Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-related protein 2/3 complex subunit 1, putative

Species:

Leishmania braziliensis

UniProt:

A4H9K0_LEIBR

TriTrypDb:

LbrM.18.0980 , LBRM2903_180015500

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005885	Arp2/3 protein complex	2	9
GO:0032991	protein-containing complex	1	9

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Expansion

Sequence features

A4H9K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9K0

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007015	actin filament organization	5	9
GO:0008064	regulation of actin polymerization or depolymerization	6	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0030029	actin filament-based process	2	1
GO:0030036	actin cytoskeleton organization	3	1
GO:0030832	regulation of actin filament length	5	9
GO:0030833	regulation of actin filament polymerization	7	9

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Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	9
GO:0005198	structural molecule activity	1	1
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0008092	cytoskeletal protein binding	3	9
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	446	450	PF00656	0.556
CLV_C14_Caspase3-7	526	530	PF00656	0.523
CLV_NRD_NRD_1	47	49	PF00675	0.543
CLV_PCSK_KEX2_1	47	49	PF00082	0.543
DEG_SPOP_SBC_1	479	483	PF00917	0.589
DOC_CDC14_PxL_1	174	182	PF14671	0.468
DOC_CDC14_PxL_1	384	392	PF14671	0.409
DOC_USP7_MATH_1	11	15	PF00917	0.602
DOC_USP7_MATH_1	351	355	PF00917	0.577
DOC_USP7_MATH_1	411	415	PF00917	0.566

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H8	Leptomonas seymouri	40%	97%
A0A1X0P764	Trypanosomatidae	28%	100%
A0A3Q8IA03	Leishmania donovani	60%	91%
A4HXW5	Leishmania infantum	60%	91%
C9ZZT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ARM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	91%
Q4QDV0	Leishmania major	70%	100%

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