Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-related protein 2/3 complex subunit 1, putative

Species:

Leishmania braziliensis

UniProt:

A4H9K0_LEIBR

TriTrypDb:

LbrM.18.0980 , LBRM2903_180015500

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005885	Arp2/3 protein complex	2	9
GO:0032991	protein-containing complex	1	9

Expansion

Sequence features

A4H9K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9K0

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	9
GO:0008064	regulation of actin polymerization or depolymerization	6	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0030832	regulation of actin filament length	5	9
GO:0030833	regulation of actin filament polymerization	7	9
GO:0032271	regulation of protein polymerization	6	9
GO:0032535	regulation of cellular component size	4	9
GO:0032956	regulation of actin cytoskeleton organization	5	9
GO:0032970	regulation of actin filament-based process	4	9
GO:0033043	regulation of organelle organization	5	9
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	9
GO:0043254	regulation of protein-containing complex assembly	5	9
GO:0044087	regulation of cellular component biogenesis	4	9
GO:0045010	actin nucleation	6	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0051128	regulation of cellular component organization	4	9
GO:0051493	regulation of cytoskeleton organization	6	9
GO:0065007	biological regulation	1	9
GO:0065008	regulation of biological quality	2	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0090066	regulation of anatomical structure size	3	9
GO:0097435	supramolecular fiber organization	4	9
GO:0110053	regulation of actin filament organization	6	9
GO:1902903	regulation of supramolecular fiber organization	5	9
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0030029	actin filament-based process	2	1
GO:0030036	actin cytoskeleton organization	3	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	9
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0008092	cytoskeletal protein binding	3	9
GO:0005198	structural molecule activity	1	1
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	446	450	PF00656	0.556
CLV_C14_Caspase3-7	526	530	PF00656	0.523
CLV_NRD_NRD_1	47	49	PF00675	0.543
CLV_PCSK_KEX2_1	47	49	PF00082	0.543
DEG_SPOP_SBC_1	479	483	PF00917	0.589
DOC_CDC14_PxL_1	174	182	PF14671	0.468
DOC_CDC14_PxL_1	384	392	PF14671	0.409
DOC_USP7_MATH_1	11	15	PF00917	0.602
DOC_USP7_MATH_1	351	355	PF00917	0.577
DOC_USP7_MATH_1	411	415	PF00917	0.566
DOC_USP7_MATH_1	448	452	PF00917	0.635
DOC_USP7_MATH_1	480	484	PF00917	0.617
DOC_USP7_MATH_1	494	498	PF00917	0.523
DOC_WW_Pin1_4	161	166	PF00397	0.621
DOC_WW_Pin1_4	24	29	PF00397	0.625
DOC_WW_Pin1_4	243	248	PF00397	0.568
DOC_WW_Pin1_4	305	310	PF00397	0.369
DOC_WW_Pin1_4	326	331	PF00397	0.328
DOC_WW_Pin1_4	352	357	PF00397	0.528
DOC_WW_Pin1_4	504	509	PF00397	0.696
LIG_14-3-3_CanoR_1	22	30	PF00244	0.501
LIG_14-3-3_CanoR_1	251	256	PF00244	0.547
LIG_14-3-3_CanoR_1	424	430	PF00244	0.502
LIG_14-3-3_CanoR_1	474	480	PF00244	0.666
LIG_14-3-3_CanoR_1	506	512	PF00244	0.573
LIG_CaM_IQ_9	416	432	PF13499	0.393
LIG_CSL_BTD_1	130	133	PF09270	0.432
LIG_CSL_BTD_1	327	330	PF09270	0.358
LIG_FHA_1	114	120	PF00498	0.391
LIG_FHA_1	149	155	PF00498	0.511
LIG_FHA_1	209	215	PF00498	0.408
LIG_FHA_1	274	280	PF00498	0.423
LIG_FHA_1	436	442	PF00498	0.681
LIG_FHA_1	457	463	PF00498	0.799
LIG_FHA_1	508	514	PF00498	0.588
LIG_FHA_1	77	83	PF00498	0.615
LIG_FHA_2	120	126	PF00498	0.444
LIG_FHA_2	153	159	PF00498	0.532
LIG_Integrin_RGD_1	467	469	PF01839	0.534
LIG_LIR_Apic_2	78	83	PF02991	0.477
LIG_LIR_Gen_1	171	182	PF02991	0.407
LIG_LIR_Gen_1	308	318	PF02991	0.263
LIG_LIR_Gen_1	91	99	PF02991	0.343
LIG_LIR_Nem_3	171	177	PF02991	0.490
LIG_LIR_Nem_3	308	313	PF02991	0.263
LIG_LIR_Nem_3	428	432	PF02991	0.394
LIG_LIR_Nem_3	91	96	PF02991	0.356
LIG_SH2_PTP2	312	315	PF00017	0.255
LIG_SH2_STAT5	204	207	PF00017	0.322
LIG_SH2_STAT5	312	315	PF00017	0.364
LIG_SH3_1	558	564	PF00018	0.671
LIG_SH3_2	561	566	PF14604	0.547
LIG_SH3_3	127	133	PF00018	0.420
LIG_SH3_3	350	356	PF00018	0.495
LIG_SH3_3	514	520	PF00018	0.613
LIG_SH3_3	537	543	PF00018	0.441
LIG_SH3_3	557	563	PF00018	0.653
LIG_SUMO_SIM_anti_2	510	517	PF11976	0.587
LIG_UBA3_1	515	524	PF00899	0.598
MOD_CDC14_SPxK_1	248	251	PF00782	0.429
MOD_CDK_SPxK_1	245	251	PF00069	0.441
MOD_CK1_1	16	22	PF00069	0.658
MOD_CK1_1	166	172	PF00069	0.477
MOD_CK1_1	208	214	PF00069	0.472
MOD_CK1_1	286	292	PF00069	0.521
MOD_CK1_1	425	431	PF00069	0.395
MOD_CK1_1	456	462	PF00069	0.598
MOD_CK1_1	478	484	PF00069	0.629
MOD_CK1_1	5	11	PF00069	0.636
MOD_CK1_1	507	513	PF00069	0.637
MOD_CK1_1	78	84	PF00069	0.623
MOD_CK1_1	91	97	PF00069	0.454
MOD_CK2_1	144	150	PF00069	0.525
MOD_CK2_1	152	158	PF00069	0.520
MOD_GlcNHglycan	122	125	PF01048	0.420
MOD_GlcNHglycan	15	18	PF01048	0.602
MOD_GlcNHglycan	168	171	PF01048	0.642
MOD_GlcNHglycan	183	186	PF01048	0.426
MOD_GlcNHglycan	196	199	PF01048	0.364
MOD_GlcNHglycan	207	210	PF01048	0.395
MOD_GlcNHglycan	239	243	PF01048	0.567
MOD_GlcNHglycan	24	27	PF01048	0.513
MOD_GlcNHglycan	288	291	PF01048	0.625
MOD_GlcNHglycan	301	304	PF01048	0.540
MOD_GlcNHglycan	330	333	PF01048	0.399
MOD_GlcNHglycan	341	344	PF01048	0.411
MOD_GlcNHglycan	366	370	PF01048	0.728
MOD_GlcNHglycan	413	416	PF01048	0.455
MOD_GlcNHglycan	445	448	PF01048	0.725
MOD_GlcNHglycan	449	453	PF01048	0.706
MOD_GlcNHglycan	477	480	PF01048	0.617
MOD_GlcNHglycan	497	500	PF01048	0.535
MOD_GlcNHglycan	536	539	PF01048	0.681
MOD_GlcNHglycan	71	74	PF01048	0.545
MOD_GlcNHglycan	99	102	PF01048	0.346
MOD_GSK3_1	144	151	PF00069	0.510
MOD_GSK3_1	194	201	PF00069	0.433
MOD_GSK3_1	204	211	PF00069	0.553
MOD_GSK3_1	243	250	PF00069	0.566
MOD_GSK3_1	279	286	PF00069	0.554
MOD_GSK3_1	33	40	PF00069	0.532
MOD_GSK3_1	365	372	PF00069	0.732
MOD_GSK3_1	411	418	PF00069	0.607
MOD_GSK3_1	474	481	PF00069	0.756
MOD_GSK3_1	504	511	PF00069	0.703
MOD_GSK3_1	519	526	PF00069	0.730
MOD_GSK3_1	527	534	PF00069	0.517
MOD_GSK3_1	550	557	PF00069	0.581
MOD_GSK3_1	7	14	PF00069	0.654
MOD_GSK3_1	78	85	PF00069	0.606
MOD_N-GLC_1	69	74	PF02516	0.393
MOD_NEK2_1	119	124	PF00069	0.389
MOD_NEK2_1	144	149	PF00069	0.511
MOD_NEK2_1	273	278	PF00069	0.442
MOD_NEK2_1	462	467	PF00069	0.542
MOD_NEK2_1	531	536	PF00069	0.593
MOD_PIKK_1	416	422	PF00454	0.455
MOD_PIKK_1	435	441	PF00454	0.560
MOD_PIKK_1	88	94	PF00454	0.359
MOD_PK_1	163	169	PF00069	0.472
MOD_PK_1	251	257	PF00069	0.433
MOD_PKA_2	232	238	PF00069	0.605
MOD_PKA_2	360	366	PF00069	0.767
MOD_Plk_1	531	537	PF00069	0.580
MOD_Plk_2-3	393	399	PF00069	0.407
MOD_Plk_4	163	169	PF00069	0.486
MOD_Plk_4	37	43	PF00069	0.525
MOD_Plk_4	531	537	PF00069	0.580
MOD_ProDKin_1	161	167	PF00069	0.620
MOD_ProDKin_1	24	30	PF00069	0.610
MOD_ProDKin_1	243	249	PF00069	0.566
MOD_ProDKin_1	305	311	PF00069	0.353
MOD_ProDKin_1	326	332	PF00069	0.328
MOD_ProDKin_1	352	358	PF00069	0.528
MOD_ProDKin_1	504	510	PF00069	0.687
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.385
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.420
TRG_ENDOCYTIC_2	312	315	PF00928	0.269
TRG_ER_diArg_1	46	48	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H8	Leptomonas seymouri	40%	97%
A0A1X0P764	Trypanosomatidae	28%	100%
A0A3Q8IA03	Leishmania donovani	60%	91%
A4HXW5	Leishmania infantum	60%	91%
C9ZZT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ARM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	91%
Q4QDV0	Leishmania major	70%	100%