOD_GlcNHglycan	735	738	PF01048	0.595
MOD_GlcNHglycan	769	772	PF01048	0.758
MOD_GlcNHglycan	801	804	PF01048	0.569
MOD_GlcNHglycan	820	823	PF01048	0.704
MOD_GlcNHglycan	875	878	PF01048	0.602
MOD_GSK3_1	110	117	PF00069	0.773
MOD_GSK3_1	126	133	PF00069	0.617
MOD_GSK3_1	147	154	PF00069	0.719
MOD_GSK3_1	156	163	PF00069	0.700
MOD_GSK3_1	166	173	PF00069	0.608
MOD_GSK3_1	220	227	PF00069	0.611
MOD_GSK3_1	288	295	PF00069	0.748
MOD_GSK3_1	388	395	PF00069	0.674
MOD_GSK3_1	433	440	PF00069	0.616
MOD_GSK3_1	466	473	PF00069	0.645
MOD_GSK3_1	491	498	PF00069	0.532
MOD_GSK3_1	519	526	PF00069	0.527
MOD_GSK3_1	540	547	PF00069	0.538
MOD_GSK3_1	550	557	PF00069	0.531
MOD_GSK3_1	574	581	PF00069	0.386
MOD_GSK3_1	60	67	PF00069	0.573
MOD_GSK3_1	729	736	PF00069	0.527
MOD_GSK3_1	809	816	PF00069	0.673
MOD_GSK3_1	839	846	PF00069	0.766
MOD_GSK3_1	873	880	PF00069	0.666
MOD_N-GLC_1	388	393	PF02516	0.557
MOD_N-GLC_1	4	9	PF02516	0.705
MOD_N-GLC_1	453	458	PF02516	0.574
MOD_N-GLC_1	532	537	PF02516	0.584
MOD_N-GLC_1	843	848	PF02516	0.575
MOD_NEK2_1	131	136	PF00069	0.693
MOD_NEK2_1	41	46	PF00069	0.631
MOD_NEK2_1	424	429	PF00069	0.623
MOD_NEK2_1	585	590	PF00069	0.522
MOD_NEK2_1	609	614	PF00069	0.518
MOD_NEK2_1	681	686	PF00069	0.373
MOD_NEK2_2	119	124	PF00069	0.551
MOD_NEK2_2	445	450	PF00069	0.687
MOD_NEK2_2	752	757	PF00069	0.481
MOD_PIKK_1	134	140	PF00454	0.536
MOD_PIKK_1	388	394	PF00454	0.568
MOD_PIKK_1	458	464	PF00454	0.665
MOD_PIKK_1	491	497	PF00454	0.553
MOD_PIKK_1	532	538	PF00454	0.615
MOD_PIKK_1	574	580	PF00454	0.387
MOD_PIKK_1	625	631	PF00454	0.513
MOD_PIKK_1	848	854	PF00454	0.558
MOD_PK_1	433	439	PF00069	0.525
MOD_PKA_1	316	322	PF00069	0.661
MOD_PKA_1	505	511	PF00069	0.534
MOD_PKA_2	316	322	PF00069	0.668
MOD_PKA_2	332	338	PF00069	0.653
MOD_PKA_2	392	398	PF00069	0.623
MOD_PKA_2	505	511	PF00069	0.655
MOD_PKA_2	695	701	PF00069	0.488
MOD_PKA_2	732	738	PF00069	0.591
MOD_PKA_2	766	772	PF00069	0.631
MOD_PKA_2	808	814	PF00069	0.595
MOD_PKB_1	503	511	PF00069	0.538
MOD_Plk_1	185	191	PF00069	0.502
MOD_Plk_1	220	226	PF00069	0.515
MOD_Plk_1	506	512	PF00069	0.532
MOD_Plk_1	792	798	PF00069	0.573
MOD_Plk_2-3	659	665	PF00069	0.372
MOD_Plk_4	127	133	PF00069	0.666
MOD_Plk_4	187	193	PF00069	0.690
MOD_Plk_4	22	28	PF00069	0.508
MOD_Plk_4	433	439	PF00069	0.525
MOD_Plk_4	541	547	PF00069	0.538
MOD_Plk_4	551	557	PF00069	0.556
MOD_Plk_4	591	597	PF00069	0.517
MOD_ProDKin_1	147	153	PF00069	0.702
MOD_ProDKin_1	156	162	PF00069	0.582
MOD_ProDKin_1	288	294	PF00069	0.749
MOD_ProDKin_1	295	301	PF00069	0.672
MOD_ProDKin_1	380	386	PF00069	0.747
MOD_ProDKin_1	401	407	PF00069	0.669
MOD_ProDKin_1	415	421	PF00069	0.550
MOD_ProDKin_1	425	431	PF00069	0.585
MOD_ProDKin_1	514	520	PF00069	0.641
MOD_ProDKin_1	776	782	PF00069	0.711
MOD_ProDKin_1	809	815	PF00069	0.748
MOD_ProDKin_1	861	867	PF00069	0.580
MOD_SUMO_for_1	123	126	PF00179	0.542
MOD_SUMO_for_1	263	266	PF00179	0.665
MOD_SUMO_rev_2	665	675	PF00179	0.360
TRG_DiLeu_BaEn_1	695	700	PF01217	0.529
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.613
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.549
TRG_DiLeu_BaLyEn_6	821	826	PF01217	0.573
TRG_ENDOCYTIC_2	207	210	PF00928	0.634
TRG_ENDOCYTIC_2	58	61	PF00928	0.522
TRG_ENDOCYTIC_2	714	717	PF00928	0.387
TRG_ER_diArg_1	47	49	PF00400	0.417
TRG_ER_diArg_1	502	505	PF00400	0.573
TRG_ER_diArg_1	633	636	PF00400	0.420
TRG_ER_diArg_1	72	74	PF00400	0.623
TRG_NLS_Bipartite_1	316	332	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	635	640	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	697	702	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	824	829	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUY5	Leishmania donovani	54%	99%
A4HXW6	Leishmania infantum	54%	99%
E9ARN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q4QDU9	Leishmania major	52%	97%